Putative dynein arm light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein arm light chain, putative

Species:

Leishmania mexicana

UniProt:

E9AV86_LEIMU

TriTrypDb:

LmxM.21.1020

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AV86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV86

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.452
CLV_C14_Caspase3-7	285	289	PF00656	0.258
CLV_NRD_NRD_1	100	102	PF00675	0.426
CLV_NRD_NRD_1	128	130	PF00675	0.389
CLV_NRD_NRD_1	170	172	PF00675	0.339
CLV_NRD_NRD_1	219	221	PF00675	0.395
CLV_NRD_NRD_1	265	267	PF00675	0.351
CLV_NRD_NRD_1	59	61	PF00675	0.568
CLV_PCSK_KEX2_1	128	130	PF00082	0.383
CLV_PCSK_KEX2_1	170	172	PF00082	0.345
CLV_PCSK_KEX2_1	219	221	PF00082	0.303
CLV_PCSK_KEX2_1	265	267	PF00082	0.358
CLV_PCSK_KEX2_1	294	296	PF00082	0.302
CLV_PCSK_KEX2_1	300	302	PF00082	0.227
CLV_PCSK_KEX2_1	59	61	PF00082	0.601
CLV_PCSK_KEX2_1	95	97	PF00082	0.363
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.313
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.251
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.363
CLV_PCSK_SKI1_1	178	182	PF00082	0.305
CLV_PCSK_SKI1_1	191	195	PF00082	0.220
CLV_PCSK_SKI1_1	200	204	PF00082	0.243
CLV_PCSK_SKI1_1	219	223	PF00082	0.263
CLV_PCSK_SKI1_1	231	235	PF00082	0.248
CLV_PCSK_SKI1_1	96	100	PF00082	0.397
CLV_Separin_Metazoa	188	192	PF03568	0.389
CLV_Separin_Metazoa	262	266	PF03568	0.134
DOC_CKS1_1	124	129	PF01111	0.341
DOC_CYCLIN_RxL_1	175	184	PF00134	0.282
DOC_CYCLIN_RxL_1	216	224	PF00134	0.259
DOC_CYCLIN_RxL_1	93	103	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	308	314	PF00134	0.599
DOC_MAPK_gen_1	95	106	PF00069	0.428
DOC_MAPK_MEF2A_6	111	119	PF00069	0.465
DOC_MAPK_MEF2A_6	200	207	PF00069	0.248
DOC_MAPK_NFAT4_5	200	208	PF00069	0.263
DOC_MAPK_RevD_3	115	129	PF00069	0.389
DOC_PIKK_1	42	49	PF02985	0.348
DOC_PP2B_LxvP_1	308	311	PF13499	0.514
DOC_PP4_FxxP_1	124	127	PF00568	0.282
DOC_USP7_MATH_1	11	15	PF00917	0.674
DOC_USP7_MATH_1	145	149	PF00917	0.389
DOC_USP7_MATH_1	176	180	PF00917	0.263
DOC_USP7_MATH_1	94	98	PF00917	0.401
DOC_USP7_UBL2_3	238	242	PF12436	0.377
DOC_USP7_UBL2_3	95	99	PF12436	0.409
DOC_WW_Pin1_4	123	128	PF00397	0.328
DOC_WW_Pin1_4	141	146	PF00397	0.111
DOC_WW_Pin1_4	172	177	PF00397	0.375
LIG_14-3-3_CanoR_1	101	105	PF00244	0.454
LIG_14-3-3_CanoR_1	12	20	PF00244	0.526
LIG_14-3-3_CanoR_1	191	198	PF00244	0.248
LIG_APCC_ABBA_1	205	210	PF00400	0.282
LIG_FHA_1	133	139	PF00498	0.421
LIG_FHA_1	172	178	PF00498	0.389
LIG_FHA_2	42	48	PF00498	0.354
LIG_LIR_Apic_2	122	127	PF02991	0.263
LIG_LIR_Gen_1	209	217	PF02991	0.242
LIG_LIR_Nem_3	209	214	PF02991	0.339
LIG_PCNA_TLS_4	118	125	PF02747	0.263
LIG_PCNA_yPIPBox_3	50	60	PF02747	0.513
LIG_SH2_CRK	85	89	PF00017	0.387
LIG_SH2_NCK_1	85	89	PF00017	0.368
LIG_SH2_PTP2	69	72	PF00017	0.416
LIG_SH2_SRC	69	72	PF00017	0.522
LIG_SH2_SRC	85	88	PF00017	0.443
LIG_SH2_SRC	89	92	PF00017	0.460
LIG_SH2_STAT5	69	72	PF00017	0.416
LIG_SH3_1	85	91	PF00018	0.386
LIG_SH3_2	91	96	PF14604	0.426
LIG_SH3_3	109	115	PF00018	0.441
LIG_SH3_3	5	11	PF00018	0.487
LIG_SH3_3	69	75	PF00018	0.426
LIG_SH3_3	85	91	PF00018	0.423
LIG_TRAF2_1	61	64	PF00917	0.647
LIG_WRC_WIRS_1	121	126	PF05994	0.263
MOD_CDC14_SPxK_1	175	178	PF00782	0.341
MOD_CDK_SPK_2	123	128	PF00069	0.341
MOD_CDK_SPxK_1	123	129	PF00069	0.389
MOD_CDK_SPxK_1	172	178	PF00069	0.341
MOD_CK1_1	123	129	PF00069	0.351
MOD_CK1_1	13	19	PF00069	0.679
MOD_CK1_1	41	47	PF00069	0.657
MOD_CK2_1	266	272	PF00069	0.321
MOD_GlcNHglycan	13	16	PF01048	0.487
MOD_GlcNHglycan	2	5	PF01048	0.619
MOD_GlcNHglycan	71	75	PF01048	0.520
MOD_GSK3_1	141	148	PF00069	0.262
MOD_GSK3_1	172	179	PF00069	0.349
MOD_GSK3_1	38	45	PF00069	0.632
MOD_N-GLC_1	41	46	PF02516	0.419
MOD_N-GLC_1	78	83	PF02516	0.556
MOD_NEK2_1	100	105	PF00069	0.571
MOD_NEK2_1	221	226	PF00069	0.235
MOD_NEK2_2	94	99	PF00069	0.424
MOD_PIKK_1	153	159	PF00454	0.389
MOD_PKA_1	59	65	PF00069	0.497
MOD_PKA_2	100	106	PF00069	0.450
MOD_PKA_2	11	17	PF00069	0.517
MOD_PKA_2	169	175	PF00069	0.272
MOD_PKA_2	59	65	PF00069	0.703
MOD_Plk_1	41	47	PF00069	0.530
MOD_Plk_1	78	84	PF00069	0.403
MOD_Plk_4	120	126	PF00069	0.242
MOD_Plk_4	78	84	PF00069	0.371
MOD_ProDKin_1	123	129	PF00069	0.328
MOD_ProDKin_1	141	147	PF00069	0.111
MOD_ProDKin_1	172	178	PF00069	0.375
MOD_SUMO_for_1	234	237	PF00179	0.263
MOD_SUMO_for_1	241	244	PF00179	0.263
MOD_SUMO_for_1	293	296	PF00179	0.282
TRG_DiLeu_BaEn_1	199	204	PF01217	0.248
TRG_DiLeu_BaEn_1	276	281	PF01217	0.263
TRG_ENDOCYTIC_2	69	72	PF00928	0.400
TRG_ER_diArg_1	127	129	PF00400	0.389
TRG_ER_diArg_1	219	221	PF00400	0.414
TRG_ER_diArg_1	264	266	PF00400	0.373
TRG_ER_diArg_1	58	60	PF00400	0.637
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.235
TRG_Pf-PMV_PEXEL_1	265	270	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q9	Leptomonas seymouri	77%	100%
A0A0S4KGN7	Bodo saltans	58%	100%
A0A1X0NVG2	Trypanosomatidae	36%	100%
A0A1X0NXR5	Trypanosomatidae	62%	100%
A0A3Q8IC16	Leishmania donovani	32%	100%
A0A3R7KMX9	Trypanosoma rangeli	35%	100%
A0A3S7WWL7	Leishmania donovani	95%	100%
A0A422NWB3	Trypanosoma rangeli	58%	100%
A4HBW2	Leishmania braziliensis	86%	99%
A4I0S3	Leishmania infantum	32%	100%
D0A1A2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AGX0	Leishmania infantum	94%	100%
E9AIH0	Leishmania braziliensis	32%	100%
E9AWS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
O14645	Homo sapiens	32%	100%
Q39604	Chlamydomonas reinhardtii	33%	100%
Q4FZV3	Rattus norvegicus	32%	100%
Q4QAP9	Leishmania major	32%	100%
Q4QC94	Leishmania major	94%	100%
Q4R3K5	Macaca fascicularis	35%	100%
Q9VGG6	Drosophila melanogaster	30%	100%
V5BR59	Trypanosoma cruzi	33%	100%