Tau95 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA polymerase III transcription factor (TF)IIIC subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AV94_LEIMU

TriTrypDb:

LmxM.21.1100

Length:

693

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000127	transcription factor TFIIIC complex	4	10
GO:0005667	transcription regulator complex	2	10
GO:0032991	protein-containing complex	1	10
GO:0090576	RNA polymerase III transcription regulator complex	3	10

Expansion

Sequence features

E9AV94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV94

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006352	DNA-templated transcription initiation	6	10
GO:0006384	transcription initiation at RNA polymerase III promoter	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0018130	heterocycle biosynthetic process	4	10
GO:0019438	aromatic compound biosynthetic process	4	10
GO:0032774	RNA biosynthetic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034654	nucleobase-containing compound biosynthetic process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901362	organic cyclic compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.819
CLV_C14_Caspase3-7	197	201	PF00656	0.452
CLV_C14_Caspase3-7	260	264	PF00656	0.619
CLV_C14_Caspase3-7	275	279	PF00656	0.692
CLV_C14_Caspase3-7	417	421	PF00656	0.444
CLV_C14_Caspase3-7	447	451	PF00656	0.344
CLV_NRD_NRD_1	214	216	PF00675	0.674
CLV_NRD_NRD_1	243	245	PF00675	0.575
CLV_NRD_NRD_1	246	248	PF00675	0.551
CLV_NRD_NRD_1	509	511	PF00675	0.471
CLV_NRD_NRD_1	540	542	PF00675	0.538
CLV_NRD_NRD_1	552	554	PF00675	0.531
CLV_NRD_NRD_1	565	567	PF00675	0.550
CLV_NRD_NRD_1	59	61	PF00675	0.676
CLV_NRD_NRD_1	602	604	PF00675	0.566
CLV_NRD_NRD_1	606	608	PF00675	0.579
CLV_NRD_NRD_1	638	640	PF00675	0.524
CLV_PCSK_FUR_1	212	216	PF00082	0.711
CLV_PCSK_FUR_1	240	244	PF00082	0.582
CLV_PCSK_FUR_1	538	542	PF00082	0.527
CLV_PCSK_KEX2_1	131	133	PF00082	0.812
CLV_PCSK_KEX2_1	211	213	PF00082	0.637
CLV_PCSK_KEX2_1	214	216	PF00082	0.642
CLV_PCSK_KEX2_1	242	244	PF00082	0.571
CLV_PCSK_KEX2_1	246	248	PF00082	0.519
CLV_PCSK_KEX2_1	509	511	PF00082	0.471
CLV_PCSK_KEX2_1	540	542	PF00082	0.476
CLV_PCSK_KEX2_1	552	554	PF00082	0.502
CLV_PCSK_KEX2_1	565	567	PF00082	0.550
CLV_PCSK_KEX2_1	59	61	PF00082	0.644
CLV_PCSK_KEX2_1	602	604	PF00082	0.518
CLV_PCSK_KEX2_1	606	608	PF00082	0.540
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.812
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.666
CLV_PCSK_PC7_1	238	244	PF00082	0.668
CLV_PCSK_PC7_1	536	542	PF00082	0.547
CLV_PCSK_PC7_1	602	608	PF00082	0.616
CLV_PCSK_SKI1_1	215	219	PF00082	0.768
CLV_PCSK_SKI1_1	531	535	PF00082	0.518
DEG_APCC_DBOX_1	144	152	PF00400	0.789
DEG_APCC_DBOX_1	552	560	PF00400	0.518
DEG_SCF_FBW7_1	33	38	PF00400	0.742
DEG_SPOP_SBC_1	108	112	PF00917	0.736
DEG_SPOP_SBC_1	37	41	PF00917	0.716
DEG_SPOP_SBC_1	658	662	PF00917	0.749
DOC_CDC14_PxL_1	318	326	PF14671	0.672
DOC_CKS1_1	312	317	PF01111	0.666
DOC_CYCLIN_RxL_1	525	537	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	302	308	PF00134	0.582
DOC_CYCLIN_yCln2_LP_2	569	575	PF00134	0.516
DOC_MAPK_gen_1	506	515	PF00069	0.557
DOC_MAPK_gen_1	562	571	PF00069	0.496
DOC_MAPK_MEF2A_6	22	31	PF00069	0.578
DOC_MAPK_MEF2A_6	232	239	PF00069	0.532
DOC_MAPK_MEF2A_6	509	517	PF00069	0.555
DOC_MAPK_MEF2A_6	565	573	PF00069	0.491
DOC_MAPK_NFAT4_5	232	240	PF00069	0.652
DOC_PP2B_LxvP_1	569	572	PF13499	0.536
DOC_PP2B_PxIxI_1	388	394	PF00149	0.485
DOC_PP4_FxxP_1	70	73	PF00568	0.573
DOC_USP7_MATH_1	10	14	PF00917	0.776
DOC_USP7_MATH_1	109	113	PF00917	0.740
DOC_USP7_MATH_1	20	24	PF00917	0.684
DOC_USP7_MATH_1	283	287	PF00917	0.728
DOC_USP7_MATH_1	320	324	PF00917	0.624
DOC_USP7_MATH_1	357	361	PF00917	0.457
DOC_USP7_MATH_1	395	399	PF00917	0.498
DOC_USP7_MATH_1	407	411	PF00917	0.495
DOC_USP7_MATH_1	491	495	PF00917	0.355
DOC_USP7_MATH_1	50	54	PF00917	0.752
DOC_USP7_MATH_1	657	661	PF00917	0.717
DOC_USP7_MATH_1	92	96	PF00917	0.652
DOC_WW_Pin1_4	31	36	PF00397	0.656
DOC_WW_Pin1_4	311	316	PF00397	0.637
DOC_WW_Pin1_4	4	9	PF00397	0.762
DOC_WW_Pin1_4	520	525	PF00397	0.534
DOC_WW_Pin1_4	76	81	PF00397	0.662
LIG_14-3-3_CanoR_1	184	190	PF00244	0.609
LIG_14-3-3_CanoR_1	22	28	PF00244	0.600
LIG_14-3-3_CanoR_1	502	506	PF00244	0.374
LIG_14-3-3_CanoR_1	509	517	PF00244	0.428
LIG_14-3-3_CanoR_1	552	557	PF00244	0.496
LIG_14-3-3_CanoR_1	607	615	PF00244	0.482
LIG_Actin_WH2_2	496	511	PF00022	0.485
LIG_BIR_II_1	1	5	PF00653	0.682
LIG_BIR_III_1	1	5	PF00653	0.517
LIG_BIR_III_3	1	5	PF00653	0.517
LIG_BIR_III_4	373	377	PF00653	0.408
LIG_BIR_III_4	646	650	PF00653	0.570
LIG_BRCT_BRCA1_1	675	679	PF00533	0.755
LIG_CtBP_PxDLS_1	597	601	PF00389	0.616
LIG_eIF4E_1	230	236	PF01652	0.548
LIG_EVH1_2	331	335	PF00568	0.369
LIG_FHA_1	158	164	PF00498	0.628
LIG_FHA_1	251	257	PF00498	0.591
LIG_FHA_1	283	289	PF00498	0.680
LIG_FHA_1	307	313	PF00498	0.680
LIG_FHA_1	32	38	PF00498	0.744
LIG_FHA_1	388	394	PF00498	0.390
LIG_FHA_1	470	476	PF00498	0.344
LIG_FHA_1	502	508	PF00498	0.412
LIG_FHA_2	553	559	PF00498	0.462
LIG_FHA_2	650	656	PF00498	0.784
LIG_GBD_Chelix_1	444	452	PF00786	0.444
LIG_Integrin_RGD_1	86	88	PF01839	0.758
LIG_LIR_Apic_2	69	73	PF02991	0.582
LIG_LIR_Gen_1	216	226	PF02991	0.669
LIG_LIR_Gen_1	23	32	PF02991	0.677
LIG_LIR_Gen_1	307	318	PF02991	0.672
LIG_LIR_Gen_1	384	393	PF02991	0.435
