Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVB1_LEIMU

TriTrypDb:

LmxM.21.1270

Length:

839

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVB1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.548
CLV_C14_Caspase3-7	550	554	PF00656	0.393
CLV_C14_Caspase3-7	576	580	PF00656	0.432
CLV_NRD_NRD_1	31	33	PF00675	0.497
CLV_NRD_NRD_1	371	373	PF00675	0.541
CLV_NRD_NRD_1	387	389	PF00675	0.483
CLV_NRD_NRD_1	520	522	PF00675	0.739
CLV_NRD_NRD_1	621	623	PF00675	0.502
CLV_PCSK_KEX2_1	370	372	PF00082	0.559
CLV_PCSK_KEX2_1	520	522	PF00082	0.739
CLV_PCSK_KEX2_1	621	623	PF00082	0.502
CLV_PCSK_KEX2_1	688	690	PF00082	0.508
CLV_PCSK_KEX2_1	836	838	PF00082	0.704
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.508
CLV_PCSK_PC1ET2_1	836	838	PF00082	0.704
CLV_PCSK_SKI1_1	165	169	PF00082	0.408
CLV_PCSK_SKI1_1	237	241	PF00082	0.426
CLV_PCSK_SKI1_1	621	625	PF00082	0.494
CLV_PCSK_SKI1_1	680	684	PF00082	0.580
DEG_APCC_DBOX_1	232	240	PF00400	0.524
DEG_SPOP_SBC_1	363	367	PF00917	0.552
DOC_ANK_TNKS_1	402	409	PF00023	0.453
DOC_CKS1_1	88	93	PF01111	0.623
DOC_MAPK_gen_1	32	40	PF00069	0.602
DOC_MAPK_gen_1	611	620	PF00069	0.456
DOC_MAPK_MEF2A_6	432	439	PF00069	0.492
DOC_MAPK_MEF2A_6	655	663	PF00069	0.394
DOC_MAPK_NFAT4_5	432	440	PF00069	0.494
DOC_PP1_RVXF_1	307	313	PF00149	0.413
DOC_PP2B_LxvP_1	435	438	PF13499	0.502
DOC_USP7_MATH_1	105	109	PF00917	0.536
DOC_USP7_MATH_1	291	295	PF00917	0.427
DOC_USP7_MATH_1	325	329	PF00917	0.578
DOC_USP7_MATH_1	343	347	PF00917	0.802
DOC_USP7_MATH_1	354	358	PF00917	0.592
DOC_USP7_MATH_1	363	367	PF00917	0.647
DOC_USP7_MATH_1	390	394	PF00917	0.466
DOC_USP7_MATH_1	506	510	PF00917	0.785
DOC_USP7_MATH_1	532	536	PF00917	0.455
DOC_USP7_MATH_1	552	556	PF00917	0.391
DOC_USP7_MATH_1	751	755	PF00917	0.622
DOC_USP7_MATH_1	759	763	PF00917	0.620
DOC_USP7_MATH_1	796	800	PF00917	0.436
DOC_USP7_MATH_1	832	836	PF00917	0.553
DOC_USP7_MATH_2	722	728	PF00917	0.632
DOC_USP7_UBL2_3	680	684	PF12436	0.462
DOC_WW_Pin1_4	331	336	PF00397	0.666
DOC_WW_Pin1_4	339	344	PF00397	0.641
DOC_WW_Pin1_4	359	364	PF00397	0.524
DOC_WW_Pin1_4	427	432	PF00397	0.453
DOC_WW_Pin1_4	590	595	PF00397	0.524
DOC_WW_Pin1_4	730	735	PF00397	0.595
DOC_WW_Pin1_4	87	92	PF00397	0.625
LIG_14-3-3_CanoR_1	159	167	PF00244	0.420
LIG_14-3-3_CanoR_1	427	431	PF00244	0.568
LIG_14-3-3_CanoR_1	87	91	PF00244	0.499
LIG_APCC_ABBA_1	436	441	PF00400	0.575
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BIR_III_4	126	130	PF00653	0.448
LIG_BRCT_BRCA1_1	27	31	PF00533	0.571
LIG_BRCT_BRCA1_2	27	33	PF00533	0.592
LIG_CtBP_PxDLS_1	222	226	PF00389	0.561
LIG_CtBP_PxDLS_1	658	662	PF00389	0.390
LIG_deltaCOP1_diTrp_1	642	648	PF00928	0.512
LIG_EH1_1	415	423	PF00400	0.413
LIG_eIF4E_1	416	422	PF01652	0.408
LIG_eIF4E_1	788	794	PF01652	0.691
LIG_EVH1_1	502	506	PF00568	0.543
LIG_FHA_1	112	118	PF00498	0.487
LIG_FHA_1	188	194	PF00498	0.538
LIG_FHA_1	251	257	PF00498	0.310
LIG_FHA_1	293	299	PF00498	0.426
LIG_FHA_1	311	317	PF00498	0.413
LIG_FHA_1	35	41	PF00498	0.482
LIG_FHA_1	47	53	PF00498	0.422
LIG_FHA_1	537	543	PF00498	0.522
LIG_FHA_1	654	660	PF00498	0.400
LIG_FHA_1	816	822	PF00498	0.308
LIG_FHA_1	83	89	PF00498	0.604
LIG_FHA_2	107	113	PF00498	0.535
LIG_FHA_2	179	185	PF00498	0.574
LIG_FHA_2	480	486	PF00498	0.636
LIG_FHA_2	763	769	PF00498	0.516
LIG_LIR_Gen_1	152	157	PF02991	0.413
LIG_LIR_Gen_1	232	243	PF02991	0.423
LIG_LIR_Gen_1	246	256	PF02991	0.429
LIG_LIR_Gen_1	279	289	PF02991	0.407
LIG_LIR_Gen_1	306	315	PF02991	0.416
LIG_LIR_Gen_1	35	43	PF02991	0.455
LIG_LIR_Gen_1	642	652	PF02991	0.384
LIG_LIR_Gen_1	708	717	PF02991	0.519
LIG_LIR_Gen_1	802	811	PF02991	0.408
LIG_LIR_Nem_3	112	118	PF02991	0.431
LIG_LIR_Nem_3	125	131	PF02991	0.417
LIG_LIR_Nem_3	152	156	PF02991	0.419
LIG_LIR_Nem_3	232	238	PF02991	0.403
LIG_LIR_Nem_3	246	251	PF02991	0.419
LIG_LIR_Nem_3	306	310	PF02991	0.430
LIG_LIR_Nem_3	35	39	PF02991	0.475
LIG_LIR_Nem_3	547	551	PF02991	0.444
LIG_LIR_Nem_3	625	630	PF02991	0.363
LIG_LIR_Nem_3	641	647	PF02991	0.397
LIG_LIR_Nem_3	708	712	PF02991	0.518
LIG_LIR_Nem_3	802	806	PF02991	0.397
LIG_NRP_CendR_1	836	839	PF00754	0.722
LIG_PCNA_PIPBox_1	418	427	PF02747	0.414
LIG_Pex14_1	644	648	PF04695	0.503
LIG_Pex14_2	153	157	PF04695	0.410
LIG_Pex14_2	264	268	PF04695	0.382
LIG_SH2_CRK	102	106	PF00017	0.525
LIG_SH2_CRK	3	7	PF00017	0.654
LIG_SH2_CRK	307	311	PF00017	0.414
LIG_SH2_CRK	36	40	PF00017	0.577
LIG_SH2_CRK	709	713	PF00017	0.507
LIG_SH2_CRK	803	807	PF00017	0.388
LIG_SH2_GRB2like	215	218	PF00017	0.298
LIG_SH2_GRB2like	788	791	PF00017	0.560
LIG_SH2_NCK_1	287	291	PF00017	0.461
LIG_SH2_NCK_1	778	782	PF00017	0.632
LIG_SH2_SRC	628	631	PF00017	0.357
LIG_SH2_STAP1	281	285	PF00017	0.392
LIG_SH2_STAP1	36	40	PF00017	0.577
LIG_SH2_STAP1	628	632	PF00017	0.385
LIG_SH2_STAT3	215	218	PF00017	0.419
LIG_SH2_STAT3	377	380	PF00017	0.550
LIG_SH2_STAT3	564	567	PF00017	0.589
LIG_SH2_STAT5	118	121	PF00017	0.520
LIG_SH2_STAT5	192	195	PF00017	0.387
LIG_SH2_STAT5	215	218	PF00017	0.537
LIG_SH2_STAT5	235	238	PF00017	0.248
LIG_SH2_STAT5	36	39	PF00017	0.580
LIG_SH2_STAT5	377	380	PF00017	0.432
LIG_SH2_STAT5	416	419	PF00017	0.415
LIG_SH2_STAT5	425	428	PF00017	0.431
LIG_SH2_STAT5	434	437	PF00017	0.490
LIG_SH2_STAT5	530	533	PF00017	0.487
LIG_SH2_STAT5	540	543	PF00017	0.404
LIG_SH2_STAT5	607	610	PF00017	0.391
LIG_SH2_STAT5	647	650	PF00017	0.436
LIG_SH2_STAT5	778	781	PF00017	0.635
LIG_SH3_1	523	529	PF00018	0.634
LIG_SH3_2	503	508	PF14604	0.622
LIG_SH3_3	334	340	PF00018	0.668
LIG_SH3_3	5	11	PF00018	0.527
LIG_SH3_3	500	506	PF00018	0.625
LIG_SH3_3	523	529	PF00018	0.634
LIG_SH3_3	75	81	PF00018	0.509
LIG_SH3_CIN85_PxpxPR_1	522	527	PF14604	0.593
LIG_SUMO_SIM_anti_2	179	184	PF11976	0.457
LIG_SUMO_SIM_anti_2	68	73	PF11976	0.532
LIG_SUMO_SIM_par_1	176	181	PF11976	0.426
LIG_TRAF2_1	290	293	PF00917	0.489
LIG_TRAF2_1	482	485	PF00917	0.767
LIG_TRAF2_1	51	54	PF00917	0.390
LIG_TRAF2_1	534	537	PF00917	0.419
LIG_TRAF2_1	766	769	PF00917	0.631
LIG_TRAF2_1	828	831	PF00917	0.585
LIG_TRFH_1	475	479	PF08558	0.618
LIG_TYR_ITIM	603	608	PF00017	0.373
LIG_TYR_ITIM	801	806	PF00017	0.510
LIG_UBA3_1	394	399	PF00899	0.439
LIG_UBA3_1	541	546	PF00899	0.406
LIG_WW_3	338	342	PF00397	0.717
MOD_CDK_SPK_2	427	432	PF00069	0.453
MOD_CDK_SPxxK_3	87	94	PF00069	0.621
MOD_CK1_1	108	114	PF00069	0.479
MOD_CK1_1	186	192	PF00069	0.546
MOD_CK1_1	250	256	PF00069	0.314
MOD_CK1_1	321	327	PF00069	0.452
MOD_CK1_1	361	367	PF00069	0.684
MOD_CK1_1	451	457	PF00069	0.543
MOD_CK1_1	547	553	PF00069	0.419
MOD_CK1_1	673	679	PF00069	0.571
MOD_CK1_1	762	768	PF00069	0.658
MOD_CK1_1	776	782	PF00069	0.623
MOD_CK1_1	786	792	PF00069	0.593
MOD_CK1_1	799	805	PF00069	0.366
MOD_CK2_1	300	306	PF00069	0.452
MOD_CK2_1	390	396	PF00069	0.463
MOD_CK2_1	455	461	PF00069	0.683
MOD_CK2_1	47	53	PF00069	0.540
MOD_CK2_1	479	485	PF00069	0.591
MOD_CK2_1	531	537	PF00069	0.458
MOD_CK2_1	762	768	PF00069	0.516
MOD_DYRK1A_RPxSP_1	427	431	PF00069	0.568
MOD_GlcNHglycan	172	175	PF01048	0.577
MOD_GlcNHglycan	27	30	PF01048	0.556
MOD_GlcNHglycan	320	323	PF01048	0.551
MOD_GlcNHglycan	345	348	PF01048	0.692
MOD_GlcNHglycan	356	359	PF01048	0.598
MOD_GlcNHglycan	418	421	PF01048	0.411
MOD_GlcNHglycan	49	52	PF01048	0.458
MOD_GlcNHglycan	560	563	PF01048	0.450
MOD_GlcNHglycan	575	578	PF01048	0.371
MOD_GlcNHglycan	726	729	PF01048	0.712
MOD_GlcNHglycan	762	765	PF01048	0.794
MOD_GlcNHglycan	779	782	PF01048	0.697
MOD_GlcNHglycan	794	797	PF01048	0.443
MOD_GSK3_1	183	190	PF00069	0.553
MOD_GSK3_1	217	224	PF00069	0.443
MOD_GSK3_1	321	328	PF00069	0.592
MOD_GSK3_1	329	336	PF00069	0.633
MOD_GSK3_1	339	346	PF00069	0.734
MOD_GSK3_1	354	361	PF00069	0.674
MOD_GSK3_1	362	369	PF00069	0.648
MOD_GSK3_1	412	419	PF00069	0.434
MOD_GSK3_1	451	458	PF00069	0.543
MOD_GSK3_1	532	539	PF00069	0.597
MOD_GSK3_1	666	673	PF00069	0.494
MOD_GSK3_1	773	780	PF00069	0.666
MOD_GSK3_1	792	799	PF00069	0.377
MOD_GSK3_1	82	89	PF00069	0.563
MOD_N-GLC_1	100	105	PF02516	0.569
MOD_N-GLC_1	269	274	PF02516	0.435
MOD_N-GLC_1	730	735	PF02516	0.691
MOD_N-GLC_1	751	756	PF02516	0.761
