tRNA_edit domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Aminoacyl-tRNA editing domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AV75_LEIMU

TriTrypDb:

LmxM.21.0910

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AV75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV75

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0002161	aminoacyl-tRNA editing activity	5	12
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0052689	carboxylic ester hydrolase activity	4	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0004812	aminoacyl-tRNA ligase activity	4	2
GO:0016874	ligase activity	2	2
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.353
CLV_NRD_NRD_1	85	87	PF00675	0.440
CLV_PCSK_KEX2_1	113	115	PF00082	0.353
CLV_PCSK_KEX2_1	18	20	PF00082	0.447
CLV_PCSK_KEX2_1	85	87	PF00082	0.491
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.411
CLV_PCSK_SKI1_1	114	118	PF00082	0.370
CLV_PCSK_SKI1_1	127	131	PF00082	0.228
DEG_SCF_TRCP1_1	90	96	PF00400	0.361
DOC_CYCLIN_yCln2_LP_2	185	191	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	222	228	PF00134	0.483
DOC_PP2B_LxvP_1	117	120	PF13499	0.294
DOC_PP2B_LxvP_1	222	225	PF13499	0.462
DOC_SPAK_OSR1_1	19	23	PF12202	0.416
DOC_USP7_MATH_1	4	8	PF00917	0.584
DOC_USP7_MATH_1	48	52	PF00917	0.690
LIG_14-3-3_CanoR_1	247	255	PF00244	0.224
LIG_Actin_WH2_2	23	39	PF00022	0.521
LIG_BRCT_BRCA1_1	94	98	PF00533	0.313
LIG_CSL_BTD_1	99	102	PF09270	0.421
LIG_FHA_2	135	141	PF00498	0.474
LIG_FHA_2	259	265	PF00498	0.487
LIG_LIR_Gen_1	147	157	PF02991	0.462
LIG_LIR_Gen_1	242	253	PF02991	0.493
LIG_LIR_Gen_1	95	106	PF02991	0.481
LIG_LIR_Nem_3	147	153	PF02991	0.462
LIG_LIR_Nem_3	242	248	PF02991	0.460
LIG_LIR_Nem_3	95	101	PF02991	0.328
LIG_SH2_SRC	154	157	PF00017	0.472
LIG_SH2_STAT5	150	153	PF00017	0.465
LIG_SH2_STAT5	156	159	PF00017	0.465
LIG_SH2_STAT5	228	231	PF00017	0.507
LIG_SH3_3	59	65	PF00018	0.594
LIG_SH3_3	72	78	PF00018	0.580
LIG_SUMO_SIM_par_1	211	216	PF11976	0.443
LIG_TRAF2_1	168	171	PF00917	0.457
LIG_TRAF2_1	261	264	PF00917	0.386
LIG_TYR_ITIM	152	157	PF00017	0.539
MOD_CK1_1	51	57	PF00069	0.676
MOD_CK2_1	258	264	PF00069	0.411
MOD_CK2_1	4	10	PF00069	0.431
MOD_Cter_Amidation	176	179	PF01082	0.237
MOD_GlcNHglycan	198	201	PF01048	0.329
MOD_GlcNHglycan	24	27	PF01048	0.414
MOD_GlcNHglycan	59	62	PF01048	0.640
MOD_GlcNHglycan	67	71	PF01048	0.493
MOD_GlcNHglycan	90	93	PF01048	0.396
MOD_GSK3_1	192	199	PF00069	0.500
MOD_GSK3_1	213	220	PF00069	0.505
MOD_GSK3_1	254	261	PF00069	0.354
MOD_GSK3_1	47	54	PF00069	0.681
MOD_GSK3_1	88	95	PF00069	0.300
MOD_N-GLC_1	144	149	PF02516	0.257
MOD_NEK2_1	125	130	PF00069	0.437
MOD_NEK2_1	131	136	PF00069	0.438
MOD_PIKK_1	217	223	PF00454	0.450
MOD_PKA_2	192	198	PF00069	0.396
MOD_PKA_2	246	252	PF00069	0.529
MOD_Plk_1	144	150	PF00069	0.432
MOD_Plk_1	51	57	PF00069	0.676
MOD_Plk_1	66	72	PF00069	0.643
MOD_Plk_4	125	131	PF00069	0.444
MOD_SUMO_rev_2	69	78	PF00179	0.396
TRG_ENDOCYTIC_2	149	152	PF00928	0.465
TRG_ENDOCYTIC_2	154	157	PF00928	0.465
TRG_ER_diArg_1	112	114	PF00400	0.346
TRG_ER_diArg_1	84	86	PF00400	0.446
TRG_NES_CRM1_1	11	24	PF08389	0.422
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I030	Leptomonas seymouri	73%	100%
A0A0S4IHR6	Bodo saltans	48%	100%
A0A1X0NXR2	Trypanosomatidae	49%	100%
A0A3Q8IDY4	Leishmania donovani	88%	99%
A0A422NWD3	Trypanosoma rangeli	49%	100%
A4HK97	Leishmania braziliensis	80%	100%
D0A1C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AGV9	Leishmania infantum	89%	71%
Q4QCA6	Leishmania major	90%	100%
V5B6I0	Trypanosoma cruzi	50%	100%