BAG domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV61_LEIMU

TriTrypDb:

LmxM.21.0855

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AV61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV61

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0051087	protein-folding chaperone binding	3	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.676
CLV_C14_Caspase3-7	223	227	PF00656	0.629
CLV_NRD_NRD_1	133	135	PF00675	0.497
CLV_NRD_NRD_1	157	159	PF00675	0.315
CLV_NRD_NRD_1	186	188	PF00675	0.449
CLV_NRD_NRD_1	220	222	PF00675	0.377
CLV_NRD_NRD_1	269	271	PF00675	0.349
CLV_NRD_NRD_1	282	284	PF00675	0.326
CLV_NRD_NRD_1	88	90	PF00675	0.408
CLV_NRD_NRD_1	97	99	PF00675	0.475
CLV_PCSK_KEX2_1	132	134	PF00082	0.507
CLV_PCSK_KEX2_1	157	159	PF00082	0.315
CLV_PCSK_KEX2_1	185	187	PF00082	0.417
CLV_PCSK_KEX2_1	269	271	PF00082	0.340
CLV_PCSK_KEX2_1	282	284	PF00082	0.347
CLV_PCSK_KEX2_1	88	90	PF00082	0.444
CLV_PCSK_KEX2_1	97	99	PF00082	0.493
CLV_PCSK_SKI1_1	270	274	PF00082	0.370
CLV_PCSK_SKI1_1	282	286	PF00082	0.381
DEG_APCC_DBOX_1	281	289	PF00400	0.465
DEG_Nend_Nbox_1	1	3	PF02207	0.424
DEG_SPOP_SBC_1	22	26	PF00917	0.446
DOC_MAPK_DCC_7	283	293	PF00069	0.584
DOC_PP4_FxxP_1	144	147	PF00568	0.596
DOC_USP7_MATH_1	110	114	PF00917	0.680
DOC_USP7_MATH_1	147	151	PF00917	0.499
DOC_USP7_MATH_1	21	25	PF00917	0.478
DOC_USP7_MATH_1	210	214	PF00917	0.676
DOC_USP7_UBL2_3	267	271	PF12436	0.593
DOC_WW_Pin1_4	23	28	PF00397	0.491
DOC_WW_Pin1_4	36	41	PF00397	0.472
LIG_14-3-3_CanoR_1	97	106	PF00244	0.768
LIG_BIR_III_4	209	213	PF00653	0.586
LIG_BRCT_BRCA1_1	149	153	PF00533	0.544
LIG_FHA_1	247	253	PF00498	0.499
LIG_FHA_1	279	285	PF00498	0.548
LIG_FHA_1	75	81	PF00498	0.306
LIG_FHA_2	170	176	PF00498	0.667
LIG_LIR_Apic_2	141	147	PF02991	0.616
LIG_LIR_Gen_1	150	159	PF02991	0.526
LIG_LIR_Nem_3	149	155	PF02991	0.525
LIG_LIR_Nem_3	39	45	PF02991	0.457
LIG_LIR_Nem_3	4	8	PF02991	0.369
LIG_MLH1_MIPbox_1	149	153	PF16413	0.544
LIG_SH2_NCK_1	20	24	PF00017	0.467
LIG_SH2_NCK_1	65	69	PF00017	0.318
LIG_SH2_SRC	63	66	PF00017	0.363
LIG_SH2_STAP1	206	210	PF00017	0.581
LIG_SH2_STAP1	65	69	PF00017	0.318
LIG_SH2_STAT3	59	62	PF00017	0.406
LIG_SH2_STAT5	155	158	PF00017	0.574
LIG_SH2_STAT5	63	66	PF00017	0.363
LIG_SH3_1	283	289	PF00018	0.583
LIG_SH3_3	283	289	PF00018	0.598
LIG_SH3_3	7	13	PF00018	0.438
LIG_SUMO_SIM_par_1	72	79	PF11976	0.363
LIG_UBA3_1	44	51	PF00899	0.450
MOD_CDK_SPxxK_3	36	43	PF00069	0.467
MOD_CK1_1	100	106	PF00069	0.648
MOD_CK1_1	16	22	PF00069	0.417
MOD_CK1_1	25	31	PF00069	0.415
MOD_CK1_1	4	10	PF00069	0.449
MOD_CK1_1	46	52	PF00069	0.465
MOD_CK2_1	169	175	PF00069	0.536
MOD_CMANNOS	2	5	PF00535	0.637
MOD_Cter_Amidation	95	98	PF01082	0.473
MOD_GlcNHglycan	112	115	PF01048	0.480
MOD_GlcNHglycan	14	18	PF01048	0.667
MOD_GlcNHglycan	149	152	PF01048	0.334
MOD_GlcNHglycan	216	219	PF01048	0.473
MOD_GlcNHglycan	226	229	PF01048	0.421
MOD_GlcNHglycan	32	35	PF01048	0.737
MOD_GlcNHglycan	45	48	PF01048	0.598
MOD_GlcNHglycan	66	69	PF01048	0.358
MOD_GlcNHglycan	99	102	PF01048	0.467
MOD_GSK3_1	147	154	PF00069	0.637
MOD_GSK3_1	169	176	PF00069	0.568
MOD_GSK3_1	21	28	PF00069	0.473
MOD_GSK3_1	210	217	PF00069	0.740
MOD_GSK3_1	46	53	PF00069	0.420
MOD_GSK3_1	72	79	PF00069	0.492
MOD_NEK2_1	1	6	PF00069	0.473
MOD_NEK2_1	29	34	PF00069	0.563
MOD_NEK2_1	72	77	PF00069	0.401
MOD_PIKK_1	246	252	PF00454	0.498
MOD_PIKK_1	46	52	PF00454	0.486
MOD_PKA_1	97	103	PF00069	0.700
MOD_PKA_2	260	266	PF00069	0.596
MOD_PKA_2	97	103	PF00069	0.714
MOD_Plk_4	100	106	PF00069	0.576
MOD_Plk_4	76	82	PF00069	0.453
MOD_ProDKin_1	23	29	PF00069	0.491
MOD_ProDKin_1	36	42	PF00069	0.471
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.568
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.429
TRG_ER_diArg_1	132	134	PF00400	0.616
TRG_ER_diArg_1	156	158	PF00400	0.519
TRG_ER_diArg_1	184	187	PF00400	0.613
TRG_ER_diArg_1	282	284	PF00400	0.578
TRG_ER_diArg_1	97	99	PF00400	0.645
TRG_NES_CRM1_1	250	264	PF08389	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P829	Leptomonas seymouri	40%	100%
A0A1X0NYB3	Trypanosomatidae	31%	75%
A0A3Q8IB47	Leishmania donovani	85%	99%
A4HBT9	Leishmania braziliensis	69%	100%
A4HZ86	Leishmania infantum	85%	99%
Q4QCC0	Leishmania major	85%	100%