Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV74_LEIMU

TriTrypDb:

LmxM.21.0905

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AV74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV74

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.643
CLV_C14_Caspase3-7	374	378	PF00656	0.570
CLV_C14_Caspase3-7	388	392	PF00656	0.691
CLV_C14_Caspase3-7	80	84	PF00656	0.662
CLV_NRD_NRD_1	121	123	PF00675	0.668
CLV_NRD_NRD_1	188	190	PF00675	0.804
CLV_NRD_NRD_1	239	241	PF00675	0.644
CLV_NRD_NRD_1	263	265	PF00675	0.765
CLV_NRD_NRD_1	332	334	PF00675	0.667
CLV_NRD_NRD_1	356	358	PF00675	0.594
CLV_PCSK_KEX2_1	121	123	PF00082	0.668
CLV_PCSK_KEX2_1	187	189	PF00082	0.821
CLV_PCSK_KEX2_1	239	241	PF00082	0.644
CLV_PCSK_KEX2_1	263	265	PF00082	0.761
CLV_PCSK_SKI1_1	240	244	PF00082	0.409
CLV_PCSK_SKI1_1	294	298	PF00082	0.583
DEG_APCC_DBOX_1	120	128	PF00400	0.402
DEG_SCF_TRCP1_1	315	320	PF00400	0.492
DEG_SPOP_SBC_1	177	181	PF00917	0.654
DEG_SPOP_SBC_1	306	310	PF00917	0.752
DOC_ANK_TNKS_1	187	194	PF00023	0.598
DOC_MAPK_DCC_7	263	272	PF00069	0.461
DOC_MAPK_gen_1	263	270	PF00069	0.688
DOC_MAPK_MEF2A_6	263	272	PF00069	0.678
DOC_PP2B_LxvP_1	24	27	PF13499	0.731
DOC_USP7_MATH_1	155	159	PF00917	0.698
DOC_USP7_MATH_1	191	195	PF00917	0.546
DOC_USP7_MATH_1	253	257	PF00917	0.693
DOC_USP7_MATH_1	262	266	PF00917	0.652
DOC_USP7_MATH_1	305	309	PF00917	0.700
DOC_USP7_MATH_1	313	317	PF00917	0.716
DOC_USP7_MATH_1	82	86	PF00917	0.628
LIG_14-3-3_CanoR_1	239	248	PF00244	0.402
LIG_14-3-3_CanoR_1	263	270	PF00244	0.688
LIG_14-3-3_CanoR_1	357	361	PF00244	0.584
LIG_14-3-3_CanoR_1	98	102	PF00244	0.644
LIG_Actin_WH2_2	60	76	PF00022	0.693
LIG_BRCT_BRCA1_1	17	21	PF00533	0.603
LIG_FHA_1	179	185	PF00498	0.754
LIG_FHA_1	205	211	PF00498	0.658
LIG_FHA_1	283	289	PF00498	0.629
LIG_FHA_1	343	349	PF00498	0.532
LIG_FHA_1	6	12	PF00498	0.612
LIG_FHA_1	68	74	PF00498	0.494
LIG_FHA_1	98	104	PF00498	0.629
LIG_FHA_2	163	169	PF00498	0.823
LIG_FHA_2	219	225	PF00498	0.549
LIG_FHA_2	424	430	PF00498	0.725
LIG_HCF-1_HBM_1	22	25	PF13415	0.458
LIG_LIR_Gen_1	100	108	PF02991	0.528
LIG_LIR_Gen_1	18	29	PF02991	0.623
LIG_LIR_Gen_1	338	348	PF02991	0.554
LIG_LIR_Gen_1	412	421	PF02991	0.587
LIG_LIR_Gen_1	47	54	PF02991	0.668
LIG_LIR_Nem_3	100	104	PF02991	0.529
LIG_LIR_Nem_3	18	24	PF02991	0.639
LIG_LIR_Nem_3	338	343	PF02991	0.532
LIG_LIR_Nem_3	412	416	PF02991	0.625
LIG_LIR_Nem_3	47	52	PF02991	0.696
LIG_SH2_CRK	101	105	PF00017	0.352
LIG_SH2_SRC	136	139	PF00017	0.529
LIG_SH2_SRC	375	378	PF00017	0.571
LIG_SH2_STAP1	101	105	PF00017	0.352
LIG_SH2_STAP1	344	348	PF00017	0.522
LIG_SH2_STAP1	403	407	PF00017	0.763
LIG_SH2_STAT5	136	139	PF00017	0.529
LIG_SH2_STAT5	344	347	PF00017	0.526
LIG_SH2_STAT5	375	378	PF00017	0.571
LIG_SH3_3	245	251	PF00018	0.754
LIG_SH3_3	393	399	PF00018	0.704
LIG_SUMO_SIM_anti_2	199	204	PF11976	0.474
LIG_SUMO_SIM_par_1	102	107	PF11976	0.506
