RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV63_LEIMU

TriTrypDb:

LmxM.21.0865

Length:

684

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AV63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV63

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051536	iron-sulfur cluster binding	3	2
GO:0051537	2 iron, 2 sulfur cluster binding	4	2
GO:0051540	metal cluster binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.567
CLV_C14_Caspase3-7	223	227	PF00656	0.520
CLV_C14_Caspase3-7	523	527	PF00656	0.426
CLV_C14_Caspase3-7	571	575	PF00656	0.690
CLV_C14_Caspase3-7	623	627	PF00656	0.537
CLV_C14_Caspase3-7	77	81	PF00656	0.809
CLV_NRD_NRD_1	190	192	PF00675	0.420
CLV_NRD_NRD_1	2	4	PF00675	0.556
CLV_NRD_NRD_1	585	587	PF00675	0.597
CLV_NRD_NRD_1	6	8	PF00675	0.585
CLV_PCSK_FUR_1	583	587	PF00082	0.563
CLV_PCSK_KEX2_1	2	4	PF00082	0.556
CLV_PCSK_KEX2_1	582	584	PF00082	0.568
CLV_PCSK_KEX2_1	585	587	PF00082	0.536
CLV_PCSK_KEX2_1	6	8	PF00082	0.585
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.620
CLV_PCSK_PC7_1	2	8	PF00082	0.584
CLV_PCSK_SKI1_1	191	195	PF00082	0.563
CLV_PCSK_SKI1_1	47	51	PF00082	0.647
CLV_PCSK_SKI1_1	505	509	PF00082	0.531
DEG_Nend_UBRbox_1	1	4	PF02207	0.459
DEG_SPOP_SBC_1	98	102	PF00917	0.628
DOC_CYCLIN_RxL_1	502	510	PF00134	0.481
DOC_MAPK_DCC_7	177	187	PF00069	0.354
DOC_MAPK_gen_1	358	365	PF00069	0.462
DOC_MAPK_MEF2A_6	177	184	PF00069	0.499
DOC_MAPK_MEF2A_6	312	319	PF00069	0.451
DOC_PP1_RVXF_1	129	135	PF00149	0.615
DOC_SPAK_OSR1_1	360	364	PF12202	0.406
DOC_USP7_MATH_1	103	107	PF00917	0.726
DOC_USP7_MATH_1	222	226	PF00917	0.507
DOC_USP7_MATH_1	232	236	PF00917	0.710
DOC_USP7_MATH_1	26	30	PF00917	0.546
DOC_USP7_MATH_1	293	297	PF00917	0.454
DOC_USP7_MATH_1	412	416	PF00917	0.685
DOC_USP7_MATH_1	431	435	PF00917	0.735
DOC_USP7_MATH_1	470	474	PF00917	0.391
DOC_USP7_MATH_1	531	535	PF00917	0.603
DOC_USP7_MATH_1	620	624	PF00917	0.544
DOC_USP7_MATH_1	74	78	PF00917	0.755
DOC_USP7_MATH_1	98	102	PF00917	0.684
DOC_WW_Pin1_4	15	20	PF00397	0.631
DOC_WW_Pin1_4	176	181	PF00397	0.523
DOC_WW_Pin1_4	33	38	PF00397	0.663
DOC_WW_Pin1_4	402	407	PF00397	0.589
DOC_WW_Pin1_4	419	424	PF00397	0.704
DOC_WW_Pin1_4	427	432	PF00397	0.687
DOC_WW_Pin1_4	442	447	PF00397	0.598
DOC_WW_Pin1_4	455	460	PF00397	0.464
DOC_WW_Pin1_4	516	521	PF00397	0.547
DOC_WW_Pin1_4	534	539	PF00397	0.433
DOC_WW_Pin1_4	54	59	PF00397	0.793
DOC_WW_Pin1_4	87	92	PF00397	0.727
LIG_14-3-3_CanoR_1	191	197	PF00244	0.511
LIG_14-3-3_CanoR_1	295	300	PF00244	0.434
LIG_14-3-3_CanoR_1	360	366	PF00244	0.534
LIG_14-3-3_CanoR_1	464	469	PF00244	0.464
LIG_14-3-3_CanoR_1	6	10	PF00244	0.550
LIG_14-3-3_CanoR_1	666	676	PF00244	0.423
LIG_Actin_WH2_2	180	196	PF00022	0.445
LIG_BIR_III_4	147	151	PF00653	0.609
LIG_Clathr_ClatBox_1	184	188	PF01394	0.479
LIG_FHA_1	177	183	PF00498	0.466
LIG_FHA_1	312	318	PF00498	0.493
LIG_FHA_2	161	167	PF00498	0.562
LIG_FHA_2	193	199	PF00498	0.484
LIG_FHA_2	299	305	PF00498	0.626
LIG_FHA_2	91	97	PF00498	0.687
LIG_Integrin_RGDW_4	650	653	PF00362	0.360
LIG_LIR_Apic_2	652	656	PF02991	0.367
LIG_LIR_Gen_1	118	124	PF02991	0.654
LIG_LIR_Gen_1	307	317	PF02991	0.515
LIG_LIR_Gen_1	558	569	PF02991	0.522
LIG_LIR_Nem_3	118	122	PF02991	0.660
LIG_LIR_Nem_3	396	401	PF02991	0.560
LIG_LIR_Nem_3	558	564	PF02991	0.494
LIG_NRBOX	503	509	PF00104	0.414
LIG_Pex14_1	134	138	PF04695	0.579
LIG_SH2_CRK	487	491	PF00017	0.443
LIG_SH2_CRK	561	565	PF00017	0.516
LIG_SH2_STAT5	261	264	PF00017	0.400
LIG_SH2_STAT5	444	447	PF00017	0.356
LIG_SH3_1	177	183	PF00018	0.441
LIG_SH3_3	107	113	PF00018	0.577
LIG_SH3_3	16	22	PF00018	0.607
LIG_SH3_3	164	170	PF00018	0.582
LIG_SH3_3	177	183	PF00018	0.419
LIG_SH3_3	362	368	PF00018	0.369
LIG_SH3_3	434	440	PF00018	0.628
LIG_SUMO_SIM_par_1	183	189	PF11976	0.469
LIG_SUMO_SIM_par_1	313	318	PF11976	0.439
LIG_TRAF2_1	195	198	PF00917	0.490
MOD_CDK_SPK_2	176	181	PF00069	0.495
MOD_CDK_SPK_2	427	432	PF00069	0.482
MOD_CDK_SPK_2	534	539	PF00069	0.529
MOD_CK1_1	140	146	PF00069	0.679
MOD_CK1_1	153	159	PF00069	0.670
MOD_CK1_1	176	182	PF00069	0.548
MOD_CK1_1	225	231	PF00069	0.666
MOD_CK1_1	233	239	PF00069	0.721
MOD_CK1_1	298	304	PF00069	0.666
MOD_CK1_1	366	372	PF00069	0.503
MOD_CK1_1	405	411	PF00069	0.708
MOD_CK1_1	430	436	PF00069	0.696
MOD_CK1_1	469	475	PF00069	0.273
MOD_CK1_1	5	11	PF00069	0.574
MOD_CK1_1	534	540	PF00069	0.670
MOD_CK1_1	552	558	PF00069	0.529
MOD_CK1_1	567	573	PF00069	0.476
MOD_CK1_1	646	652	PF00069	0.397
MOD_CK1_1	657	663	PF00069	0.408
MOD_CK1_1	670	676	PF00069	0.319
MOD_CK1_1	90	96	PF00069	0.732
MOD_CK2_1	192	198	PF00069	0.484
MOD_CK2_1	90	96	PF00069	0.710
MOD_Cter_Amidation	583	586	PF01082	0.496
MOD_GlcNHglycan	101	104	PF01048	0.713
MOD_GlcNHglycan	142	145	PF01048	0.641
MOD_GlcNHglycan	152	155	PF01048	0.790
MOD_GlcNHglycan	229	232	PF01048	0.710
MOD_GlcNHglycan	28	31	PF01048	0.650
MOD_GlcNHglycan	284	287	PF01048	0.276
MOD_GlcNHglycan	295	298	PF01048	0.440
MOD_GlcNHglycan	407	410	PF01048	0.773
MOD_GlcNHglycan	414	417	PF01048	0.715
MOD_GlcNHglycan	424	427	PF01048	0.689
MOD_GlcNHglycan	433	436	PF01048	0.655
MOD_GlcNHglycan	468	471	PF01048	0.553
MOD_GlcNHglycan	509	512	PF01048	0.608
MOD_GlcNHglycan	516	519	PF01048	0.586
MOD_GlcNHglycan	522	525	PF01048	0.517
MOD_GSK3_1	136	143	PF00069	0.668
MOD_GSK3_1	150	157	PF00069	0.472
MOD_GSK3_1	171	178	PF00069	0.645
MOD_GSK3_1	192	199	PF00069	0.499
MOD_GSK3_1	222	229	PF00069	0.515
MOD_GSK3_1	232	239	PF00069	0.656
MOD_GSK3_1	327	334	PF00069	0.481
MOD_GSK3_1	408	415	PF00069	0.594
MOD_GSK3_1	427	434	PF00069	0.671
MOD_GSK3_1	442	449	PF00069	0.573
MOD_GSK3_1	464	471	PF00069	0.587
MOD_GSK3_1	512	519	PF00069	0.622
MOD_GSK3_1	564	571	PF00069	0.530
MOD_GSK3_1	667	674	PF00069	0.436
MOD_GSK3_1	76	83	PF00069	0.658
MOD_GSK3_1	85	92	PF00069	0.621
MOD_GSK3_1	99	106	PF00069	0.664
MOD_N-GLC_1	150	155	PF02516	0.660
MOD_N-GLC_1	226	231	PF02516	0.718
MOD_N-GLC_1	331	336	PF02516	0.572
MOD_N-GLC_1	446	451	PF02516	0.464
MOD_N-GLC_1	567	572	PF02516	0.501
MOD_N-GLC_1	578	583	PF02516	0.428
MOD_NEK2_1	171	176	PF00069	0.664
MOD_NEK2_1	361	366	PF00069	0.390
MOD_NEK2_1	507	512	PF00069	0.579
MOD_NEK2_1	549	554	PF00069	0.418
MOD_NEK2_1	59	64	PF00069	0.740
MOD_NEK2_1	628	633	PF00069	0.495
MOD_NEK2_1	644	649	PF00069	0.413
MOD_NEK2_1	99	104	PF00069	0.564
MOD_NEK2_2	248	253	PF00069	0.483
MOD_NEK2_2	261	266	PF00069	0.463
MOD_PIKK_1	446	452	PF00454	0.512
MOD_PIKK_1	66	72	PF00454	0.580
MOD_PKA_1	2	8	PF00069	0.454
MOD_PKA_2	2	8	PF00069	0.619
MOD_PKA_2	282	288	PF00069	0.266
MOD_PKA_2	311	317	PF00069	0.554
MOD_PKA_2	332	338	PF00069	0.459
MOD_PKA_2	394	400	PF00069	0.689
MOD_PKA_2	463	469	PF00069	0.469
MOD_PKA_2	667	673	PF00069	0.422
MOD_Plk_1	446	452	PF00069	0.508
MOD_Plk_1	85	91	PF00069	0.542
MOD_Plk_4	470	476	PF00069	0.529
MOD_ProDKin_1	15	21	PF00069	0.633
MOD_ProDKin_1	176	182	PF00069	0.522
MOD_ProDKin_1	33	39	PF00069	0.665
MOD_ProDKin_1	402	408	PF00069	0.591
MOD_ProDKin_1	419	425	PF00069	0.702
MOD_ProDKin_1	427	433	PF00069	0.683
MOD_ProDKin_1	442	448	PF00069	0.589
MOD_ProDKin_1	455	461	PF00069	0.459
MOD_ProDKin_1	516	522	PF00069	0.551
MOD_ProDKin_1	534	540	PF00069	0.419
MOD_ProDKin_1	54	60	PF00069	0.795
MOD_ProDKin_1	87	93	PF00069	0.727
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.563
TRG_ENDOCYTIC_2	398	401	PF00928	0.568
TRG_ENDOCYTIC_2	487	490	PF00928	0.438
TRG_ENDOCYTIC_2	561	564	PF00928	0.546
TRG_ER_diArg_1	1	3	PF00400	0.561
TRG_ER_diArg_1	265	268	PF00400	0.545
TRG_ER_diArg_1	490	493	PF00400	0.382
TRG_ER_diArg_1	583	586	PF00400	0.568
TRG_ER_diArg_1	663	666	PF00400	0.529
TRG_NLS_MonoExtC_3	581	586	PF00514	0.561
TRG_Pf-PMV_PEXEL_1	250	255	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ9	Leptomonas seymouri	40%	100%
A0A1X0NXN9	Trypanosomatidae	33%	100%
A0A3S5H797	Leishmania donovani	87%	100%
A0A422NWI0	Trypanosoma rangeli	34%	100%
A4HBU1	Leishmania braziliensis	71%	100%
A4HZ88	Leishmania infantum	87%	100%
D0A1D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4QCB8	Leishmania major	85%	99%
V5BMW0	Trypanosoma cruzi	33%	100%