LeishMANIAdb
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Putative vesicule-associated membrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative vesicule-associated membrane protein
Gene product:
vesicle-associated membrane protein, putative
Species:
Leishmania mexicana
UniProt:
E9AVB3_LEIMU
TriTrypDb:
LmxM.21.1290
Length:
258

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
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Expansion

Sequence features

E9AVB3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVB3

Function

Biological processes
TermNameLevelCount
GO:0006810 transport 3 12
GO:0016192 vesicle-mediated transport 4 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
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Could not find GO molecular_function term for this entry.

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 97 101 PF00656 0.590
CLV_NRD_NRD_1 242 244 PF00675 0.563
CLV_NRD_NRD_1 98 100 PF00675 0.390
CLV_PCSK_KEX2_1 244 246 PF00082 0.591
CLV_PCSK_KEX2_1 98 100 PF00082 0.390
CLV_PCSK_PC1ET2_1 244 246 PF00082 0.591
CLV_PCSK_SKI1_1 113 117 PF00082 0.368
CLV_PCSK_SKI1_1 136 140 PF00082 0.363
CLV_PCSK_SKI1_1 219 223 PF00082 0.427
CLV_PCSK_SKI1_1 23 27 PF00082 0.336
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P366 Leptomonas seymouri 77% 97%
A0A0S4JL59 Bodo saltans 45% 100%
A0A1X0NYJ8 Trypanosomatidae 57% 100%
A0A3Q8IE03 Leishmania donovani 95% 100%
A0A422NSS3 Trypanosoma rangeli 58% 100%
A4HBY4 Leishmania braziliensis 86% 100%
A4HZC6 Leishmania infantum 95% 100%
D0A159 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
Q4QC67 Leishmania major 92% 100%
V5BHA3 Trypanosoma cruzi 57% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS