Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV97_LEIMU

TriTrypDb:

LmxM.21.1130

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	7
GO:0016020	membrane	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	8
GO:0000139	Golgi membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0031984	organelle subcompartment	2	1
GO:0031985	Golgi cisterna	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098791	Golgi apparatus subcompartment	3	1

Expansion

Sequence features

E9AV97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV97

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	8
GO:0007030	Golgi organization	5	8
GO:0009987	cellular process	1	8
GO:0016043	cellular component organization	3	8
GO:0071840	cellular component organization or biogenesis	2	8
GO:0000301	retrograde transport, vesicle recycling within Golgi	7	1
GO:0006810	transport	3	1
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0016192	vesicle-mediated transport	4	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.678
CLV_C14_Caspase3-7	172	176	PF00656	0.666
CLV_C14_Caspase3-7	277	281	PF00656	0.556
CLV_C14_Caspase3-7	536	540	PF00656	0.701
CLV_C14_Caspase3-7	566	570	PF00656	0.614
CLV_NRD_NRD_1	144	146	PF00675	0.412
CLV_NRD_NRD_1	379	381	PF00675	0.446
CLV_NRD_NRD_1	390	392	PF00675	0.409
CLV_NRD_NRD_1	542	544	PF00675	0.530
CLV_PCSK_KEX2_1	144	146	PF00082	0.412
CLV_PCSK_KEX2_1	379	381	PF00082	0.468
CLV_PCSK_KEX2_1	390	392	PF00082	0.556
CLV_PCSK_KEX2_1	541	543	PF00082	0.472
CLV_PCSK_PC7_1	375	381	PF00082	0.443
CLV_PCSK_SKI1_1	233	237	PF00082	0.453
CLV_PCSK_SKI1_1	375	379	PF00082	0.436
CLV_PCSK_SKI1_1	447	451	PF00082	0.490
CLV_PCSK_SKI1_1	503	507	PF00082	0.393
CLV_PCSK_SKI1_1	577	581	PF00082	0.428
CLV_PCSK_SKI1_1	587	591	PF00082	0.300
CLV_Separin_Metazoa	387	391	PF03568	0.634
DEG_APCC_DBOX_1	374	382	PF00400	0.643
DEG_APCC_DBOX_1	426	434	PF00400	0.627
DEG_Nend_Nbox_1	1	3	PF02207	0.623
DEG_SCF_FBW7_1	531	537	PF00400	0.603
DEG_SPOP_SBC_1	45	49	PF00917	0.618
DOC_CKS1_1	531	536	PF01111	0.605
DOC_CYCLIN_yClb5_NLxxxL_5	433	442	PF00134	0.606
DOC_MAPK_gen_1	342	350	PF00069	0.660
DOC_MAPK_gen_1	425	433	PF00069	0.634
DOC_MAPK_gen_1	541	550	PF00069	0.678
DOC_MAPK_MEF2A_6	344	352	PF00069	0.623
DOC_MIT_MIM_1	303	311	PF04212	0.630
DOC_PP2B_LxvP_1	122	125	PF13499	0.704
DOC_PP4_FxxP_1	490	493	PF00568	0.789
DOC_USP7_MATH_1	135	139	PF00917	0.624
DOC_USP7_MATH_1	165	169	PF00917	0.717
DOC_USP7_MATH_1	177	181	PF00917	0.709
DOC_USP7_MATH_1	190	194	PF00917	0.612
DOC_USP7_MATH_1	227	231	PF00917	0.625
DOC_USP7_MATH_1	283	287	PF00917	0.736
DOC_USP7_MATH_1	360	364	PF00917	0.584
DOC_USP7_MATH_1	395	399	PF00917	0.679
DOC_USP7_MATH_1	494	498	PF00917	0.708
DOC_USP7_MATH_1	534	538	PF00917	0.827
DOC_USP7_MATH_1	563	567	PF00917	0.643
DOC_WW_Pin1_4	131	136	PF00397	0.628
DOC_WW_Pin1_4	391	396	PF00397	0.714
DOC_WW_Pin1_4	518	523	PF00397	0.618
DOC_WW_Pin1_4	530	535	PF00397	0.741
DOC_WW_Pin1_4	95	100	PF00397	0.808
LIG_14-3-3_CanoR_1	154	164	PF00244	0.599
LIG_14-3-3_CanoR_1	226	236	PF00244	0.651
LIG_14-3-3_CanoR_1	285	291	PF00244	0.733
LIG_14-3-3_CanoR_1	379	389	PF00244	0.616
LIG_14-3-3_CanoR_1	38	45	PF00244	0.721
LIG_14-3-3_CanoR_1	503	512	PF00244	0.617
LIG_14-3-3_CanoR_1	577	586	PF00244	0.715
LIG_Actin_WH2_2	374	392	PF00022	0.534
LIG_AP2alpha_2	162	164	PF02296	0.627
LIG_APCC_ABBA_1	257	262	PF00400	0.623
LIG_BRCT_BRCA1_1	486	490	PF00533	0.718
LIG_BRCT_BRCA1_1	89	93	PF00533	0.755
LIG_CaM_IQ_9	336	351	PF13499	0.643
LIG_EVH1_1	490	494	PF00568	0.706
LIG_FHA_1	14	20	PF00498	0.681
LIG_FHA_1	331	337	PF00498	0.768
LIG_FHA_1	46	52	PF00498	0.667
LIG_FHA_1	606	612	PF00498	0.357
LIG_FHA_2	157	163	PF00498	0.749
LIG_FHA_2	381	387	PF00498	0.612
LIG_FHA_2	530	536	PF00498	0.731
LIG_GBD_Chelix_1	601	609	PF00786	0.313
LIG_LIR_Apic_2	487	493	PF02991	0.714
LIG_LIR_Gen_1	454	463	PF02991	0.533
LIG_LIR_Nem_3	454	459	PF02991	0.536
LIG_LIR_Nem_3	521	526	PF02991	0.602
LIG_MYND_1	57	61	PF01753	0.709
LIG_SH2_PTP2	593	596	PF00017	0.351
LIG_SH2_STAT5	593	596	PF00017	0.292
LIG_SH3_2	58	63	PF14604	0.715
LIG_SH3_3	488	494	PF00018	0.771
LIG_SH3_3	52	58	PF00018	0.705
LIG_SH3_3	528	534	PF00018	0.601
LIG_SH3_3	614	620	PF00018	0.479
LIG_SH3_3	621	627	PF00018	0.513
LIG_SH3_4	290	297	PF00018	0.578
LIG_SUMO_SIM_par_1	120	126	PF11976	0.707
LIG_SUMO_SIM_par_1	607	614	PF11976	0.518
LIG_TRAF2_1	23	26	PF00917	0.592
LIG_TRAF2_2	291	296	PF00917	0.696
LIG_WRC_WIRS_1	128	133	PF05994	0.674
LIG_WRC_WIRS_1	568	573	PF05994	0.492
MOD_CK1_1	123	129	PF00069	0.657
MOD_CK1_1	168	174	PF00069	0.689
MOD_CK1_1	191	197	PF00069	0.624
MOD_CK1_1	286	292	PF00069	0.656
MOD_CK1_1	393	399	PF00069	0.683
MOD_CK1_1	47	53	PF00069	0.601
MOD_CK1_1	567	573	PF00069	0.551
MOD_CK2_1	192	198	PF00069	0.574
MOD_CK2_1	529	535	PF00069	0.659
MOD_Cter_Amidation	142	145	PF01082	0.510
MOD_GlcNHglycan	105	108	PF01048	0.618
MOD_GlcNHglycan	180	183	PF01048	0.721
MOD_GlcNHglycan	229	232	PF01048	0.574
