LeishMANIAdb
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Surface antigen-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Surface antigen-like protein
Gene product:
surface antigen-like protein
Species:
Leishmania mexicana
UniProt:
E9AVA1_LEIMU
TriTrypDb:
LmxM.21.1170
Length:
461

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 115
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 55, no: 11
NetGPI no yes: 0, no: 66
Cellular components
Term Name Level Count
GO:0005929 cilium 4 67
GO:0042995 cell projection 2 67
GO:0043226 organelle 2 67
GO:0043227 membrane-bounded organelle 3 67
GO:0110165 cellular anatomical entity 1 67
GO:0120025 plasma membrane bounded cell projection 3 67
GO:0016020 membrane 2 24
GO:0005886 plasma membrane 3 5

Expansion

Sequence features

E9AVA1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVA1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 51 53 PF00675 0.535
CLV_NRD_NRD_1 9 11 PF00675 0.658
CLV_PCSK_FUR_1 7 11 PF00082 0.345
CLV_PCSK_KEX2_1 9 11 PF00082 0.658
CLV_PCSK_SKI1_1 201 205 PF00082 0.445
CLV_PCSK_SKI1_1 52 56 PF00082 0.300
CLV_PCSK_SKI1_1 78 82 PF00082 0.526
CLV_PCSK_SKI1_1 9 13 PF00082 0.453
DOC_CYCLIN_yClb5_NLxxxL_5 174 183 PF00134 0.166
DOC_MAPK_gen_1 214 223 PF00069 0.204
DOC_MAPK_gen_1 237 247 PF00069 0.478
DOC_MAPK_MEF2A_6 192 199 PF00069 0.325
DOC_PP1_RVXF_1 284 290 PF00149 0.489
DOC_PP2B_LxvP_1 25 28 PF13499 0.591
DOC_PP4_MxPP_1 1 4 PF00568 0.440
DOC_USP7_MATH_1 105 109 PF00917 0.521
DOC_USP7_MATH_1 310 314 PF00917 0.341
DOC_USP7_MATH_1 436 440 PF00917 0.440
DOC_USP7_MATH_1 442 446 PF00917 0.484
DOC_USP7_MATH_1 98 102 PF00917 0.544
DOC_USP7_MATH_2 160 166 PF00917 0.253
LIG_14-3-3_CanoR_1 214 219 PF00244 0.396
LIG_14-3-3_CanoR_1 240 246 PF00244 0.439
LIG_14-3-3_CanoR_1 42 49 PF00244 0.535
LIG_AP2alpha_1 54 58 PF02296 0.229
LIG_APCC_ABBA_1 363 368 PF00400 0.205
LIG_BIR_II_1 1 5 PF00653 0.537
LIG_BIR_III_1 1 5 PF00653 0.407
LIG_BIR_III_3 1 5 PF00653 0.407
LIG_deltaCOP1_diTrp_1 235 238 PF00928 0.392
LIG_deltaCOP1_diTrp_1 283 289 PF00928 0.472
LIG_DLG_GKlike_1 214 221 PF00625 0.187
LIG_FHA_1 154 160 PF00498 0.381
LIG_FHA_1 242 248 PF00498 0.277
LIG_FHA_1 275 281 PF00498 0.317
LIG_FHA_1 325 331 PF00498 0.292
LIG_FHA_1 338 344 PF00498 0.341
LIG_FHA_1 35 41 PF00498 0.308
LIG_FHA_1 90 96 PF00498 0.405
LIG_FHA_2 386 392 PF00498 0.521
LIG_FHA_2 68 74 PF00498 0.456
LIG_LIR_Gen_1 162 171 PF02991 0.357
LIG_LIR_Gen_1 265 276 PF02991 0.242
LIG_LIR_Gen_1 283 290 PF02991 0.358
LIG_LIR_Gen_1 307 316 PF02991 0.269
LIG_LIR_Gen_1 361 372 PF02991 0.407
LIG_LIR_LC3C_4 167 171 PF02991 0.270
LIG_LIR_Nem_3 138 142 PF02991 0.390
LIG_LIR_Nem_3 162 166 PF02991 0.339
LIG_LIR_Nem_3 265 271 PF02991 0.289
LIG_LIR_Nem_3 283 287 PF02991 0.338
LIG_LIR_Nem_3 361 367 PF02991 0.345
LIG_Pex14_2 54 58 PF04695 0.229
LIG_SH2_NCK_1 43 47 PF00017 0.497
LIG_SH2_STAP1 420 424 PF00017 0.592
LIG_SH2_STAT5 173 176 PF00017 0.291
