Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV98_LEIMU

TriTrypDb:

LmxM.21.1140

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AV98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.450
CLV_C14_Caspase3-7	267	271	PF00656	0.582
CLV_NRD_NRD_1	245	247	PF00675	0.705
CLV_PCSK_KEX2_1	245	247	PF00082	0.705
CLV_PCSK_SKI1_1	222	226	PF00082	0.498
DEG_Nend_UBRbox_3	1	3	PF02207	0.482
DEG_SPOP_SBC_1	166	170	PF00917	0.585
DOC_CYCLIN_yCln2_LP_2	24	30	PF00134	0.451
DOC_MAPK_HePTP_8	18	30	PF00069	0.462
DOC_MAPK_MEF2A_6	21	30	PF00069	0.458
DOC_MAPK_MEF2A_6	47	54	PF00069	0.482
DOC_PP2B_LxvP_1	24	27	PF13499	0.455
DOC_PP4_MxPP_1	92	95	PF00568	0.512
DOC_USP7_MATH_1	166	170	PF00917	0.768
DOC_USP7_MATH_2	95	101	PF00917	0.540
DOC_USP7_UBL2_3	84	88	PF12436	0.545
DOC_WW_Pin1_4	167	172	PF00397	0.723
DOC_WW_Pin1_4	216	221	PF00397	0.606
DOC_WW_Pin1_4	307	312	PF00397	0.521
DOC_WW_Pin1_4	99	104	PF00397	0.592
LIG_14-3-3_CanoR_1	9	18	PF00244	0.675
LIG_CtBP_PxDLS_1	27	31	PF00389	0.532
LIG_FHA_1	11	17	PF00498	0.656
LIG_FHA_1	226	232	PF00498	0.666
LIG_FHA_1	237	243	PF00498	0.566
LIG_LIR_Nem_3	306	312	PF02991	0.607
LIG_NRBOX	146	152	PF00104	0.536
LIG_PDZ_Class_1	307	312	PF00595	0.521
LIG_SH2_STAT3	247	250	PF00017	0.540
LIG_SH2_STAT5	116	119	PF00017	0.534
LIG_TRAF2_1	296	299	PF00917	0.578
LIG_TRAF2_1	94	97	PF00917	0.596
LIG_TYR_ITIM	307	312	PF00017	0.597
MOD_CDC14_SPxK_1	219	222	PF00782	0.619
MOD_CDK_SPxK_1	216	222	PF00069	0.612
MOD_CK1_1	102	108	PF00069	0.721
MOD_CK1_1	160	166	PF00069	0.553
MOD_CK2_1	293	299	PF00069	0.640
MOD_GlcNHglycan	159	162	PF01048	0.623
MOD_GlcNHglycan	70	73	PF01048	0.627
MOD_GlcNHglycan	96	102	PF01048	0.593
MOD_GSK3_1	166	173	PF00069	0.600
MOD_N-GLC_1	28	33	PF02516	0.489
MOD_N-GLC_2	110	112	PF02516	0.612
MOD_NEK2_1	28	33	PF00069	0.487
MOD_NEK2_1	68	73	PF00069	0.604
MOD_PIKK_1	170	176	PF00454	0.686
MOD_Plk_1	117	123	PF00069	0.444
MOD_Plk_1	236	242	PF00069	0.708
MOD_Plk_1	28	34	PF00069	0.483
MOD_Plk_2-3	293	299	PF00069	0.597
MOD_Plk_4	28	34	PF00069	0.479
MOD_ProDKin_1	167	173	PF00069	0.722
MOD_ProDKin_1	216	222	PF00069	0.612
MOD_ProDKin_1	99	105	PF00069	0.589
TRG_ENDOCYTIC_2	137	140	PF00928	0.429
TRG_ENDOCYTIC_2	304	307	PF00928	0.563
TRG_ENDOCYTIC_2	309	312	PF00928	0.552
TRG_ER_diArg_1	113	116	PF00400	0.462
TRG_ER_diArg_1	245	247	PF00400	0.711
TRG_ER_diArg_1	300	303	PF00400	0.597
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P3	Leptomonas seymouri	35%	98%
A0A3Q8IL55	Leishmania donovani	83%	100%
A4HC50	Leishmania braziliensis	68%	100%
A4HZ90	Leishmania infantum	83%	100%
Q4QC82	Leishmania major	83%	96%