RF_PROK_I domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RF-1 domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVB5_LEIMU

TriTrypDb:

LmxM.21.1300

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVB5

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003747	translation release factor activity	5	11
GO:0005488	binding	1	11
GO:0008079	translation termination factor activity	4	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.626
CLV_C14_Caspase3-7	490	494	PF00656	0.484
CLV_C14_Caspase3-7	563	567	PF00656	0.530
CLV_NRD_NRD_1	117	119	PF00675	0.737
CLV_NRD_NRD_1	138	140	PF00675	0.588
CLV_NRD_NRD_1	249	251	PF00675	0.519
CLV_NRD_NRD_1	257	259	PF00675	0.504
CLV_NRD_NRD_1	338	340	PF00675	0.431
CLV_NRD_NRD_1	512	514	PF00675	0.284
CLV_NRD_NRD_1	88	90	PF00675	0.747
CLV_PCSK_FUR_1	254	258	PF00082	0.530
CLV_PCSK_KEX2_1	101	103	PF00082	0.745
CLV_PCSK_KEX2_1	256	258	PF00082	0.516
CLV_PCSK_KEX2_1	338	340	PF00082	0.431
CLV_PCSK_KEX2_1	449	451	PF00082	0.523
CLV_PCSK_KEX2_1	512	514	PF00082	0.284
CLV_PCSK_KEX2_1	88	90	PF00082	0.747
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.705
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.523
CLV_PCSK_SKI1_1	162	166	PF00082	0.585
CLV_PCSK_SKI1_1	174	178	PF00082	0.598
CLV_PCSK_SKI1_1	446	450	PF00082	0.494
CLV_PCSK_SKI1_1	495	499	PF00082	0.276
CLV_PCSK_SKI1_1	560	564	PF00082	0.412
CLV_PCSK_SKI1_1	89	93	PF00082	0.715
DEG_APCC_DBOX_1	171	179	PF00400	0.475
DEG_Nend_UBRbox_3	1	3	PF02207	0.642
DEG_SPOP_SBC_1	220	224	PF00917	0.651
DEG_SPOP_SBC_1	226	230	PF00917	0.684
DEG_SPOP_SBC_1	60	64	PF00917	0.696
DOC_ANK_TNKS_1	458	465	PF00023	0.476
DOC_CYCLIN_RxL_1	507	519	PF00134	0.525
DOC_MAPK_gen_1	174	184	PF00069	0.476
DOC_MAPK_gen_1	254	264	PF00069	0.488
DOC_MAPK_MEF2A_6	256	264	PF00069	0.482
DOC_MAPK_RevD_3	124	140	PF00069	0.555
DOC_PP1_RVXF_1	510	517	PF00149	0.525
DOC_USP7_MATH_1	219	223	PF00917	0.661
DOC_USP7_MATH_1	244	248	PF00917	0.593
DOC_USP7_MATH_1	290	294	PF00917	0.570
DOC_USP7_MATH_1	394	398	PF00917	0.610
DOC_USP7_MATH_1	438	442	PF00917	0.407
DOC_USP7_MATH_1	458	462	PF00917	0.481
DOC_USP7_MATH_1	491	495	PF00917	0.487
DOC_USP7_MATH_1	70	74	PF00917	0.757
DOC_USP7_MATH_1	79	83	PF00917	0.705
DOC_USP7_MATH_1	95	99	PF00917	0.606
DOC_USP7_UBL2_3	25	29	PF12436	0.583
DOC_WW_Pin1_4	423	428	PF00397	0.717
DOC_WW_Pin1_4	56	61	PF00397	0.678
DOC_WW_Pin1_4	83	88	PF00397	0.754
LIG_14-3-3_CanoR_1	273	283	PF00244	0.611
LIG_14-3-3_CanoR_1	383	393	PF00244	0.579
LIG_14-3-3_CanoR_1	450	454	PF00244	0.448
