Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AV51_LEIMU

TriTrypDb:

LmxM.21.0823

Length:

984

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005773	vacuole	5	1
GO:0005776	autophagosome	6	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AV51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV51

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0006914	autophagy	3	5
GO:0008152	metabolic process	1	6
GO:0009056	catabolic process	2	5
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044248	cellular catabolic process	3	5
GO:0061919	process utilizing autophagic mechanism	2	5
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0006996	organelle organization	4	1
GO:0007033	vacuole organization	5	1
GO:0016043	cellular component organization	3	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0046777	protein autophosphorylation	6	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1905037	autophagosome organization	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	458	462	PF00656	0.556
CLV_C14_Caspase3-7	735	739	PF00656	0.583
CLV_C14_Caspase3-7	80	84	PF00656	0.540
CLV_C14_Caspase3-7	826	830	PF00656	0.555
CLV_NRD_NRD_1	143	145	PF00675	0.291
CLV_NRD_NRD_1	217	219	PF00675	0.290
CLV_NRD_NRD_1	479	481	PF00675	0.544
CLV_NRD_NRD_1	516	518	PF00675	0.545
CLV_NRD_NRD_1	881	883	PF00675	0.530
CLV_NRD_NRD_1	962	964	PF00675	0.432
CLV_PCSK_KEX2_1	143	145	PF00082	0.302
CLV_PCSK_KEX2_1	215	217	PF00082	0.290
CLV_PCSK_KEX2_1	881	883	PF00082	0.530
CLV_PCSK_KEX2_1	962	964	PF00082	0.432
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.290
CLV_PCSK_PC7_1	877	883	PF00082	0.520
CLV_PCSK_SKI1_1	137	141	PF00082	0.328
CLV_PCSK_SKI1_1	201	205	PF00082	0.290
CLV_PCSK_SKI1_1	222	226	PF00082	0.339
CLV_PCSK_SKI1_1	304	308	PF00082	0.342
CLV_PCSK_SKI1_1	552	556	PF00082	0.685
CLV_PCSK_SKI1_1	611	615	PF00082	0.455
CLV_PCSK_SKI1_1	877	881	PF00082	0.476
CLV_PCSK_SKI1_1	882	886	PF00082	0.477
CLV_PCSK_SKI1_1	944	948	PF00082	0.564
CLV_Separin_Metazoa	325	329	PF03568	0.290
CLV_Separin_Metazoa	343	347	PF03568	0.290
DEG_Kelch_Keap1_1	160	165	PF01344	0.217
DEG_Nend_UBRbox_2	1	3	PF02207	0.669
DEG_SCF_FBW7_2	60	67	PF00400	0.616
DEG_SPOP_SBC_1	490	494	PF00917	0.679
DEG_SPOP_SBC_1	94	98	PF00917	0.653
DOC_ANK_TNKS_1	900	907	PF00023	0.585
DOC_CKS1_1	294	299	PF01111	0.290
DOC_CKS1_1	61	66	PF01111	0.624
DOC_CYCLIN_RxL_1	608	617	PF00134	0.462
DOC_CYCLIN_yCln2_LP_2	918	924	PF00134	0.554
DOC_MAPK_DCC_7	393	403	PF00069	0.609
DOC_MAPK_gen_1	167	175	PF00069	0.299
DOC_MAPK_gen_1	222	231	PF00069	0.335
DOC_MAPK_gen_1	881	887	PF00069	0.465
DOC_MAPK_JIP1_4	225	231	PF00069	0.290
DOC_MAPK_MEF2A_6	167	175	PF00069	0.290
DOC_MAPK_MEF2A_6	871	880	PF00069	0.488
DOC_MAPK_MEF2A_6	944	953	PF00069	0.501
DOC_PP1_RVXF_1	942	948	PF00149	0.568
DOC_PP2B_LxvP_1	139	142	PF13499	0.342
DOC_PP2B_LxvP_1	776	779	PF13499	0.640
DOC_PP4_FxxP_1	403	406	PF00568	0.577
DOC_PP4_FxxP_1	576	579	PF00568	0.604
DOC_PP4_FxxP_1	99	102	PF00568	0.663
DOC_USP7_MATH_1	153	157	PF00917	0.242
DOC_USP7_MATH_1	486	490	PF00917	0.669
DOC_USP7_MATH_1	509	513	PF00917	0.641
DOC_USP7_MATH_1	522	526	PF00917	0.564
DOC_USP7_MATH_1	590	594	PF00917	0.527
DOC_USP7_MATH_1	646	650	PF00917	0.528
DOC_USP7_MATH_1	739	743	PF00917	0.584
DOC_USP7_MATH_1	751	755	PF00917	0.621
DOC_USP7_MATH_1	863	867	PF00917	0.636
DOC_USP7_MATH_1	88	92	PF00917	0.684
DOC_USP7_MATH_1	914	918	PF00917	0.630
DOC_USP7_MATH_1	933	937	PF00917	0.483
DOC_USP7_MATH_1	94	98	PF00917	0.758
DOC_USP7_MATH_1	979	983	PF00917	0.555
DOC_USP7_MATH_2	3	9	PF00917	0.504
DOC_USP7_UBL2_3	514	518	PF12436	0.542
DOC_WW_Pin1_4	104	109	PF00397	0.604
DOC_WW_Pin1_4	157	162	PF00397	0.285
DOC_WW_Pin1_4	284	289	PF00397	0.360
DOC_WW_Pin1_4	293	298	PF00397	0.251
DOC_WW_Pin1_4	424	429	PF00397	0.688
DOC_WW_Pin1_4	558	563	PF00397	0.643
DOC_WW_Pin1_4	60	65	PF00397	0.575
DOC_WW_Pin1_4	817	822	PF00397	0.584
DOC_WW_Pin1_4	848	853	PF00397	0.629
DOC_WW_Pin1_4	905	910	PF00397	0.787
LIG_14-3-3_CanoR_1	201	206	PF00244	0.314
LIG_14-3-3_CanoR_1	369	375	PF00244	0.302
LIG_14-3-3_CanoR_1	378	382	PF00244	0.336
LIG_14-3-3_CanoR_1	386	390	PF00244	0.364
LIG_14-3-3_CanoR_1	470	474	PF00244	0.525
LIG_14-3-3_CanoR_1	480	486	PF00244	0.520
LIG_14-3-3_CanoR_1	611	616	PF00244	0.453
LIG_14-3-3_CanoR_1	686	692	PF00244	0.436
LIG_14-3-3_CanoR_1	789	794	PF00244	0.532
LIG_14-3-3_CanoR_1	845	854	PF00244	0.670
LIG_14-3-3_CanoR_1	858	867	PF00244	0.528
LIG_14-3-3_CanoR_1	962	966	PF00244	0.423
LIG_14-3-3_CanoR_1	974	983	PF00244	0.405
LIG_APCC_ABBAyCdc20_2	217	223	PF00400	0.290
LIG_BRCT_BRCA1_1	168	172	PF00533	0.439
LIG_BRCT_BRCA1_1	286	290	PF00533	0.339
LIG_BRCT_BRCA1_1	95	99	PF00533	0.660
LIG_CaM_NSCaTE_8	698	705	PF13499	0.410
LIG_EVH1_1	920	924	PF00568	0.499
LIG_EVH1_2	399	403	PF00568	0.572
LIG_FHA_1	153	159	PF00498	0.334
LIG_FHA_1	202	208	PF00498	0.311
LIG_FHA_1	238	244	PF00498	0.376
LIG_FHA_1	400	406	PF00498	0.645
