ABC transporter domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC transporter, putative

Species:

Leishmania mexicana

UniProt:

E9AV67_LEIMU

TriTrypDb:

LmxM.21.0880

Length:

954

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AV67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV67

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0005215	transporter activity	1	5
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0015399	primary active transmembrane transporter activity	4	5
GO:0017076	purine nucleotide binding	4	7
GO:0022804	active transmembrane transporter activity	3	5
GO:0022857	transmembrane transporter activity	2	5
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0042626	ATPase-coupled transmembrane transporter activity	2	5
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140359	ABC-type transporter activity	3	5
GO:0140657	ATP-dependent activity	1	5
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.750
CLV_C14_Caspase3-7	483	487	PF00656	0.773
CLV_C14_Caspase3-7	542	546	PF00656	0.705
CLV_C14_Caspase3-7	56	60	PF00656	0.676
CLV_NRD_NRD_1	260	262	PF00675	0.302
CLV_NRD_NRD_1	310	312	PF00675	0.370
CLV_NRD_NRD_1	470	472	PF00675	0.548
CLV_NRD_NRD_1	690	692	PF00675	0.256
CLV_NRD_NRD_1	82	84	PF00675	0.513
CLV_NRD_NRD_1	877	879	PF00675	0.586
CLV_NRD_NRD_1	918	920	PF00675	0.534
CLV_NRD_NRD_1	948	950	PF00675	0.403
CLV_PCSK_FUR_1	79	83	PF00082	0.504
CLV_PCSK_FUR_1	945	949	PF00082	0.397
CLV_PCSK_KEX2_1	259	261	PF00082	0.303
CLV_PCSK_KEX2_1	310	312	PF00082	0.411
CLV_PCSK_KEX2_1	470	472	PF00082	0.548
CLV_PCSK_KEX2_1	690	692	PF00082	0.256
CLV_PCSK_KEX2_1	81	83	PF00082	0.518
CLV_PCSK_KEX2_1	877	879	PF00082	0.586
CLV_PCSK_KEX2_1	918	920	PF00082	0.534
CLV_PCSK_KEX2_1	947	949	PF00082	0.404
CLV_PCSK_PC7_1	77	83	PF00082	0.503
CLV_PCSK_SKI1_1	261	265	PF00082	0.275
CLV_PCSK_SKI1_1	266	270	PF00082	0.282
CLV_PCSK_SKI1_1	400	404	PF00082	0.341
CLV_PCSK_SKI1_1	417	421	PF00082	0.320
CLV_PCSK_SKI1_1	449	453	PF00082	0.427
CLV_PCSK_SKI1_1	747	751	PF00082	0.478
CLV_PCSK_SKI1_1	888	892	PF00082	0.672
CLV_PCSK_SKI1_1	948	952	PF00082	0.383
DEG_Kelch_Keap1_1	518	523	PF01344	0.624
DEG_SCF_FBW7_1	348	355	PF00400	0.660
DEG_SCF_FBW7_1	365	371	PF00400	0.684
DEG_SPOP_SBC_1	369	373	PF00917	0.638
DOC_AGCK_PIF_1	696	701	PF00069	0.452
DOC_AGCK_PIF_1	782	787	PF00069	0.291
DOC_CKS1_1	349	354	PF01111	0.679
DOC_CKS1_1	365	370	PF01111	0.711
DOC_CKS1_1	466	471	PF01111	0.711
DOC_CYCLIN_RxL_1	260	273	PF00134	0.475
DOC_CYCLIN_yCln2_LP_2	299	305	PF00134	0.491
DOC_MAPK_gen_1	250	258	PF00069	0.534
DOC_MAPK_gen_1	918	925	PF00069	0.325
DOC_MAPK_gen_1	945	952	PF00069	0.550
DOC_MAPK_MEF2A_6	747	756	PF00069	0.275
DOC_MAPK_MEF2A_6	918	927	PF00069	0.260
DOC_PP1_RVXF_1	432	439	PF00149	0.546
DOC_PP1_RVXF_1	779	786	PF00149	0.529
DOC_PP2B_LxvP_1	299	302	PF13499	0.532
DOC_PP2B_LxvP_1	579	582	PF13499	0.480
DOC_PP2B_PxIxI_1	535	541	PF00149	0.660
DOC_PP4_FxxP_1	379	382	PF00568	0.712
DOC_PP4_FxxP_1	609	612	PF00568	0.608
DOC_PP4_FxxP_1	739	742	PF00568	0.275
DOC_SPAK_OSR1_1	764	768	PF12202	0.356
DOC_SPAK_OSR1_1	781	785	PF12202	0.469
DOC_USP7_MATH_1	178	182	PF00917	0.485
DOC_USP7_MATH_1	363	367	PF00917	0.744
DOC_USP7_MATH_1	42	46	PF00917	0.664
DOC_USP7_MATH_1	443	447	PF00917	0.662
DOC_USP7_MATH_1	478	482	PF00917	0.621
DOC_USP7_MATH_1	546	550	PF00917	0.650
DOC_USP7_MATH_1	556	560	PF00917	0.725
DOC_USP7_MATH_1	757	761	PF00917	0.499
DOC_USP7_MATH_1	820	824	PF00917	0.282
DOC_USP7_MATH_1	86	90	PF00917	0.738
DOC_USP7_MATH_1	880	884	PF00917	0.465
DOC_WW_Pin1_4	348	353	PF00397	0.704
DOC_WW_Pin1_4	361	366	PF00397	0.733
DOC_WW_Pin1_4	371	376	PF00397	0.714
DOC_WW_Pin1_4	38	43	PF00397	0.831
DOC_WW_Pin1_4	465	470	PF00397	0.730
DOC_WW_Pin1_4	571	576	PF00397	0.677
DOC_WW_Pin1_4	67	72	PF00397	0.721
DOC_WW_Pin1_4	912	917	PF00397	0.381
LIG_14-3-3_CanoR_1	224	234	PF00244	0.475
LIG_14-3-3_CanoR_1	35	41	PF00244	0.725
LIG_14-3-3_CanoR_1	470	475	PF00244	0.701
LIG_14-3-3_CanoR_1	550	560	PF00244	0.748
LIG_14-3-3_CanoR_1	764	768	PF00244	0.207
LIG_14-3-3_CanoR_1	850	858	PF00244	0.561
LIG_14-3-3_CanoR_1	881	886	PF00244	0.524
LIG_14-3-3_CanoR_1	98	107	PF00244	0.706
LIG_14-3-3_CterR_2	949	954	PF00244	0.615
LIG_Actin_WH2_2	210	226	PF00022	0.475
LIG_Actin_WH2_2	936	953	PF00022	0.423
LIG_BIR_II_1	1	5	PF00653	0.717
LIG_BRCT_BRCA1_1	125	129	PF00533	0.595
LIG_BRCT_BRCA1_1	765	769	PF00533	0.207
LIG_Clathr_ClatBox_1	274	278	PF01394	0.400
LIG_CSL_BTD_1	772	775	PF09270	0.475
LIG_deltaCOP1_diTrp_1	741	750	PF00928	0.275
LIG_FHA_1	100	106	PF00498	0.634
LIG_FHA_1	133	139	PF00498	0.507
LIG_FHA_1	178	184	PF00498	0.453
LIG_FHA_1	453	459	PF00498	0.754
LIG_FHA_1	49	55	PF00498	0.639
LIG_FHA_1	60	66	PF00498	0.639
LIG_FHA_1	7	13	PF00498	0.740
LIG_FHA_1	707	713	PF00498	0.475
LIG_FHA_1	715	721	PF00498	0.312
LIG_FHA_1	787	793	PF00498	0.388
LIG_FHA_1	88	94	PF00498	0.760
LIG_FHA_2	210	216	PF00498	0.475
LIG_FHA_2	365	371	PF00498	0.688
LIG_FHA_2	376	382	PF00498	0.760
LIG_FHA_2	47	53	PF00498	0.708
LIG_FHA_2	564	570	PF00498	0.697
LIG_FHA_2	801	807	PF00498	0.388
LIG_FHA_2	902	908	PF00498	0.345
LIG_Integrin_isoDGR_2	117	119	PF01839	0.311
LIG_IRF3_LxIS_1	946	953	PF10401	0.533
LIG_LIR_Apic_2	2	7	PF02991	0.642
LIG_LIR_Apic_2	376	382	PF02991	0.724
