Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin, putative

Species:

Leishmania mexicana

UniProt:

E9AV88_LEIMU

TriTrypDb:

LmxM.21.1040

Length:

2129

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005819	spindle	5	1
GO:0005874	microtubule	6	1
GO:0005876	spindle microtubule	7	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0072686	mitotic spindle	6	1
GO:0099080	supramolecular complex	2	1

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Expansion

Sequence features

E9AV88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0000070	mitotic sister chromatid segregation	4	1
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000819	sister chromatid segregation	4	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	9
GO:0007018	microtubule-based movement	3	9
GO:0007051	spindle organization	3	1
GO:0007052	mitotic spindle organization	4	1
GO:0007059	chromosome segregation	2	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003774	cytoskeletal motor activity	1	9
GO:0003777	microtubule motor activity	2	9
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	9
GO:0005515	protein binding	2	9
GO:0005524	ATP binding	5	9
GO:0008017	microtubule binding	5	9
GO:0008092	cytoskeletal protein binding	3	9
GO:0008574	plus-end-directed microtubule motor activity	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1004	1008	PF00656	0.655
CLV_C14_Caspase3-7	1339	1343	PF00656	0.548
CLV_C14_Caspase3-7	356	360	PF00656	0.275
CLV_C14_Caspase3-7	716	720	PF00656	0.315
CLV_NRD_NRD_1	1015	1017	PF00675	0.723
CLV_NRD_NRD_1	1028	1030	PF00675	0.550
CLV_NRD_NRD_1	1053	1055	PF00675	0.530
CLV_NRD_NRD_1	106	108	PF00675	0.598
CLV_NRD_NRD_1	1077	1079	PF00675	0.580
CLV_NRD_NRD_1	1164	1166	PF00675	0.523

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRC5	Leptomonas seymouri	60%	96%
A0A3Q8IF66	Leishmania donovani	93%	100%
A0A422NWF4	Trypanosoma rangeli	44%	100%
A4HBW4	Leishmania braziliensis	79%	100%
D0A1A6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AGX2	Leishmania infantum	93%	100%
Q4QC92	Leishmania major	92%	100%

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