Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U4/U6 small nuclear ribonuclear protein, putative

Species:

Leishmania mexicana

UniProt:

E9AV96_LEIMU

TriTrypDb:

LmxM.21.1120

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0097526	spliceosomal tri-snRNP complex	5	1
GO:0110165	cellular anatomical entity	1	6
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	5
GO:0005840	ribosome	5	4
GO:0043228	non-membrane-bounded organelle	3	4
GO:0043232	intracellular non-membrane-bounded organelle	4	4

Expansion

Sequence features

E9AV96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV96

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	4
GO:0005488	binding	1	1
GO:0016740	transferase activity	2	4
GO:0017069	snRNA binding	5	1
GO:0017070	U6 snRNA binding	6	1
GO:0030621	U4 snRNA binding	6	1
GO:0030627	pre-mRNA 5'-splice site binding	6	1
GO:0036002	pre-mRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.477
CLV_C14_Caspase3-7	235	239	PF00656	0.641
CLV_C14_Caspase3-7	324	328	PF00656	0.477
CLV_NRD_NRD_1	383	385	PF00675	0.564
CLV_NRD_NRD_1	573	575	PF00675	0.628
CLV_NRD_NRD_1	611	613	PF00675	0.715
CLV_PCSK_SKI1_1	132	136	PF00082	0.474
CLV_PCSK_SKI1_1	275	279	PF00082	0.542
CLV_PCSK_SKI1_1	355	359	PF00082	0.316
CLV_PCSK_SKI1_1	78	82	PF00082	0.472
CLV_PCSK_SKI1_1	84	88	PF00082	0.490
CLV_Separin_Metazoa	609	613	PF03568	0.615
DEG_APCC_DBOX_1	427	435	PF00400	0.414
DEG_APCC_DBOX_1	472	480	PF00400	0.578
DEG_SCF_TRCP1_1	122	128	PF00400	0.571
DEG_SPOP_SBC_1	125	129	PF00917	0.419
DEG_SPOP_SBC_1	183	187	PF00917	0.459
DEG_SPOP_SBC_1	237	241	PF00917	0.647
DOC_CYCLIN_yClb3_PxF_3	477	483	PF00134	0.505
DOC_MAPK_gen_1	198	207	PF00069	0.554
DOC_MAPK_gen_1	78	88	PF00069	0.476
DOC_PP1_RVXF_1	329	336	PF00149	0.381
DOC_PP2B_LxvP_1	102	105	PF13499	0.483
DOC_SPAK_OSR1_1	540	544	PF12202	0.551
DOC_USP7_MATH_1	105	109	PF00917	0.438
DOC_USP7_MATH_1	117	121	PF00917	0.610
DOC_USP7_MATH_1	152	156	PF00917	0.427
DOC_USP7_MATH_1	23	27	PF00917	0.669
DOC_USP7_MATH_1	318	322	PF00917	0.397
DOC_USP7_MATH_1	412	416	PF00917	0.539
DOC_USP7_MATH_1	516	520	PF00917	0.703
DOC_USP7_MATH_1	532	536	PF00917	0.492
DOC_USP7_MATH_1	587	591	PF00917	0.682
DOC_WW_Pin1_4	11	16	PF00397	0.690
DOC_WW_Pin1_4	148	153	PF00397	0.565
DOC_WW_Pin1_4	179	184	PF00397	0.505
DOC_WW_Pin1_4	19	24	PF00397	0.574
DOC_WW_Pin1_4	285	290	PF00397	0.628
DOC_WW_Pin1_4	291	296	PF00397	0.551
DOC_WW_Pin1_4	360	365	PF00397	0.448
DOC_WW_Pin1_4	477	482	PF00397	0.565
LIG_14-3-3_CanoR_1	204	208	PF00244	0.417
LIG_14-3-3_CanoR_1	355	361	PF00244	0.421
