MsrB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVB2_LEIMU

TriTrypDb:

LmxM.21.1280

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	362	366	PF00656	0.555
CLV_NRD_NRD_1	259	261	PF00675	0.604
CLV_PCSK_FUR_1	257	261	PF00082	0.602
CLV_PCSK_KEX2_1	259	261	PF00082	0.588
CLV_PCSK_SKI1_1	397	401	PF00082	0.460
DEG_Nend_UBRbox_2	1	3	PF02207	0.629
DEG_SCF_FBW7_1	452	457	PF00400	0.581
DEG_SPOP_SBC_1	10	14	PF00917	0.654
DEG_SPOP_SBC_1	454	458	PF00917	0.585
DOC_CKS1_1	243	248	PF01111	0.508
DOC_CYCLIN_RxL_1	19	30	PF00134	0.646
DOC_CYCLIN_yClb5_NLxxxL_5	443	452	PF00134	0.441
DOC_MAPK_gen_1	19	27	PF00069	0.646
DOC_MAPK_JIP1_4	21	27	PF00069	0.646
DOC_MAPK_MEF2A_6	274	283	PF00069	0.448
DOC_PP2B_LxvP_1	155	158	PF13499	0.351
DOC_PP2B_LxvP_1	175	178	PF13499	0.366
DOC_SPAK_OSR1_1	289	293	PF12202	0.368
DOC_USP7_MATH_1	100	104	PF00917	0.557
DOC_USP7_MATH_1	158	162	PF00917	0.401
DOC_USP7_MATH_1	180	184	PF00917	0.609
DOC_USP7_MATH_1	253	257	PF00917	0.624
DOC_USP7_MATH_1	268	272	PF00917	0.570
DOC_USP7_MATH_1	315	319	PF00917	0.492
DOC_USP7_MATH_1	368	372	PF00917	0.593
DOC_USP7_MATH_1	454	458	PF00917	0.726
DOC_USP7_MATH_1	87	91	PF00917	0.653
DOC_USP7_MATH_1	9	13	PF00917	0.836
DOC_WW_Pin1_4	167	172	PF00397	0.433
DOC_WW_Pin1_4	206	211	PF00397	0.384
DOC_WW_Pin1_4	242	247	PF00397	0.482
DOC_WW_Pin1_4	260	265	PF00397	0.630
DOC_WW_Pin1_4	323	328	PF00397	0.493
DOC_WW_Pin1_4	450	455	PF00397	0.572
LIG_14-3-3_CanoR_1	257	267	PF00244	0.616
LIG_14-3-3_CanoR_1	321	327	PF00244	0.492
LIG_14-3-3_CanoR_1	70	80	PF00244	0.645
LIG_APCC_ABBA_1	188	193	PF00400	0.489
LIG_BRCT_BRCA1_1	262	266	PF00533	0.628
LIG_BRCT_BRCA1_1	44	48	PF00533	0.513
LIG_FHA_1	158	164	PF00498	0.407
LIG_FHA_1	243	249	PF00498	0.685
LIG_FHA_1	48	54	PF00498	0.626
LIG_FHA_2	136	142	PF00498	0.443
LIG_FHA_2	360	366	PF00498	0.538
LIG_FHA_2	70	76	PF00498	0.531
LIG_Integrin_isoDGR_2	272	274	PF01839	0.494
LIG_LIR_Gen_1	187	193	PF02991	0.383
LIG_LIR_Gen_1	436	446	PF02991	0.528
LIG_LIR_Nem_3	187	192	PF02991	0.381
LIG_LIR_Nem_3	344	348	PF02991	0.416
LIG_LIR_Nem_3	436	442	PF02991	0.525
LIG_NRBOX	395	401	PF00104	0.460
LIG_Pex14_1	164	168	PF04695	0.349
LIG_SH2_CRK	202	206	PF00017	0.322
LIG_SH2_PTP2	168	171	PF00017	0.411
LIG_SH2_STAP1	159	163	PF00017	0.400
LIG_SH2_STAT5	120	123	PF00017	0.433
LIG_SH2_STAT5	159	162	PF00017	0.402
LIG_SH2_STAT5	168	171	PF00017	0.421
LIG_SH3_2	61	66	PF14604	0.626
LIG_SH3_3	240	246	PF00018	0.452
LIG_SH3_3	261	267	PF00018	0.522
LIG_SH3_3	58	64	PF00018	0.621
LIG_SH3_3	89	95	PF00018	0.631
LIG_TRAF2_1	104	107	PF00917	0.542