LIG_SH2_STAT5 364 367 PF00017 0.365
LIG_SH2_STAT5 43 46 PF00017 0.452
LIG_SUMO_SIM_anti_2 167 173 PF11976 0.265
LIG_SUMO_SIM_anti_2 193 198 PF11976 0.178
LIG_SUMO_SIM_par_1 193 198 PF11976 0.235
LIG_SUMO_SIM_par_1 315 320 PF11976 0.281
LIG_TYR_ITIM 362 367 PF00017 0.509
MOD_CK1_1 190 196 PF00069 0.364
MOD_CK1_1 320 326 PF00069 0.344
MOD_CK1_1 334 340 PF00069 0.271
MOD_CK1_1 41 47 PF00069 0.474
MOD_CK1_1 418 424 PF00069 0.517
MOD_CK1_1 443 449 PF00069 0.459
MOD_CK1_1 97 103 PF00069 0.412
MOD_CK2_1 183 189 PF00069 0.311
MOD_CK2_1 261 267 PF00069 0.404
MOD_GlcNHglycan 100 103 PF01048 0.423
MOD_GlcNHglycan 108 111 PF01048 0.390
MOD_GlcNHglycan 131 134 PF01048 0.387
MOD_GlcNHglycan 228 231 PF01048 0.310
MOD_GlcNHglycan 251 255 PF01048 0.363
MOD_GlcNHglycan 307 311 PF01048 0.350
MOD_GlcNHglycan 324 327 PF01048 0.346
MOD_GlcNHglycan 348 351 PF01048 0.350
MOD_GlcNHglycan 412 415 PF01048 0.444
MOD_GlcNHglycan 422 425 PF01048 0.497
MOD_GlcNHglycan 442 445 PF01048 0.440
MOD_GlcNHglycan 450 454 PF01048 0.539
MOD_GlcNHglycan 89 92 PF01048 0.433
MOD_GlcNHglycan 96 99 PF01048 0.553
MOD_GSK3_1 131 138 PF00069 0.376
MOD_GSK3_1 149 156 PF00069 0.377
MOD_GSK3_1 179 186 PF00069 0.329
MOD_GSK3_1 270 277 PF00069 0.316
MOD_GSK3_1 306 313 PF00069 0.314
MOD_GSK3_1 320 327 PF00069 0.305
MOD_GSK3_1 330 337 PF00069 0.309
MOD_GSK3_1 34 41 PF00069 0.551
MOD_GSK3_1 410 417 PF00069 0.529
MOD_GSK3_1 436 443 PF00069 0.459
MOD_GSK3_1 445 452 PF00069 0.520
MOD_GSK3_1 85 92 PF00069 0.371
MOD_GSK3_1 94 101 PF00069 0.484
MOD_N-GLC_1 129 134 PF02516 0.334
MOD_N-GLC_1 378 383 PF02516 0.469
MOD_N-GLC_1 448 453 PF02516 0.448
MOD_N-GLC_2 402 404 PF02516 0.543
MOD_NEK2_1 118 123 PF00069 0.350
MOD_NEK2_1 129 134 PF00069 0.361
MOD_NEK2_1 155 160 PF00069 0.365
MOD_NEK2_1 172 177 PF00069 0.276
MOD_NEK2_1 179 184 PF00069 0.262
MOD_NEK2_1 204 209 PF00069 0.330
MOD_NEK2_1 228 233 PF00069 0.302
MOD_NEK2_1 252 257 PF00069 0.274
MOD_NEK2_1 276 281 PF00069 0.290
MOD_NEK2_1 300 305 PF00069 0.286
MOD_NEK2_1 317 322 PF00069 0.357
MOD_NEK2_1 324 329 PF00069 0.291
MOD_NEK2_1 331 336 PF00069 0.285
MOD_NEK2_1 348 353 PF00069 0.387
MOD_NEK2_1 378 383 PF00069 0.350
MOD_NEK2_1 58 63 PF00069 0.323
MOD_NEK2_2 187 192 PF00069 0.178
MOD_OFUCOSY 75 82 PF10250 0.358
MOD_PIKK_1 112 118 PF00454 0.499
MOD_PKA_1 9 15 PF00069 0.328
MOD_PKA_2 226 232 PF00069 0.429
MOD_PKA_2 274 280 PF00069 0.446
MOD_PKA_2 41 47 PF00069 0.447
MOD_PKA_2 9 15 PF00069 0.515
MOD_PKB_1 7 15 PF00069 0.325
MOD_Plk_1 112 118 PF00069 0.315
MOD_Plk_1 161 167 PF00069 0.243
MOD_Plk_1 306 312 PF00069 0.288
MOD_Plk_1 85 91 PF00069 0.255
MOD_Plk_2-3 162 168 PF00069 0.358
MOD_Plk_4 190 196 PF00069 0.353
MOD_Plk_4 241 247 PF00069 0.287
MOD_Plk_4 358 364 PF00069 0.232
TRG_ENDOCYTIC_2 364 367 PF00928 0.338
TRG_ER_diArg_1 225 228 PF00400 0.408
TRG_ER_diArg_1 8 10 PF00400 0.599
TRG_NES_CRM1_1 189 200 PF08389 0.149
TRG_Pf-PMV_PEXEL_1 143 147 PF00026 0.382

