DUF4833 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV54_LEIMU

TriTrypDb:

LmxM.21.0830

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AV54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.454
CLV_C14_Caspase3-7	318	322	PF00656	0.383
CLV_NRD_NRD_1	122	124	PF00675	0.508
CLV_NRD_NRD_1	253	255	PF00675	0.597
CLV_NRD_NRD_1	364	366	PF00675	0.215
CLV_PCSK_KEX2_1	121	123	PF00082	0.493
CLV_PCSK_KEX2_1	253	255	PF00082	0.597
CLV_PCSK_KEX2_1	338	340	PF00082	0.332
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.332
CLV_PCSK_SKI1_1	10	14	PF00082	0.514
CLV_PCSK_SKI1_1	124	128	PF00082	0.336
CLV_PCSK_SKI1_1	46	50	PF00082	0.303
DEG_SPOP_SBC_1	262	266	PF00917	0.588
DOC_CKS1_1	160	165	PF01111	0.332
DOC_CKS1_1	219	224	PF01111	0.262
DOC_CKS1_1	35	40	PF01111	0.438
DOC_MAPK_gen_1	10	20	PF00069	0.477
DOC_MAPK_gen_1	171	181	PF00069	0.384
DOC_PP4_FxxP_1	26	29	PF00568	0.403
DOC_USP7_MATH_1	202	206	PF00917	0.562
DOC_USP7_MATH_1	29	33	PF00917	0.450
DOC_USP7_UBL2_3	329	333	PF12436	0.504
DOC_WW_Pin1_4	144	149	PF00397	0.457
DOC_WW_Pin1_4	159	164	PF00397	0.531
DOC_WW_Pin1_4	218	223	PF00397	0.267
DOC_WW_Pin1_4	34	39	PF00397	0.485
LIG_14-3-3_CanoR_1	24	29	PF00244	0.362
LIG_14-3-3_CanoR_1	253	258	PF00244	0.670
LIG_14-3-3_CterR_2	365	368	PF00244	0.375
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_BRCT_BRCA1_1	15	19	PF00533	0.442
LIG_CSL_BTD_1	219	222	PF09270	0.265
LIG_FHA_1	149	155	PF00498	0.428
LIG_FHA_1	301	307	PF00498	0.503
LIG_FHA_1	76	82	PF00498	0.352
LIG_FHA_2	256	262	PF00498	0.699
LIG_FHA_2	264	270	PF00498	0.792
LIG_FHA_2	316	322	PF00498	0.342
LIG_FHA_2	9	15	PF00498	0.516
LIG_LIR_Apic_2	218	222	PF02991	0.413
LIG_LIR_Apic_2	23	29	PF02991	0.449
LIG_LIR_Apic_2	32	38	PF02991	0.488
LIG_LIR_Gen_1	164	172	PF02991	0.489
LIG_LIR_Gen_1	228	237	PF02991	0.475
LIG_LIR_Gen_1	347	356	PF02991	0.335
LIG_LIR_Nem_3	16	22	PF02991	0.434
LIG_LIR_Nem_3	164	169	PF02991	0.458
LIG_LIR_Nem_3	218	223	PF02991	0.446
LIG_LIR_Nem_3	228	233	PF02991	0.431
LIG_LIR_Nem_3	235	239	PF02991	0.427
LIG_LIR_Nem_3	347	351	PF02991	0.355
LIG_PCNA_yPIPBox_3	42	54	PF02747	0.304
LIG_Pex14_1	219	223	PF04695	0.436
LIG_RPA_C_Fungi	248	260	PF08784	0.529
LIG_SH2_CRK	341	345	PF00017	0.383
LIG_SH2_CRK	35	39	PF00017	0.538
LIG_SH2_PTP2	348	351	PF00017	0.335
LIG_SH2_SRC	348	351	PF00017	0.335
LIG_SH2_STAP1	77	81	PF00017	0.384
LIG_SH2_STAT3	157	160	PF00017	0.314
LIG_SH2_STAT5	109	112	PF00017	0.436
LIG_SH2_STAT5	117	120	PF00017	0.486
LIG_SH2_STAT5	161	164	PF00017	0.333
LIG_SH2_STAT5	226	229	PF00017	0.419
LIG_SH2_STAT5	331	334	PF00017	0.348
LIG_SH2_STAT5	348	351	PF00017	0.348
LIG_SH2_STAT5	65	68	PF00017	0.465
LIG_SH2_STAT5	77	80	PF00017	0.339
LIG_SH3_2	97	102	PF14604	0.286
LIG_SH3_3	219	225	PF00018	0.442
LIG_SH3_3	228	234	PF00018	0.339
LIG_SH3_3	94	100	PF00018	0.417
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.434
LIG_SUMO_SIM_anti_2	308	318	PF11976	0.364
LIG_SUMO_SIM_anti_2	323	328	PF11976	0.255
LIG_SUMO_SIM_par_1	308	318	PF11976	0.383
LIG_TYR_ITIM	346	351	PF00017	0.335
LIG_UBA3_1	239	248	PF00899	0.415
MOD_CK1_1	205	211	PF00069	0.437
MOD_CK1_1	252	258	PF00069	0.701
MOD_CK1_1	265	271	PF00069	0.693
MOD_CK1_1	355	361	PF00069	0.383
MOD_CK1_1	8	14	PF00069	0.544
MOD_CK2_1	113	119	PF00069	0.432
MOD_CK2_1	131	137	PF00069	0.505
MOD_CK2_1	255	261	PF00069	0.739
MOD_CK2_1	322	328	PF00069	0.383
MOD_CK2_1	8	14	PF00069	0.480
MOD_GlcNHglycan	144	147	PF01048	0.378
MOD_GlcNHglycan	175	178	PF01048	0.429
MOD_GlcNHglycan	190	194	PF01048	0.697
MOD_GlcNHglycan	202	205	PF01048	0.662
MOD_GlcNHglycan	303	306	PF01048	0.572
MOD_GlcNHglycan	7	10	PF01048	0.562
MOD_GlcNHglycan	91	94	PF01048	0.464
MOD_GSK3_1	109	116	PF00069	0.521
MOD_GSK3_1	144	151	PF00069	0.418
MOD_GSK3_1	20	27	PF00069	0.532
MOD_GSK3_1	248	255	PF00069	0.660
MOD_GSK3_1	261	268	PF00069	0.632
MOD_GSK3_1	283	290	PF00069	0.714
MOD_GSK3_1	30	37	PF00069	0.314
MOD_GSK3_1	301	308	PF00069	0.516
MOD_GSK3_1	355	362	PF00069	0.383
MOD_LATS_1	87	93	PF00433	0.316
MOD_N-GLC_1	287	292	PF02516	0.602
MOD_NEK2_1	136	141	PF00069	0.443
MOD_NEK2_1	20	25	PF00069	0.282
MOD_NEK2_1	283	288	PF00069	0.658
MOD_NEK2_1	352	357	PF00069	0.342
MOD_NEK2_1	5	10	PF00069	0.570
MOD_PIKK_1	30	36	PF00454	0.477
MOD_PK_1	24	30	PF00069	0.424
MOD_PK_1	253	259	PF00069	0.608
MOD_PKA_1	253	259	PF00069	0.608
MOD_PKA_2	252	258	PF00069	0.666
MOD_Plk_1	131	137	PF00069	0.578
MOD_Plk_1	287	293	PF00069	0.652
MOD_Plk_1	309	315	PF00069	0.357
MOD_Plk_1	322	328	PF00069	0.272
MOD_Plk_2-3	131	137	PF00069	0.434
MOD_Plk_4	113	119	PF00069	0.488
MOD_Plk_4	131	137	PF00069	0.434
MOD_Plk_4	150	156	PF00069	0.440
MOD_Plk_4	215	221	PF00069	0.477
MOD_Plk_4	309	315	PF00069	0.383
MOD_Plk_4	322	328	PF00069	0.383
MOD_ProDKin_1	144	150	PF00069	0.461
MOD_ProDKin_1	159	165	PF00069	0.528
MOD_ProDKin_1	218	224	PF00069	0.271
MOD_ProDKin_1	34	40	PF00069	0.481
MOD_SUMO_for_1	344	347	PF00179	0.395
MOD_SUMO_rev_2	167	176	PF00179	0.384
MOD_SUMO_rev_2	334	340	PF00179	0.385
TRG_ENDOCYTIC_2	348	351	PF00928	0.350
TRG_ER_diArg_1	121	123	PF00400	0.493
TRG_ER_diArg_1	49	52	PF00400	0.527
TRG_NES_CRM1_1	323	336	PF08389	0.323
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J1	Leptomonas seymouri	35%	100%
A0A0N0P3Y3	Leptomonas seymouri	62%	98%
A0A3Q8IAB9	Leishmania donovani	86%	96%
A0A3Q8IF47	Leishmania donovani	36%	100%
A4HZM6	Leishmania infantum	36%	100%
A4HZM7	Leishmania infantum	85%	96%
E9AV55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
Q4QCC6	Leishmania major	35%	91%
Q4QCC7	Leishmania major	84%	100%