Putative vesicule-associated membrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vesicle-associated membrane protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVB3_LEIMU

TriTrypDb:

LmxM.21.1290

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AVB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVB3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0016192	vesicle-mediated transport	4	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	97	101	PF00656	0.590
CLV_NRD_NRD_1	242	244	PF00675	0.563
CLV_NRD_NRD_1	98	100	PF00675	0.390
CLV_PCSK_KEX2_1	244	246	PF00082	0.591
CLV_PCSK_KEX2_1	98	100	PF00082	0.390
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.591
CLV_PCSK_SKI1_1	113	117	PF00082	0.368
CLV_PCSK_SKI1_1	136	140	PF00082	0.363
CLV_PCSK_SKI1_1	219	223	PF00082	0.427
CLV_PCSK_SKI1_1	23	27	PF00082	0.336
DOC_MAPK_gen_1	154	162	PF00069	0.536
DOC_MAPK_MEF2A_6	154	162	PF00069	0.560
DOC_PP4_FxxP_1	116	119	PF00568	0.661
DOC_PP4_FxxP_1	131	134	PF00568	0.498
DOC_PP4_FxxP_1	37	40	PF00568	0.595
DOC_USP7_MATH_1	147	151	PF00917	0.705
DOC_WW_Pin1_4	26	31	PF00397	0.644
LIG_14-3-3_CanoR_1	50	54	PF00244	0.593
LIG_14-3-3_CanoR_1	57	64	PF00244	0.560
LIG_BRCT_BRCA1_1	58	62	PF00533	0.484
LIG_CaM_IQ_9	197	212	PF13499	0.494
LIG_FHA_1	188	194	PF00498	0.504
LIG_FHA_1	80	86	PF00498	0.446
LIG_Integrin_isoDGR_2	241	243	PF01839	0.552
LIG_LIR_Apic_2	129	134	PF02991	0.576
LIG_LIR_Apic_2	34	40	PF02991	0.600
LIG_LIR_Gen_1	42	48	PF02991	0.561
LIG_LIR_Gen_1	7	17	PF02991	0.472
LIG_LIR_Gen_1	75	86	PF02991	0.547
LIG_LIR_Nem_3	42	47	PF02991	0.563
LIG_LIR_Nem_3	58	64	PF02991	0.580
LIG_LIR_Nem_3	7	12	PF02991	0.516
LIG_MLH1_MIPbox_1	58	62	PF16413	0.484
LIG_PCNA_yPIPBox_3	124	136	PF02747	0.621
LIG_Pex14_2	112	116	PF04695	0.552
LIG_PTAP_UEV_1	29	34	PF05743	0.541
LIG_SH2_CRK	13	17	PF00017	0.522
LIG_SH2_CRK	88	92	PF00017	0.595
LIG_SH2_STAT5	234	237	PF00017	0.427
LIG_SH3_3	114	120	PF00018	0.669
LIG_SH3_3	27	33	PF00018	0.605
LIG_TRAF2_1	70	73	PF00917	0.710
LIG_WRC_WIRS_1	234	239	PF05994	0.474
MOD_CK1_1	247	253	PF00069	0.714
MOD_CK1_1	31	37	PF00069	0.545
MOD_CK1_1	49	55	PF00069	0.477
MOD_Cter_Amidation	241	244	PF01082	0.518
MOD_GlcNHglycan	143	146	PF01048	0.530
MOD_GlcNHglycan	149	152	PF01048	0.620
MOD_GlcNHglycan	254	257	PF01048	0.738
MOD_GlcNHglycan	30	33	PF01048	0.418
MOD_GlcNHglycan	51	54	PF01048	0.512
MOD_GlcNHglycan	58	61	PF01048	0.503
MOD_GSK3_1	31	38	PF00069	0.488
MOD_N-GLC_1	62	67	PF02516	0.501
MOD_NEK2_1	140	145	PF00069	0.590
MOD_NEK2_1	200	205	PF00069	0.337
MOD_NEK2_1	211	216	PF00069	0.371
MOD_NEK2_1	56	61	PF00069	0.429
MOD_NEK2_2	212	217	PF00069	0.368
MOD_PIKK_1	247	253	PF00454	0.700
MOD_PK_1	244	250	PF00069	0.483
MOD_PKA_1	244	250	PF00069	0.535
MOD_PKA_2	201	207	PF00069	0.371
MOD_PKA_2	244	250	PF00069	0.483
MOD_PKA_2	49	55	PF00069	0.462
MOD_PKA_2	56	62	PF00069	0.405
MOD_Plk_1	72	78	PF00069	0.552
MOD_ProDKin_1	26	32	PF00069	0.548
MOD_SUMO_rev_2	150	156	PF00179	0.348
MOD_SUMO_rev_2	163	168	PF00179	0.492
TRG_DiLeu_BaEn_4	7	13	PF01217	0.575
TRG_ENDOCYTIC_2	13	16	PF00928	0.376
TRG_ENDOCYTIC_2	234	237	PF00928	0.427
TRG_ENDOCYTIC_2	78	81	PF00928	0.406
TRG_ENDOCYTIC_2	88	91	PF00928	0.393
TRG_NES_CRM1_1	106	118	PF08389	0.557
TRG_Pf-PMV_PEXEL_1	205	210	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P366	Leptomonas seymouri	77%	97%
A0A0S4JL59	Bodo saltans	45%	100%
A0A1X0NYJ8	Trypanosomatidae	57%	100%
A0A3Q8IE03	Leishmania donovani	95%	100%
A0A422NSS3	Trypanosoma rangeli	58%	100%
A4HBY4	Leishmania braziliensis	86%	100%
A4HZC6	Leishmania infantum	95%	100%
D0A159	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
Q4QC67	Leishmania major	92%	100%
V5BHA3	Trypanosoma cruzi	57%	100%