DUF4833 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV55_LEIMU

TriTrypDb:

LmxM.21.0835

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AV55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.470
CLV_NRD_NRD_1	136	138	PF00675	0.355
CLV_NRD_NRD_1	152	154	PF00675	0.267
CLV_NRD_NRD_1	185	187	PF00675	0.296
CLV_NRD_NRD_1	60	62	PF00675	0.414
CLV_PCSK_KEX2_1	135	137	PF00082	0.363
CLV_PCSK_KEX2_1	185	187	PF00082	0.394
CLV_PCSK_KEX2_1	60	62	PF00082	0.392
CLV_PCSK_KEX2_1	81	83	PF00082	0.334
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.394
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.414
DOC_CDC14_PxL_1	215	223	PF14671	0.384
DOC_MAPK_gen_1	185	193	PF00069	0.397
DOC_MAPK_gen_1	81	90	PF00069	0.304
DOC_PP2B_LxvP_1	216	219	PF13499	0.367
DOC_USP7_MATH_1	103	107	PF00917	0.316
DOC_USP7_MATH_1	108	112	PF00917	0.304
DOC_USP7_MATH_1	181	185	PF00917	0.457
DOC_USP7_MATH_1	207	211	PF00917	0.447
DOC_USP7_MATH_1	227	231	PF00917	0.459
DOC_USP7_UBL2_3	284	288	PF12436	0.463
DOC_WW_Pin1_4	237	242	PF00397	0.737
LIG_14-3-3_CanoR_1	265	269	PF00244	0.375
LIG_FHA_1	143	149	PF00498	0.313
LIG_LIR_Gen_1	192	202	PF02991	0.381
LIG_LIR_Gen_1	302	311	PF02991	0.281
LIG_LIR_Nem_3	167	173	PF02991	0.482
LIG_LIR_Nem_3	192	198	PF02991	0.399
LIG_LIR_Nem_3	302	306	PF02991	0.303
LIG_LIR_Nem_3	315	321	PF02991	0.398
LIG_NRP_CendR_1	320	323	PF00754	0.460
LIG_Rb_pABgroove_1	189	197	PF01858	0.425
LIG_SH2_CRK	296	300	PF00017	0.344
LIG_SH2_NCK_1	195	199	PF00017	0.291
LIG_SH2_PTP2	303	306	PF00017	0.301
LIG_SH2_SRC	195	198	PF00017	0.290
LIG_SH2_SRC	303	306	PF00017	0.332
LIG_SH2_STAT5	286	289	PF00017	0.328
LIG_SH2_STAT5	303	306	PF00017	0.328
LIG_SH2_STAT5	51	54	PF00017	0.335
LIG_SH2_STAT5	79	82	PF00017	0.338
LIG_SH3_3	10	16	PF00018	0.429
LIG_SH3_3	114	120	PF00018	0.231
LIG_SUMO_SIM_anti_2	189	197	PF11976	0.372
LIG_TYR_ITIM	193	198	PF00017	0.319
LIG_TYR_ITIM	301	306	PF00017	0.301
LIG_WRC_WIRS_1	9	14	PF05994	0.235
MOD_CK1_1	111	117	PF00069	0.354
MOD_CK1_1	237	243	PF00069	0.754
MOD_CK1_1	310	316	PF00069	0.344
MOD_CK2_1	313	319	PF00069	0.457
MOD_CK2_1	80	86	PF00069	0.334
MOD_CMANNOS	211	214	PF00535	0.462
MOD_GlcNHglycan	105	108	PF01048	0.328
MOD_GlcNHglycan	28	31	PF01048	0.689
MOD_GlcNHglycan	37	40	PF01048	0.636
MOD_GSK3_1	22	29	PF00069	0.627
MOD_GSK3_1	306	313	PF00069	0.369
MOD_GSK3_1	31	38	PF00069	0.668
MOD_NEK2_1	8	13	PF00069	0.311
MOD_NEK2_1	95	100	PF00069	0.425
MOD_NEK2_2	17	22	PF00069	0.537
MOD_PIKK_1	41	47	PF00454	0.510
MOD_PKA_2	264	270	PF00069	0.457
MOD_Plk_1	111	117	PF00069	0.403
MOD_Plk_1	314	320	PF00069	0.412
MOD_Plk_2-3	254	260	PF00069	0.492
MOD_Plk_4	264	270	PF00069	0.363
MOD_Plk_4	277	283	PF00069	0.274
MOD_Plk_4	8	14	PF00069	0.331
MOD_ProDKin_1	237	243	PF00069	0.734
MOD_SUMO_for_1	299	302	PF00179	0.442
MOD_SUMO_rev_2	147	156	PF00179	0.390
MOD_SUMO_rev_2	289	295	PF00179	0.330
TRG_DiLeu_BaEn_1	189	194	PF01217	0.374
TRG_ENDOCYTIC_2	195	198	PF00928	0.320
TRG_ENDOCYTIC_2	303	306	PF00928	0.298
TRG_ENDOCYTIC_2	318	321	PF00928	0.394
TRG_ER_diArg_1	135	137	PF00400	0.385
TRG_ER_diArg_1	59	61	PF00400	0.411
TRG_NLS_MonoExtC_3	80	86	PF00514	0.183

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J1	Leptomonas seymouri	56%	100%
A0A0N0P3Y3	Leptomonas seymouri	35%	86%
A0A1X0NXM7	Trypanosomatidae	37%	100%
A0A3Q8IAB9	Leishmania donovani	34%	84%
A0A3Q8IF47	Leishmania donovani	89%	100%
A0A3R7N4N0	Trypanosoma rangeli	37%	100%
A4HBT1	Leishmania braziliensis	74%	96%
A4HZM6	Leishmania infantum	89%	100%
A4HZM7	Leishmania infantum	34%	84%
D0A1E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AV54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
Q4QCC6	Leishmania major	86%	98%
Q4QCC7	Leishmania major	35%	100%
V5BDR4	Trypanosoma cruzi	33%	100%