Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV65_LEIMU

TriTrypDb:

LmxM.21.0873

Length:

844

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AV65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV65

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	5
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004672	protein kinase activity	3	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:0140096	catalytic activity, acting on a protein	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.427
CLV_NRD_NRD_1	207	209	PF00675	0.388
CLV_NRD_NRD_1	302	304	PF00675	0.458
CLV_NRD_NRD_1	833	835	PF00675	0.595
CLV_NRD_NRD_1	84	86	PF00675	0.448
CLV_PCSK_KEX2_1	127	129	PF00082	0.477
CLV_PCSK_KEX2_1	207	209	PF00082	0.388
CLV_PCSK_KEX2_1	833	835	PF00082	0.710
CLV_PCSK_KEX2_1	84	86	PF00082	0.338
CLV_PCSK_PC7_1	80	86	PF00082	0.299
CLV_PCSK_SKI1_1	118	122	PF00082	0.378
CLV_PCSK_SKI1_1	318	322	PF00082	0.284
CLV_PCSK_SKI1_1	429	433	PF00082	0.320
CLV_PCSK_SKI1_1	534	538	PF00082	0.376
CLV_PCSK_SKI1_1	679	683	PF00082	0.456
CLV_PCSK_SKI1_1	84	88	PF00082	0.354
CLV_Separin_Metazoa	368	372	PF03568	0.338
DEG_APCC_DBOX_1	355	363	PF00400	0.425
DEG_SCF_FBW7_1	684	691	PF00400	0.628
DEG_SIAH_1	687	695	PF03145	0.579
DEG_SPOP_SBC_1	627	631	PF00917	0.703
DOC_CKS1_1	18	23	PF01111	0.450
DOC_CKS1_1	410	415	PF01111	0.395
DOC_CKS1_1	680	685	PF01111	0.457
DOC_CKS1_1	693	698	PF01111	0.624
DOC_CYCLIN_RxL_1	3	13	PF00134	0.501
DOC_CYCLIN_RxL_1	426	436	PF00134	0.324
DOC_MAPK_gen_1	207	213	PF00069	0.422
DOC_MAPK_gen_1	427	434	PF00069	0.429
DOC_MAPK_gen_1	84	91	PF00069	0.335
DOC_MAPK_MEF2A_6	427	434	PF00069	0.412
DOC_MAPK_MEF2A_6	505	514	PF00069	0.301
DOC_MAPK_NFAT4_5	427	435	PF00069	0.325
DOC_MAPK_RevD_3	113	128	PF00069	0.342
DOC_PP2B_LxvP_1	746	749	PF13499	0.451
DOC_PP2B_LxvP_1	797	800	PF13499	0.602
DOC_PP2B_LxvP_1	89	92	PF13499	0.345
DOC_PP4_FxxP_1	361	364	PF00568	0.368
DOC_USP7_MATH_1	155	159	PF00917	0.392
DOC_USP7_MATH_1	376	380	PF00917	0.587
DOC_USP7_MATH_1	478	482	PF00917	0.491
DOC_USP7_MATH_1	51	55	PF00917	0.410
DOC_USP7_MATH_1	548	552	PF00917	0.307
DOC_USP7_MATH_1	615	619	PF00917	0.513
DOC_USP7_MATH_1	66	70	PF00917	0.521
DOC_USP7_MATH_1	675	679	PF00917	0.636
DOC_USP7_MATH_1	777	781	PF00917	0.643
DOC_USP7_MATH_1	814	818	PF00917	0.700
DOC_USP7_MATH_1	823	827	PF00917	0.603
DOC_USP7_MATH_2	218	224	PF00917	0.477
DOC_USP7_UBL2_3	831	835	PF12436	0.577
DOC_WW_Pin1_4	17	22	PF00397	0.431
DOC_WW_Pin1_4	195	200	PF00397	0.553
DOC_WW_Pin1_4	30	35	PF00397	0.399
DOC_WW_Pin1_4	409	414	PF00397	0.413
DOC_WW_Pin1_4	439	444	PF00397	0.380
DOC_WW_Pin1_4	517	522	PF00397	0.477
DOC_WW_Pin1_4	570	575	PF00397	0.438
DOC_WW_Pin1_4	629	634	PF00397	0.601
DOC_WW_Pin1_4	679	684	PF00397	0.662
DOC_WW_Pin1_4	692	697	PF00397	0.660
DOC_WW_Pin1_4	766	771	PF00397	0.767
DOC_WW_Pin1_4	787	792	PF00397	0.739
DOC_WW_Pin1_4	810	815	PF00397	0.500
LIG_14-3-3_CanoR_1	263	268	PF00244	0.447
LIG_14-3-3_CanoR_1	281	285	PF00244	0.243
LIG_14-3-3_CanoR_1	35	41	PF00244	0.470
LIG_14-3-3_CanoR_1	645	650	PF00244	0.650
LIG_14-3-3_CanoR_1	80	84	PF00244	0.365
LIG_14-3-3_CanoR_1	804	811	PF00244	0.484
LIG_14-3-3_CanoR_1	85	90	PF00244	0.340
LIG_Actin_WH2_2	264	279	PF00022	0.484
LIG_Actin_WH2_2	380	398	PF00022	0.474
LIG_Actin_WH2_2	523	540	PF00022	0.406
LIG_BIR_II_1	1	5	PF00653	0.449
LIG_BIR_III_4	240	244	PF00653	0.354
LIG_BRCT_BRCA1_1	677	681	PF00533	0.457
LIG_Clathr_ClatBox_1	182	186	PF01394	0.272
LIG_Clathr_ClatBox_1	331	335	PF01394	0.417
LIG_Clathr_ClatBox_1	431	435	PF01394	0.333
LIG_CtBP_PxDLS_1	218	222	PF00389	0.497
LIG_eIF4E_1	410	416	PF01652	0.337
LIG_eIF4E_1	468	474	PF01652	0.342
LIG_FHA_1	104	110	PF00498	0.325
LIG_FHA_1	249	255	PF00498	0.410
LIG_FHA_1	410	416	PF00498	0.411
LIG_FHA_1	507	513	PF00498	0.313
LIG_FHA_1	55	61	PF00498	0.401
LIG_FHA_1	584	590	PF00498	0.541
LIG_FHA_1	693	699	PF00498	0.611
LIG_FHA_1	816	822	PF00498	0.633
LIG_FHA_2	132	138	PF00498	0.510
LIG_FHA_2	253	259	PF00498	0.449
LIG_FHA_2	42	48	PF00498	0.450
LIG_FHA_2	578	584	PF00498	0.500
LIG_Integrin_isoDGR_2	261	263	PF01839	0.449
LIG_IRF3_LxIS_1	393	398	PF10401	0.323
LIG_LIR_Apic_2	29	34	PF02991	0.516
LIG_LIR_Apic_2	408	413	PF02991	0.362
LIG_LIR_Gen_1	644	653	PF02991	0.492
LIG_LIR_Nem_3	177	183	PF02991	0.284
LIG_LIR_Nem_3	319	324	PF02991	0.423
LIG_LIR_Nem_3	405	410	PF02991	0.351
LIG_LIR_Nem_3	644	650	PF02991	0.659
LIG_LIR_Nem_3	678	684	PF02991	0.457
LIG_MAD2	341	349	PF02301	0.218
LIG_NRBOX	327	333	PF00104	0.402
LIG_Pex14_2	179	183	PF04695	0.355
LIG_PTAP_UEV_1	748	753	PF05743	0.563
LIG_PTB_Apo_2	309	316	PF02174	0.380
LIG_REV1ctd_RIR_1	1	10	PF16727	0.506
LIG_SH2_CRK	215	219	PF00017	0.359
LIG_SH2_CRK	31	35	PF00017	0.447
LIG_SH2_CRK	428	432	PF00017	0.323
LIG_SH2_CRK	460	464	PF00017	0.462
LIG_SH2_CRK	532	536	PF00017	0.396
LIG_SH2_NCK_1	249	253	PF00017	0.389
LIG_SH2_NCK_1	460	464	PF00017	0.431
LIG_SH2_PTP2	410	413	PF00017	0.310
LIG_SH2_STAP1	138	142	PF00017	0.438
LIG_SH2_STAP1	437	441	PF00017	0.256
LIG_SH2_STAP1	468	472	PF00017	0.338
LIG_SH2_STAT5	108	111	PF00017	0.284
LIG_SH2_STAT5	130	133	PF00017	0.533
LIG_SH2_STAT5	31	34	PF00017	0.491
LIG_SH2_STAT5	410	413	PF00017	0.310
LIG_SH2_STAT5	532	535	PF00017	0.401
LIG_SH3_3	12	18	PF00018	0.404
LIG_SH3_3	669	675	PF00018	0.627
LIG_SH3_3	677	683	PF00018	0.640
LIG_SH3_3	746	752	PF00018	0.757
LIG_Sin3_3	470	477	PF02671	0.380
LIG_SUMO_SIM_anti_2	329	335	PF11976	0.421
LIG_SUMO_SIM_par_1	234	240	PF11976	0.380
LIG_SUMO_SIM_par_1	573	578	PF11976	0.379
LIG_TRAF2_1	134	137	PF00917	0.287
LIG_TRAF2_1	255	258	PF00917	0.473
LIG_TYR_ITIM	247	252	PF00017	0.268
LIG_TYR_ITIM	426	431	PF00017	0.358
MOD_CDK_SPK_2	30	35	PF00069	0.385
MOD_CK1_1	174	180	PF00069	0.363
MOD_CK1_1	223	229	PF00069	0.468
MOD_CK1_1	293	299	PF00069	0.479
MOD_CK1_1	398	404	PF00069	0.370
MOD_CK1_1	461	467	PF00069	0.359
MOD_CK1_1	54	60	PF00069	0.424
MOD_CK1_1	573	579	PF00069	0.471
MOD_CK1_1	581	587	PF00069	0.443
MOD_CK1_1	628	634	PF00069	0.684
MOD_CK1_1	654	660	PF00069	0.617
MOD_CK1_1	709	715	PF00069	0.711
MOD_CK1_1	747	753	PF00069	0.584
MOD_CK1_1	759	765	PF00069	0.659
MOD_CK1_1	769	775	PF00069	0.580
MOD_CK1_1	780	786	PF00069	0.696
MOD_CK1_1	817	823	PF00069	0.679
MOD_CK1_1	824	830	PF00069	0.640
MOD_CK2_1	131	137	PF00069	0.387
MOD_CK2_1	252	258	PF00069	0.452
MOD_CK2_1	269	275	PF00069	0.497
MOD_CK2_1	342	348	PF00069	0.526
MOD_CK2_1	461	467	PF00069	0.387
MOD_CK2_1	577	583	PF00069	0.462
MOD_CK2_1	645	651	PF00069	0.492
MOD_GlcNHglycan	173	176	PF01048	0.367
MOD_GlcNHglycan	188	191	PF01048	0.328
MOD_GlcNHglycan	195	198	PF01048	0.530
MOD_GlcNHglycan	204	207	PF01048	0.341
MOD_GlcNHglycan	225	228	PF01048	0.555
MOD_GlcNHglycan	231	234	PF01048	0.493
MOD_GlcNHglycan	271	274	PF01048	0.460
MOD_GlcNHglycan	318	321	PF01048	0.396
MOD_GlcNHglycan	328	331	PF01048	0.462
MOD_GlcNHglycan	379	382	PF01048	0.574
MOD_GlcNHglycan	420	423	PF01048	0.489
MOD_GlcNHglycan	437	440	PF01048	0.317
MOD_GlcNHglycan	467	471	PF01048	0.365
MOD_GlcNHglycan	559	562	PF01048	0.353
MOD_GlcNHglycan	580	583	PF01048	0.549
MOD_GlcNHglycan	60	63	PF01048	0.490
MOD_GlcNHglycan	606	609	PF01048	0.591
MOD_GlcNHglycan	656	659	PF01048	0.615
MOD_GlcNHglycan	672	675	PF01048	0.662
MOD_GlcNHglycan	68	71	PF01048	0.507
MOD_GlcNHglycan	708	711	PF01048	0.702
MOD_GlcNHglycan	740	743	PF01048	0.680
MOD_GlcNHglycan	746	749	PF01048	0.617
MOD_GlcNHglycan	758	761	PF01048	0.635
MOD_GlcNHglycan	779	782	PF01048	0.628
MOD_GlcNHglycan	800	803	PF01048	0.715
MOD_GlcNHglycan	823	826	PF01048	0.601
MOD_GSK3_1	167	174	PF00069	0.420
MOD_GSK3_1	248	255	PF00069	0.394
MOD_GSK3_1	26	33	PF00069	0.401
MOD_GSK3_1	280	287	PF00069	0.370
MOD_GSK3_1	435	442	PF00069	0.272
MOD_GSK3_1	513	520	PF00069	0.433
MOD_GSK3_1	54	61	PF00069	0.406
MOD_GSK3_1	548	555	PF00069	0.365
MOD_GSK3_1	573	580	PF00069	0.520
MOD_GSK3_1	583	590	PF00069	0.505
MOD_GSK3_1	62	69	PF00069	0.519
MOD_GSK3_1	622	629	PF00069	0.641
MOD_GSK3_1	641	648	PF00069	0.561
MOD_GSK3_1	654	661	PF00069	0.608
MOD_GSK3_1	670	677	PF00069	0.634
MOD_GSK3_1	684	691	PF00069	0.659
MOD_GSK3_1	762	769	PF00069	0.759
MOD_GSK3_1	782	789	PF00069	0.676
MOD_GSK3_1	810	817	PF00069	0.723
MOD_GSK3_1	819	826	PF00069	0.675
MOD_N-GLC_1	269	274	PF02516	0.481
MOD_N-GLC_1	506	511	PF02516	0.291
MOD_N-GLC_2	278	280	PF02516	0.442
MOD_NEK2_1	10	15	PF00069	0.424
MOD_NEK2_1	202	207	PF00069	0.506
MOD_NEK2_1	221	226	PF00069	0.452
MOD_NEK2_1	248	253	PF00069	0.364
MOD_NEK2_1	295	300	PF00069	0.421
MOD_NEK2_1	302	307	PF00069	0.403
MOD_NEK2_1	334	339	PF00069	0.457
MOD_NEK2_1	36	41	PF00069	0.377
MOD_NEK2_1	369	374	PF00069	0.373
MOD_NEK2_1	383	388	PF00069	0.448
MOD_NEK2_1	458	463	PF00069	0.300
MOD_NEK2_1	480	485	PF00069	0.417
MOD_NEK2_1	56	61	PF00069	0.454
MOD_NEK2_1	564	569	PF00069	0.402
MOD_NEK2_1	592	597	PF00069	0.487
MOD_NEK2_1	738	743	PF00069	0.623
MOD_NEK2_2	26	31	PF00069	0.401
MOD_NEK2_2	51	56	PF00069	0.353
MOD_NEK2_2	548	553	PF00069	0.357
MOD_NEK2_2	79	84	PF00069	0.456
MOD_PIKK_1	334	340	PF00454	0.398
MOD_PIKK_1	41	47	PF00454	0.495
MOD_PIKK_1	520	526	PF00454	0.469
MOD_PIKK_1	601	607	PF00454	0.325
MOD_PIKK_1	733	739	PF00454	0.703
MOD_PK_1	263	269	PF00069	0.474
MOD_PKA_2	280	286	PF00069	0.431
MOD_PKA_2	302	308	PF00069	0.385
MOD_PKA_2	51	57	PF00069	0.397
MOD_PKA_2	654	660	PF00069	0.439
MOD_PKA_2	79	85	PF00069	0.436
MOD_PKA_2	803	809	PF00069	0.603
MOD_Plk_1	506	512	PF00069	0.302
MOD_Plk_1	795	801	PF00069	0.516
MOD_Plk_4	103	109	PF00069	0.316
MOD_Plk_4	167	173	PF00069	0.273
MOD_Plk_4	26	32	PF00069	0.256
MOD_Plk_4	406	412	PF00069	0.333
MOD_Plk_4	480	486	PF00069	0.458
MOD_Plk_4	51	57	PF00069	0.317
MOD_Plk_4	564	570	PF00069	0.364
MOD_Plk_4	587	593	PF00069	0.426
MOD_Plk_4	688	694	PF00069	0.693
MOD_Plk_4	85	91	PF00069	0.331
MOD_ProDKin_1	17	23	PF00069	0.443
MOD_ProDKin_1	195	201	PF00069	0.539
MOD_ProDKin_1	30	36	PF00069	0.394
MOD_ProDKin_1	409	415	PF00069	0.408
MOD_ProDKin_1	439	445	PF00069	0.375
MOD_ProDKin_1	517	523	PF00069	0.480
MOD_ProDKin_1	570	576	PF00069	0.438
MOD_ProDKin_1	629	635	PF00069	0.598
MOD_ProDKin_1	679	685	PF00069	0.662
MOD_ProDKin_1	692	698	PF00069	0.660
MOD_ProDKin_1	766	772	PF00069	0.765
MOD_ProDKin_1	787	793	PF00069	0.741
MOD_ProDKin_1	810	816	PF00069	0.511
TRG_DiLeu_BaEn_2	310	316	PF01217	0.393
TRG_ENDOCYTIC_2	249	252	PF00928	0.257
TRG_ENDOCYTIC_2	428	431	PF00928	0.313
TRG_ER_diArg_1	126	128	PF00400	0.415
TRG_ER_diArg_1	300	303	PF00400	0.566
TRG_ER_diArg_1	83	85	PF00400	0.450
TRG_ER_diArg_1	832	834	PF00400	0.603
TRG_NES_CRM1_1	323	335	PF08389	0.395
TRG_Pf-PMV_PEXEL_1	562	566	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PER2	Leptomonas seymouri	54%	94%
A0A0S4KHN7	Bodo saltans	36%	100%
A0A1X0NY37	Trypanosomatidae	38%	100%
A0A3S5IS35	Trypanosoma rangeli	36%	100%
A0A3S7WWH4	Leishmania donovani	89%	99%
A4HBU3	Leishmania braziliensis	75%	99%
A6QLH6	Bos taurus	27%	100%
D0A1C9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AGU9	Leishmania infantum	89%	99%
Q28FH2	Xenopus tropicalis	27%	100%
Q4QCB6	Leishmania major	88%	100%
Q55GS2	Dictyostelium discoideum	25%	100%
Q5M9F8	Rattus norvegicus	26%	100%
Q96KG9	Homo sapiens	27%	100%
Q9EQC5	Mus musculus	26%	100%