MOD_GlcNHglycan	375	378	PF01048	0.613
MOD_GlcNHglycan	397	400	PF01048	0.675
MOD_GlcNHglycan	42	45	PF01048	0.681
MOD_GlcNHglycan	476	479	PF01048	0.723
MOD_GlcNHglycan	487	490	PF01048	0.651
MOD_GlcNHglycan	515	518	PF01048	0.665
MOD_GlcNHglycan	535	539	PF01048	0.772
MOD_GlcNHglycan	612	616	PF01048	0.585
MOD_GSK3_1	123	130	PF00069	0.668
MOD_GSK3_1	131	138	PF00069	0.545
MOD_GSK3_1	165	172	PF00069	0.584
MOD_GSK3_1	188	195	PF00069	0.589
MOD_GSK3_1	391	398	PF00069	0.656
MOD_GSK3_1	40	47	PF00069	0.623
MOD_GSK3_1	429	436	PF00069	0.578
MOD_GSK3_1	447	454	PF00069	0.543
MOD_GSK3_1	526	533	PF00069	0.652
MOD_GSK3_1	563	570	PF00069	0.544
MOD_GSK3_1	83	90	PF00069	0.539
MOD_GSK3_1	98	105	PF00069	0.647
MOD_N-GLC_1	83	88	PF02516	0.649
MOD_N-GLC_2	484	486	PF02516	0.533
MOD_NEK2_1	103	108	PF00069	0.651
MOD_NEK2_1	169	174	PF00069	0.621
MOD_NEK2_1	39	44	PF00069	0.576
MOD_NEK2_1	433	438	PF00069	0.514
MOD_NEK2_1	474	479	PF00069	0.609
MOD_NEK2_1	611	616	PF00069	0.557
MOD_NEK2_1	70	75	PF00069	0.659
MOD_PIKK_1	169	175	PF00454	0.650
MOD_PIKK_1	261	267	PF00454	0.514
MOD_PIKK_1	380	386	PF00454	0.507
MOD_PIKK_1	577	583	PF00454	0.530
MOD_PKA_1	390	396	PF00069	0.667
MOD_PKA_2	243	249	PF00069	0.612
MOD_PKA_2	284	290	PF00069	0.674
MOD_PKA_2	360	366	PF00069	0.569
MOD_PKA_2	390	396	PF00069	0.584
MOD_PKA_2	474	480	PF00069	0.745
MOD_Plk_2-3	13	19	PF00069	0.545
MOD_Plk_4	165	171	PF00069	0.604
MOD_Plk_4	98	104	PF00069	0.581
MOD_ProDKin_1	131	137	PF00069	0.534
MOD_ProDKin_1	391	397	PF00069	0.653
MOD_ProDKin_1	518	524	PF00069	0.516
MOD_ProDKin_1	530	536	PF00069	0.693
MOD_ProDKin_1	95	101	PF00069	0.783
MOD_SUMO_rev_2	10	16	PF00179	0.538
MOD_SUMO_rev_2	269	278	PF00179	0.609
MOD_SUMO_rev_2	286	291	PF00179	0.500
MOD_SUMO_rev_2	448	454	PF00179	0.553
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.506
TRG_ENDOCYTIC_2	456	459	PF00928	0.547
TRG_ENDOCYTIC_2	593	596	PF00928	0.351
TRG_ER_diArg_1	378	380	PF00400	0.559
TRG_ER_diArg_1	389	391	PF00400	0.488
TRG_ER_diArg_1	541	543	PF00400	0.693
TRG_ER_diArg_1	79	82	PF00400	0.700
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	379	384	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	577	581	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL5	Leptomonas seymouri	40%	94%
A0A1X0NXW6	Trypanosomatidae	23%	100%
A0A3Q8IB66	Leishmania donovani	89%	100%
A4HBX1	Leishmania braziliensis	73%	100%
A4HZ89	Leishmania infantum	88%	100%
Q4QC83	Leishmania major	88%	100%