RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVB4_LEIMU

TriTrypDb:

LmxM.21.1295

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0005634	nucleus	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9AVB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVB4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0005488	binding	1	2
GO:0005515	protein binding	2	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0097602	cullin family protein binding	3	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	184	186	PF00675	0.499
CLV_PCSK_SKI1_1	187	191	PF00082	0.670
CLV_PCSK_SKI1_1	233	237	PF00082	0.436
CLV_PCSK_SKI1_1	254	258	PF00082	0.443
DEG_SPOP_SBC_1	123	127	PF00917	0.526
DOC_CDC14_PxL_1	69	77	PF14671	0.752
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.720
DOC_PP4_FxxP_1	192	195	PF00568	0.484
DOC_PP4_FxxP_1	247	250	PF00568	0.299
DOC_USP7_MATH_1	122	126	PF00917	0.816
DOC_USP7_MATH_1	134	138	PF00917	0.683
DOC_USP7_MATH_1	196	200	PF00917	0.675
DOC_USP7_MATH_1	213	217	PF00917	0.545
DOC_USP7_MATH_1	57	61	PF00917	0.750
DOC_USP7_MATH_2	102	108	PF00917	0.758
DOC_WW_Pin1_4	115	120	PF00397	0.622
DOC_WW_Pin1_4	136	141	PF00397	0.785
DOC_WW_Pin1_4	173	178	PF00397	0.553
DOC_WW_Pin1_4	19	24	PF00397	0.471
DOC_WW_Pin1_4	191	196	PF00397	0.751
DOC_WW_Pin1_4	265	270	PF00397	0.483
DOC_WW_Pin1_4	80	85	PF00397	0.779
DOC_WW_Pin1_4	98	103	PF00397	0.712
LIG_14-3-3_CanoR_1	254	259	PF00244	0.513
LIG_BIR_III_4	36	40	PF00653	0.576
LIG_FHA_1	106	112	PF00498	0.676
LIG_FHA_1	218	224	PF00498	0.728
LIG_FHA_1	27	33	PF00498	0.748
LIG_FHA_1	80	86	PF00498	0.530
LIG_FHA_2	235	241	PF00498	0.438
LIG_LIR_Apic_2	190	195	PF02991	0.489
LIG_LIR_Gen_1	107	116	PF02991	0.627
LIG_LIR_Nem_3	107	112	PF02991	0.630
LIG_LIR_Nem_3	49	55	PF02991	0.634
LIG_NRBOX	74	80	PF00104	0.689
LIG_Pex14_2	2	6	PF04695	0.648
LIG_SH2_CRK	261	265	PF00017	0.389
LIG_SH2_STAT5	242	245	PF00017	0.411
LIG_SH3_3	108	114	PF00018	0.598
LIG_SH3_3	137	143	PF00018	0.710
LIG_SH3_3	192	198	PF00018	0.713
LIG_SH3_3	203	209	PF00018	0.641
LIG_SH3_3	96	102	PF00018	0.719
LIG_SUMO_SIM_par_1	74	83	PF11976	0.771
LIG_TRAF2_1	101	104	PF00917	0.748
LIG_WRC_WIRS_1	106	111	PF05994	0.673
LIG_WW_2	195	198	PF00397	0.466
MOD_CK1_1	118	124	PF00069	0.706
MOD_CK1_1	173	179	PF00069	0.756
MOD_CK1_1	199	205	PF00069	0.768
MOD_CK1_1	207	213	PF00069	0.661
MOD_CK1_1	217	223	PF00069	0.597
MOD_CK1_1	80	86	PF00069	0.705
MOD_CK1_1	9	15	PF00069	0.622
MOD_CK2_1	124	130	PF00069	0.711
MOD_CK2_1	173	179	PF00069	0.672
MOD_CK2_1	234	240	PF00069	0.513
MOD_CK2_1	98	104	PF00069	0.725
MOD_GlcNHglycan	172	175	PF01048	0.743
MOD_GlcNHglycan	3	6	PF01048	0.720
MOD_GlcNHglycan	52	55	PF01048	0.671
MOD_GlcNHglycan	59	62	PF01048	0.644
MOD_GlcNHglycan	8	11	PF01048	0.670
MOD_GSK3_1	1	8	PF00069	0.758
MOD_GSK3_1	114	121	PF00069	0.660
MOD_GSK3_1	124	131	PF00069	0.645
MOD_GSK3_1	134	141	PF00069	0.589
MOD_GSK3_1	166	173	PF00069	0.660
MOD_GSK3_1	175	182	PF00069	0.530
MOD_GSK3_1	187	194	PF00069	0.521
MOD_GSK3_1	196	203	PF00069	0.707
MOD_GSK3_1	204	211	PF00069	0.594
MOD_GSK3_1	213	220	PF00069	0.559
MOD_GSK3_1	46	53	PF00069	0.599
MOD_GSK3_1	80	87	PF00069	0.684
MOD_NEK2_1	79	84	PF00069	0.639
MOD_PIKK_1	196	202	PF00454	0.700
MOD_PKA_2	158	164	PF00069	0.659
MOD_Plk_1	134	140	PF00069	0.656
MOD_Plk_2-3	234	240	PF00069	0.513
MOD_Plk_4	158	164	PF00069	0.679
MOD_Plk_4	200	206	PF00069	0.484
MOD_Plk_4	26	32	PF00069	0.744
MOD_ProDKin_1	115	121	PF00069	0.625
MOD_ProDKin_1	136	142	PF00069	0.782
MOD_ProDKin_1	173	179	PF00069	0.555
MOD_ProDKin_1	19	25	PF00069	0.468
MOD_ProDKin_1	191	197	PF00069	0.752
MOD_ProDKin_1	265	271	PF00069	0.487
MOD_ProDKin_1	80	86	PF00069	0.781
MOD_ProDKin_1	98	104	PF00069	0.711
MOD_SUMO_rev_2	178	188	PF00179	0.548
MOD_SUMO_rev_2	230	238	PF00179	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K6	Leptomonas seymouri	37%	94%
A0A3S7WWM2	Leishmania donovani	85%	99%
A4HBY6	Leishmania braziliensis	67%	100%
A4HZC7	Leishmania infantum	84%	99%
Q4QC66	Leishmania major	84%	100%