ABC transmembrane type-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV78_LEIMU

TriTrypDb:

LmxM.21.0940

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AV78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV78

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.329
CLV_C14_Caspase3-7	299	303	PF00656	0.474
CLV_NRD_NRD_1	148	150	PF00675	0.529
CLV_PCSK_SKI1_1	10	14	PF00082	0.447
CLV_PCSK_SKI1_1	150	154	PF00082	0.563
CLV_PCSK_SKI1_1	210	214	PF00082	0.604
DOC_CYCLIN_RxL_1	182	194	PF00134	0.543
DOC_CYCLIN_RxL_1	7	17	PF00134	0.602
DOC_CYCLIN_yCln2_LP_2	311	317	PF00134	0.190
DOC_MAPK_gen_1	149	155	PF00069	0.351
DOC_MAPK_gen_1	182	191	PF00069	0.547
DOC_PP1_RVXF_1	180	186	PF00149	0.451
DOC_PP2B_LxvP_1	311	314	PF13499	0.280
DOC_PP4_FxxP_1	331	334	PF00568	0.576
DOC_USP7_MATH_1	173	177	PF00917	0.395
DOC_WW_Pin1_4	276	281	PF00397	0.634
DOC_WW_Pin1_4	4	9	PF00397	0.659
DOC_WW_Pin1_4	42	47	PF00397	0.682
LIG_14-3-3_CanoR_1	184	190	PF00244	0.500
LIG_Actin_WH2_2	196	212	PF00022	0.554
LIG_Actin_WH2_2	89	107	PF00022	0.506
LIG_BIR_III_2	211	215	PF00653	0.453
LIG_BIR_III_2	302	306	PF00653	0.398
LIG_EH_1	303	307	PF12763	0.442
LIG_EH1_1	305	313	PF00400	0.274
LIG_FHA_1	172	178	PF00498	0.251
LIG_FHA_1	62	68	PF00498	0.474
LIG_FHA_1	85	91	PF00498	0.351
LIG_FHA_1	93	99	PF00498	0.336
LIG_FHA_2	206	212	PF00498	0.417
LIG_FHA_2	297	303	PF00498	0.572
LIG_FHA_2	314	320	PF00498	0.219
LIG_GBD_Chelix_1	232	240	PF00786	0.426
LIG_LIR_Gen_1	107	115	PF02991	0.377
LIG_LIR_Gen_1	319	326	PF02991	0.458
LIG_LIR_Gen_1	53	62	PF02991	0.613
LIG_LIR_Gen_1	85	93	PF02991	0.371
LIG_LIR_Nem_3	107	111	PF02991	0.369
LIG_LIR_Nem_3	11	16	PF02991	0.572
LIG_LIR_Nem_3	120	126	PF02991	0.358
LIG_LIR_Nem_3	17	23	PF02991	0.576
LIG_LIR_Nem_3	201	205	PF02991	0.402
LIG_LIR_Nem_3	319	323	PF02991	0.458
LIG_LIR_Nem_3	53	57	PF02991	0.602
LIG_LIR_Nem_3	85	89	PF02991	0.401
LIG_Pex14_1	296	300	PF04695	0.396
LIG_Rb_LxCxE_1	94	107	PF01857	0.406
LIG_SH2_CRK	54	58	PF00017	0.638
LIG_SH2_CRK	86	90	PF00017	0.395
LIG_SH2_GRB2like	112	115	PF00017	0.376
LIG_SH2_NCK_1	115	119	PF00017	0.424
LIG_SH2_NCK_1	300	304	PF00017	0.253
LIG_SH2_NCK_1	54	58	PF00017	0.649
LIG_SH2_PTP2	202	205	PF00017	0.529
LIG_SH2_STAP1	115	119	PF00017	0.400
LIG_SH2_STAP1	54	58	PF00017	0.631
LIG_SH2_STAP1	86	90	PF00017	0.369
LIG_SH2_STAT5	202	205	PF00017	0.493
LIG_SH2_STAT5	300	303	PF00017	0.264
LIG_SH2_STAT5	320	323	PF00017	0.347
LIG_SH2_STAT5	47	50	PF00017	0.634
LIG_SH2_STAT5	86	89	PF00017	0.385
LIG_SUMO_SIM_par_1	87	95	PF11976	0.349
LIG_UBA3_1	12	18	PF00899	0.600
MOD_CDC14_SPxK_1	7	10	PF00782	0.694
MOD_CDK_SPK_2	276	281	PF00069	0.634
MOD_CDK_SPxK_1	4	10	PF00069	0.710
MOD_CK1_1	194	200	PF00069	0.401
MOD_CK1_1	4	10	PF00069	0.674
MOD_CK1_1	53	59	PF00069	0.631
MOD_CK2_1	313	319	PF00069	0.326
MOD_GlcNHglycan	220	223	PF01048	0.572
MOD_GSK3_1	194	201	PF00069	0.473
MOD_GSK3_1	276	283	PF00069	0.488
MOD_GSK3_1	4	11	PF00069	0.641
MOD_NEK2_1	104	109	PF00069	0.364
MOD_NEK2_1	185	190	PF00069	0.573
MOD_NEK2_1	191	196	PF00069	0.365
MOD_NEK2_1	198	203	PF00069	0.314
MOD_NEK2_1	205	210	PF00069	0.213
MOD_NEK2_1	288	293	PF00069	0.442
MOD_NEK2_1	82	87	PF00069	0.399
MOD_NEK2_2	8	13	PF00069	0.641
MOD_PKA_1	218	224	PF00069	0.414
MOD_Plk_1	205	211	PF00069	0.373
MOD_Plk_1	273	279	PF00069	0.629
MOD_Plk_2-3	273	279	PF00069	0.637
MOD_Plk_4	173	179	PF00069	0.406
MOD_Plk_4	198	204	PF00069	0.447
MOD_Plk_4	235	241	PF00069	0.349
MOD_Plk_4	84	90	PF00069	0.364
MOD_ProDKin_1	276	282	PF00069	0.625
MOD_ProDKin_1	4	10	PF00069	0.658
MOD_ProDKin_1	42	48	PF00069	0.684
MOD_SUMO_rev_2	102	107	PF00179	0.408
TRG_DiLeu_BaEn_1	94	99	PF01217	0.407
TRG_ENDOCYTIC_2	123	126	PF00928	0.369
TRG_ENDOCYTIC_2	202	205	PF00928	0.488
TRG_ENDOCYTIC_2	268	271	PF00928	0.452
TRG_ENDOCYTIC_2	320	323	PF00928	0.458
TRG_ENDOCYTIC_2	54	57	PF00928	0.609
TRG_ENDOCYTIC_2	86	89	PF00928	0.395
TRG_ER_diArg_1	181	184	PF00400	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II52	Leptomonas seymouri	59%	98%
A0A0S4JMI1	Bodo saltans	31%	100%
A0A1X0NXQ9	Trypanosomatidae	33%	98%
A0A3S5H798	Leishmania donovani	86%	100%
A0A422NWG5	Trypanosoma rangeli	36%	100%
A4HBV4	Leishmania braziliensis	74%	100%
D0A1C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	98%
E9AGW2	Leishmania infantum	87%	100%
Q4QCA2	Leishmania major	88%	100%
V5BFJ0	Trypanosoma cruzi	33%	99%