LeishMANIAdb
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DUF4220 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF4220 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AV68_LEIMU
TriTrypDb:
LmxM.21.0882
Length:
108

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AV68
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV68

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 45 47 PF00675 0.487
CLV_PCSK_KEX2_1 47 49 PF00082 0.462
CLV_PCSK_PC1ET2_1 47 49 PF00082 0.462
DOC_USP7_UBL2_3 20 24 PF12436 0.531
LIG_14-3-3_CanoR_1 18 27 PF00244 0.598
LIG_BIR_II_1 1 5 PF00653 0.669
LIG_BIR_III_4 71 75 PF00653 0.562
LIG_FHA_1 20 26 PF00498 0.611
LIG_SH2_NCK_1 37 41 PF00017 0.692
MOD_CK1_1 2 8 PF00069 0.662
MOD_CK2_1 39 45 PF00069 0.640
MOD_GlcNHglycan 1 4 PF01048 0.515
MOD_GlcNHglycan 94 97 PF01048 0.733
MOD_NEK2_1 50 55 PF00069 0.475
MOD_Plk_1 50 56 PF00069 0.475
MOD_Plk_4 50 56 PF00069 0.494
MOD_Plk_4 61 67 PF00069 0.369
MOD_Plk_4 8 14 PF00069 0.523

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IA12 Leptomonas seymouri 58% 100%
A0A3S7WWH6 Leishmania donovani 92% 100%
A4HBU6 Leishmania braziliensis 84% 100%
E9AGV2 Leishmania infantum 92% 100%
Q4QCB3 Leishmania major 93% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS