Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AVA7_LEIMU

TriTrypDb:

LmxM.21.1230

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	5
GO:0032991	protein-containing complex	1	5
GO:0043226	organelle	2	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5
GO:1990904	ribonucleoprotein complex	2	5

Expansion

Sequence features

E9AVA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	350	354	PF00656	0.409
CLV_MEL_PAP_1	304	310	PF00089	0.383
CLV_NRD_NRD_1	16	18	PF00675	0.572
CLV_NRD_NRD_1	224	226	PF00675	0.576
CLV_NRD_NRD_1	535	537	PF00675	0.594
CLV_NRD_NRD_1	57	59	PF00675	0.497
CLV_NRD_NRD_1	9	11	PF00675	0.701
CLV_NRD_NRD_1	95	97	PF00675	0.436
CLV_PCSK_KEX2_1	16	18	PF00082	0.604
CLV_PCSK_KEX2_1	535	537	PF00082	0.594
CLV_PCSK_KEX2_1	57	59	PF00082	0.547
CLV_PCSK_KEX2_1	95	97	PF00082	0.436
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.604
CLV_PCSK_SKI1_1	239	243	PF00082	0.356
CLV_PCSK_SKI1_1	44	48	PF00082	0.590
DEG_APCC_DBOX_1	238	246	PF00400	0.348
DEG_APCC_DBOX_1	511	519	PF00400	0.523
DEG_Nend_UBRbox_1	1	4	PF02207	0.606
DEG_SPOP_SBC_1	320	324	PF00917	0.455
DOC_MAPK_gen_1	517	525	PF00069	0.494
DOC_MAPK_gen_1	535	542	PF00069	0.533
DOC_MAPK_MEF2A_6	239	246	PF00069	0.335
DOC_MAPK_MEF2A_6	437	444	PF00069	0.559
DOC_MAPK_MEF2A_6	458	466	PF00069	0.579
DOC_PP4_FxxP_1	361	364	PF00568	0.426
DOC_USP7_MATH_1	184	188	PF00917	0.500
DOC_USP7_MATH_1	320	324	PF00917	0.546
DOC_USP7_MATH_1	383	387	PF00917	0.661
DOC_USP7_MATH_1	421	425	PF00917	0.646
DOC_USP7_MATH_1	456	460	PF00917	0.580
DOC_USP7_MATH_1	9	13	PF00917	0.801
DOC_USP7_UBL2_3	368	372	PF12436	0.464
DOC_USP7_UBL2_3	503	507	PF12436	0.498
DOC_WW_Pin1_4	558	563	PF00397	0.566
LIG_14-3-3_CanoR_1	136	145	PF00244	0.438
LIG_14-3-3_CanoR_1	17	21	PF00244	0.666
LIG_14-3-3_CanoR_1	186	192	PF00244	0.471
LIG_14-3-3_CanoR_1	331	335	PF00244	0.471
LIG_14-3-3_CanoR_1	39	47	PF00244	0.530
LIG_14-3-3_CanoR_1	416	421	PF00244	0.791
LIG_14-3-3_CanoR_1	437	441	PF00244	0.464
LIG_14-3-3_CanoR_1	535	542	PF00244	0.733
LIG_14-3-3_CanoR_1	64	70	PF00244	0.454
LIG_Actin_WH2_2	123	138	PF00022	0.412
LIG_Actin_WH2_2	364	380	PF00022	0.604
LIG_CtBP_PxDLS_1	35	39	PF00389	0.492
LIG_deltaCOP1_diTrp_1	353	361	PF00928	0.395
LIG_EH1_1	437	445	PF00400	0.448
LIG_FHA_1	129	135	PF00498	0.421
LIG_FHA_1	140	146	PF00498	0.355
LIG_FHA_1	167	173	PF00498	0.281
LIG_FHA_1	207	213	PF00498	0.459
LIG_FHA_1	248	254	PF00498	0.383
LIG_FHA_1	271	277	PF00498	0.391
LIG_FHA_1	338	344	PF00498	0.483
LIG_FHA_1	437	443	PF00498	0.525
LIG_FHA_1	535	541	PF00498	0.582
LIG_FHA_1	562	568	PF00498	0.551
LIG_FHA_1	80	86	PF00498	0.419
LIG_FHA_2	188	194	PF00498	0.476
LIG_FHA_2	348	354	PF00498	0.401
LIG_FHA_2	360	366	PF00498	0.454
LIG_FHA_2	46	52	PF00498	0.560
LIG_FHA_2	488	494	PF00498	0.443
LIG_LIR_Apic_2	190	194	PF02991	0.396
LIG_LIR_Gen_1	171	179	PF02991	0.367
LIG_LIR_Nem_3	54	59	PF02991	0.369
LIG_PDZ_Class_2	591	596	PF00595	0.477
LIG_RPA_C_Fungi	91	103	PF08784	0.317
LIG_SH2_STAP1	146	150	PF00017	0.333
LIG_SH2_STAP1	174	178	PF00017	0.342
LIG_SH2_STAT3	129	132	PF00017	0.301
LIG_SH2_STAT5	129	132	PF00017	0.301
LIG_SH2_STAT5	154	157	PF00017	0.321
LIG_SH2_STAT5	191	194	PF00017	0.339
LIG_SH2_STAT5	232	235	PF00017	0.345
LIG_SH2_STAT5	370	373	PF00017	0.522
LIG_SH3_2	6	11	PF14604	0.596
LIG_SH3_3	3	9	PF00018	0.639
LIG_SUMO_SIM_anti_2	243	250	PF11976	0.351
LIG_SUMO_SIM_anti_2	333	338	PF11976	0.469
LIG_SUMO_SIM_anti_2	439	444	PF11976	0.559
LIG_SUMO_SIM_anti_2	571	578	PF11976	0.564
LIG_SUMO_SIM_par_1	243	250	PF11976	0.351
LIG_SUMO_SIM_par_1	521	528	PF11976	0.608
MOD_CK1_1	187	193	PF00069	0.342
MOD_CK1_1	257	263	PF00069	0.345
MOD_CK1_1	268	274	PF00069	0.399
MOD_CK1_1	323	329	PF00069	0.610
MOD_CK1_1	37	43	PF00069	0.495
MOD_CK1_1	392	398	PF00069	0.525
MOD_CK1_1	45	51	PF00069	0.685
MOD_CK1_1	561	567	PF00069	0.573
MOD_CK1_1	63	69	PF00069	0.373
MOD_CK2_1	359	365	PF00069	0.435
MOD_CK2_1	487	493	PF00069	0.561
MOD_CK2_1	569	575	PF00069	0.571
MOD_CK2_1	87	93	PF00069	0.408
MOD_CMANNOS	356	359	PF00535	0.380
MOD_Cter_Amidation	14	17	PF01082	0.614
MOD_GlcNHglycan	111	114	PF01048	0.434
MOD_GlcNHglycan	18	21	PF01048	0.665
MOD_GlcNHglycan	195	198	PF01048	0.351
MOD_GlcNHglycan	202	205	PF01048	0.345
MOD_GlcNHglycan	258	262	PF01048	0.346
MOD_GlcNHglycan	294	297	PF01048	0.360
MOD_GlcNHglycan	323	326	PF01048	0.564
MOD_GlcNHglycan	403	406	PF01048	0.691
MOD_GlcNHglycan	416	419	PF01048	0.620
MOD_GlcNHglycan	44	47	PF01048	0.593
MOD_GlcNHglycan	506	510	PF01048	0.531
MOD_GlcNHglycan	555	558	PF01048	0.573
MOD_GlcNHglycan	65	68	PF01048	0.378
MOD_GlcNHglycan	89	92	PF01048	0.412
MOD_GSK3_1	135	142	PF00069	0.427