LIG_TRAF2_1	138	141	PF00917	0.508
MOD_CDK_SPxxK_3	242	249	PF00069	0.508
MOD_CK1_1	262	268	PF00069	0.674
MOD_CK1_1	392	398	PF00069	0.615
MOD_CK1_1	5	11	PF00069	0.630
MOD_CK1_1	73	79	PF00069	0.590
MOD_CK2_1	135	141	PF00069	0.461
MOD_CK2_1	145	151	PF00069	0.327
MOD_CK2_1	382	388	PF00069	0.609
MOD_Cter_Amidation	257	260	PF01082	0.516
MOD_DYRK1A_RPxSP_1	242	246	PF00069	0.466
MOD_DYRK1A_RPxSP_1	260	264	PF00069	0.628
MOD_GlcNHglycan	102	105	PF01048	0.559
MOD_GlcNHglycan	182	185	PF01048	0.506
MOD_GlcNHglycan	249	252	PF01048	0.492
MOD_GlcNHglycan	29	32	PF01048	0.608
MOD_GlcNHglycan	313	316	PF01048	0.466
MOD_GlcNHglycan	370	373	PF01048	0.572
MOD_GlcNHglycan	384	387	PF01048	0.511
MOD_GlcNHglycan	391	394	PF01048	0.636
MOD_GlcNHglycan	7	10	PF01048	0.621
MOD_GlcNHglycan	89	92	PF01048	0.637
MOD_GSK3_1	191	198	PF00069	0.553
MOD_GSK3_1	247	254	PF00069	0.573
MOD_GSK3_1	258	265	PF00069	0.672
MOD_GSK3_1	307	314	PF00069	0.384
MOD_GSK3_1	354	361	PF00069	0.452
MOD_GSK3_1	363	370	PF00069	0.501
MOD_GSK3_1	450	457	PF00069	0.549
MOD_GSK3_1	5	12	PF00069	0.638
MOD_GSK3_1	69	76	PF00069	0.608
MOD_N-GLC_1	359	364	PF02516	0.612
MOD_N-GLC_2	298	300	PF02516	0.357
MOD_N-GLC_2	447	449	PF02516	0.445
MOD_NEK2_1	145	150	PF00069	0.351
MOD_NEK2_1	27	32	PF00069	0.645
MOD_NEK2_1	354	359	PF00069	0.464
MOD_NEK2_1	455	460	PF00069	0.561
MOD_NEK2_2	221	226	PF00069	0.430
MOD_NEK2_2	376	381	PF00069	0.612
MOD_PIKK_1	191	197	PF00454	0.479
MOD_PIKK_1	251	257	PF00454	0.510
MOD_PKA_1	259	265	PF00069	0.586
MOD_PKA_2	258	264	PF00069	0.605
MOD_PKA_2	37	43	PF00069	0.606
MOD_PKA_2	382	388	PF00069	0.660
MOD_PKA_2	69	75	PF00069	0.655
MOD_PKB_1	257	265	PF00069	0.602
MOD_Plk_1	354	360	PF00069	0.472
MOD_Plk_1	435	441	PF00069	0.526
MOD_Plk_1	74	80	PF00069	0.518
MOD_Plk_2-3	151	157	PF00069	0.363
MOD_Plk_4	354	360	PF00069	0.472
MOD_Plk_4	376	382	PF00069	0.612
MOD_ProDKin_1	167	173	PF00069	0.441
MOD_ProDKin_1	206	212	PF00069	0.383
MOD_ProDKin_1	242	248	PF00069	0.496
MOD_ProDKin_1	260	266	PF00069	0.629
MOD_ProDKin_1	323	329	PF00069	0.486
MOD_ProDKin_1	450	456	PF00069	0.575
TRG_DiLeu_BaEn_1	141	146	PF01217	0.414
TRG_ENDOCYTIC_2	202	205	PF00928	0.318
TRG_ER_diArg_1	257	260	PF00400	0.516
TRG_ER_diArg_1	319	322	PF00400	0.511
TRG_ER_diArg_1	348	351	PF00400	0.504
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	55	60	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9M4	Leptomonas seymouri	42%	72%
A0A3S7WWN0	Leishmania donovani	80%	100%
A4HZC5	Leishmania infantum	80%	100%
Q4QC68	Leishmania major	77%	96%