SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV81_LEIMU

TriTrypDb:

LmxM.21.0970

Length:

711

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AV81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV81

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.634
CLV_C14_Caspase3-7	350	354	PF00656	0.533
CLV_C14_Caspase3-7	383	387	PF00656	0.636
CLV_C14_Caspase3-7	478	482	PF00656	0.513
CLV_C14_Caspase3-7	535	539	PF00656	0.665
CLV_NRD_NRD_1	163	165	PF00675	0.463
CLV_NRD_NRD_1	302	304	PF00675	0.805
CLV_NRD_NRD_1	42	44	PF00675	0.502
CLV_NRD_NRD_1	513	515	PF00675	0.513
CLV_NRD_NRD_1	576	578	PF00675	0.628
CLV_NRD_NRD_1	589	591	PF00675	0.477
CLV_NRD_NRD_1	604	606	PF00675	0.419
CLV_NRD_NRD_1	644	646	PF00675	0.436
CLV_NRD_NRD_1	95	97	PF00675	0.463
CLV_PCSK_KEX2_1	163	165	PF00082	0.463
CLV_PCSK_KEX2_1	302	304	PF00082	0.757
CLV_PCSK_KEX2_1	42	44	PF00082	0.502
CLV_PCSK_KEX2_1	515	517	PF00082	0.545
CLV_PCSK_KEX2_1	591	593	PF00082	0.486
CLV_PCSK_KEX2_1	604	606	PF00082	0.405
CLV_PCSK_KEX2_1	644	646	PF00082	0.461
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.571
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.526
CLV_PCSK_SKI1_1	163	167	PF00082	0.430
CLV_PCSK_SKI1_1	169	173	PF00082	0.419
CLV_PCSK_SKI1_1	235	239	PF00082	0.518
CLV_PCSK_SKI1_1	36	40	PF00082	0.438
CLV_PCSK_SKI1_1	377	381	PF00082	0.597
CLV_PCSK_SKI1_1	393	397	PF00082	0.561
CLV_PCSK_SKI1_1	470	474	PF00082	0.514
CLV_PCSK_SKI1_1	529	533	PF00082	0.608
CLV_PCSK_SKI1_1	581	585	PF00082	0.480
CLV_PCSK_SKI1_1	591	595	PF00082	0.443
CLV_PCSK_SKI1_1	644	648	PF00082	0.503
CLV_PCSK_SKI1_1	91	95	PF00082	0.545
CLV_PCSK_SKI1_1	97	101	PF00082	0.530
DEG_APCC_DBOX_1	644	652	PF00400	0.412
DEG_SCF_FBW7_1	544	551	PF00400	0.489
DEG_SPOP_SBC_1	560	564	PF00917	0.708
DOC_CKS1_1	229	234	PF01111	0.457
DOC_CKS1_1	545	550	PF01111	0.494
DOC_CYCLIN_RxL_1	464	474	PF00134	0.517
DOC_CYCLIN_RxL_1	641	650	PF00134	0.391
DOC_MAPK_DCC_7	500	508	PF00069	0.581
DOC_MAPK_gen_1	372	380	PF00069	0.508
DOC_MAPK_gen_1	428	437	PF00069	0.494
DOC_MAPK_gen_1	500	509	PF00069	0.367
DOC_MAPK_gen_1	96	107	PF00069	0.518
DOC_MAPK_MEF2A_6	428	437	PF00069	0.491
DOC_MAPK_MEF2A_6	470	479	PF00069	0.558
DOC_MAPK_MEF2A_6	500	509	PF00069	0.500
DOC_PP1_RVXF_1	468	474	PF00149	0.593
DOC_PP2B_LxvP_1	188	191	PF13499	0.504
DOC_PP2B_LxvP_1	331	334	PF13499	0.709
DOC_PP2B_LxvP_1	359	362	PF13499	0.469
DOC_PP2B_LxvP_1	477	480	PF13499	0.391
DOC_PP4_FxxP_1	274	277	PF00568	0.461
DOC_USP7_MATH_1	124	128	PF00917	0.802
DOC_USP7_MATH_1	156	160	PF00917	0.417
DOC_USP7_MATH_1	225	229	PF00917	0.707
DOC_USP7_MATH_1	237	241	PF00917	0.641
DOC_USP7_MATH_1	548	552	PF00917	0.592
DOC_USP7_MATH_1	560	564	PF00917	0.758
DOC_USP7_MATH_1	61	65	PF00917	0.712
DOC_USP7_MATH_1	658	662	PF00917	0.604
DOC_USP7_MATH_1	672	676	PF00917	0.495
DOC_USP7_MATH_1	691	695	PF00917	0.610
DOC_USP7_UBL2_3	525	529	PF12436	0.455
DOC_USP7_UBL2_3	97	101	PF12436	0.600
DOC_WW_Pin1_4	228	233	PF00397	0.672
DOC_WW_Pin1_4	329	334	PF00397	0.758
DOC_WW_Pin1_4	336	341	PF00397	0.720
DOC_WW_Pin1_4	53	58	PF00397	0.750
DOC_WW_Pin1_4	544	549	PF00397	0.515
DOC_WW_Pin1_4	59	64	PF00397	0.739
DOC_WW_Pin1_4	9	14	PF00397	0.642
LIG_14-3-3_CanoR_1	157	163	PF00244	0.452
LIG_14-3-3_CanoR_1	169	178	PF00244	0.398
LIG_14-3-3_CanoR_1	302	312	PF00244	0.556
LIG_14-3-3_CanoR_1	408	417	PF00244	0.569
LIG_14-3-3_CanoR_1	43	52	PF00244	0.525
LIG_14-3-3_CanoR_1	470	476	PF00244	0.465
LIG_14-3-3_CanoR_1	542	548	PF00244	0.559
LIG_14-3-3_CanoR_1	590	599	PF00244	0.464
LIG_14-3-3_CanoR_1	604	612	PF00244	0.355
LIG_Actin_WH2_2	639	654	PF00022	0.445
LIG_BIR_III_2	688	692	PF00653	0.490
LIG_deltaCOP1_diTrp_1	465	473	PF00928	0.514
LIG_EVH1_1	357	361	PF00568	0.524
LIG_FHA_1	136	142	PF00498	0.622
LIG_FHA_1	218	224	PF00498	0.537
LIG_FHA_1	432	438	PF00498	0.610
LIG_FHA_1	439	445	PF00498	0.559
LIG_FHA_1	466	472	PF00498	0.581
LIG_FHA_1	567	573	PF00498	0.617
LIG_FHA_1	594	600	PF00498	0.525
LIG_FHA_2	239	245	PF00498	0.618
LIG_FHA_2	314	320	PF00498	0.569
LIG_FHA_2	621	627	PF00498	0.490
LIG_LIR_Apic_2	273	277	PF02991	0.455
LIG_LIR_Gen_1	174	181	PF02991	0.537
LIG_LIR_Gen_1	421	431	PF02991	0.602
LIG_LIR_Nem_3	174	180	PF02991	0.498
LIG_LIR_Nem_3	183	189	PF02991	0.508
LIG_NRBOX	33	39	PF00104	0.435
LIG_NRBOX	471	477	PF00104	0.546
LIG_NRBOX	612	618	PF00104	0.430
LIG_PDZ_Class_2	706	711	PF00595	0.516
LIG_PTB_Apo_2	148	155	PF02174	0.583
LIG_PTB_Apo_2	364	371	PF02174	0.631
LIG_PTB_Phospho_1	364	370	PF10480	0.638
LIG_Rb_pABgroove_1	488	496	PF01858	0.518
LIG_SH2_CRK	585	589	PF00017	0.508
LIG_SH2_NCK_1	417	421	PF00017	0.542
LIG_SH2_NCK_1	585	589	PF00017	0.472
LIG_SH2_SRC	177	180	PF00017	0.517
LIG_SH2_STAT5	177	180	PF00017	0.469
LIG_SH2_STAT5	187	190	PF00017	0.487
LIG_SH2_STAT5	215	218	PF00017	0.587
LIG_SH3_3	128	134	PF00018	0.605
LIG_SH3_3	193	199	PF00018	0.710
LIG_SH3_3	352	358	PF00018	0.548
LIG_SH3_4	97	104	PF00018	0.541
LIG_SH3_CIN85_PxpxPR_1	230	235	PF14604	0.460
LIG_SUMO_SIM_anti_2	12	18	PF11976	0.552
LIG_SUMO_SIM_par_1	474	481	PF11976	0.580
LIG_TRAF2_1	267	270	PF00917	0.608
LIG_TRAF2_1	412	415	PF00917	0.504
LIG_TRAF2_1	454	457	PF00917	0.698
LIG_TRFH_1	329	333	PF08558	0.674
LIG_TYR_ITIM	583	588	PF00017	0.487
LIG_UBA3_1	423	430	PF00899	0.516
MOD_CDK_SPxxK_3	228	235	PF00069	0.595
MOD_CK1_1	228	234	PF00069	0.711
MOD_CK1_1	240	246	PF00069	0.611
MOD_CK1_1	29	35	PF00069	0.502
MOD_CK1_1	306	312	PF00069	0.702
MOD_CK1_1	53	59	PF00069	0.736
MOD_CK1_1	533	539	PF00069	0.690
MOD_CK1_1	559	565	PF00069	0.789
MOD_CK1_1	62	68	PF00069	0.691
MOD_CK1_1	675	681	PF00069	0.475
MOD_CK2_1	238	244	PF00069	0.639
MOD_CK2_1	313	319	PF00069	0.682
MOD_CK2_1	409	415	PF00069	0.520
MOD_CK2_1	603	609	PF00069	0.482
MOD_CK2_1	620	626	PF00069	0.417
MOD_GlcNHglycan	125	129	PF01048	0.642
MOD_GlcNHglycan	138	141	PF01048	0.771
MOD_GlcNHglycan	174	177	PF01048	0.517
MOD_GlcNHglycan	192	195	PF01048	0.487
MOD_GlcNHglycan	28	31	PF01048	0.537
MOD_GlcNHglycan	319	323	PF01048	0.763
MOD_GlcNHglycan	326	329	PF01048	0.681
MOD_GlcNHglycan	521	524	PF01048	0.651
MOD_GlcNHglycan	534	538	PF01048	0.750