LIG_14-3-3_CanoR_1	428	437	PF00244	0.414
LIG_14-3-3_CanoR_1	47	52	PF00244	0.495
LIG_14-3-3_CanoR_1	540	544	PF00244	0.637
LIG_APCC_ABBA_1	391	396	PF00400	0.612
LIG_BIR_III_4	327	331	PF00653	0.475
LIG_BIR_III_4	396	400	PF00653	0.508
LIG_BRCT_BRCA1_1	13	17	PF00533	0.717
LIG_BRCT_BRCA1_1	414	418	PF00533	0.437
LIG_BRCT_BRCA1_1	479	483	PF00533	0.654
LIG_CSL_BTD_1	361	364	PF09270	0.480
LIG_DLG_GKlike_1	47	54	PF00625	0.350
LIG_FHA_1	226	232	PF00498	0.510
LIG_FHA_1	254	260	PF00498	0.377
LIG_FHA_1	264	270	PF00498	0.347
LIG_FHA_1	291	297	PF00498	0.549
LIG_FHA_1	309	315	PF00498	0.270
LIG_FHA_1	439	445	PF00498	0.464
LIG_FHA_2	141	147	PF00498	0.435
LIG_FHA_2	156	162	PF00498	0.410
LIG_FHA_2	230	236	PF00498	0.671
LIG_FHA_2	322	328	PF00498	0.463
LIG_FHA_2	440	446	PF00498	0.448
LIG_FHA_2	520	526	PF00498	0.577
LIG_LIR_Apic_2	417	422	PF02991	0.510
LIG_LIR_Gen_1	194	202	PF02991	0.506
LIG_LIR_Gen_1	538	548	PF02991	0.553
LIG_LIR_Gen_1	7	15	PF02991	0.668
LIG_LIR_Nem_3	162	168	PF02991	0.474
LIG_LIR_Nem_3	194	199	PF02991	0.515
LIG_LIR_Nem_3	538	544	PF02991	0.549
LIG_LIR_Nem_3	7	11	PF02991	0.670
LIG_MYND_1	474	478	PF01753	0.595
LIG_PCNA_yPIPBox_3	30	43	PF02747	0.542
LIG_Rb_pABgroove_1	375	383	PF01858	0.539
LIG_SH2_CRK	419	423	PF00017	0.473
LIG_SH2_CRK	55	59	PF00017	0.536
LIG_SH2_GRB2like	419	422	PF00017	0.504
LIG_SH2_NCK_1	305	309	PF00017	0.529
LIG_SH2_PTP2	8	11	PF00017	0.718
LIG_SH2_SRC	159	162	PF00017	0.496
LIG_SH2_SRC	419	422	PF00017	0.504
LIG_SH2_STAP1	501	505	PF00017	0.356
LIG_SH2_STAT5	8	11	PF00017	0.699
LIG_SH3_1	574	580	PF00018	0.720
LIG_SH3_3	110	116	PF00018	0.482
LIG_SH3_3	169	175	PF00018	0.425
LIG_SH3_3	471	477	PF00018	0.525
LIG_SH3_3	574	580	PF00018	0.720
LIG_SUMO_SIM_anti_2	485	493	PF11976	0.440
LIG_SUMO_SIM_par_1	139	146	PF11976	0.406
LIG_UBA3_1	570	576	PF00899	0.626
MOD_CDK_SPK_2	11	16	PF00069	0.712
MOD_CDK_SPxxK_3	11	18	PF00069	0.702
MOD_CK1_1	120	126	PF00069	0.651
MOD_CK1_1	127	133	PF00069	0.635
MOD_CK1_1	154	160	PF00069	0.439
MOD_CK1_1	182	188	PF00069	0.511
MOD_CK1_1	230	236	PF00069	0.708
MOD_CK1_1	240	246	PF00069	0.481
MOD_CK1_1	321	327	PF00069	0.384
MOD_CK1_1	519	525	PF00069	0.610
MOD_CK1_1	542	548	PF00069	0.606
MOD_CK1_1	560	566	PF00069	0.650
MOD_CK2_1	229	235	PF00069	0.662
MOD_CK2_1	238	244	PF00069	0.634
MOD_CK2_1	519	525	PF00069	0.576
MOD_GlcNHglycan	119	122	PF01048	0.696
MOD_GlcNHglycan	129	132	PF01048	0.303
MOD_GlcNHglycan	136	139	PF01048	0.526
MOD_GlcNHglycan	218	221	PF01048	0.657
MOD_GlcNHglycan	240	243	PF01048	0.666
