Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVB0_LEIMU

TriTrypDb:

LmxM.21.1260

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

E9AVB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVB0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.661
CLV_C14_Caspase3-7	342	346	PF00656	0.664
CLV_C14_Caspase3-7	399	403	PF00656	0.714
CLV_C14_Caspase3-7	421	425	PF00656	0.746
CLV_C14_Caspase3-7	478	482	PF00656	0.631
CLV_NRD_NRD_1	201	203	PF00675	0.637
CLV_NRD_NRD_1	205	207	PF00675	0.599
CLV_NRD_NRD_1	214	216	PF00675	0.545
CLV_NRD_NRD_1	379	381	PF00675	0.718
CLV_NRD_NRD_1	97	99	PF00675	0.580
CLV_PCSK_KEX2_1	201	203	PF00082	0.637
CLV_PCSK_KEX2_1	205	207	PF00082	0.599
CLV_PCSK_KEX2_1	213	215	PF00082	0.564
CLV_PCSK_KEX2_1	379	381	PF00082	0.718
CLV_PCSK_KEX2_1	97	99	PF00082	0.580
CLV_PCSK_PC7_1	201	207	PF00082	0.654
CLV_PCSK_SKI1_1	464	468	PF00082	0.524
DEG_APCC_DBOX_1	212	220	PF00400	0.678
DEG_APCC_DBOX_1	62	70	PF00400	0.587
DOC_CKS1_1	33	38	PF01111	0.326
DOC_USP7_MATH_1	149	153	PF00917	0.670
DOC_USP7_MATH_1	221	225	PF00917	0.649
DOC_USP7_MATH_1	237	241	PF00917	0.647
DOC_USP7_MATH_1	391	395	PF00917	0.708
DOC_USP7_MATH_1	420	424	PF00917	0.695
DOC_USP7_MATH_1	431	435	PF00917	0.695
DOC_WW_Pin1_4	154	159	PF00397	0.647
DOC_WW_Pin1_4	207	212	PF00397	0.414
DOC_WW_Pin1_4	233	238	PF00397	0.755
DOC_WW_Pin1_4	251	256	PF00397	0.549
DOC_WW_Pin1_4	264	269	PF00397	0.714
DOC_WW_Pin1_4	32	37	PF00397	0.330
DOC_WW_Pin1_4	351	356	PF00397	0.783
DOC_WW_Pin1_4	411	416	PF00397	0.779
LIG_14-3-3_CanoR_1	238	247	PF00244	0.762
LIG_14-3-3_CanoR_1	302	307	PF00244	0.505
LIG_14-3-3_CanoR_1	404	412	PF00244	0.621
LIG_14-3-3_CanoR_1	63	67	PF00244	0.597
LIG_Actin_WH2_2	381	398	PF00022	0.634
LIG_BIR_II_1	1	5	PF00653	0.487
LIG_BIR_III_2	481	485	PF00653	0.691
LIG_EVH1_1	446	450	PF00568	0.726
LIG_FHA_1	194	200	PF00498	0.330
LIG_FHA_1	42	48	PF00498	0.513
LIG_FHA_1	66	72	PF00498	0.499
LIG_FHA_2	419	425	PF00498	0.741
LIG_LIR_Apic_2	444	449	PF02991	0.737
LIG_LIR_Gen_1	91	101	PF02991	0.370
LIG_LIR_Nem_3	174	178	PF02991	0.544
LIG_LIR_Nem_3	91	96	PF02991	0.369
LIG_PCNA_yPIPBox_3	75	85	PF02747	0.283
LIG_RPA_C_Fungi	196	208	PF08784	0.406
LIG_SH2_PTP2	175	178	PF00017	0.542
LIG_SH2_STAT3	369	372	PF00017	0.661
LIG_SH2_STAT5	145	148	PF00017	0.486
LIG_SH2_STAT5	175	178	PF00017	0.542
LIG_SH2_STAT5	326	329	PF00017	0.619
LIG_SH2_STAT5	369	372	PF00017	0.564
LIG_SH2_STAT5	429	432	PF00017	0.645
LIG_SH3_2	447	452	PF14604	0.734
LIG_SH3_3	244	250	PF00018	0.812
LIG_SH3_3	356	362	PF00018	0.545
LIG_SH3_3	409	415	PF00018	0.730
LIG_SH3_3	444	450	PF00018	0.630
LIG_SH3_5	322	326	PF00018	0.740
LIG_SUMO_SIM_par_1	2	10	PF11976	0.596
LIG_SUMO_SIM_par_1	38	44	PF11976	0.592
LIG_SUMO_SIM_par_1	67	72	PF11976	0.502
LIG_TYR_ITIM	173	178	PF00017	0.546
LIG_UBA3_1	457	464	PF00899	0.519
MOD_CDC14_SPxK_1	210	213	PF00782	0.433
MOD_CDK_SPK_2	233	238	PF00069	0.736
MOD_CDK_SPxK_1	207	213	PF00069	0.422
MOD_CDK_SPxxK_3	207	214	PF00069	0.428
MOD_CK1_1	14	20	PF00069	0.316
MOD_CK1_1	22	28	PF00069	0.284
MOD_CK1_1	351	357	PF00069	0.738
MOD_CK1_1	41	47	PF00069	0.476
MOD_CK1_1	419	425	PF00069	0.649
MOD_CK1_1	91	97	PF00069	0.499
MOD_CK2_1	391	397	PF00069	0.714
MOD_CK2_1	431	437	PF00069	0.538
MOD_GlcNHglycan	147	150	PF01048	0.682
MOD_GlcNHglycan	151	154	PF01048	0.594
MOD_GlcNHglycan	21	24	PF01048	0.428
MOD_GlcNHglycan	223	226	PF01048	0.747
MOD_GlcNHglycan	240	243	PF01048	0.658
MOD_GlcNHglycan	327	330	PF01048	0.806
MOD_GlcNHglycan	333	336	PF01048	0.724
MOD_GlcNHglycan	345	349	PF01048	0.568
MOD_GlcNHglycan	380	383	PF01048	0.748
MOD_GlcNHglycan	397	401	PF01048	0.536
MOD_GlcNHglycan	433	436	PF01048	0.740
MOD_GlcNHglycan	90	93	PF01048	0.488
MOD_GSK3_1	145	152	PF00069	0.658
MOD_GSK3_1	233	240	PF00069	0.623
MOD_GSK3_1	325	332	PF00069	0.643
MOD_GSK3_1	344	351	PF00069	0.645
MOD_GSK3_1	367	374	PF00069	0.645
MOD_GSK3_1	380	387	PF00069	0.599
MOD_GSK3_1	416	423	PF00069	0.777
MOD_GSK3_1	427	434	PF00069	0.535
MOD_GSK3_1	65	72	PF00069	0.462
MOD_LATS_1	378	384	PF00433	0.834
MOD_N-GLC_1	391	396	PF02516	0.677
MOD_N-GLC_1	77	82	PF02516	0.497
MOD_NEK2_1	1	6	PF00069	0.633
MOD_NEK2_1	344	349	PF00069	0.551
MOD_NEK2_1	86	91	PF00069	0.452
MOD_NEK2_2	120	125	PF00069	0.633
MOD_NEK2_2	391	396	PF00069	0.638
MOD_NEK2_2	62	67	PF00069	0.590
MOD_PK_1	302	308	PF00069	0.504
MOD_PK_1	380	386	PF00069	0.755
MOD_PKA_1	214	220	PF00069	0.465
MOD_PKA_2	193	199	PF00069	0.544
MOD_PKA_2	214	220	PF00069	0.724
MOD_PKA_2	221	227	PF00069	0.561
MOD_PKA_2	237	243	PF00069	0.549
MOD_PKA_2	301	307	PF00069	0.718
MOD_PKA_2	378	384	PF00069	0.718
MOD_PKA_2	62	68	PF00069	0.590
MOD_Plk_1	14	20	PF00069	0.393
MOD_Plk_1	178	184	PF00069	0.535
MOD_Plk_1	329	335	PF00069	0.649
MOD_Plk_1	391	397	PF00069	0.637
MOD_Plk_1	77	83	PF00069	0.394
MOD_Plk_4	1	7	PF00069	0.627
MOD_Plk_4	14	20	PF00069	0.392
MOD_Plk_4	424	430	PF00069	0.544
MOD_ProDKin_1	154	160	PF00069	0.649
MOD_ProDKin_1	207	213	PF00069	0.422
MOD_ProDKin_1	233	239	PF00069	0.756
MOD_ProDKin_1	251	257	PF00069	0.553
MOD_ProDKin_1	264	270	PF00069	0.716
MOD_ProDKin_1	32	38	PF00069	0.327
MOD_ProDKin_1	351	357	PF00069	0.784
MOD_ProDKin_1	411	417	PF00069	0.779
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.517
TRG_ENDOCYTIC_2	175	178	PF00928	0.542
TRG_ER_diArg_1	191	194	PF00400	0.423
TRG_ER_diArg_1	205	208	PF00400	0.647
TRG_ER_diArg_1	213	215	PF00400	0.630
TRG_ER_diArg_1	96	98	PF00400	0.579
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WWT1	Leishmania donovani	78%	98%
A4HBY1	Leishmania braziliensis	53%	99%
A4HZC3	Leishmania infantum	78%	98%
Q4QC70	Leishmania major	77%	100%