LIG_SUMO_SIM_par_1	206	211	PF11976	0.615
LIG_SUMO_SIM_par_1	268	273	PF11976	0.552
LIG_UBA3_1	287	294	PF00899	0.660
LIG_WRC_WIRS_1	351	356	PF05994	0.684
MOD_CK1_1	116	122	PF00069	0.536
MOD_CK1_1	162	168	PF00069	0.768
MOD_CK1_1	171	177	PF00069	0.672
MOD_CK1_1	346	352	PF00069	0.563
MOD_CK1_1	77	83	PF00069	0.575
MOD_CK1_1	94	100	PF00069	0.560
MOD_CK2_1	155	161	PF00069	0.560
MOD_CK2_1	218	224	PF00069	0.537
MOD_CK2_1	243	249	PF00069	0.651
MOD_CK2_1	350	356	PF00069	0.534
MOD_CK2_1	375	381	PF00069	0.433
MOD_CK2_1	423	429	PF00069	0.715
MOD_GlcNHglycan	115	118	PF01048	0.654
MOD_GlcNHglycan	127	130	PF01048	0.469
MOD_GlcNHglycan	157	160	PF01048	0.726
MOD_GlcNHglycan	161	164	PF01048	0.686
MOD_GlcNHglycan	210	213	PF01048	0.768
MOD_GlcNHglycan	221	224	PF01048	0.480
MOD_GlcNHglycan	229	232	PF01048	0.444
MOD_GlcNHglycan	235	238	PF01048	0.531
MOD_GlcNHglycan	254	258	PF01048	0.498
MOD_GlcNHglycan	315	318	PF01048	0.593
MOD_GlcNHglycan	381	384	PF01048	0.755
MOD_GlcNHglycan	41	44	PF01048	0.564
MOD_GlcNHglycan	417	420	PF01048	0.629
MOD_GlcNHglycan	76	79	PF01048	0.630
MOD_GlcNHglycan	80	83	PF01048	0.671
MOD_GlcNHglycan	84	87	PF01048	0.697
MOD_GlcNHglycan	91	94	PF01048	0.728
MOD_GSK3_1	155	162	PF00069	0.733
MOD_GSK3_1	176	183	PF00069	0.756
MOD_GSK3_1	204	211	PF00069	0.712
MOD_GSK3_1	295	302	PF00069	0.574
MOD_GSK3_1	307	314	PF00069	0.626
MOD_GSK3_1	342	349	PF00069	0.537
MOD_GSK3_1	35	42	PF00069	0.750
MOD_GSK3_1	352	359	PF00069	0.521
MOD_GSK3_1	361	368	PF00069	0.336
MOD_GSK3_1	375	382	PF00069	0.585
MOD_GSK3_1	74	81	PF00069	0.580
MOD_N-GLC_1	169	174	PF02516	0.765
MOD_N-GLC_1	204	209	PF02516	0.597
MOD_N-GLC_1	213	218	PF02516	0.650
MOD_NEK2_1	169	174	PF00069	0.551
MOD_NEK2_1	213	218	PF00069	0.650
MOD_NEK2_1	274	279	PF00069	0.531
MOD_NEK2_1	295	300	PF00069	0.387
MOD_NEK2_1	343	348	PF00069	0.528
MOD_NEK2_2	307	312	PF00069	0.693
MOD_NEK2_2	44	49	PF00069	0.741
MOD_NEK2_2	5	10	PF00069	0.643
MOD_PIKK_1	282	288	PF00454	0.564
MOD_PIKK_1	328	334	PF00454	0.683
MOD_PIKK_1	65	71	PF00454	0.618
MOD_PKA_2	262	268	PF00069	0.725
MOD_PKA_2	356	362	PF00069	0.539
MOD_PKA_2	97	103	PF00069	0.648
MOD_Plk_1	204	210	PF00069	0.711
MOD_Plk_1	317	323	PF00069	0.597
MOD_Plk_1	349	355	PF00069	0.555
MOD_Plk_2-3	350	356	PF00069	0.584
MOD_Plk_4	191	197	PF00069	0.564
MOD_Plk_4	307	313	PF00069	0.743
MOD_Plk_4	317	323	PF00069	0.665
MOD_Plk_4	343	349	PF00069	0.532
MOD_Plk_4	44	50	PF00069	0.742
MOD_Plk_4	67	73	PF00069	0.555
MOD_SUMO_rev_2	350	360	PF00179	0.577
TRG_ENDOCYTIC_2	101	104	PF00928	0.517
TRG_ENDOCYTIC_2	344	347	PF00928	0.467
TRG_ER_diArg_1	187	189	PF00400	0.817
TRG_ER_diArg_1	239	241	PF00400	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILY1	Leptomonas seymouri	47%	100%
A0A3S7WWI8	Leishmania donovani	85%	96%
A4HK96	Leishmania braziliensis	70%	100%
E9AGV8	Leishmania infantum	84%	96%
Q4QCA7	Leishmania major	87%	100%