LIG_FHA_1	586	592	PF00498	0.491
LIG_FHA_1	682	688	PF00498	0.494
LIG_FHA_1	838	844	PF00498	0.584
LIG_FHA_1	971	977	PF00498	0.411
LIG_FHA_2	230	236	PF00498	0.342
LIG_FHA_2	269	275	PF00498	0.402
LIG_FHA_2	369	375	PF00498	0.307
LIG_FHA_2	456	462	PF00498	0.535
LIG_FHA_2	706	712	PF00498	0.550
LIG_FHA_2	859	865	PF00498	0.668
LIG_FHA_2	884	890	PF00498	0.549
LIG_GBD_Chelix_1	615	623	PF00786	0.496
LIG_LIR_Apic_2	296	302	PF02991	0.290
LIG_LIR_Apic_2	402	406	PF02991	0.580
LIG_LIR_Apic_2	544	550	PF02991	0.560
LIG_LIR_Apic_2	573	579	PF02991	0.605
LIG_LIR_Apic_2	917	923	PF02991	0.629
LIG_LIR_Apic_2	96	102	PF02991	0.797
LIG_LIR_Gen_1	133	142	PF02991	0.342
LIG_LIR_Gen_1	169	178	PF02991	0.346
LIG_LIR_Gen_1	525	534	PF02991	0.627
LIG_LIR_Gen_1	593	602	PF02991	0.516
LIG_LIR_Nem_3	133	138	PF02991	0.342
LIG_LIR_Nem_3	169	175	PF02991	0.346
LIG_LIR_Nem_3	284	289	PF02991	0.342
LIG_LIR_Nem_3	347	352	PF02991	0.342
LIG_LIR_Nem_3	525	530	PF02991	0.636
LIG_LIR_Nem_3	593	597	PF02991	0.513
LIG_MAD2	218	226	PF02301	0.290
LIG_MAD2	944	952	PF02301	0.564
LIG_MYND_1	396	400	PF01753	0.619
LIG_MYND_1	905	909	PF01753	0.566
LIG_MYND_1	925	929	PF01753	0.632
LIG_NRBOX	618	624	PF00104	0.360
LIG_NRBOX	875	881	PF00104	0.477
LIG_Pex14_2	286	290	PF04695	0.504
LIG_Rb_pABgroove_1	112	120	PF01858	0.342
LIG_SH2_CRK	39	43	PF00017	0.415
LIG_SH2_CRK	547	551	PF00017	0.583
LIG_SH2_NCK_1	24	28	PF00017	0.386
LIG_SH2_PTP2	13	16	PF00017	0.487
LIG_SH2_SRC	599	602	PF00017	0.478
LIG_SH2_STAP1	118	122	PF00017	0.342
LIG_SH2_STAP1	627	631	PF00017	0.499
LIG_SH2_STAP1	683	687	PF00017	0.485
LIG_SH2_STAT3	601	604	PF00017	0.477
LIG_SH2_STAT5	13	16	PF00017	0.503
LIG_SH2_STAT5	178	181	PF00017	0.323
LIG_SH2_STAT5	599	602	PF00017	0.481
LIG_SH2_STAT5	618	621	PF00017	0.653
LIG_SH2_STAT5	630	633	PF00017	0.439
LIG_SH2_STAT5	666	669	PF00017	0.594
LIG_SH2_STAT5	683	686	PF00017	0.476
LIG_SH3_1	393	399	PF00018	0.602
LIG_SH3_1	518	524	PF00018	0.518
LIG_SH3_1	547	553	PF00018	0.631
LIG_SH3_1	920	926	PF00018	0.562
LIG_SH3_2	465	470	PF14604	0.653
LIG_SH3_2	521	526	PF14604	0.568
LIG_SH3_3	135	141	PF00018	0.496
LIG_SH3_3	391	397	PF00018	0.575
LIG_SH3_3	450	456	PF00018	0.822
LIG_SH3_3	462	468	PF00018	0.590
LIG_SH3_3	482	488	PF00018	0.733
LIG_SH3_3	518	524	PF00018	0.573
LIG_SH3_3	547	553	PF00018	0.583
LIG_SH3_3	58	64	PF00018	0.568
LIG_SH3_3	725	731	PF00018	0.651
LIG_SH3_3	776	782	PF00018	0.635
LIG_SH3_3	918	924	PF00018	0.620
LIG_SH3_3	946	952	PF00018	0.517
LIG_SH3_3	99	105	PF00018	0.638
LIG_Sin3_3	227	234	PF02671	0.342
LIG_SUMO_SIM_anti_2	112	119	PF11976	0.290
LIG_SUMO_SIM_anti_2	593	599	PF11976	0.511
LIG_SUMO_SIM_par_1	320	325	PF11976	0.290
LIG_SUMO_SIM_par_1	883	889	PF11976	0.474
LIG_TRAF2_1	727	730	PF00917	0.596
LIG_TRFH_1	576	580	PF08558	0.607
LIG_TYR_ITIM	37	42	PF00017	0.421
LIG_TYR_ITIM	597	602	PF00017	0.521
LIG_UBA3_1	211	215	PF00899	0.342
LIG_WRC_WIRS_1	591	596	PF05994	0.515
LIG_WW_2	396	399	PF00397	0.616
LIG_WW_3	140	144	PF00397	0.342
MOD_CDC14_SPxK_1	301	304	PF00782	0.290
MOD_CDK_SPxK_1	298	304	PF00069	0.290
MOD_CK1_1	148	154	PF00069	0.223
MOD_CK1_1	156	162	PF00069	0.240
MOD_CK1_1	163	169	PF00069	0.430
MOD_CK1_1	437	443	PF00069	0.665
MOD_CK1_1	447	453	PF00069	0.530
MOD_CK1_1	489	495	PF00069	0.773
MOD_CK1_1	737	743	PF00069	0.601
MOD_CK1_1	754	760	PF00069	0.551
MOD_CK1_1	938	944	PF00069	0.637
MOD_CK1_1	95	101	PF00069	0.806
MOD_CK1_1	978	984	PF00069	0.559
MOD_CK2_1	159	165	PF00069	0.342
MOD_CK2_1	268	274	PF00069	0.367
MOD_CK2_1	481	487	PF00069	0.671
MOD_CK2_1	706	712	PF00069	0.591
MOD_CK2_1	740	746	PF00069	0.559
MOD_CK2_1	883	889	PF00069	0.491
MOD_Cter_Amidation	478	481	PF01082	0.545
MOD_GlcNHglycan	147	150	PF01048	0.305
MOD_GlcNHglycan	162	165	PF01048	0.217
MOD_GlcNHglycan	232	235	PF01048	0.342
MOD_GlcNHglycan	263	266	PF01048	0.319
MOD_GlcNHglycan	317	320	PF01048	0.290
MOD_GlcNHglycan	434	437	PF01048	0.829
MOD_GlcNHglycan	449	452	PF01048	0.551
MOD_GlcNHglycan	45	48	PF01048	0.467
MOD_GlcNHglycan	487	491	PF01048	0.615
MOD_GlcNHglycan	543	546	PF01048	0.629
MOD_GlcNHglycan	568	571	PF01048	0.591
MOD_GlcNHglycan	693	696	PF01048	0.532
MOD_GlcNHglycan	7	10	PF01048	0.633
MOD_GlcNHglycan	738	742	PF01048	0.567
MOD_GlcNHglycan	749	752	PF01048	0.557
MOD_GlcNHglycan	898	901	PF01048	0.685
MOD_GlcNHglycan	90	93	PF01048	0.683
MOD_GlcNHglycan	937	940	PF01048	0.504
MOD_GlcNHglycan	977	980	PF01048	0.535
MOD_GSK3_1	144	151	PF00069	0.339
MOD_GSK3_1	152	159	PF00069	0.283
MOD_GSK3_1	289	296	PF00069	0.355
MOD_GSK3_1	335	342	PF00069	0.342
MOD_GSK3_1	430	437	PF00069	0.680
MOD_GSK3_1	486	493	PF00069	0.687
MOD_GSK3_1	558	565	PF00069	0.585
MOD_GSK3_1	566	573	PF00069	0.556
MOD_GSK3_1	633	640	PF00069	0.567
MOD_GSK3_1	642	649	PF00069	0.431
MOD_GSK3_1	681	688	PF00069	0.398
MOD_GSK3_1	747	754	PF00069	0.597
MOD_GSK3_1	808	815	PF00069	0.580
MOD_GSK3_1	848	855	PF00069	0.581
MOD_GSK3_1	88	95	PF00069	0.808
MOD_GSK3_1	953	960	PF00069	0.565
MOD_GSK3_1	970	977	PF00069	0.414
MOD_N-GLC_1	845	850	PF02516	0.670
MOD_N-GLC_2	648	650	PF02516	0.538
MOD_NEK2_1	229	234	PF00069	0.348
MOD_NEK2_1	327	332	PF00069	0.301
MOD_NEK2_1	385	390	PF00069	0.313
MOD_NEK2_1	563	568	PF00069	0.758
MOD_NEK2_1	637	642	PF00069	0.527
MOD_NEK2_1	747	752	PF00069	0.670
MOD_NEK2_1	788	793	PF00069	0.585
MOD_NEK2_2	210	215	PF00069	0.290
MOD_PIKK_1	335	341	PF00454	0.290
MOD_PIKK_1	434	440	PF00454	0.672
MOD_PIKK_1	500	506	PF00454	0.603
MOD_PK_1	481	487	PF00069	0.671
MOD_PK_1	789	795	PF00069	0.573
MOD_PKA_1	480	486	PF00069	0.535
MOD_PKA_2	166	172	PF00069	0.290
MOD_PKA_2	327	333	PF00069	0.301
MOD_PKA_2	368	374	PF00069	0.290
MOD_PKA_2	377	383	PF00069	0.290
MOD_PKA_2	385	391	PF00069	0.290
MOD_PKA_2	469	475	PF00069	0.525
MOD_PKA_2	516	522	PF00069	0.669
MOD_PKA_2	641	647	PF00069	0.532
MOD_PKA_2	685	691	PF00069	0.437
MOD_PKA_2	788	794	PF00069	0.580
MOD_PKA_2	846	852	PF00069	0.544
MOD_PKA_2	857	863	PF00069	0.530
MOD_PKA_2	961	967	PF00069	0.424
MOD_PKB_1	787	795	PF00069	0.456
MOD_PKB_1	845	853	PF00069	0.545
MOD_Plk_1	837	843	PF00069	0.557
MOD_Plk_1	863	869	PF00069	0.614
MOD_Plk_2-3	961	967	PF00069	0.549
MOD_Plk_4	153	159	PF00069	0.204
MOD_Plk_4	385	391	PF00069	0.342
MOD_Plk_4	45	51	PF00069	0.453
MOD_Plk_4	611	617	PF00069	0.607
MOD_Plk_4	812	818	PF00069	0.607
MOD_ProDKin_1	104	110	PF00069	0.594
MOD_ProDKin_1	157	163	PF00069	0.285
MOD_ProDKin_1	284	290	PF00069	0.360
MOD_ProDKin_1	293	299	PF00069	0.251
MOD_ProDKin_1	424	430	PF00069	0.688
MOD_ProDKin_1	558	564	PF00069	0.640
MOD_ProDKin_1	60	66	PF00069	0.582
MOD_ProDKin_1	817	823	PF00069	0.584
MOD_ProDKin_1	848	854	PF00069	0.631
MOD_ProDKin_1	905	911	PF00069	0.786
MOD_SUMO_for_1	334	337	PF00179	0.342
MOD_SUMO_rev_2	77	84	PF00179	0.679
TRG_DiLeu_BaEn_4	729	735	PF01217	0.511
TRG_DiLeu_BaLyEn_6	698	703	PF01217	0.474
TRG_DiLeu_BaLyEn_6	771	776	PF01217	0.647
TRG_ENDOCYTIC_2	13	16	PF00928	0.487
TRG_ENDOCYTIC_2	39	42	PF00928	0.416
TRG_ENDOCYTIC_2	599	602	PF00928	0.545
TRG_ER_diArg_1	142	144	PF00400	0.294
TRG_ER_diArg_1	216	218	PF00400	0.290
TRG_ER_diArg_1	698	701	PF00400	0.500
TRG_ER_diArg_1	787	790	PF00400	0.479
TRG_ER_diArg_1	880	882	PF00400	0.527
TRG_NLS_MonoCore_2	214	219	PF00514	0.290
TRG_NLS_MonoExtC_3	513	518	PF00514	0.540
TRG_NLS_MonoExtN_4	514	521	PF00514	0.535
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGM5	Leptomonas seymouri	43%	92%
A0A3S7WWM5	Leishmania donovani	90%	100%
A4HZ84	Leishmania infantum	90%	100%
Q4QCD0	Leishmania major	88%	99%