Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVA4_LEIMU

TriTrypDb:

LmxM.21.1200

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	97	101	PF00656	0.528
CLV_NRD_NRD_1	147	149	PF00675	0.629
CLV_NRD_NRD_1	165	167	PF00675	0.424
CLV_NRD_NRD_1	226	228	PF00675	0.430
CLV_NRD_NRD_1	281	283	PF00675	0.508
CLV_PCSK_FUR_1	145	149	PF00082	0.600
CLV_PCSK_KEX2_1	147	149	PF00082	0.592
CLV_PCSK_KEX2_1	165	167	PF00082	0.405
CLV_PCSK_KEX2_1	226	228	PF00082	0.430
CLV_PCSK_KEX2_1	281	283	PF00082	0.508
CLV_PCSK_KEX2_1	63	65	PF00082	0.632
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.632
CLV_PCSK_SKI1_1	166	170	PF00082	0.479
CLV_PCSK_SKI1_1	226	230	PF00082	0.446
CLV_PCSK_SKI1_1	46	50	PF00082	0.469
DEG_APCC_DBOX_1	15	23	PF00400	0.590
DEG_COP1_1	263	272	PF00400	0.448
DEG_SPOP_SBC_1	108	112	PF00917	0.517
DEG_SPOP_SBC_1	151	155	PF00917	0.417
DEG_SPOP_SBC_1	93	97	PF00917	0.623
DOC_CYCLIN_RxL_1	163	171	PF00134	0.492
DOC_CYCLIN_RxL_1	41	53	PF00134	0.459
DOC_MAPK_gen_1	226	233	PF00069	0.442
DOC_MAPK_MEF2A_6	226	233	PF00069	0.442
DOC_MAPK_RevD_3	47	62	PF00069	0.530
DOC_PP4_FxxP_1	288	291	PF00568	0.459
DOC_USP7_MATH_1	106	110	PF00917	0.569
DOC_USP7_MATH_1	146	150	PF00917	0.658
DOC_USP7_MATH_1	283	287	PF00917	0.544
DOC_WW_Pin1_4	115	120	PF00397	0.552
DOC_WW_Pin1_4	132	137	PF00397	0.584
DOC_WW_Pin1_4	76	81	PF00397	0.525
LIG_14-3-3_CanoR_1	11	16	PF00244	0.544
LIG_14-3-3_CanoR_1	145	151	PF00244	0.639
LIG_14-3-3_CanoR_1	282	291	PF00244	0.437
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_BRCT_BRCA1_1	34	38	PF00533	0.711
LIG_FHA_1	228	234	PF00498	0.454
LIG_FHA_1	257	263	PF00498	0.637
LIG_FHA_1	32	38	PF00498	0.568
LIG_FHA_1	52	58	PF00498	0.779
LIG_FHA_1	94	100	PF00498	0.593
LIG_FHA_2	232	238	PF00498	0.444
LIG_LIR_Apic_2	286	291	PF02991	0.451
LIG_LIR_Nem_3	179	185	PF02991	0.445
LIG_NRBOX	224	230	PF00104	0.503
LIG_SH2_CRK	182	186	PF00017	0.445
LIG_SH2_STAT3	250	253	PF00017	0.457
LIG_SH2_STAT5	209	212	PF00017	0.424
LIG_SH2_STAT5	250	253	PF00017	0.468
LIG_SH3_3	12	18	PF00018	0.528
LIG_SH3_3	264	270	PF00018	0.605
LIG_SUMO_SIM_par_1	47	54	PF11976	0.582
LIG_SUMO_SIM_par_1	90	97	PF11976	0.478
LIG_TRAF2_1	234	237	PF00917	0.514
LIG_WRC_WIRS_1	285	290	PF05994	0.447
MOD_CK1_1	109	115	PF00069	0.740
MOD_CK1_1	27	33	PF00069	0.628
MOD_CK1_1	50	56	PF00069	0.745
MOD_CK1_1	66	72	PF00069	0.693
MOD_CK2_1	231	237	PF00069	0.446
MOD_GlcNHglycan	182	185	PF01048	0.387
MOD_GlcNHglycan	26	29	PF01048	0.560
MOD_GlcNHglycan	262	265	PF01048	0.446
MOD_GlcNHglycan	87	90	PF01048	0.602
MOD_GSK3_1	104	111	PF00069	0.665
MOD_GSK3_1	146	153	PF00069	0.600
MOD_GSK3_1	203	210	PF00069	0.429
MOD_GSK3_1	227	234	PF00069	0.453
MOD_GSK3_1	256	263	PF00069	0.433
MOD_GSK3_1	27	34	PF00069	0.523
MOD_GSK3_1	47	54	PF00069	0.728
MOD_GSK3_1	71	78	PF00069	0.581
MOD_LATS_1	9	15	PF00433	0.475
MOD_NEK2_1	168	173	PF00069	0.473
MOD_NEK2_1	202	207	PF00069	0.448
MOD_NEK2_1	49	54	PF00069	0.613
MOD_NEK2_1	83	88	PF00069	0.595
MOD_PK_1	11	17	PF00069	0.476
MOD_PKA_1	63	69	PF00069	0.612
MOD_PKA_2	10	16	PF00069	0.552
MOD_PKA_2	146	152	PF00069	0.583
MOD_PKA_2	207	213	PF00069	0.429
MOD_PKA_2	63	69	PF00069	0.612
MOD_Plk_1	178	184	PF00069	0.440
MOD_ProDKin_1	115	121	PF00069	0.550
MOD_ProDKin_1	132	138	PF00069	0.585
MOD_ProDKin_1	76	82	PF00069	0.521
MOD_SUMO_for_1	176	179	PF00179	0.498
TRG_DiLeu_BaEn_1	224	229	PF01217	0.436
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.528
TRG_DiLeu_LyEn_5	224	229	PF01217	0.500
TRG_ENDOCYTIC_2	182	185	PF00928	0.435
TRG_ENDOCYTIC_2	186	189	PF00928	0.414
TRG_ENDOCYTIC_2	209	212	PF00928	0.424
TRG_ER_diArg_1	145	148	PF00400	0.605
TRG_ER_diArg_1	164	166	PF00400	0.366
TRG_ER_diArg_1	225	227	PF00400	0.439
TRG_NLS_MonoCore_2	60	65	PF00514	0.571
TRG_NLS_MonoExtN_4	61	66	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P384	Leptomonas seymouri	45%	100%
A0A3S7WWL4	Leishmania donovani	88%	100%
A4HBX6	Leishmania braziliensis	75%	99%
A4HZ96	Leishmania infantum	88%	100%
Q4QC76	Leishmania major	87%	100%