HTTM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4499), putative

Species:

Leishmania mexicana

UniProt:

E9AV69_LEIMU

TriTrypDb:

LmxM.21.0883

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AV69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.551
CLV_NRD_NRD_1	83	85	PF00675	0.528
CLV_PCSK_KEX2_1	83	85	PF00082	0.642
CLV_PCSK_PC7_1	79	85	PF00082	0.520
CLV_PCSK_SKI1_1	160	164	PF00082	0.292
CLV_PCSK_SKI1_1	6	10	PF00082	0.450
CLV_PCSK_SKI1_1	79	83	PF00082	0.653
DEG_SPOP_SBC_1	22	26	PF00917	0.550
DOC_CYCLIN_RxL_1	61	70	PF00134	0.309
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.292
DOC_MAPK_MEF2A_6	34	43	PF00069	0.520
DOC_PP1_RVXF_1	144	150	PF00149	0.531
DOC_PP2B_LxvP_1	39	42	PF13499	0.292
DOC_PP2B_LxvP_1	66	69	PF13499	0.361
DOC_PP2B_PxIxI_1	174	180	PF00149	0.212
DOC_USP7_MATH_1	21	25	PF00917	0.719
DOC_WW_Pin1_4	10	15	PF00397	0.712
DOC_WW_Pin1_4	171	176	PF00397	0.320
LIG_14-3-3_CanoR_1	146	156	PF00244	0.488
LIG_14-3-3_CanoR_1	188	196	PF00244	0.260
LIG_14-3-3_CanoR_1	83	87	PF00244	0.248
LIG_BIR_III_4	60	64	PF00653	0.349
LIG_FHA_1	11	17	PF00498	0.627
LIG_FHA_1	188	194	PF00498	0.426
LIG_FHA_1	63	69	PF00498	0.217
LIG_FHA_1	91	97	PF00498	0.485
LIG_Pex14_2	145	149	PF04695	0.482
LIG_PTB_Apo_2	49	56	PF02174	0.292
LIG_SH2_SRC	40	43	PF00017	0.292
LIG_SH2_STAT5	40	43	PF00017	0.315
LIG_SH2_STAT5	71	74	PF00017	0.434
LIG_SH3_2	2	7	PF14604	0.627
LIG_SUMO_SIM_par_1	64	70	PF11976	0.430
MOD_CDK_SPxxK_3	171	178	PF00069	0.372
MOD_CK1_1	25	31	PF00069	0.559
MOD_GlcNHglycan	123	126	PF01048	0.531
MOD_GSK3_1	147	154	PF00069	0.471
MOD_GSK3_1	21	28	PF00069	0.693
MOD_GSK3_1	6	13	PF00069	0.656
MOD_N-GLC_1	151	156	PF02516	0.282
MOD_NEK2_1	119	124	PF00069	0.247
MOD_NEK2_1	155	160	PF00069	0.385
MOD_NEK2_1	162	167	PF00069	0.390
MOD_NEK2_1	187	192	PF00069	0.403
MOD_NEK2_1	82	87	PF00069	0.298
MOD_OFUCOSY	144	151	PF10250	0.331
MOD_PIKK_1	168	174	PF00454	0.314
MOD_PKA_1	6	12	PF00069	0.713
MOD_PKA_2	187	193	PF00069	0.364
MOD_PKA_2	82	88	PF00069	0.245
MOD_Plk_1	151	157	PF00069	0.528
MOD_Plk_4	108	114	PF00069	0.321
MOD_Plk_4	151	157	PF00069	0.575
MOD_Plk_4	62	68	PF00069	0.261
MOD_ProDKin_1	10	16	PF00069	0.710
MOD_ProDKin_1	171	177	PF00069	0.320
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.267
TRG_ENDOCYTIC_2	40	43	PF00928	0.345
TRG_ER_diArg_1	197	200	PF00400	0.318
TRG_ER_diArg_1	82	84	PF00400	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P5	Leptomonas seymouri	49%	100%
A0A0S4IZY4	Bodo saltans	34%	100%
A0A1X0NXR6	Trypanosomatidae	39%	100%
A0A3Q8IAC8	Leishmania donovani	86%	100%
A0A3R7KU69	Trypanosoma rangeli	35%	100%
A4HBU7	Leishmania braziliensis	64%	100%
D0A1C5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AGV3	Leishmania infantum	85%	100%
Q4QCB2	Leishmania major	83%	100%