MOD_GSK3_1	189	196	PF00069	0.379
MOD_GSK3_1	202	209	PF00069	0.228
MOD_GSK3_1	213	220	PF00069	0.466
MOD_GSK3_1	266	273	PF00069	0.378
MOD_GSK3_1	302	309	PF00069	0.381
MOD_GSK3_1	319	326	PF00069	0.636
MOD_GSK3_1	392	399	PF00069	0.588
MOD_GSK3_1	408	415	PF00069	0.699
MOD_GSK3_1	429	436	PF00069	0.506
MOD_GSK3_1	45	52	PF00069	0.512
MOD_GSK3_1	530	537	PF00069	0.457
MOD_N-GLC_1	109	114	PF02516	0.428
MOD_N-GLC_1	359	364	PF02516	0.417
MOD_N-GLC_1	412	417	PF02516	0.593
MOD_NEK2_1	135	140	PF00069	0.431
MOD_NEK2_1	172	177	PF00069	0.560
MOD_NEK2_1	270	275	PF00069	0.385
MOD_NEK2_1	429	434	PF00069	0.544
MOD_NEK2_1	444	449	PF00069	0.557
MOD_NEK2_1	70	75	PF00069	0.326
MOD_NEK2_2	530	535	PF00069	0.459
MOD_PIKK_1	128	134	PF00454	0.386
MOD_PIKK_1	136	142	PF00454	0.393
MOD_PIKK_1	314	320	PF00454	0.482
MOD_PIKK_1	392	398	PF00454	0.561
MOD_PIKK_1	487	493	PF00454	0.536
MOD_PIKK_1	569	575	PF00454	0.571
MOD_PK_1	403	409	PF00069	0.610
MOD_PK_1	96	102	PF00069	0.324
MOD_PKA_1	16	22	PF00069	0.603
MOD_PKA_2	135	141	PF00069	0.529
MOD_PKA_2	16	22	PF00069	0.568
MOD_PKA_2	23	29	PF00069	0.511
MOD_PKA_2	306	312	PF00069	0.430
MOD_PKA_2	330	336	PF00069	0.455
MOD_PKA_2	389	395	PF00069	0.619
MOD_PKA_2	396	402	PF00069	0.569
MOD_PKA_2	429	435	PF00069	0.533
MOD_PKA_2	436	442	PF00069	0.509
MOD_PKA_2	534	540	PF00069	0.737
MOD_PKA_2	553	559	PF00069	0.470
MOD_PKA_2	63	69	PF00069	0.385
MOD_PKA_2	9	15	PF00069	0.713
MOD_Plk_1	213	219	PF00069	0.454
MOD_Plk_1	257	263	PF00069	0.352
MOD_Plk_1	265	271	PF00069	0.368
MOD_Plk_1	359	365	PF00069	0.486
MOD_Plk_4	240	246	PF00069	0.327
MOD_Plk_4	271	277	PF00069	0.368
MOD_Plk_4	289	295	PF00069	0.372
MOD_Plk_4	332	338	PF00069	0.516
MOD_Plk_4	366	372	PF00069	0.514
MOD_Plk_4	51	57	PF00069	0.576
MOD_Plk_4	536	542	PF00069	0.576
MOD_Plk_4	79	85	PF00069	0.346
MOD_ProDKin_1	558	564	PF00069	0.561
MOD_SUMO_rev_2	187	196	PF00179	0.342
MOD_SUMO_rev_2	424	429	PF00179	0.595
TRG_ENDOCYTIC_2	165	168	PF00928	0.388
TRG_ENDOCYTIC_2	174	177	PF00928	0.278
TRG_ER_diArg_1	534	536	PF00400	0.602
TRG_ER_diArg_1	56	58	PF00400	0.512
TRG_ER_diArg_1	94	96	PF00400	0.462
TRG_NES_CRM1_1	565	580	PF08389	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P386	Leptomonas seymouri	55%	99%
A0A3Q8IAY0	Leishmania donovani	85%	99%
A4HZC0	Leishmania infantum	85%	99%
Q4QC73	Leishmania major	85%	100%