LIG_LIR_Gen_1	497	508	PF02991	0.444
LIG_LIR_Nem_3	23	27	PF02991	0.633
LIG_LIR_Nem_3	307	313	PF02991	0.580
LIG_LIR_Nem_3	384	388	PF02991	0.380
LIG_LIR_Nem_3	497	503	PF02991	0.416
LIG_LIR_Nem_3	543	547	PF02991	0.484
LIG_NRBOX	529	535	PF00104	0.500
LIG_NRBOX	625	631	PF00104	0.518
LIG_PCNA_PIPBox_1	224	233	PF02747	0.559
LIG_PCNA_yPIPBox_3	224	238	PF02747	0.539
LIG_PTB_Apo_2	225	232	PF02174	0.657
LIG_PTB_Apo_2	474	481	PF02174	0.369
LIG_PTB_Phospho_1	225	231	PF10480	0.660
LIG_SH2_CRK	158	162	PF00017	0.741
LIG_SH2_CRK	544	548	PF00017	0.608
LIG_SH2_NCK_1	492	496	PF00017	0.416
LIG_SH2_NCK_1	500	504	PF00017	0.379
LIG_SH2_PTP2	24	27	PF00017	0.658
LIG_SH2_SRC	346	349	PF00017	0.444
LIG_SH2_STAP1	615	619	PF00017	0.538
LIG_SH2_STAP1	622	626	PF00017	0.471
LIG_SH2_STAT5	158	161	PF00017	0.597
LIG_SH2_STAT5	24	27	PF00017	0.658
LIG_SH2_STAT5	473	476	PF00017	0.344
LIG_SH2_STAT5	570	573	PF00017	0.481
LIG_SH3_3	13	19	PF00018	0.702
LIG_SH3_3	24	30	PF00018	0.599
LIG_SH3_3	326	332	PF00018	0.485
LIG_SUMO_SIM_par_1	389	394	PF11976	0.485
LIG_SUMO_SIM_par_1	623	633	PF11976	0.365
LIG_TRAF2_1	176	179	PF00917	0.762
LIG_TRAF2_1	264	267	PF00917	0.706
LIG_TRAF2_1	394	397	PF00917	0.484
LIG_TRAF2_1	95	98	PF00917	0.750
LIG_TRAF2_2	572	577	PF00917	0.497
LIG_TYR_ITIM	498	503	PF00017	0.408
LIG_TYR_ITIM	542	547	PF00017	0.524
MOD_CK1_1	110	116	PF00069	0.778
MOD_CK1_1	117	123	PF00069	0.779
MOD_CK1_1	23	29	PF00069	0.647
MOD_CK1_1	286	292	PF00069	0.663
MOD_CK1_1	414	420	PF00069	0.485
MOD_CK1_1	494	500	PF00069	0.444
MOD_CK1_1	660	666	PF00069	0.722
MOD_CK2_1	173	179	PF00069	0.712
MOD_CK2_1	261	267	PF00069	0.651
MOD_CK2_1	391	397	PF00069	0.463
MOD_CK2_1	552	558	PF00069	0.481
MOD_CK2_1	662	668	PF00069	0.737
MOD_CK2_1	684	690	PF00069	0.653
MOD_CK2_1	92	98	PF00069	0.763
MOD_GlcNHglycan	112	115	PF01048	0.738
MOD_GlcNHglycan	118	122	PF01048	0.736
MOD_GlcNHglycan	164	167	PF01048	0.607
MOD_GlcNHglycan	173	176	PF01048	0.661
MOD_GlcNHglycan	190	193	PF01048	0.790
MOD_GlcNHglycan	263	266	PF01048	0.735
MOD_GlcNHglycan	271	274	PF01048	0.814
MOD_GlcNHglycan	285	288	PF01048	0.672
MOD_GlcNHglycan	336	339	PF01048	0.393
MOD_GlcNHglycan	359	362	PF01048	0.429
MOD_GlcNHglycan	393	396	PF01048	0.459
MOD_GlcNHglycan	40	43	PF01048	0.747
MOD_GlcNHglycan	454	457	PF01048	0.369
MOD_GlcNHglycan	493	496	PF01048	0.446
MOD_GlcNHglycan	52	55	PF01048	0.669
MOD_GlcNHglycan	592	595	PF01048	0.451
MOD_GlcNHglycan	672	678	PF01048	0.693
MOD_GlcNHglycan	681	684	PF01048	0.653
MOD_GlcNHglycan	94	97	PF01048	0.805
MOD_GSK3_1	108	115	PF00069	0.791
MOD_GSK3_1	162	169	PF00069	0.662
MOD_GSK3_1	279	286	PF00069	0.738
MOD_GSK3_1	31	38	PF00069	0.620
MOD_GSK3_1	351	358	PF00069	0.426
MOD_GSK3_1	387	394	PF00069	0.484
MOD_GSK3_1	396	403	PF00069	0.426
MOD_GSK3_1	407	414	PF00069	0.399
MOD_GSK3_1	44	51	PF00069	0.631
MOD_GSK3_1	657	664	PF00069	0.694
MOD_GSK3_1	673	680	PF00069	0.720
MOD_GSK3_1	76	83	PF00069	0.686
MOD_LATS_1	550	556	PF00433	0.516
MOD_N-GLC_1	649	654	PF02516	0.777
MOD_NEK2_1	411	416	PF00069	0.485
MOD_NEK2_1	452	457	PF00069	0.444
MOD_NEK2_1	679	684	PF00069	0.709
MOD_PKA_1	552	558	PF00069	0.474
MOD_PKA_2	167	173	PF00069	0.727
MOD_PKA_2	183	189	PF00069	0.764
MOD_PKA_2	279	285	PF00069	0.769
MOD_PKA_2	439	445	PF00069	0.485
MOD_PKA_2	501	507	PF00069	0.374
MOD_PKA_2	508	514	PF00069	0.434
MOD_PKA_2	552	558	PF00069	0.447
MOD_PKB_1	516	524	PF00069	0.543
MOD_Plk_1	306	312	PF00069	0.674
MOD_Plk_1	395	401	PF00069	0.485
MOD_Plk_1	673	679	PF00069	0.730
MOD_Plk_4	396	402	PF00069	0.414
MOD_Plk_4	407	413	PF00069	0.493
MOD_Plk_4	439	445	PF00069	0.463
MOD_Plk_4	494	500	PF00069	0.487
MOD_Plk_4	525	531	PF00069	0.483
MOD_Plk_4	552	558	PF00069	0.434
MOD_Plk_4	66	72	PF00069	0.555
MOD_ProDKin_1	31	37	PF00069	0.659
MOD_ProDKin_1	311	317	PF00069	0.634
MOD_ProDKin_1	4	10	PF00069	0.762
MOD_ProDKin_1	520	526	PF00069	0.527
MOD_ProDKin_1	76	82	PF00069	0.668
MOD_SUMO_rev_2	537	547	PF00179	0.502
MOD_SUMO_rev_2	648	658	PF00179	0.492
TRG_DiLeu_BaEn_1	222	227	PF01217	0.679
TRG_DiLeu_BaEn_2	60	66	PF01217	0.685
TRG_DiLeu_BaEn_4	396	402	PF01217	0.444
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.401
TRG_DiLeu_BaLyEn_6	503	508	PF01217	0.485
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.509
TRG_ENDOCYTIC_2	158	161	PF00928	0.738
TRG_ENDOCYTIC_2	24	27	PF00928	0.592
TRG_ENDOCYTIC_2	500	503	PF00928	0.416
TRG_ENDOCYTIC_2	544	547	PF00928	0.597
TRG_ENDOCYTIC_2	570	573	PF00928	0.453
TRG_ER_diArg_1	212	215	PF00400	0.668
TRG_ER_diArg_1	237	240	PF00400	0.533
TRG_ER_diArg_1	242	244	PF00400	0.550
TRG_ER_diArg_1	245	247	PF00400	0.509
TRG_ER_diArg_1	482	485	PF00400	0.344
TRG_ER_diArg_1	508	510	PF00400	0.551
TRG_ER_diArg_1	515	518	PF00400	0.490
TRG_ER_diArg_1	538	541	PF00400	0.534
TRG_ER_diArg_1	564	566	PF00400	0.557
TRG_ER_diArg_1	636	639	PF00400	0.556
TRG_NLS_MonoCore_2	210	215	PF00514	0.704
TRG_NLS_MonoExtC_3	210	215	PF00514	0.704
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	639	644	PF00026	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2I9	Leptomonas seymouri	52%	93%
A0A1X0NZE8	Trypanosomatidae	32%	100%
A0A3S7WWK4	Leishmania donovani	92%	99%
A0A422NAG1	Trypanosoma rangeli	34%	100%
A4HIW4	Leishmania braziliensis	82%	99%
D0A185	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AGX8	Leishmania infantum	92%	99%
Q4QC86	Leishmania major	92%	100%