MOD_GlcNHglycan	283	286	PF01048	0.699
MOD_GlcNHglycan	338	341	PF01048	0.439
MOD_GlcNHglycan	370	373	PF01048	0.296
MOD_GlcNHglycan	518	521	PF01048	0.704
MOD_GlcNHglycan	530	533	PF01048	0.602
MOD_GlcNHglycan	534	537	PF01048	0.519
MOD_GlcNHglycan	559	562	PF01048	0.647
MOD_GlcNHglycan	585	588	PF01048	0.749
MOD_GlcNHglycan	589	592	PF01048	0.620
MOD_GlcNHglycan	593	596	PF01048	0.616
MOD_GSK3_1	120	127	PF00069	0.682
MOD_GSK3_1	148	155	PF00069	0.486
MOD_GSK3_1	179	186	PF00069	0.559
MOD_GSK3_1	19	26	PF00069	0.628
MOD_GSK3_1	225	232	PF00069	0.550
MOD_GSK3_1	233	240	PF00069	0.613
MOD_GSK3_1	281	288	PF00069	0.638
MOD_GSK3_1	304	311	PF00069	0.429
MOD_GSK3_1	318	325	PF00069	0.420
MOD_GSK3_1	356	363	PF00069	0.396
MOD_GSK3_1	440	447	PF00069	0.495
MOD_GSK3_1	528	535	PF00069	0.747
MOD_GSK3_1	539	546	PF00069	0.517
MOD_GSK3_1	555	562	PF00069	0.659
MOD_GSK3_1	583	590	PF00069	0.656
MOD_NEK2_1	17	22	PF00069	0.676
MOD_NEK2_1	189	194	PF00069	0.357
MOD_NEK2_1	260	265	PF00069	0.427
MOD_NEK2_1	278	283	PF00069	0.572
MOD_NEK2_1	312	317	PF00069	0.323
MOD_NEK2_1	439	444	PF00069	0.450
MOD_NEK2_1	483	488	PF00069	0.609
MOD_NEK2_1	539	544	PF00069	0.669
MOD_NEK2_1	70	75	PF00069	0.550
MOD_OFUCOSY	103	109	PF10250	0.392
MOD_PIKK_1	152	158	PF00454	0.503
MOD_PIKK_1	17	23	PF00454	0.646
MOD_PIKK_1	38	44	PF00454	0.617
MOD_PIKK_1	429	435	PF00454	0.457
MOD_PK_1	167	173	PF00069	0.463
MOD_PKA_1	384	390	PF00069	0.602
MOD_PKA_2	203	209	PF00069	0.407
MOD_PKA_2	539	545	PF00069	0.665
MOD_Plk_1	444	450	PF00069	0.539
MOD_Plk_2-3	600	606	PF00069	0.746
MOD_Plk_4	140	146	PF00069	0.360
MOD_Plk_4	167	173	PF00069	0.481
MOD_Plk_4	191	197	PF00069	0.402
MOD_Plk_4	318	324	PF00069	0.388
MOD_Plk_4	4	10	PF00069	0.712
MOD_Plk_4	414	420	PF00069	0.513
MOD_ProDKin_1	11	17	PF00069	0.680
MOD_ProDKin_1	148	154	PF00069	0.563
MOD_ProDKin_1	179	185	PF00069	0.497
MOD_ProDKin_1	19	25	PF00069	0.569
MOD_ProDKin_1	285	291	PF00069	0.622
MOD_ProDKin_1	360	366	PF00069	0.448
MOD_ProDKin_1	477	483	PF00069	0.565
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.552
TRG_ENDOCYTIC_2	8	11	PF00928	0.718
TRG_ER_diArg_1	76	79	PF00400	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A5	Leptomonas seymouri	59%	95%
A0A0S4JGF5	Bodo saltans	32%	100%
A0A1X0NYH8	Trypanosomatidae	34%	94%
A0A3S7WWM8	Leishmania donovani	91%	100%
A0A422NAK4	Trypanosoma rangeli	41%	100%
A4HBX0	Leishmania braziliensis	81%	99%
D0A183	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AGY0	Leishmania infantum	91%	100%
Q4QC84	Leishmania major	90%	100%
V5B548	Trypanosoma cruzi	36%	100%