Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVB6_LEIMU

TriTrypDb:

LmxM.21.1310

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVB6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016491	oxidoreductase activity	2	3
GO:0051213	dioxygenase activity	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	206	208	PF00675	0.444
CLV_NRD_NRD_1	321	323	PF00675	0.535
CLV_PCSK_KEX2_1	321	323	PF00082	0.425
CLV_PCSK_SKI1_1	134	138	PF00082	0.388
CLV_PCSK_SKI1_1	172	176	PF00082	0.350
CLV_PCSK_SKI1_1	20	24	PF00082	0.480
DEG_Nend_UBRbox_1	1	4	PF02207	0.546
DOC_CKS1_1	188	193	PF01111	0.353
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.236
DOC_MAPK_gen_1	169	178	PF00069	0.344
DOC_PP2B_LxvP_1	109	112	PF13499	0.545
DOC_PP2B_LxvP_1	151	154	PF13499	0.372
DOC_PP4_FxxP_1	160	163	PF00568	0.440
DOC_PP4_FxxP_1	37	40	PF00568	0.507
DOC_USP7_MATH_1	100	104	PF00917	0.391
DOC_USP7_MATH_1	154	158	PF00917	0.468
DOC_USP7_MATH_1	256	260	PF00917	0.364
DOC_WW_Pin1_4	181	186	PF00397	0.346
DOC_WW_Pin1_4	187	192	PF00397	0.339
DOC_WW_Pin1_4	231	236	PF00397	0.484
LIG_14-3-3_CanoR_1	195	203	PF00244	0.421
LIG_14-3-3_CanoR_1	207	211	PF00244	0.297
LIG_BRCT_BRCA1_1	156	160	PF00533	0.483
LIG_EH_1	254	258	PF12763	0.335
LIG_eIF4E_2	38	44	PF01652	0.370
LIG_FHA_1	115	121	PF00498	0.451
LIG_FHA_1	146	152	PF00498	0.449
LIG_FHA_1	188	194	PF00498	0.353
LIG_FHA_1	23	29	PF00498	0.508
LIG_FHA_2	347	353	PF00498	0.581
LIG_FHA_2	79	85	PF00498	0.432
LIG_Integrin_RGD_1	221	223	PF01839	0.446
LIG_LIR_Apic_2	157	163	PF02991	0.434
LIG_LIR_Apic_2	35	41	PF02991	0.382
LIG_LIR_Gen_1	201	210	PF02991	0.364
LIG_LIR_Gen_1	50	60	PF02991	0.329
LIG_LIR_Nem_3	201	206	PF02991	0.371
LIG_LIR_Nem_3	338	342	PF02991	0.436
LIG_LIR_Nem_3	50	55	PF02991	0.313
LIG_PDZ_Class_1	353	358	PF00595	0.515
LIG_SH2_CRK	203	207	PF00017	0.369
LIG_SH2_CRK	38	42	PF00017	0.382
LIG_SH2_SRC	38	41	PF00017	0.412
LIG_SH2_STAT3	273	276	PF00017	0.452
LIG_SH2_STAT5	226	229	PF00017	0.374
LIG_SH2_STAT5	273	276	PF00017	0.332
LIG_SH2_STAT5	52	55	PF00017	0.308
LIG_SH3_3	26	32	PF00018	0.421
LIG_SH3_3	96	102	PF00018	0.441
LIG_SUMO_SIM_anti_2	171	177	PF11976	0.328
LIG_SUMO_SIM_par_1	190	197	PF11976	0.473
LIG_WRC_WIRS_1	275	280	PF05994	0.343
MOD_CDK_SPxxK_3	231	238	PF00069	0.484
MOD_CK1_1	125	131	PF00069	0.423
MOD_CK1_1	196	202	PF00069	0.386
MOD_CK1_1	277	283	PF00069	0.347
MOD_CK2_1	102	108	PF00069	0.533
MOD_CK2_1	257	263	PF00069	0.359
MOD_CK2_1	328	334	PF00069	0.396
MOD_CK2_1	346	352	PF00069	0.551
MOD_CK2_1	78	84	PF00069	0.390
MOD_GlcNHglycan	104	107	PF01048	0.580
MOD_GlcNHglycan	124	127	PF01048	0.410
MOD_GlcNHglycan	259	262	PF01048	0.447
MOD_GSK3_1	125	132	PF00069	0.462
MOD_GSK3_1	137	144	PF00069	0.306
MOD_GSK3_1	239	246	PF00069	0.540
MOD_GSK3_1	267	274	PF00069	0.443
MOD_GSK3_1	346	353	PF00069	0.635
MOD_N-GLC_1	280	285	PF02516	0.338
MOD_NEK2_1	137	142	PF00069	0.451
MOD_NEK2_1	193	198	PF00069	0.422
MOD_NEK2_1	206	211	PF00069	0.299
MOD_NEK2_1	257	262	PF00069	0.356
MOD_NEK2_1	267	272	PF00069	0.308
MOD_NEK2_1	308	313	PF00069	0.300
MOD_NEK2_1	350	355	PF00069	0.542
MOD_NEK2_1	55	60	PF00069	0.479
MOD_PIKK_1	70	76	PF00454	0.469
MOD_PK_1	161	167	PF00069	0.322
MOD_PKA_2	168	174	PF00069	0.354
MOD_PKA_2	194	200	PF00069	0.398
MOD_PKA_2	206	212	PF00069	0.306
MOD_Plk_4	125	131	PF00069	0.399
MOD_Plk_4	161	167	PF00069	0.338
MOD_Plk_4	246	252	PF00069	0.549
MOD_Plk_4	268	274	PF00069	0.332
MOD_Plk_4	323	329	PF00069	0.465
MOD_ProDKin_1	181	187	PF00069	0.353
MOD_ProDKin_1	231	237	PF00069	0.482
MOD_SUMO_for_1	335	338	PF00179	0.522
MOD_SUMO_rev_2	351	356	PF00179	0.507
TRG_DiLeu_BaEn_1	263	268	PF01217	0.427
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.427
TRG_DiLeu_LyEn_5	26	31	PF01217	0.415
TRG_ENDOCYTIC_2	203	206	PF00928	0.388
TRG_ENDOCYTIC_2	52	55	PF00928	0.308
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBK0	Leptomonas seymouri	82%	99%
A0A0S4JR98	Bodo saltans	51%	100%
A0A1X0NXW7	Trypanosomatidae	62%	100%
A0A3S7WWQ0	Leishmania donovani	95%	100%
A0A422NSQ3	Trypanosoma rangeli	60%	100%
A4HZC9	Leishmania infantum	94%	100%
D0A155	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AIQ4	Leishmania braziliensis	88%	100%
Q4QC64	Leishmania major	95%	100%
V5BRD2	Trypanosoma cruzi	64%	100%