LIG_Actin_WH2_2	178	195	PF00022	0.615
LIG_BIR_III_2	391	395	PF00653	0.591
LIG_CaM_IQ_9	154	169	PF13499	0.545
LIG_FHA_1	39	45	PF00498	0.679
LIG_FHA_1	524	530	PF00498	0.419
LIG_FHA_1	556	562	PF00498	0.544
LIG_FHA_2	163	169	PF00498	0.582
LIG_FHA_2	561	567	PF00498	0.402
LIG_LIR_Gen_1	127	136	PF02991	0.466
LIG_LIR_Gen_1	228	238	PF02991	0.692
LIG_LIR_Gen_1	301	311	PF02991	0.461
LIG_LIR_Gen_1	348	356	PF02991	0.500
LIG_LIR_Gen_1	365	374	PF02991	0.466
LIG_LIR_Gen_1	473	484	PF02991	0.562
LIG_LIR_Nem_3	127	133	PF02991	0.467
LIG_LIR_Nem_3	145	150	PF02991	0.468
LIG_LIR_Nem_3	228	234	PF02991	0.677
LIG_LIR_Nem_3	301	307	PF02991	0.468
LIG_LIR_Nem_3	348	353	PF02991	0.514
LIG_LIR_Nem_3	365	370	PF02991	0.477
LIG_LIR_Nem_3	473	479	PF02991	0.562
LIG_Pex14_2	402	406	PF04695	0.438
LIG_PTB_Apo_2	366	373	PF02174	0.259
LIG_SH2_CRK	231	235	PF00017	0.522
LIG_SH2_CRK	350	354	PF00017	0.387
LIG_SH2_CRK	476	480	PF00017	0.562
LIG_SH2_PTP2	333	336	PF00017	0.529
LIG_SH2_STAP1	350	354	PF00017	0.403
LIG_SH2_STAP1	404	408	PF00017	0.456
LIG_SH2_STAP1	476	480	PF00017	0.576
LIG_SH2_STAP1	487	491	PF00017	0.545
LIG_SH2_STAT3	148	151	PF00017	0.533
LIG_SH2_STAT5	333	336	PF00017	0.486
LIG_SH2_STAT5	340	343	PF00017	0.444
LIG_SH2_STAT5	366	369	PF00017	0.559
LIG_SH2_STAT5	385	388	PF00017	0.210
LIG_SH2_STAT5	487	490	PF00017	0.490
LIG_SH3_3	54	60	PF00018	0.659
LIG_Sin3_3	477	484	PF02671	0.373
LIG_SUMO_SIM_anti_2	181	188	PF11976	0.466
LIG_SxIP_EBH_1	23	35	PF03271	0.627
LIG_TRAF2_1	295	298	PF00917	0.609
LIG_TRAF2_1	521	524	PF00917	0.539
LIG_TRAF2_1	544	547	PF00917	0.509
LIG_UBA3_1	26	35	PF00899	0.715
LIG_WRC_WIRS_1	353	358	PF05994	0.456
MOD_CDC14_SPxK_1	86	89	PF00782	0.583
MOD_CDK_SPK_2	83	88	PF00069	0.661
MOD_CDK_SPxK_1	83	89	PF00069	0.584
MOD_CK1_1	106	112	PF00069	0.660
MOD_CK1_1	170	176	PF00069	0.483
MOD_CK1_1	269	275	PF00069	0.572
MOD_CK1_1	293	299	PF00069	0.533
MOD_CK1_1	419	425	PF00069	0.651
MOD_CK1_1	496	502	PF00069	0.537
MOD_CK1_1	58	64	PF00069	0.766
MOD_CK1_1	73	79	PF00069	0.723
MOD_CK1_1	82	88	PF00069	0.669
MOD_CK2_1	110	116	PF00069	0.609
MOD_CK2_1	149	155	PF00069	0.531
MOD_CK2_1	162	168	PF00069	0.561
MOD_CK2_1	496	502	PF00069	0.518
MOD_GlcNHglycan	105	108	PF01048	0.671
MOD_GlcNHglycan	276	279	PF01048	0.536
MOD_GlcNHglycan	396	399	PF01048	0.536
MOD_GlcNHglycan	434	437	PF01048	0.476
MOD_GlcNHglycan	440	443	PF01048	0.453
MOD_GlcNHglycan	460	463	PF01048	0.268
MOD_GlcNHglycan	495	498	PF01048	0.267
MOD_GlcNHglycan	65	68	PF01048	0.670
MOD_GlcNHglycan	72	75	PF01048	0.672
MOD_GlcNHglycan	81	84	PF01048	0.624
MOD_GlcNHglycan	97	100	PF01048	0.583
MOD_GSK3_1	106	113	PF00069	0.652
MOD_GSK3_1	163	170	PF00069	0.595
MOD_GSK3_1	215	222	PF00069	0.677
MOD_GSK3_1	262	269	PF00069	0.465
MOD_GSK3_1	34	41	PF00069	0.665
MOD_GSK3_1	419	426	PF00069	0.630
MOD_GSK3_1	454	461	PF00069	0.476
MOD_GSK3_1	55	62	PF00069	0.712
MOD_GSK3_1	70	77	PF00069	0.635
MOD_GSK3_1	79	86	PF00069	0.656
MOD_N-GLC_1	103	108	PF02516	0.777
MOD_N-GLC_1	269	274	PF02516	0.624
MOD_N-GLC_1	38	43	PF02516	0.659
MOD_N-GLC_1	468	473	PF02516	0.259
MOD_N-GLC_1	516	521	PF02516	0.381
MOD_NEK2_1	103	108	PF00069	0.762
MOD_NEK2_1	192	197	PF00069	0.588
MOD_NEK2_1	202	207	PF00069	0.478
MOD_NEK2_1	262	267	PF00069	0.485
MOD_NEK2_1	274	279	PF00069	0.527
MOD_NEK2_1	4	9	PF00069	0.609
MOD_NEK2_1	406	411	PF00069	0.460
MOD_NEK2_1	431	436	PF00069	0.424
MOD_NEK2_1	516	521	PF00069	0.547
MOD_PIKK_1	293	299	PF00454	0.641
MOD_PIKK_1	34	40	PF00454	0.636
MOD_PIKK_1	4	10	PF00454	0.622
MOD_PIKK_1	470	476	PF00454	0.476
MOD_PK_1	449	455	PF00069	0.530
MOD_PKA_1	449	455	PF00069	0.530
MOD_PKA_2	192	198	PF00069	0.622
MOD_PKA_2	419	425	PF00069	0.614
MOD_PKA_2	449	455	PF00069	0.443
MOD_PKA_2	458	464	PF00069	0.480
MOD_Plk_1	167	173	PF00069	0.507
MOD_Plk_1	269	275	PF00069	0.602
MOD_Plk_1	516	522	PF00069	0.581
MOD_ProDKin_1	423	429	PF00069	0.707
MOD_ProDKin_1	56	62	PF00069	0.679
MOD_ProDKin_1	83	89	PF00069	0.755
MOD_SUMO_for_1	176	179	PF00179	0.608
MOD_SUMO_for_1	209	212	PF00179	0.655
MOD_SUMO_for_1	278	281	PF00179	0.626
MOD_SUMO_rev_2	155	164	PF00179	0.623
MOD_SUMO_rev_2	368	377	PF00179	0.462
TRG_AP2beta_CARGO_1	127	137	PF09066	0.466
TRG_DiLeu_BaEn_1	524	529	PF01217	0.586
TRG_DiLeu_BaLyEn_6	257	262	PF01217	0.484
TRG_ENDOCYTIC_2	147	150	PF00928	0.599
TRG_ENDOCYTIC_2	231	234	PF00928	0.675
TRG_ENDOCYTIC_2	333	336	PF00928	0.458
TRG_ENDOCYTIC_2	350	353	PF00928	0.249
TRG_ENDOCYTIC_2	476	479	PF00928	0.562
TRG_ER_diArg_1	136	139	PF00400	0.561
TRG_ER_diArg_1	254	257	PF00400	0.512
TRG_ER_diArg_1	337	339	PF00400	0.423
TRG_ER_diArg_1	512	514	PF00400	0.513
TRG_ER_diArg_1	87	89	PF00400	0.740
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P368	Leptomonas seymouri	61%	89%
A0A0S4JFA6	Bodo saltans	37%	88%
A0A1X0NXZ0	Trypanosomatidae	43%	82%
A0A3Q8IB76	Leishmania donovani	91%	100%
A0A422NSQ1	Trypanosoma rangeli	43%	89%
A4HBY7	Leishmania braziliensis	80%	100%
A4HZC8	Leishmania infantum	91%	100%
D0A156	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	92%
Q4QC65	Leishmania major	90%	100%
V5BLU1	Trypanosoma cruzi	41%	91%