PDCD2_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Programmed cell death protein 2, C-terminal putative domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AV79_LEIMU

TriTrypDb:

LmxM.21.0950

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AV79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV79

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.383
CLV_NRD_NRD_1	362	364	PF00675	0.437
CLV_PCSK_KEX2_1	362	364	PF00082	0.449
CLV_PCSK_KEX2_1	4	6	PF00082	0.753
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.753
CLV_PCSK_SKI1_1	223	227	PF00082	0.434
CLV_PCSK_SKI1_1	379	383	PF00082	0.673
CLV_PCSK_SKI1_1	400	404	PF00082	0.686
DOC_MAPK_DCC_7	221	230	PF00069	0.475
DOC_MAPK_gen_1	234	241	PF00069	0.420
DOC_MAPK_gen_1	362	368	PF00069	0.363
DOC_PP4_FxxP_1	229	232	PF00568	0.344
DOC_USP7_MATH_1	137	141	PF00917	0.589
DOC_USP7_MATH_1	214	218	PF00917	0.409
DOC_USP7_MATH_1	305	309	PF00917	0.403
DOC_USP7_MATH_1	72	76	PF00917	0.406
DOC_USP7_MATH_1	82	86	PF00917	0.383
DOC_WW_Pin1_4	14	19	PF00397	0.488
DOC_WW_Pin1_4	284	289	PF00397	0.433
DOC_WW_Pin1_4	299	304	PF00397	0.250
DOC_WW_Pin1_4	308	313	PF00397	0.220
DOC_WW_Pin1_4	50	55	PF00397	0.448
LIG_14-3-3_CanoR_1	162	170	PF00244	0.720
LIG_14-3-3_CanoR_1	34	40	PF00244	0.458
LIG_14-3-3_CanoR_1	7	14	PF00244	0.440
LIG_14-3-3_CanoR_1	80	89	PF00244	0.448
LIG_BIR_II_1	1	5	PF00653	0.778
LIG_BIR_III_2	136	140	PF00653	0.613
LIG_BIR_III_2	277	281	PF00653	0.184
LIG_FHA_1	113	119	PF00498	0.717
LIG_FHA_1	174	180	PF00498	0.586
LIG_FHA_1	250	256	PF00498	0.404
LIG_FHA_1	340	346	PF00498	0.315
LIG_FHA_1	363	369	PF00498	0.449
LIG_FHA_1	392	398	PF00498	0.703
LIG_FHA_2	102	108	PF00498	0.621
LIG_FHA_2	145	151	PF00498	0.551
LIG_FHA_2	162	168	PF00498	0.525
LIG_FHA_2	23	29	PF00498	0.378
LIG_FHA_2	322	328	PF00498	0.475
LIG_FHA_2	371	377	PF00498	0.672
LIG_FHA_2	396	402	PF00498	0.732
LIG_LIR_Gen_1	185	196	PF02991	0.327
LIG_LIR_Gen_1	261	272	PF02991	0.361
LIG_LIR_Nem_3	185	191	PF02991	0.327
LIG_LIR_Nem_3	19	24	PF02991	0.504
LIG_LIR_Nem_3	261	267	PF02991	0.361
LIG_LIR_Nem_3	268	273	PF02991	0.365
LIG_LIR_Nem_3	339	343	PF02991	0.363
LIG_LIR_Nem_3	49	55	PF02991	0.493
LIG_NRBOX	398	404	PF00104	0.691
LIG_PTAP_UEV_1	55	60	PF05743	0.618
LIG_SH2_CRK	270	274	PF00017	0.413
LIG_SH2_CRK	52	56	PF00017	0.589
LIG_SH2_PTP2	132	135	PF00017	0.543
LIG_SH2_SRC	132	135	PF00017	0.605
LIG_SH2_SRC	264	267	PF00017	0.449
LIG_SH2_STAP1	206	210	PF00017	0.437
LIG_SH2_STAP1	270	274	PF00017	0.449
LIG_SH2_STAT5	132	135	PF00017	0.543
LIG_SH2_STAT5	20	23	PF00017	0.538
LIG_SH2_STAT5	264	267	PF00017	0.315
LIG_SH2_STAT5	270	273	PF00017	0.321
LIG_SH2_STAT5	346	349	PF00017	0.392
LIG_SH2_STAT5	69	72	PF00017	0.365
LIG_SH2_STAT5	77	80	PF00017	0.408
LIG_SH3_3	114	120	PF00018	0.598
LIG_SH3_3	124	130	PF00018	0.463
LIG_SH3_3	140	146	PF00018	0.533
LIG_SH3_3	207	213	PF00018	0.290
LIG_SH3_3	236	242	PF00018	0.410
LIG_SH3_3	301	307	PF00018	0.281
LIG_SH3_3	53	59	PF00018	0.520
LIG_TRAF2_1	166	169	PF00917	0.656
LIG_TYR_ITIM	262	267	PF00017	0.344
LIG_WW_1	129	132	PF00397	0.519
MOD_CDK_SPxxK_3	308	315	PF00069	0.184
MOD_CK1_1	163	169	PF00069	0.718
MOD_CK1_1	249	255	PF00069	0.447
MOD_CK1_1	268	274	PF00069	0.161
MOD_CK1_1	284	290	PF00069	0.294
MOD_CK1_1	308	314	PF00069	0.350
MOD_CK1_1	317	323	PF00069	0.336
MOD_CK1_1	46	52	PF00069	0.452
MOD_CK2_1	144	150	PF00069	0.539
MOD_CK2_1	163	169	PF00069	0.571
MOD_CK2_1	321	327	PF00069	0.475
MOD_CK2_1	395	401	PF00069	0.734
MOD_GlcNHglycan	216	219	PF01048	0.427
MOD_GlcNHglycan	248	251	PF01048	0.378
MOD_GlcNHglycan	283	286	PF01048	0.328
MOD_GlcNHglycan	307	310	PF01048	0.408
MOD_GlcNHglycan	316	319	PF01048	0.487
MOD_GlcNHglycan	74	77	PF01048	0.451
MOD_GSK3_1	16	23	PF00069	0.346
MOD_GSK3_1	299	306	PF00069	0.438
MOD_GSK3_1	313	320	PF00069	0.441
MOD_GSK3_1	391	398	PF00069	0.703
MOD_GSK3_1	46	53	PF00069	0.465
MOD_GSK3_1	72	79	PF00069	0.352
MOD_NEK2_1	281	286	PF00069	0.407
MOD_NEK2_2	341	346	PF00069	0.328
MOD_PIKK_1	290	296	PF00454	0.359
MOD_PIKK_1	46	52	PF00454	0.452
MOD_PKA_1	362	368	PF00069	0.449
MOD_PKA_2	161	167	PF00069	0.680
MOD_PKA_2	314	320	PF00069	0.184
MOD_PKA_2	33	39	PF00069	0.501
MOD_PKA_2	362	368	PF00069	0.484
MOD_PKA_2	6	12	PF00069	0.556
MOD_PKB_1	5	13	PF00069	0.609
MOD_Plk_1	173	179	PF00069	0.597
MOD_Plk_1	206	212	PF00069	0.411
MOD_Plk_1	268	274	PF00069	0.475
MOD_Plk_2-3	370	376	PF00069	0.661
MOD_Plk_4	16	22	PF00069	0.494
MOD_Plk_4	258	264	PF00069	0.326
MOD_Plk_4	43	49	PF00069	0.502
MOD_Plk_4	82	88	PF00069	0.491
MOD_ProDKin_1	14	20	PF00069	0.490
MOD_ProDKin_1	284	290	PF00069	0.433
MOD_ProDKin_1	299	305	PF00069	0.250
MOD_ProDKin_1	308	314	PF00069	0.220
MOD_ProDKin_1	50	56	PF00069	0.462
MOD_SUMO_rev_2	178	184	PF00179	0.629
MOD_SUMO_rev_2	219	228	PF00179	0.378
MOD_SUMO_rev_2	6	14	PF00179	0.536
TRG_DiLeu_BaEn_4	168	174	PF01217	0.692
TRG_DiLeu_LyEn_5	114	119	PF01217	0.698
TRG_ENDOCYTIC_2	132	135	PF00928	0.543
TRG_ENDOCYTIC_2	188	191	PF00928	0.381
TRG_ENDOCYTIC_2	264	267	PF00928	0.342
TRG_ENDOCYTIC_2	270	273	PF00928	0.252
TRG_ENDOCYTIC_2	52	55	PF00928	0.550
TRG_ER_diArg_1	191	194	PF00400	0.328
TRG_ER_diArg_1	361	363	PF00400	0.449
TRG_NES_CRM1_1	168	181	PF08389	0.600
TRG_NES_CRM1_1	256	269	PF08389	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTP0	Leptomonas seymouri	67%	95%
A0A0S4JIG4	Bodo saltans	35%	100%
A0A1X0NZ44	Trypanosomatidae	46%	100%
A0A3Q8IC20	Leishmania donovani	89%	97%
A0A3S5IS34	Trypanosoma rangeli	44%	100%
A4HBV5	Leishmania braziliensis	81%	99%
D0A195	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AGW3	Leishmania infantum	89%	99%
Q4QCA1	Leishmania major	90%	100%
V5AR10	Trypanosoma cruzi	45%	100%