LIG_LIR_Apic_2	607	612	PF02991	0.612
LIG_LIR_Apic_2	737	742	PF02991	0.275
LIG_LIR_Gen_1	101	112	PF02991	0.570
LIG_LIR_Gen_1	145	154	PF02991	0.529
LIG_LIR_Gen_1	289	300	PF02991	0.576
LIG_LIR_Gen_1	435	445	PF02991	0.577
LIG_LIR_Gen_1	480	489	PF02991	0.654
LIG_LIR_Gen_1	637	647	PF02991	0.340
LIG_LIR_Gen_1	692	701	PF02991	0.475
LIG_LIR_Gen_1	709	718	PF02991	0.475
LIG_LIR_Gen_1	727	736	PF02991	0.236
LIG_LIR_Gen_1	812	821	PF02991	0.275
LIG_LIR_Gen_1	906	916	PF02991	0.390
LIG_LIR_Gen_1	917	927	PF02991	0.249
LIG_LIR_Gen_1	937	946	PF02991	0.347
LIG_LIR_Nem_3	101	107	PF02991	0.594
LIG_LIR_Nem_3	145	150	PF02991	0.561
LIG_LIR_Nem_3	289	295	PF02991	0.578
LIG_LIR_Nem_3	480	485	PF02991	0.663
LIG_LIR_Nem_3	531	537	PF02991	0.742
LIG_LIR_Nem_3	637	642	PF02991	0.340
LIG_LIR_Nem_3	692	696	PF02991	0.475
LIG_LIR_Nem_3	700	704	PF02991	0.475
LIG_LIR_Nem_3	709	713	PF02991	0.475
LIG_LIR_Nem_3	727	731	PF02991	0.312
LIG_LIR_Nem_3	741	746	PF02991	0.220
LIG_LIR_Nem_3	786	790	PF02991	0.330
LIG_LIR_Nem_3	812	816	PF02991	0.275
LIG_LIR_Nem_3	906	911	PF02991	0.345
LIG_LIR_Nem_3	917	923	PF02991	0.322
LIG_NRBOX	237	243	PF00104	0.498
LIG_PDZ_Class_2	949	954	PF00595	0.547
LIG_Pex14_2	623	627	PF04695	0.521
LIG_Pex14_2	739	743	PF04695	0.275
LIG_Pex14_2	761	765	PF04695	0.331
LIG_Pex14_2	769	773	PF04695	0.290
LIG_SH2_CRK	4	8	PF00017	0.660
LIG_SH2_CRK	746	750	PF00017	0.275
LIG_SH2_NCK_1	482	486	PF00017	0.640
LIG_SH2_SRC	4	7	PF00017	0.606
LIG_SH2_STAP1	219	223	PF00017	0.475
LIG_SH2_STAP1	788	792	PF00017	0.312
LIG_SH2_STAP1	821	825	PF00017	0.275
LIG_SH2_STAP1	908	912	PF00017	0.388
LIG_SH2_STAT3	176	179	PF00017	0.475
LIG_SH2_STAT3	655	658	PF00017	0.275
LIG_SH2_STAT5	104	107	PF00017	0.552
LIG_SH2_STAT5	257	260	PF00017	0.475
LIG_SH2_STAT5	292	295	PF00017	0.613
LIG_SH2_STAT5	350	353	PF00017	0.678
LIG_SH2_STAT5	710	713	PF00017	0.510
LIG_SH2_STAT5	788	791	PF00017	0.312
LIG_SH2_STAT5	903	906	PF00017	0.333
LIG_SH3_2	466	471	PF14604	0.711
LIG_SH3_3	362	368	PF00018	0.721
LIG_SH3_3	427	433	PF00018	0.567
LIG_SH3_3	463	469	PF00018	0.708
LIG_SH3_3	506	512	PF00018	0.558
LIG_SH3_3	600	606	PF00018	0.637
LIG_Sin3_3	146	153	PF02671	0.486
LIG_SUMO_SIM_anti_2	273	279	PF11976	0.475
LIG_SUMO_SIM_anti_2	409	414	PF11976	0.508
LIG_SUMO_SIM_anti_2	751	756	PF11976	0.388
LIG_SUMO_SIM_anti_2	930	937	PF11976	0.226
LIG_SUMO_SIM_par_1	273	279	PF11976	0.475
LIG_SUMO_SIM_par_1	390	395	PF11976	0.508
LIG_SUMO_SIM_par_1	409	414	PF11976	0.508
LIG_SUMO_SIM_par_1	682	688	PF11976	0.312
LIG_SUMO_SIM_par_1	753	760	PF11976	0.316
LIG_SUMO_SIM_par_1	8	13	PF11976	0.716
LIG_SUMO_SIM_par_1	930	937	PF11976	0.233
LIG_WRC_WIRS_1	725	730	PF05994	0.388
LIG_WRC_WIRS_1	758	763	PF05994	0.388
LIG_WRC_WIRS_1	784	789	PF05994	0.291
MOD_CDC14_SPxK_1	915	918	PF00782	0.439
MOD_CDK_SPK_2	348	353	PF00069	0.597
MOD_CDK_SPK_2	38	43	PF00069	0.535
MOD_CDK_SPK_2	465	470	PF00069	0.654
MOD_CDK_SPxK_1	465	471	PF00069	0.715
MOD_CDK_SPxK_1	912	918	PF00069	0.424
MOD_CDK_SPxxK_3	912	919	PF00069	0.421
MOD_CK1_1	13	19	PF00069	0.691
MOD_CK1_1	172	178	PF00069	0.330
MOD_CK1_1	331	337	PF00069	0.587
MOD_CK1_1	364	370	PF00069	0.760
MOD_CK1_1	373	379	PF00069	0.653
MOD_CK1_1	45	51	PF00069	0.628
MOD_CK1_1	549	555	PF00069	0.754
MOD_CK1_1	67	73	PF00069	0.591
MOD_CK1_1	682	688	PF00069	0.301
MOD_CK1_1	760	766	PF00069	0.475
MOD_CK1_1	812	818	PF00069	0.312
MOD_CK1_1	849	855	PF00069	0.539
MOD_CK2_1	178	184	PF00069	0.388
MOD_CK2_1	187	193	PF00069	0.296
MOD_CK2_1	209	215	PF00069	0.350
MOD_CK2_1	230	236	PF00069	0.352
MOD_CK2_1	381	387	PF00069	0.595
MOD_CK2_1	46	52	PF00069	0.703
MOD_CK2_1	800	806	PF00069	0.373
MOD_CK2_1	901	907	PF00069	0.494
MOD_GlcNHglycan	112	115	PF01048	0.392
MOD_GlcNHglycan	144	147	PF01048	0.363
MOD_GlcNHglycan	171	174	PF01048	0.312
MOD_GlcNHglycan	193	198	PF01048	0.371
MOD_GlcNHglycan	203	206	PF01048	0.323
MOD_GlcNHglycan	227	230	PF01048	0.321
MOD_GlcNHglycan	330	333	PF01048	0.577
MOD_GlcNHglycan	358	361	PF01048	0.731
MOD_GlcNHglycan	445	448	PF01048	0.688
MOD_GlcNHglycan	520	523	PF01048	0.729
MOD_GlcNHglycan	556	559	PF01048	0.655
MOD_GlcNHglycan	692	696	PF01048	0.307
MOD_GlcNHglycan	72	75	PF01048	0.608
MOD_GlcNHglycan	851	854	PF01048	0.600
MOD_GlcNHglycan	858	861	PF01048	0.751
MOD_GlcNHglycan	929	932	PF01048	0.318
MOD_GSK3_1	14	21	PF00069	0.726
MOD_GSK3_1	157	164	PF00069	0.457
MOD_GSK3_1	193	200	PF00069	0.327
MOD_GSK3_1	348	355	PF00069	0.683
MOD_GSK3_1	364	371	PF00069	0.626
MOD_GSK3_1	38	45	PF00069	0.743
MOD_GSK3_1	452	459	PF00069	0.681
MOD_GSK3_1	546	553	PF00069	0.744
MOD_GSK3_1	6	13	PF00069	0.677
MOD_GSK3_1	756	763	PF00069	0.468
MOD_GSK3_1	800	807	PF00069	0.345
MOD_GSK3_1	820	827	PF00069	0.332
MOD_GSK3_1	914	921	PF00069	0.443
MOD_GSK3_1	99	106	PF00069	0.602
MOD_LATS_1	354	360	PF00433	0.577
MOD_LATS_1	879	885	PF00433	0.520
MOD_N-GLC_1	252	257	PF02516	0.291
MOD_N-GLC_1	838	843	PF02516	0.514
MOD_N-GLC_2	139	141	PF02516	0.391
MOD_N-GLC_2	416	418	PF02516	0.430
MOD_N-GLC_2	900	902	PF02516	0.500
MOD_NEK2_1	420	425	PF00069	0.460
MOD_NEK2_1	437	442	PF00069	0.679
MOD_NEK2_1	673	678	PF00069	0.388
MOD_NEK2_1	734	739	PF00069	0.312
MOD_NEK2_1	750	755	PF00069	0.312
MOD_NEK2_1	756	761	PF00069	0.326
MOD_NEK2_1	830	835	PF00069	0.325
MOD_NEK2_1	93	98	PF00069	0.460
MOD_NEK2_1	934	939	PF00069	0.348
MOD_NEK2_2	209	214	PF00069	0.291
MOD_NEK2_2	219	224	PF00069	0.291
MOD_PIKK_1	286	292	PF00454	0.483
MOD_PIKK_1	574	580	PF00454	0.439
MOD_PIKK_1	824	830	PF00454	0.388
MOD_PKA_1	470	476	PF00069	0.527
MOD_PKA_1	81	87	PF00069	0.567
MOD_PKA_1	918	924	PF00069	0.457
MOD_PKA_2	132	138	PF00069	0.377
MOD_PKA_2	198	204	PF00069	0.331
MOD_PKA_2	352	358	PF00069	0.608
MOD_PKA_2	36	42	PF00069	0.706
MOD_PKA_2	470	476	PF00069	0.619
MOD_PKA_2	549	555	PF00069	0.694
MOD_PKA_2	763	769	PF00069	0.207
MOD_PKA_2	81	87	PF00069	0.628
MOD_PKA_2	849	855	PF00069	0.629
MOD_PKA_2	880	886	PF00069	0.650
MOD_PKA_2	918	924	PF00069	0.457
MOD_PKB_1	79	87	PF00069	0.572
MOD_Plk_1	123	129	PF00069	0.405
MOD_Plk_1	209	215	PF00069	0.312
MOD_Plk_1	252	258	PF00069	0.312
MOD_Plk_1	485	491	PF00069	0.591
MOD_Plk_1	691	697	PF00069	0.207
MOD_Plk_1	750	756	PF00069	0.388
MOD_Plk_1	93	99	PF00069	0.510
MOD_Plk_4	100	106	PF00069	0.504
MOD_Plk_4	161	167	PF00069	0.492
MOD_Plk_4	178	184	PF00069	0.248
MOD_Plk_4	252	258	PF00069	0.312
MOD_Plk_4	270	276	PF00069	0.312
MOD_Plk_4	291	297	PF00069	0.375
MOD_Plk_4	392	398	PF00069	0.385
MOD_Plk_4	6	12	PF00069	0.670
MOD_Plk_4	612	618	PF00069	0.480
MOD_Plk_4	679	685	PF00069	0.240
MOD_Plk_4	706	712	PF00069	0.431
MOD_Plk_4	724	730	PF00069	0.465
MOD_Plk_4	750	756	PF00069	0.412
MOD_Plk_4	812	818	PF00069	0.312
MOD_Plk_4	881	887	PF00069	0.538
MOD_Plk_4	934	940	PF00069	0.348
MOD_ProDKin_1	348	354	PF00069	0.633
MOD_ProDKin_1	361	367	PF00069	0.673
MOD_ProDKin_1	371	377	PF00069	0.644
MOD_ProDKin_1	38	44	PF00069	0.809
MOD_ProDKin_1	465	471	PF00069	0.670
MOD_ProDKin_1	571	577	PF00069	0.591
MOD_ProDKin_1	67	73	PF00069	0.656
MOD_ProDKin_1	912	918	PF00069	0.462
TRG_DiLeu_BaEn_2	906	912	PF01217	0.476
TRG_ENDOCYTIC_2	104	107	PF00928	0.419
TRG_ENDOCYTIC_2	292	295	PF00928	0.445
TRG_ENDOCYTIC_2	482	485	PF00928	0.574
TRG_ENDOCYTIC_2	693	696	PF00928	0.312
TRG_ENDOCYTIC_2	710	713	PF00928	0.312
TRG_ENDOCYTIC_2	746	749	PF00928	0.339
TRG_ENDOCYTIC_2	908	911	PF00928	0.413
TRG_ER_diArg_1	258	261	PF00400	0.350
TRG_ER_diArg_1	310	312	PF00400	0.444
TRG_ER_diArg_1	469	471	PF00400	0.656
TRG_ER_diArg_1	689	691	PF00400	0.327
TRG_ER_diArg_1	76	79	PF00400	0.675
TRG_ER_diArg_1	81	83	PF00400	0.660
TRG_ER_diArg_1	918	920	PF00400	0.394
TRG_ER_diArg_1	944	947	PF00400	0.473
TRG_ER_diArg_1	948	950	PF00400	0.471
TRG_NES_CRM1_1	809	822	PF08389	0.340
TRG_Pf-PMV_PEXEL_1	449	453	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8B6	Leptomonas seymouri	54%	99%
A0A3Q8IBV9	Leishmania donovani	87%	100%
A4HBU5	Leishmania braziliensis	71%	100%
E9AGV1	Leishmania infantum	87%	100%
Q4QCB4	Leishmania major	86%	100%