Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AV64_LEIMU

TriTrypDb:

LmxM.21.0870

Length:

906

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AV64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV64

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.641
CLV_C14_Caspase3-7	260	264	PF00656	0.761
CLV_C14_Caspase3-7	307	311	PF00656	0.582
CLV_C14_Caspase3-7	517	521	PF00656	0.615
CLV_C14_Caspase3-7	685	689	PF00656	0.832
CLV_NRD_NRD_1	123	125	PF00675	0.853
CLV_NRD_NRD_1	178	180	PF00675	0.697
CLV_NRD_NRD_1	333	335	PF00675	0.655
CLV_NRD_NRD_1	582	584	PF00675	0.599
CLV_NRD_NRD_1	654	656	PF00675	0.588
CLV_NRD_NRD_1	721	723	PF00675	0.590
CLV_NRD_NRD_1	822	824	PF00675	0.757
CLV_PCSK_KEX2_1	123	125	PF00082	0.853
CLV_PCSK_KEX2_1	178	180	PF00082	0.697
CLV_PCSK_KEX2_1	582	584	PF00082	0.599
CLV_PCSK_KEX2_1	654	656	PF00082	0.588
CLV_PCSK_KEX2_1	821	823	PF00082	0.764
CLV_PCSK_PC7_1	650	656	PF00082	0.586
CLV_PCSK_SKI1_1	190	194	PF00082	0.633
CLV_PCSK_SKI1_1	394	398	PF00082	0.833
CLV_PCSK_SKI1_1	498	502	PF00082	0.584
CLV_PCSK_SKI1_1	67	71	PF00082	0.729
CLV_PCSK_SKI1_1	673	677	PF00082	0.745
CLV_PCSK_SKI1_1	741	745	PF00082	0.814
DEG_Nend_UBRbox_1	1	4	PF02207	0.723
DEG_SCF_FBW7_1	364	371	PF00400	0.837
DEG_SCF_FBW7_1	500	505	PF00400	0.575
DEG_SCF_FBW7_1	737	742	PF00400	0.802
DEG_SPOP_SBC_1	141	145	PF00917	0.731
DEG_SPOP_SBC_1	792	796	PF00917	0.699
DOC_CDC14_PxL_1	879	887	PF14671	0.597
DOC_CKS1_1	227	232	PF01111	0.812
DOC_CKS1_1	400	405	PF01111	0.752
DOC_CKS1_1	588	593	PF01111	0.606
DOC_CKS1_1	775	780	PF01111	0.822
DOC_CYCLIN_yCln2_LP_2	642	648	PF00134	0.606
DOC_MAPK_DCC_7	226	235	PF00069	0.812
DOC_MAPK_gen_1	115	122	PF00069	0.814
DOC_MAPK_gen_1	226	235	PF00069	0.812
DOC_MAPK_gen_1	821	829	PF00069	0.754
DOC_MAPK_JIP1_4	823	829	PF00069	0.584
DOC_MAPK_MEF2A_6	226	235	PF00069	0.812
DOC_MAPK_MEF2A_6	638	646	PF00069	0.689
DOC_MAPK_MEF2A_6	96	105	PF00069	0.733
DOC_PP2B_LxvP_1	12	15	PF13499	0.813
DOC_PP2B_LxvP_1	133	136	PF13499	0.782
DOC_PP2B_LxvP_1	138	141	PF13499	0.672
DOC_PP2B_LxvP_1	244	247	PF13499	0.723
DOC_PP2B_LxvP_1	397	400	PF13499	0.661
DOC_PP2B_LxvP_1	61	64	PF13499	0.580
DOC_PP2B_LxvP_1	642	645	PF13499	0.607
DOC_PP4_FxxP_1	131	134	PF00568	0.737
DOC_PP4_FxxP_1	51	54	PF00568	0.821
DOC_PP4_FxxP_1	676	679	PF00568	0.566
DOC_PP4_FxxP_1	848	851	PF00568	0.602
DOC_USP7_MATH_1	141	145	PF00917	0.752
DOC_USP7_MATH_1	282	286	PF00917	0.712
DOC_USP7_MATH_1	308	312	PF00917	0.762
DOC_USP7_MATH_1	384	388	PF00917	0.666
DOC_USP7_MATH_1	494	498	PF00917	0.641
DOC_USP7_MATH_1	503	507	PF00917	0.663
DOC_USP7_MATH_1	510	514	PF00917	0.597
DOC_USP7_MATH_1	571	575	PF00917	0.745
DOC_USP7_MATH_1	589	593	PF00917	0.652
DOC_USP7_MATH_1	599	603	PF00917	0.658
DOC_USP7_MATH_1	621	625	PF00917	0.687
DOC_USP7_MATH_1	653	657	PF00917	0.715
DOC_USP7_MATH_1	661	665	PF00917	0.621
DOC_USP7_MATH_1	666	670	PF00917	0.602
DOC_USP7_MATH_1	699	703	PF00917	0.743
DOC_USP7_MATH_1	786	790	PF00917	0.841
DOC_USP7_MATH_1	793	797	PF00917	0.772
DOC_USP7_MATH_1	94	98	PF00917	0.786
DOC_WW_Pin1_4	168	173	PF00397	0.769
DOC_WW_Pin1_4	226	231	PF00397	0.792
DOC_WW_Pin1_4	274	279	PF00397	0.849
DOC_WW_Pin1_4	36	41	PF00397	0.742
DOC_WW_Pin1_4	364	369	PF00397	0.838
DOC_WW_Pin1_4	379	384	PF00397	0.634
DOC_WW_Pin1_4	399	404	PF00397	0.546
DOC_WW_Pin1_4	455	460	PF00397	0.679
DOC_WW_Pin1_4	49	54	PF00397	0.654
DOC_WW_Pin1_4	498	503	PF00397	0.819
DOC_WW_Pin1_4	56	61	PF00397	0.606
DOC_WW_Pin1_4	560	565	PF00397	0.698
DOC_WW_Pin1_4	583	588	PF00397	0.808
DOC_WW_Pin1_4	590	595	PF00397	0.759
DOC_WW_Pin1_4	600	605	PF00397	0.767
DOC_WW_Pin1_4	617	622	PF00397	0.631
DOC_WW_Pin1_4	691	696	PF00397	0.872
DOC_WW_Pin1_4	727	732	PF00397	0.720
DOC_WW_Pin1_4	733	738	PF00397	0.763
DOC_WW_Pin1_4	75	80	PF00397	0.556
DOC_WW_Pin1_4	774	779	PF00397	0.824
DOC_WW_Pin1_4	794	799	PF00397	0.583
DOC_WW_Pin1_4	815	820	PF00397	0.659
DOC_WW_Pin1_4	841	846	PF00397	0.666
DOC_WW_Pin1_4	877	882	PF00397	0.671
DOC_WW_Pin1_4	90	95	PF00397	0.619
DOC_WW_Pin1_4	97	102	PF00397	0.702
LIG_14-3-3_CanoR_1	123	131	PF00244	0.741
LIG_14-3-3_CanoR_1	250	256	PF00244	0.653
LIG_14-3-3_CanoR_1	299	305	PF00244	0.729
LIG_14-3-3_CanoR_1	334	338	PF00244	0.713
LIG_14-3-3_CanoR_1	361	370	PF00244	0.601
LIG_14-3-3_CanoR_1	654	662	PF00244	0.607
LIG_14-3-3_CanoR_1	67	75	PF00244	0.759
LIG_14-3-3_CanoR_1	841	845	PF00244	0.578
LIG_14-3-3_CanoR_1	866	876	PF00244	0.785
LIG_14-3-3_CanoR_1	88	94	PF00244	0.803
LIG_Actin_WH2_2	392	410	PF00022	0.583
LIG_BIR_III_2	493	497	PF00653	0.833
LIG_BRCT_BRCA1_1	107	111	PF00533	0.732
LIG_BRCT_BRCA1_1	748	752	PF00533	0.578
LIG_CtBP_PxDLS_1	230	234	PF00389	0.808
LIG_CtBP_PxDLS_1	278	282	PF00389	0.775
LIG_CtBP_PxDLS_1	731	735	PF00389	0.594
LIG_FHA_1	299	305	PF00498	0.623
LIG_FHA_1	321	327	PF00498	0.750
LIG_FHA_1	365	371	PF00498	0.834
LIG_FHA_1	372	378	PF00498	0.754
LIG_FHA_1	440	446	PF00498	0.760
LIG_FHA_1	473	479	PF00498	0.804
LIG_FHA_1	503	509	PF00498	0.708
LIG_FHA_1	534	540	PF00498	0.751
LIG_FHA_1	606	612	PF00498	0.739
LIG_FHA_1	666	672	PF00498	0.743
LIG_FHA_1	90	96	PF00498	0.748
LIG_FHA_2	107	113	PF00498	0.798
LIG_FHA_2	191	197	PF00498	0.700
LIG_FHA_2	214	220	PF00498	0.727
LIG_FHA_2	858	864	PF00498	0.603
LIG_LIR_Apic_2	48	54	PF02991	0.824
LIG_LIR_Apic_2	579	584	PF02991	0.591
LIG_LIR_Gen_1	286	297	PF02991	0.809
LIG_LIR_Nem_3	253	258	PF02991	0.724
LIG_LIR_Nem_3	286	292	PF02991	0.821
LIG_LIR_Nem_3	828	833	PF02991	0.583
LIG_MYND_3	135	139	PF01753	0.547
LIG_Pex14_2	507	511	PF04695	0.592
LIG_SH2_CRK	748	752	PF00017	0.578
LIG_SH2_CRK	830	834	PF00017	0.575
LIG_SH2_STAP1	748	752	PF00017	0.578
LIG_SH3_2	400	405	PF14604	0.657
LIG_SH3_2	552	557	PF14604	0.609
LIG_SH3_2	764	769	PF14604	0.760
LIG_SH3_3	224	230	PF00018	0.817
LIG_SH3_3	351	357	PF00018	0.805
LIG_SH3_3	378	384	PF00018	0.785
LIG_SH3_3	397	403	PF00018	0.563
LIG_SH3_3	548	554	PF00018	0.822
LIG_SH3_3	581	587	PF00018	0.740
LIG_SH3_3	588	594	PF00018	0.834
LIG_SH3_3	734	740	PF00018	0.811
LIG_SH3_3	761	767	PF00018	0.759
LIG_SH3_3	8	14	PF00018	0.675
LIG_SH3_3	875	881	PF00018	0.759
LIG_SH3_3	893	899	PF00018	0.615
LIG_SH3_CIN85_PxpxPR_1	552	557	PF14604	0.609
LIG_SUMO_SIM_anti_2	241	246	PF11976	0.739
LIG_SUMO_SIM_anti_2	439	448	PF11976	0.648
LIG_SUMO_SIM_par_1	439	448	PF11976	0.686
LIG_SUMO_SIM_par_1	730	736	PF11976	0.594
LIG_SUMO_SIM_par_1	809	814	PF11976	0.833
LIG_TRAF2_1	54	57	PF00917	0.758
LIG_WRC_WIRS_1	102	107	PF05994	0.795
LIG_WW_3	554	558	PF00397	0.611
LIG_WW_3	738	742	PF00397	0.802
LIG_WW_3	85	89	PF00397	0.573
MOD_CDC14_SPxK_1	694	697	PF00782	0.836
MOD_CDC14_SPxK_1	797	800	PF00782	0.786
MOD_CDC14_SPxK_1	818	821	PF00782	0.580
MOD_CDC14_SPxK_1	93	96	PF00782	0.737
MOD_CDK_SPK_2	590	595	PF00069	0.617
MOD_CDK_SPxK_1	399	405	PF00069	0.658
MOD_CDK_SPxK_1	691	697	PF00069	0.838
MOD_CDK_SPxK_1	735	741	PF00069	0.809
MOD_CDK_SPxK_1	794	800	PF00069	0.791
MOD_CDK_SPxK_1	815	821	PF00069	0.589
MOD_CDK_SPxK_1	90	96	PF00069	0.748
MOD_CDK_SPxxK_3	815	822	PF00069	0.591
MOD_CK1_1	171	177	PF00069	0.881
MOD_CK1_1	203	209	PF00069	0.573
MOD_CK1_1	213	219	PF00069	0.669
MOD_CK1_1	238	244	PF00069	0.736
MOD_CK1_1	316	322	PF00069	0.735
MOD_CK1_1	346	352	PF00069	0.687
MOD_CK1_1	363	369	PF00069	0.838
MOD_CK1_1	41	47	PF00069	0.795
MOD_CK1_1	439	445	PF00069	0.662
MOD_CK1_1	482	488	PF00069	0.803
MOD_CK1_1	512	518	PF00069	0.676
MOD_CK1_1	52	58	PF00069	0.662
MOD_CK1_1	529	535	PF00069	0.646
MOD_CK1_1	620	626	PF00069	0.840
MOD_CK1_1	71	77	PF00069	0.588
MOD_CK1_1	730	736	PF00069	0.642
MOD_CK1_1	794	800	PF00069	0.776
MOD_CK1_1	809	815	PF00069	0.631
MOD_CK1_1	862	868	PF00069	0.832
MOD_CK1_1	891	897	PF00069	0.609
MOD_CK1_1	97	103	PF00069	0.775
MOD_CK2_1	287	293	PF00069	0.759
MOD_CK2_1	308	314	PF00069	0.855
MOD_CK2_1	36	42	PF00069	0.743
MOD_CK2_1	363	369	PF00069	0.838
MOD_CK2_1	620	626	PF00069	0.811
MOD_CK2_1	857	863	PF00069	0.740
MOD_DYRK1A_RPxSP_1	226	230	PF00069	0.815
MOD_DYRK1A_RPxSP_1	583	587	PF00069	0.690
MOD_GlcNHglycan	148	151	PF01048	0.733
MOD_GlcNHglycan	154	157	PF01048	0.639
MOD_GlcNHglycan	18	23	PF01048	0.801
MOD_GlcNHglycan	185	188	PF01048	0.664
MOD_GlcNHglycan	202	205	PF01048	0.781
MOD_GlcNHglycan	263	267	PF01048	0.749
MOD_GlcNHglycan	319	322	PF01048	0.765
MOD_GlcNHglycan	386	389	PF01048	0.567
MOD_GlcNHglycan	512	515	PF01048	0.871
MOD_GlcNHglycan	532	535	PF01048	0.580
MOD_GlcNHglycan	573	576	PF01048	0.799
MOD_GlcNHglycan	646	649	PF01048	0.673
MOD_GlcNHglycan	668	671	PF01048	0.748
MOD_GlcNHglycan	688	691	PF01048	0.583
MOD_GlcNHglycan	701	704	PF01048	0.678
MOD_GlcNHglycan	75	78	PF01048	0.646
MOD_GlcNHglycan	754	757	PF01048	0.812
MOD_GlcNHglycan	802	805	PF01048	0.650
MOD_GlcNHglycan	873	876	PF01048	0.651
MOD_GlcNHglycan	890	893	PF01048	0.656
MOD_GSK3_1	101	108	PF00069	0.589
MOD_GSK3_1	141	148	PF00069	0.733
MOD_GSK3_1	195	202	PF00069	0.674
MOD_GSK3_1	203	210	PF00069	0.714
MOD_GSK3_1	213	220	PF00069	0.574
MOD_GSK3_1	250	257	PF00069	0.817
MOD_GSK3_1	277	284	PF00069	0.777
MOD_GSK3_1	287	294	PF00069	0.610
MOD_GSK3_1	313	320	PF00069	0.715
MOD_GSK3_1	34	41	PF00069	0.805
MOD_GSK3_1	343	350	PF00069	0.693
MOD_GSK3_1	360	367	PF00069	0.860
MOD_GSK3_1	45	52	PF00069	0.677
MOD_GSK3_1	455	462	PF00069	0.792
MOD_GSK3_1	494	501	PF00069	0.727
MOD_GSK3_1	518	525	PF00069	0.659
MOD_GSK3_1	526	533	PF00069	0.794
MOD_GSK3_1	583	590	PF00069	0.780
MOD_GSK3_1	617	624	PF00069	0.789
MOD_GSK3_1	632	639	PF00069	0.749
MOD_GSK3_1	661	668	PF00069	0.789
MOD_GSK3_1	67	74	PF00069	0.688
MOD_GSK3_1	686	693	PF00069	0.826
MOD_GSK3_1	699	706	PF00069	0.569
MOD_GSK3_1	735	742	PF00069	0.749
MOD_GSK3_1	777	784	PF00069	0.831
MOD_GSK3_1	811	818	PF00069	0.737
MOD_GSK3_1	825	832	PF00069	0.675
MOD_GSK3_1	862	869	PF00069	0.706
MOD_GSK3_1	90	97	PF00069	0.652
MOD_N-GLC_1	210	215	PF02516	0.759
MOD_N-GLC_1	274	279	PF02516	0.680
MOD_N-GLC_1	282	287	PF02516	0.693
MOD_N-GLC_1	455	460	PF02516	0.723
MOD_N-GLC_1	518	523	PF02516	0.618
MOD_N-GLC_1	780	785	PF02516	0.596
MOD_N-GLC_1	825	830	PF02516	0.828
MOD_N-GLC_2	528	530	PF02516	0.822
MOD_NEK2_1	142	147	PF00069	0.735
MOD_NEK2_1	152	157	PF00069	0.601
MOD_NEK2_1	183	188	PF00069	0.649
MOD_NEK2_1	197	202	PF00069	0.779
MOD_NEK2_1	235	240	PF00069	0.736
MOD_NEK2_1	343	348	PF00069	0.648
MOD_NEK2_1	362	367	PF00069	0.796
MOD_NEK2_1	390	395	PF00069	0.758
MOD_NEK2_1	445	450	PF00069	0.664
MOD_NEK2_1	68	73	PF00069	0.832
MOD_NEK2_1	806	811	PF00069	0.835
MOD_NEK2_1	829	834	PF00069	0.681
MOD_NEK2_1	840	845	PF00069	0.651
MOD_NEK2_2	308	313	PF00069	0.684
MOD_NEK2_2	747	752	PF00069	0.718
MOD_PIKK_1	181	187	PF00454	0.820
MOD_PIKK_1	52	58	PF00454	0.757
MOD_PIKK_1	831	837	PF00454	0.664
MOD_PKA_1	822	828	PF00069	0.697
MOD_PKA_2	122	128	PF00069	0.772
MOD_PKA_2	298	304	PF00069	0.723
MOD_PKA_2	333	339	PF00069	0.703
MOD_PKA_2	360	366	PF00069	0.605
MOD_PKA_2	515	521	PF00069	0.638
MOD_PKA_2	632	638	PF00069	0.795
MOD_PKA_2	653	659	PF00069	0.608
MOD_PKA_2	71	77	PF00069	0.647
MOD_PKA_2	752	758	PF00069	0.814
MOD_PKA_2	822	828	PF00069	0.815
MOD_PKA_2	840	846	PF00069	0.557
MOD_PKA_2	865	871	PF00069	0.647
MOD_Plk_1	190	196	PF00069	0.633
MOD_Plk_1	210	216	PF00069	0.529
MOD_Plk_1	262	268	PF00069	0.764
MOD_Plk_1	429	435	PF00069	0.802
MOD_Plk_1	44	50	PF00069	0.753
MOD_Plk_1	806	812	PF00069	0.834
MOD_Plk_1	825	831	PF00069	0.569
MOD_Plk_2-3	537	543	PF00069	0.583
MOD_Plk_4	213	219	PF00069	0.800
MOD_Plk_4	430	436	PF00069	0.740
MOD_Plk_4	503	509	PF00069	0.743
MOD_Plk_4	747	753	PF00069	0.752
MOD_Plk_4	806	812	PF00069	0.834
MOD_Plk_4	825	831	PF00069	0.569
MOD_ProDKin_1	168	174	PF00069	0.770
MOD_ProDKin_1	226	232	PF00069	0.792
MOD_ProDKin_1	274	280	PF00069	0.851
MOD_ProDKin_1	36	42	PF00069	0.743
MOD_ProDKin_1	364	370	PF00069	0.838
MOD_ProDKin_1	379	385	PF00069	0.632
MOD_ProDKin_1	399	405	PF00069	0.547
MOD_ProDKin_1	455	461	PF00069	0.679
MOD_ProDKin_1	49	55	PF00069	0.652
MOD_ProDKin_1	498	504	PF00069	0.819
MOD_ProDKin_1	56	62	PF00069	0.604
MOD_ProDKin_1	560	566	PF00069	0.693
MOD_ProDKin_1	583	589	PF00069	0.808
MOD_ProDKin_1	590	596	PF00069	0.758
MOD_ProDKin_1	600	606	PF00069	0.767
MOD_ProDKin_1	617	623	PF00069	0.633
MOD_ProDKin_1	691	697	PF00069	0.873
MOD_ProDKin_1	727	733	PF00069	0.719
MOD_ProDKin_1	735	741	PF00069	0.720
MOD_ProDKin_1	75	81	PF00069	0.558
MOD_ProDKin_1	774	780	PF00069	0.823
MOD_ProDKin_1	794	800	PF00069	0.585
MOD_ProDKin_1	815	821	PF00069	0.661
MOD_ProDKin_1	841	847	PF00069	0.665
MOD_ProDKin_1	877	883	PF00069	0.669
MOD_ProDKin_1	90	96	PF00069	0.618
MOD_ProDKin_1	97	103	PF00069	0.703
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.700
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.714
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.738
TRG_ENDOCYTIC_2	748	751	PF00928	0.657
TRG_ENDOCYTIC_2	830	833	PF00928	0.581
TRG_ER_diArg_1	122	124	PF00400	0.840
TRG_ER_diArg_1	178	180	PF00400	0.692
TRG_ER_diArg_1	225	228	PF00400	0.821
TRG_ER_diArg_1	581	583	PF00400	0.620
TRG_ER_diArg_1	653	655	PF00400	0.580
TRG_ER_diArg_1	773	776	PF00400	0.591
TRG_ER_diArg_1	821	823	PF00400	0.773
TRG_NES_CRM1_1	805	816	PF08389	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IC08	Leishmania donovani	77%	100%
A4HBU2	Leishmania braziliensis	53%	100%
E9AGU8	Leishmania infantum	77%	99%
Q4QCB7	Leishmania major	75%	100%