MOD_NEK2_1	132	137	PF00069	0.496
MOD_NEK2_1	168	173	PF00069	0.495
MOD_NEK2_1	178	183	PF00069	0.388
MOD_NEK2_1	310	315	PF00069	0.410
MOD_NEK2_1	439	444	PF00069	0.532
MOD_NEK2_1	46	51	PF00069	0.536
MOD_NEK2_1	666	671	PF00069	0.485
MOD_NEK2_1	72	77	PF00069	0.515
MOD_NEK2_2	630	635	PF00069	0.529
MOD_NEK2_2	773	778	PF00069	0.635
MOD_PIKK_1	187	193	PF00454	0.608
MOD_PIKK_1	323	329	PF00454	0.662
MOD_PKA_1	688	694	PF00069	0.507
MOD_PKA_1	815	821	PF00069	0.312
MOD_PKA_2	158	164	PF00069	0.428
MOD_PKA_2	426	432	PF00069	0.446
MOD_PKA_2	688	694	PF00069	0.507
MOD_PKA_2	724	730	PF00069	0.662
MOD_PKA_2	796	802	PF00069	0.425
MOD_PKA_2	86	92	PF00069	0.505
MOD_Plk_1	100	106	PF00069	0.598
MOD_Plk_1	111	117	PF00069	0.380
MOD_Plk_1	178	184	PF00069	0.447
MOD_Plk_1	291	297	PF00069	0.412
MOD_Plk_1	34	40	PF00069	0.472
MOD_Plk_1	373	379	PF00069	0.449
MOD_Plk_1	552	558	PF00069	0.387
MOD_Plk_1	673	679	PF00069	0.571
MOD_Plk_4	178	184	PF00069	0.418
MOD_Plk_4	205	211	PF00069	0.301
MOD_Plk_4	311	317	PF00069	0.531
MOD_Plk_4	34	40	PF00069	0.477
MOD_Plk_4	390	396	PF00069	0.463
MOD_Plk_4	412	418	PF00069	0.437
MOD_Plk_4	536	542	PF00069	0.520
MOD_Plk_4	552	558	PF00069	0.387
MOD_Plk_4	773	779	PF00069	0.635
MOD_Plk_4	796	802	PF00069	0.440
MOD_ProDKin_1	331	337	PF00069	0.664
MOD_ProDKin_1	339	345	PF00069	0.639
MOD_ProDKin_1	359	365	PF00069	0.524
MOD_ProDKin_1	427	433	PF00069	0.459
MOD_ProDKin_1	590	596	PF00069	0.519
MOD_ProDKin_1	730	736	PF00069	0.598
MOD_ProDKin_1	87	93	PF00069	0.618
MOD_SUMO_rev_2	383	390	PF00179	0.576
MOD_SUMO_rev_2	484	494	PF00179	0.631
MOD_SUMO_rev_2	810	818	PF00179	0.551
TRG_DiLeu_BaEn_3	536	542	PF01217	0.402
TRG_DiLeu_BaEn_4	497	503	PF01217	0.723
TRG_DiLeu_BaEn_4	64	70	PF01217	0.455
TRG_ENDOCYTIC_2	235	238	PF00928	0.400
TRG_ENDOCYTIC_2	281	284	PF00928	0.392
TRG_ENDOCYTIC_2	307	310	PF00928	0.422
TRG_ENDOCYTIC_2	36	39	PF00928	0.580
TRG_ENDOCYTIC_2	434	437	PF00928	0.544
TRG_ENDOCYTIC_2	605	608	PF00928	0.379
TRG_ENDOCYTIC_2	647	650	PF00928	0.512
TRG_ENDOCYTIC_2	709	712	PF00928	0.514
TRG_ENDOCYTIC_2	803	806	PF00928	0.389
TRG_ER_diArg_1	370	372	PF00400	0.559
TRG_ER_diArg_1	520	523	PF00400	0.811
TRG_ER_diArg_1	524	527	PF00400	0.699
TRG_ER_diArg_1	620	622	PF00400	0.502
TRG_NES_CRM1_1	170	184	PF08389	0.553
TRG_NES_CRM1_1	68	82	PF08389	0.538
TRG_Pf-PMV_PEXEL_1	297	302	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	711	716	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	809	814	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P586	Leptomonas seymouri	64%	100%
A0A3S7WWR8	Leishmania donovani	93%	100%
A4HBY2	Leishmania braziliensis	82%	100%
A4HZC4	Leishmania infantum	93%	100%
Q4QC69	Leishmania major	92%	100%