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6A5 Leptomonas seymouri 37% 72%
A0A0N1I121 Leptomonas seymouri 29% 92%
A0A0N1I661 Leptomonas seymouri 31% 81%
A0A0N1I7S5 Leptomonas seymouri 31% 91%
A0A0N1II82 Leptomonas seymouri 33% 67%
A0A0S4IIK7 Bodo saltans 28% 100%
A0A0S4IJN2 Bodo saltans 30% 68%
A0A0S4IN27 Bodo saltans 36% 85%
A0A0S4IQP4 Bodo saltans 35% 100%
A0A0S4IR61 Bodo saltans 35% 100%
A0A0S4ISU4 Bodo saltans 38% 70%
A0A0S4IU23 Bodo saltans 26% 78%
A0A0S4IU73 Bodo saltans 39% 92%
A0A0S4IV96 Bodo saltans 37% 76%
A0A0S4IVN7 Bodo saltans 40% 100%
A0A0S4IVQ8 Bodo saltans 34% 77%
A0A0S4IW93 Bodo saltans 31% 76%
A0A0S4IY44 Bodo saltans 28% 69%
A0A0S4IZC7 Bodo saltans 29% 100%
A0A0S4J206 Bodo saltans 34% 75%
A0A0S4J2H8 Bodo saltans 30% 79%
A0A0S4J3T7 Bodo saltans 34% 100%
A0A0S4J5A0 Bodo saltans 34% 81%
A0A0S4JAQ6 Bodo saltans 28% 90%
A0A0S4JAW7 Bodo saltans 28% 90%
A0A0S4JB95 Bodo saltans 27% 76%
A0A0S4JBV9 Bodo saltans 30% 94%
A0A0S4JCG7 Bodo saltans 39% 100%
A0A0S4JD35 Bodo saltans 30% 77%
A0A0S4JDT0 Bodo saltans 36% 70%
A0A0S4JEK1 Bodo saltans 30% 100%
A0A0S4JEP2 Bodo saltans 27% 79%
A0A0S4JFC9 Bodo saltans 36% 96%
A0A0S4JFY5 Bodo saltans 38% 100%
A0A0S4JHM1 Bodo saltans 31% 100%
A0A0S4JL29 Bodo saltans 30% 91%
A0A0S4JP43 Bodo saltans 38% 100%
A0A0S4JQW3 Bodo saltans 28% 100%
A0A0S4JS89 Bodo saltans 29% 100%
A0A0S4JSB8 Bodo saltans 38% 83%
A0A0S4KGV4 Bodo saltans 25% 85%
A0A0S4KH41 Bodo saltans 29% 66%
A0A0S4KJA7 Bodo saltans 29% 69%
A0A0S4KK37 Bodo saltans 33% 79%
A0A0S4KMV2 Bodo saltans 31% 100%
A0A3Q8I9A6 Leishmania donovani 32% 100%
A0A3Q8IC27 Leishmania donovani 77% 97%
A0A3S5H6M3 Leishmania donovani 38% 67%
A0A3S5H6M4 Leishmania donovani 30% 70%
A0A3S7WS66 Leishmania donovani 30% 70%
A4HBX3 Leishmania braziliensis 56% 100%
A4HVB0 Leishmania infantum 29% 100%
A4HZ93 Leishmania infantum 77% 97%
A7PW81 Vitis vinifera 29% 100%
D1GJ51 Leishmania infantum 35% 100%
E9AGG2 Leishmania infantum 34% 69%
E9AGG5 Leishmania infantum 36% 100%
E9AGG7 Leishmania infantum 32% 74%
E9AGG9 Leishmania infantum 35% 85%
E9AGH0 Leishmania infantum 35% 100%
E9AP02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 99%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 66%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9AP07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
P35858 Homo sapiens 24% 76%
Q05091 Pyrus communis 30% 100%
Q4QC79 Leishmania major 70% 100%
Q4QGI0 Leishmania major 35% 100%
Q4QGI2 Leishmania major 35% 82%
Q4QGI4 Leishmania major 35% 100%
Q4QGI6 Leishmania major 36% 84%
Q4QGJ0 Leishmania major 32% 73%
Q4QGJ2 Leishmania major 34% 100%
Q4QGJ6 Leishmania major 36% 81%
Q4QGJ9 Leishmania major 34% 100%
Q4QGK0 Leishmania major 33% 100%
Q4QGK2 Leishmania major 35% 100%
Q4QGK4 Leishmania major 34% 69%
Q4QGK8 Leishmania major 35% 100%
Q4QGL2 Leishmania major 34% 100%
Q4QGL4 Leishmania major 36% 100%
Q4QGL5 Leishmania major 32% 100%
Q4QGL8 Leishmania major 37% 76%
Q5ZLN0 Gallus gallus 24% 76%
Q940E8 Zea mays 26% 75%
Q9CRC8 Mus musculus 27% 77%
Q9M5J9 Arabidopsis thaliana 27% 100%
Q9SKK5 Arabidopsis thaliana 23% 69%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS