CCDC66 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV87_LEIMU

TriTrypDb:

LmxM.21.1030

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AV87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV87

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	623	627	PF00656	0.559
CLV_C14_Caspase3-7	670	674	PF00656	0.689
CLV_C14_Caspase3-7	797	801	PF00656	0.614
CLV_NRD_NRD_1	326	328	PF00675	0.486
CLV_NRD_NRD_1	347	349	PF00675	0.485
CLV_NRD_NRD_1	355	357	PF00675	0.574
CLV_NRD_NRD_1	386	388	PF00675	0.491
CLV_NRD_NRD_1	392	394	PF00675	0.552
CLV_NRD_NRD_1	400	402	PF00675	0.612
CLV_NRD_NRD_1	47	49	PF00675	0.595
CLV_NRD_NRD_1	524	526	PF00675	0.471
CLV_NRD_NRD_1	538	540	PF00675	0.560
CLV_NRD_NRD_1	7	9	PF00675	0.507
CLV_PCSK_FUR_1	345	349	PF00082	0.413
CLV_PCSK_FUR_1	363	367	PF00082	0.645
CLV_PCSK_KEX2_1	347	349	PF00082	0.485
CLV_PCSK_KEX2_1	355	357	PF00082	0.574
CLV_PCSK_KEX2_1	365	367	PF00082	0.657
CLV_PCSK_KEX2_1	386	388	PF00082	0.576
CLV_PCSK_KEX2_1	392	394	PF00082	0.553
CLV_PCSK_KEX2_1	400	402	PF00082	0.566
CLV_PCSK_KEX2_1	47	49	PF00082	0.595
CLV_PCSK_KEX2_1	524	526	PF00082	0.471
CLV_PCSK_KEX2_1	538	540	PF00082	0.560
CLV_PCSK_KEX2_1	6	8	PF00082	0.507
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.566
CLV_PCSK_PC7_1	3	9	PF00082	0.506
CLV_PCSK_PC7_1	520	526	PF00082	0.537
CLV_PCSK_SKI1_1	319	323	PF00082	0.479
CLV_PCSK_SKI1_1	368	372	PF00082	0.509
CLV_PCSK_SKI1_1	426	430	PF00082	0.647
CLV_PCSK_SKI1_1	524	528	PF00082	0.469
CLV_PCSK_SKI1_1	638	642	PF00082	0.480
DEG_APCC_DBOX_1	519	527	PF00400	0.538
DEG_Nend_Nbox_1	1	3	PF02207	0.543
DEG_SPOP_SBC_1	442	446	PF00917	0.654
DOC_CKS1_1	738	743	PF01111	0.642
DOC_CYCLIN_RxL_1	635	642	PF00134	0.475
DOC_CYCLIN_yCln2_LP_2	170	176	PF00134	0.569
DOC_CYCLIN_yCln2_LP_2	465	471	PF00134	0.649
DOC_CYCLIN_yCln2_LP_2	493	499	PF00134	0.602
DOC_MAPK_gen_1	179	186	PF00069	0.613
DOC_MAPK_gen_1	538	546	PF00069	0.539
DOC_MAPK_MEF2A_6	179	186	PF00069	0.583
DOC_PP2B_LxvP_1	170	173	PF13499	0.632
DOC_PP2B_LxvP_1	459	462	PF13499	0.678
DOC_PP2B_LxvP_1	465	468	PF13499	0.588
DOC_PP2B_LxvP_1	493	496	PF13499	0.546
DOC_PP2B_LxvP_1	657	660	PF13499	0.603
DOC_PP4_FxxP_1	685	688	PF00568	0.583
DOC_PP4_FxxP_1	689	692	PF00568	0.586
DOC_PP4_FxxP_1	766	769	PF00568	0.653
DOC_USP7_MATH_1	102	106	PF00917	0.558
DOC_USP7_MATH_1	145	149	PF00917	0.622
DOC_USP7_MATH_1	251	255	PF00917	0.650
