LeishMANIAdb
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Barwin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Barwin domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AVB7_LEIMU
TriTrypDb:
LmxM.21.1320
Length:
161

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 6, no: 4
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AVB7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVB7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 10 12 PF00675 0.738
CLV_NRD_NRD_1 93 95 PF00675 0.574
CLV_PCSK_KEX2_1 10 12 PF00082 0.738
CLV_PCSK_KEX2_1 92 94 PF00082 0.586
CLV_PCSK_SKI1_1 102 106 PF00082 0.598
CLV_PCSK_SKI1_1 117 121 PF00082 0.369
DEG_APCC_DBOX_1 131 139 PF00400 0.456
DOC_USP7_MATH_1 22 26 PF00917 0.512
DOC_WW_Pin1_4 42 47 PF00397 0.466
LIG_14-3-3_CanoR_1 23 33 PF00244 0.454
LIG_14-3-3_CanoR_1 5 9 PF00244 0.730
LIG_APCC_ABBA_1 118 123 PF00400 0.559
LIG_APCC_ABBAyCdc20_2 117 123 PF00400 0.544
LIG_BRCT_BRCA1_1 150 154 PF00533 0.596
LIG_FHA_2 94 100 PF00498 0.512
LIG_GBD_Chelix_1 34 42 PF00786 0.569
LIG_LIR_Gen_1 151 158 PF02991 0.523
LIG_LIR_Nem_3 143 149 PF02991 0.502
LIG_LIR_Nem_3 151 157 PF02991 0.464
LIG_WRC_WIRS_1 105 110 PF05994 0.488
MOD_CK1_1 133 139 PF00069 0.609
MOD_CK1_1 24 30 PF00069 0.720
MOD_CK2_1 104 110 PF00069 0.542
MOD_CK2_1 137 143 PF00069 0.548
MOD_GlcNHglycan 134 138 PF01048 0.572
MOD_GlcNHglycan 150 153 PF01048 0.515
MOD_GlcNHglycan 87 90 PF01048 0.588
MOD_GSK3_1 121 128 PF00069 0.612
MOD_GSK3_1 133 140 PF00069 0.547
MOD_GSK3_1 21 28 PF00069 0.711
MOD_PK_1 125 131 PF00069 0.546
MOD_PKA_1 93 99 PF00069 0.546
MOD_PKA_2 22 28 PF00069 0.517
MOD_PKA_2 4 10 PF00069 0.690
MOD_PKA_2 93 99 PF00069 0.539
MOD_Plk_4 104 110 PF00069 0.570
MOD_Plk_4 125 131 PF00069 0.524
MOD_Plk_4 4 10 PF00069 0.669
MOD_Plk_4 59 65 PF00069 0.494
MOD_ProDKin_1 42 48 PF00069 0.466
TRG_DiLeu_BaEn_1 114 119 PF01217 0.517
TRG_ER_diArg_1 9 11 PF00400 0.729
TRG_ER_diArg_1 92 94 PF00400 0.638

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HSR8 Leptomonas seymouri 61% 100%
A0A0S4JJA7 Bodo saltans 44% 100%
A0A1X0NXY8 Trypanosomatidae 38% 100%
A0A3R7KIY1 Trypanosoma rangeli 45% 100%
A0A3S7WWM3 Leishmania donovani 87% 100%
A4HBY8 Leishmania braziliensis 66% 100%
A4HZD0 Leishmania infantum 87% 100%
D0A154 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
Q4QC63 Leishmania major 83% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS