Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV57_LEIMU

TriTrypDb:

LmxM.21.0843

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AV57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.576
CLV_NRD_NRD_1	223	225	PF00675	0.375
CLV_NRD_NRD_1	229	231	PF00675	0.432
CLV_NRD_NRD_1	281	283	PF00675	0.408
CLV_NRD_NRD_1	32	34	PF00675	0.702
CLV_NRD_NRD_1	8	10	PF00675	0.694
CLV_PCSK_FUR_1	202	206	PF00082	0.572
CLV_PCSK_FUR_1	279	283	PF00082	0.405
CLV_PCSK_FUR_1	39	43	PF00082	0.703
CLV_PCSK_KEX2_1	204	206	PF00082	0.498
CLV_PCSK_KEX2_1	223	225	PF00082	0.261
CLV_PCSK_KEX2_1	228	230	PF00082	0.425
CLV_PCSK_KEX2_1	264	266	PF00082	0.470
CLV_PCSK_KEX2_1	281	283	PF00082	0.408
CLV_PCSK_KEX2_1	32	34	PF00082	0.702
CLV_PCSK_KEX2_1	41	43	PF00082	0.632
CLV_PCSK_KEX2_1	7	9	PF00082	0.693
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.498
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.428
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.470
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.705
CLV_PCSK_PC7_1	224	230	PF00082	0.499
CLV_PCSK_PC7_1	4	10	PF00082	0.686
CLV_PCSK_SKI1_1	121	125	PF00082	0.601
CLV_PCSK_SKI1_1	159	163	PF00082	0.573
CLV_PCSK_SKI1_1	187	191	PF00082	0.601
CLV_PCSK_SKI1_1	205	209	PF00082	0.343
DEG_APCC_DBOX_1	186	194	PF00400	0.404
DOC_CYCLIN_RxL_1	224	238	PF00134	0.677
DOC_MAPK_gen_1	228	234	PF00069	0.685
DOC_MAPK_RevD_3	208	224	PF00069	0.343
DOC_PP1_RVXF_1	202	209	PF00149	0.298
DOC_USP7_UBL2_3	155	159	PF12436	0.280
DOC_WW_Pin1_4	243	248	PF00397	0.663
DOC_WW_Pin1_4	64	69	PF00397	0.553
DOC_WW_Pin1_4	81	86	PF00397	0.462
LIG_14-3-3_CanoR_1	121	129	PF00244	0.397
LIG_14-3-3_CanoR_1	268	274	PF00244	0.690
LIG_14-3-3_CanoR_1	9	17	PF00244	0.506
LIG_BRCT_BRCA1_1	18	22	PF00533	0.487
LIG_BRCT_BRCA1_1	74	78	PF00533	0.540
LIG_FHA_1	166	172	PF00498	0.388
LIG_FHA_2	122	128	PF00498	0.386
LIG_FHA_2	132	138	PF00498	0.405
LIG_FHA_2	21	27	PF00498	0.462
LIG_FHA_2	270	276	PF00498	0.630
LIG_LIR_Apic_2	76	82	PF02991	0.409
LIG_LIR_Gen_1	212	222	PF02991	0.343
LIG_LIR_Gen_1	241	249	PF02991	0.758
LIG_LIR_Nem_3	212	217	PF02991	0.343
LIG_Pex14_1	214	218	PF04695	0.343
LIG_SH2_STAT5	226	229	PF00017	0.606
LIG_SH3_3	79	85	PF00018	0.411
LIG_SUMO_SIM_par_1	67	72	PF11976	0.412
MOD_CK1_1	72	78	PF00069	0.763
MOD_CK1_1	94	100	PF00069	0.775
MOD_CK2_1	121	127	PF00069	0.567
MOD_CK2_1	131	137	PF00069	0.462
MOD_CK2_1	251	257	PF00069	0.744
MOD_CK2_1	269	275	PF00069	0.459
MOD_CK2_1	74	80	PF00069	0.758
MOD_GlcNHglycan	18	21	PF01048	0.605
MOD_GlcNHglycan	85	88	PF01048	0.562
MOD_GlcNHglycan	96	99	PF01048	0.739
MOD_GSK3_1	11	18	PF00069	0.606
MOD_GSK3_1	165	172	PF00069	0.466
MOD_GSK3_1	243	250	PF00069	0.580
MOD_GSK3_1	67	74	PF00069	0.783
MOD_GSK3_1	88	95	PF00069	0.668
MOD_GSK3_1	98	105	PF00069	0.692
MOD_NEK2_1	10	15	PF00069	0.621
MOD_NEK2_1	128	133	PF00069	0.478
MOD_NEK2_1	169	174	PF00069	0.448
MOD_NEK2_1	269	274	PF00069	0.591
MOD_NEK2_1	3	8	PF00069	0.624
MOD_NEK2_1	73	78	PF00069	0.765
MOD_NEK2_1	88	93	PF00069	0.561
MOD_PIKK_1	169	175	PF00454	0.480
MOD_PKA_2	113	119	PF00069	0.516
MOD_PKA_2	267	273	PF00069	0.686
MOD_PKA_2	3	9	PF00069	0.615
MOD_PKA_2	91	97	PF00069	0.609
MOD_Plk_1	165	171	PF00069	0.464
MOD_Plk_2-3	26	32	PF00069	0.445
MOD_Plk_4	209	215	PF00069	0.343
MOD_Plk_4	74	80	PF00069	0.692
MOD_ProDKin_1	243	249	PF00069	0.576
MOD_ProDKin_1	64	70	PF00069	0.695
MOD_ProDKin_1	81	87	PF00069	0.576
TRG_ENDOCYTIC_2	120	123	PF00928	0.489
TRG_ENDOCYTIC_2	146	149	PF00928	0.451
TRG_ER_diArg_1	132	135	PF00400	0.492
TRG_ER_diArg_1	222	224	PF00400	0.440
TRG_ER_diArg_1	7	9	PF00400	0.612
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	230	235	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIJ9	Leptomonas seymouri	60%	100%
A0A3S7WWJ0	Leishmania donovani	88%	100%
A4HBT5	Leishmania braziliensis	80%	100%
A4HZM4	Leishmania infantum	89%	100%
Q4QCC4	Leishmania major	89%	100%