MOD_GlcNHglycan	558	561	PF01048	0.795
MOD_GlcNHglycan	656	659	PF01048	0.664
MOD_GlcNHglycan	667	670	PF01048	0.715
MOD_GlcNHglycan	674	677	PF01048	0.740
MOD_GlcNHglycan	693	696	PF01048	0.515
MOD_GSK3_1	116	123	PF00069	0.664
MOD_GSK3_1	136	143	PF00069	0.777
MOD_GSK3_1	217	224	PF00069	0.551
MOD_GSK3_1	306	313	PF00069	0.620
MOD_GSK3_1	438	445	PF00069	0.553
MOD_GSK3_1	471	478	PF00069	0.492
MOD_GSK3_1	519	526	PF00069	0.480
MOD_GSK3_1	53	60	PF00069	0.742
MOD_GSK3_1	544	551	PF00069	0.763
MOD_GSK3_1	556	563	PF00069	0.705
MOD_GSK3_1	62	69	PF00069	0.589
MOD_GSK3_1	647	654	PF00069	0.485
MOD_N-GLC_1	431	436	PF02516	0.554
MOD_NEK2_1	171	176	PF00069	0.555
MOD_NEK2_1	238	243	PF00069	0.694
MOD_NEK2_1	380	385	PF00069	0.637
MOD_NEK2_1	396	401	PF00069	0.544
MOD_NEK2_1	471	476	PF00069	0.428
MOD_NEK2_1	50	55	PF00069	0.716
MOD_NEK2_1	519	524	PF00069	0.505
MOD_NEK2_1	584	589	PF00069	0.556
MOD_NEK2_1	647	652	PF00069	0.450
MOD_NEK2_1	67	72	PF00069	0.662
MOD_NEK2_2	658	663	PF00069	0.480
MOD_PIKK_1	140	146	PF00454	0.614
MOD_PIKK_1	303	309	PF00454	0.554
MOD_PIKK_1	572	578	PF00454	0.687
MOD_PKA_1	591	597	PF00069	0.454
MOD_PKA_2	156	162	PF00069	0.531
MOD_PKA_2	591	597	PF00069	0.509
MOD_PKA_2	603	609	PF00069	0.335
MOD_PKA_2	651	657	PF00069	0.667
MOD_Plk_1	431	437	PF00069	0.569
MOD_Plk_2-3	256	262	PF00069	0.519
MOD_Plk_2-3	286	292	PF00069	0.656
MOD_Plk_4	12	18	PF00069	0.554
MOD_Plk_4	29	35	PF00069	0.475
MOD_Plk_4	442	448	PF00069	0.499
MOD_Plk_4	63	69	PF00069	0.720
MOD_ProDKin_1	228	234	PF00069	0.668
MOD_ProDKin_1	329	335	PF00069	0.754
MOD_ProDKin_1	336	342	PF00069	0.722
MOD_ProDKin_1	53	59	PF00069	0.749
MOD_ProDKin_1	544	550	PF00069	0.518
MOD_ProDKin_1	9	15	PF00069	0.636
MOD_SUMO_for_1	246	249	PF00179	0.424
MOD_SUMO_for_1	531	534	PF00179	0.612
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.436
TRG_DiLeu_BaLyEn_6	338	343	PF01217	0.678
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.433
TRG_DiLeu_BaLyEn_6	502	507	PF01217	0.378
TRG_DiLeu_BaLyEn_6	612	617	PF01217	0.457
TRG_ENDOCYTIC_2	177	180	PF00928	0.517
TRG_ENDOCYTIC_2	585	588	PF00928	0.503
TRG_ER_diArg_1	162	164	PF00400	0.466
TRG_ER_diArg_1	301	303	PF00400	0.760
TRG_ER_diArg_1	375	378	PF00400	0.512
TRG_ER_diArg_1	514	517	PF00400	0.608
TRG_ER_diArg_1	603	605	PF00400	0.425
TRG_ER_diArg_1	643	645	PF00400	0.456
TRG_NLS_Bipartite_1	577	594	PF00514	0.426
TRG_NLS_MonoCore_2	514	519	PF00514	0.645
TRG_NLS_MonoExtC_3	513	518	PF00514	0.564
TRG_NLS_MonoExtC_3	589	595	PF00514	0.540
TRG_NLS_MonoExtN_4	514	519	PF00514	0.571
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	408	413	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	615	620	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0P8	Leptomonas seymouri	50%	100%
A0A3S5IS33	Trypanosoma rangeli	37%	100%
A0A3S7WWN7	Leishmania donovani	85%	99%
A4HBV7	Leishmania braziliensis	67%	97%
D0A197	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AGW5	Leishmania infantum	85%	93%
Q4QC99	Leishmania major	82%	99%
V5BFI7	Trypanosoma cruzi	37%	100%