DOC_USP7_MATH_1	270	274	PF00917	0.770
DOC_USP7_MATH_1	407	411	PF00917	0.523
DOC_USP7_MATH_1	428	432	PF00917	0.649
DOC_USP7_MATH_1	443	447	PF00917	0.544
DOC_USP7_MATH_1	460	464	PF00917	0.509
DOC_USP7_MATH_1	540	544	PF00917	0.584
DOC_USP7_MATH_1	560	564	PF00917	0.468
DOC_USP7_MATH_1	577	581	PF00917	0.668
DOC_USP7_MATH_1	599	603	PF00917	0.636
DOC_USP7_MATH_1	620	624	PF00917	0.700
DOC_USP7_MATH_1	645	649	PF00917	0.580
DOC_USP7_MATH_1	652	656	PF00917	0.612
DOC_USP7_MATH_1	660	664	PF00917	0.598
DOC_USP7_MATH_1	747	751	PF00917	0.632
DOC_USP7_MATH_1	754	758	PF00917	0.651
DOC_USP7_MATH_1	774	778	PF00917	0.525
DOC_USP7_MATH_1	794	798	PF00917	0.525
DOC_USP7_UBL2_3	324	328	PF12436	0.509
DOC_USP7_UBL2_3	426	430	PF12436	0.690
DOC_WW_Pin1_4	128	133	PF00397	0.520
DOC_WW_Pin1_4	199	204	PF00397	0.772
DOC_WW_Pin1_4	208	213	PF00397	0.719
DOC_WW_Pin1_4	219	224	PF00397	0.541
DOC_WW_Pin1_4	230	235	PF00397	0.657
DOC_WW_Pin1_4	242	247	PF00397	0.671
DOC_WW_Pin1_4	266	271	PF00397	0.696
DOC_WW_Pin1_4	446	451	PF00397	0.513
DOC_WW_Pin1_4	486	491	PF00397	0.581
DOC_WW_Pin1_4	575	580	PF00397	0.556
DOC_WW_Pin1_4	639	644	PF00397	0.644
DOC_WW_Pin1_4	661	666	PF00397	0.502
DOC_WW_Pin1_4	695	700	PF00397	0.627
DOC_WW_Pin1_4	737	742	PF00397	0.717
DOC_WW_Pin1_4	750	755	PF00397	0.562
DOC_WW_Pin1_4	770	775	PF00397	0.619
DOC_WW_Pin1_4	787	792	PF00397	0.654
DOC_WW_Pin1_4	810	815	PF00397	0.781
LIG_14-3-3_CanoR_1	214	223	PF00244	0.505
LIG_14-3-3_CanoR_1	241	246	PF00244	0.626
LIG_14-3-3_CanoR_1	271	279	PF00244	0.683
LIG_14-3-3_CanoR_1	594	600	PF00244	0.657
LIG_14-3-3_CanoR_1	601	610	PF00244	0.596
LIG_14-3-3_CanoR_1	690	700	PF00244	0.616
LIG_14-3-3_CanoR_1	809	816	PF00244	0.610
LIG_Actin_WH2_2	471	489	PF00022	0.609
LIG_CtBP_PxDLS_1	198	202	PF00389	0.626
LIG_EH_1	27	31	PF12763	0.566
LIG_EVH1_1	609	613	PF00568	0.592
LIG_EVH1_2	182	186	PF00568	0.585
LIG_FHA_1	514	520	PF00498	0.567
LIG_FHA_1	525	531	PF00498	0.411
LIG_FHA_1	666	672	PF00498	0.641
LIG_FHA_1	715	721	PF00498	0.643
LIG_FHA_2	422	428	PF00498	0.588
LIG_FHA_2	670	676	PF00498	0.679
LIG_FHA_2	797	803	PF00498	0.699
LIG_Integrin_RGD_1	86	88	PF01839	0.518
LIG_LIR_Apic_2	683	688	PF02991	0.586
LIG_LIR_Nem_3	155	160	PF02991	0.565
LIG_LYPXL_yS_3	144	147	PF13949	0.509
LIG_MYND_1	208	212	PF01753	0.492
LIG_Pex14_2	685	689	PF04695	0.648
LIG_SH2_CRK	129	133	PF00017	0.594
LIG_SH2_NCK_1	112	116	PF00017	0.576
LIG_SH2_NCK_1	124	128	PF00017	0.568
LIG_SH2_NCK_1	129	133	PF00017	0.594
LIG_SH2_STAT5	21	24	PF00017	0.517
LIG_SH2_STAT5	215	218	PF00017	0.524
LIG_SH2_STAT5	231	234	PF00017	0.678
LIG_SH2_STAT5	476	479	PF00017	0.588
LIG_SH2_STAT5	571	574	PF00017	0.604
LIG_SH3_1	89	95	PF00018	0.642
LIG_SH3_2	163	168	PF14604	0.475
LIG_SH3_3	156	162	PF00018	0.567
LIG_SH3_3	174	180	PF00018	0.630
LIG_SH3_3	202	208	PF00018	0.746
LIG_SH3_3	245	251	PF00018	0.637
LIG_SH3_3	410	416	PF00018	0.639
LIG_SH3_3	431	437	PF00018	0.538
LIG_SH3_3	461	467	PF00018	0.624
LIG_SH3_3	469	475	PF00018	0.537
LIG_SH3_3	607	613	PF00018	0.584
LIG_SH3_3	616	622	PF00018	0.591
LIG_SH3_3	64	70	PF00018	0.584
LIG_SH3_3	693	699	PF00018	0.627
LIG_SH3_3	726	732	PF00018	0.528
LIG_SH3_3	735	741	PF00018	0.568
LIG_SH3_3	89	95	PF00018	0.613
LIG_SUMO_SIM_par_1	197	202	PF11976	0.625
LIG_TRAF2_1	295	298	PF00917	0.526
LIG_TRAF2_1	31	34	PF00917	0.578
LIG_TRAF2_1	377	380	PF00917	0.418
LIG_WRC_WIRS_1	600	605	PF05994	0.559
LIG_WW_2	434	437	PF00397	0.482
LIG_WW_2	610	613	PF00397	0.506
MOD_CDC14_SPxK_1	211	214	PF00782	0.502
MOD_CDC14_SPxK_1	773	776	PF00782	0.613
MOD_CDK_SPK_2	219	224	PF00069	0.727
MOD_CDK_SPK_2	266	271	PF00069	0.696
MOD_CDK_SPxK_1	208	214	PF00069	0.640
MOD_CDK_SPxK_1	770	776	PF00069	0.616
MOD_CDK_SPxxK_3	230	237	PF00069	0.650
MOD_CK1_1	446	452	PF00069	0.627
MOD_CK1_1	518	524	PF00069	0.499
MOD_CK1_1	602	608	PF00069	0.575
MOD_CK1_1	661	667	PF00069	0.577
MOD_CK1_1	669	675	PF00069	0.660
MOD_CK1_1	714	720	PF00069	0.620
MOD_CK1_1	750	756	PF00069	0.633
MOD_CK1_1	808	814	PF00069	0.562
MOD_CK2_1	110	116	PF00069	0.612
MOD_CK2_1	189	195	PF00069	0.684
MOD_CK2_1	28	34	PF00069	0.565
MOD_CK2_1	291	297	PF00069	0.525
MOD_CK2_1	421	427	PF00069	0.544
MOD_CK2_1	669	675	PF00069	0.645
MOD_CK2_1	764	770	PF00069	0.612
MOD_GlcNHglycan	112	115	PF01048	0.586
MOD_GlcNHglycan	154	157	PF01048	0.558
MOD_GlcNHglycan	187	190	PF01048	0.678
MOD_GlcNHglycan	191	194	PF01048	0.649
MOD_GlcNHglycan	274	277	PF01048	0.578
MOD_GlcNHglycan	293	296	PF01048	0.506
MOD_GlcNHglycan	409	412	PF01048	0.532
MOD_GlcNHglycan	438	441	PF01048	0.629
MOD_GlcNHglycan	469	472	PF01048	0.669
MOD_GlcNHglycan	483	486	PF01048	0.571
MOD_GlcNHglycan	556	559	PF01048	0.605
MOD_GlcNHglycan	595	598	PF01048	0.643
MOD_GlcNHglycan	647	650	PF01048	0.615
MOD_GlcNHglycan	660	663	PF01048	0.523
MOD_GlcNHglycan	756	759	PF01048	0.661
MOD_GlcNHglycan	776	779	PF01048	0.538
MOD_GlcNHglycan	96	99	PF01048	0.653
MOD_GSK3_1	185	192	PF00069	0.676
MOD_GSK3_1	215	222	PF00069	0.639
MOD_GSK3_1	240	247	PF00069	0.674
MOD_GSK3_1	266	273	PF00069	0.695
MOD_GSK3_1	442	449	PF00069	0.665
MOD_GSK3_1	511	518	PF00069	0.418
MOD_GSK3_1	567	574	PF00069	0.591
MOD_GSK3_1	601	608	PF00069	0.595
MOD_GSK3_1	661	668	PF00069	0.613
MOD_GSK3_1	676	683	PF00069	0.580
MOD_GSK3_1	691	698	PF00069	0.518
MOD_GSK3_1	743	750	PF00069	0.635
MOD_GSK3_1	770	777	PF00069	0.651
MOD_N-GLC_2	503	505	PF02516	0.635
MOD_NEK2_1	429	434	PF00069	0.637
MOD_NEK2_1	666	671	PF00069	0.720
MOD_PIKK_1	145	151	PF00454	0.611
MOD_PIKK_1	386	392	PF00454	0.683
MOD_PIKK_1	513	519	PF00454	0.568
MOD_PKA_1	386	392	PF00069	0.409
MOD_PKA_1	524	530	PF00069	0.466
MOD_PKA_2	240	246	PF00069	0.785
MOD_PKA_2	270	276	PF00069	0.687
MOD_PKA_2	386	392	PF00069	0.683
MOD_PKA_2	524	530	PF00069	0.466
MOD_PKA_2	593	599	PF00069	0.653
MOD_PKA_2	808	814	PF00069	0.624
MOD_Plk_4	244	250	PF00069	0.690
MOD_Plk_4	460	466	PF00069	0.628
MOD_Plk_4	567	573	PF00069	0.609
MOD_Plk_4	652	658	PF00069	0.676
MOD_Plk_4	705	711	PF00069	0.627
MOD_ProDKin_1	128	134	PF00069	0.521
MOD_ProDKin_1	199	205	PF00069	0.765
MOD_ProDKin_1	208	214	PF00069	0.721
MOD_ProDKin_1	219	225	PF00069	0.537
MOD_ProDKin_1	230	236	PF00069	0.656
MOD_ProDKin_1	242	248	PF00069	0.674
MOD_ProDKin_1	266	272	PF00069	0.695
MOD_ProDKin_1	446	452	PF00069	0.501
MOD_ProDKin_1	486	492	PF00069	0.578
MOD_ProDKin_1	575	581	PF00069	0.557
MOD_ProDKin_1	639	645	PF00069	0.645
MOD_ProDKin_1	661	667	PF00069	0.505
MOD_ProDKin_1	695	701	PF00069	0.630
MOD_ProDKin_1	737	743	PF00069	0.718
MOD_ProDKin_1	750	756	PF00069	0.560
MOD_ProDKin_1	770	776	PF00069	0.622
MOD_ProDKin_1	787	793	PF00069	0.654
MOD_ProDKin_1	810	816	PF00069	0.778
MOD_SUMO_rev_2	364	373	PF00179	0.506
TRG_DiLeu_BaEn_2	680	686	PF01217	0.599
TRG_ENDOCYTIC_2	144	147	PF00928	0.542
TRG_ENDOCYTIC_2	600	603	PF00928	0.608
TRG_ER_diArg_1	345	348	PF00400	0.450
TRG_ER_diArg_1	36	39	PF00400	0.615
TRG_ER_diArg_1	400	403	PF00400	0.615
TRG_ER_diArg_1	46	48	PF00400	0.605
TRG_ER_diArg_1	523	525	PF00400	0.473
TRG_ER_diArg_1	6	8	PF00400	0.511
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1W4	Leptomonas seymouri	45%	92%
A0A3S7WWJ6	Leishmania donovani	89%	99%
A4HBW3	Leishmania braziliensis	68%	100%
E9AGX1	Leishmania infantum	89%	99%
Q4QC93	Leishmania major	86%	99%