Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV46_LEIMU

TriTrypDb:

LmxM.21.0780

Length:

783

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AV46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV46

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.762
CLV_C14_Caspase3-7	449	453	PF00656	0.677
CLV_NRD_NRD_1	104	106	PF00675	0.707
CLV_NRD_NRD_1	243	245	PF00675	0.557
CLV_NRD_NRD_1	284	286	PF00675	0.658
CLV_NRD_NRD_1	381	383	PF00675	0.541
CLV_NRD_NRD_1	387	389	PF00675	0.526
CLV_NRD_NRD_1	422	424	PF00675	0.697
CLV_NRD_NRD_1	511	513	PF00675	0.741
CLV_NRD_NRD_1	520	522	PF00675	0.640
CLV_NRD_NRD_1	564	566	PF00675	0.563
CLV_NRD_NRD_1	568	570	PF00675	0.546
CLV_NRD_NRD_1	626	628	PF00675	0.679
CLV_PCSK_FUR_1	102	106	PF00082	0.739
CLV_PCSK_FUR_1	508	512	PF00082	0.778
CLV_PCSK_FUR_1	518	522	PF00082	0.680
CLV_PCSK_KEX2_1	102	104	PF00082	0.697
CLV_PCSK_KEX2_1	243	245	PF00082	0.557
CLV_PCSK_KEX2_1	284	286	PF00082	0.658
CLV_PCSK_KEX2_1	381	383	PF00082	0.541
CLV_PCSK_KEX2_1	387	389	PF00082	0.526
CLV_PCSK_KEX2_1	510	512	PF00082	0.765
CLV_PCSK_KEX2_1	520	522	PF00082	0.630
CLV_PCSK_KEX2_1	564	566	PF00082	0.561
CLV_PCSK_KEX2_1	568	570	PF00082	0.548
CLV_PCSK_KEX2_1	626	628	PF00082	0.679
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.776
CLV_PCSK_PC7_1	564	570	PF00082	0.658
CLV_PCSK_SKI1_1	222	226	PF00082	0.667
CLV_PCSK_SKI1_1	244	248	PF00082	0.537
CLV_PCSK_SKI1_1	285	289	PF00082	0.598
CLV_PCSK_SKI1_1	387	391	PF00082	0.583
CLV_PCSK_SKI1_1	564	568	PF00082	0.610
CLV_PCSK_SKI1_1	583	587	PF00082	0.709
CLV_PCSK_SKI1_1	752	756	PF00082	0.567
CLV_PCSK_SKI1_1	765	769	PF00082	0.688
CLV_PCSK_SKI1_1	85	89	PF00082	0.587
DEG_APCC_DBOX_1	197	205	PF00400	0.634
DEG_APCC_DBOX_1	209	217	PF00400	0.720
DEG_APCC_DBOX_1	720	728	PF00400	0.658
DEG_APCC_DBOX_1	79	87	PF00400	0.626
DEG_SPOP_SBC_1	127	131	PF00917	0.708
DEG_SPOP_SBC_1	191	195	PF00917	0.480
DEG_SPOP_SBC_1	643	647	PF00917	0.692
DOC_CKS1_1	249	254	PF01111	0.562
DOC_CKS1_1	766	771	PF01111	0.683
DOC_CYCLIN_RxL_1	381	393	PF00134	0.577
DOC_CYCLIN_RxL_1	561	570	PF00134	0.624
DOC_CYCLIN_yCln2_LP_2	249	255	PF00134	0.655
DOC_CYCLIN_yCln2_LP_2	413	419	PF00134	0.652
DOC_MAPK_gen_1	220	227	PF00069	0.599
DOC_MAPK_gen_1	387	394	PF00069	0.634
DOC_MAPK_MEF2A_6	387	394	PF00069	0.586
DOC_MAPK_NFAT4_5	387	395	PF00069	0.593
DOC_PP1_RVXF_1	148	154	PF00149	0.625
DOC_PP1_RVXF_1	83	89	PF00149	0.583
DOC_PP2B_LxvP_1	367	370	PF13499	0.670
DOC_PP2B_LxvP_1	738	741	PF13499	0.698
DOC_USP7_MATH_1	156	160	PF00917	0.653
DOC_USP7_MATH_1	355	359	PF00917	0.728
DOC_USP7_MATH_1	578	582	PF00917	0.583
DOC_USP7_MATH_1	635	639	PF00917	0.703
DOC_USP7_MATH_1	643	647	PF00917	0.716
DOC_USP7_MATH_1	65	69	PF00917	0.629
DOC_USP7_MATH_1	771	775	PF00917	0.460
DOC_WW_Pin1_4	173	178	PF00397	0.649
DOC_WW_Pin1_4	179	184	PF00397	0.637
DOC_WW_Pin1_4	248	253	PF00397	0.558
DOC_WW_Pin1_4	305	310	PF00397	0.709
DOC_WW_Pin1_4	31	36	PF00397	0.595
DOC_WW_Pin1_4	39	44	PF00397	0.654
DOC_WW_Pin1_4	412	417	PF00397	0.655
DOC_WW_Pin1_4	631	636	PF00397	0.725
DOC_WW_Pin1_4	765	770	PF00397	0.678
LIG_14-3-3_CanoR_1	105	115	PF00244	0.705
LIG_14-3-3_CanoR_1	21	30	PF00244	0.667
LIG_14-3-3_CanoR_1	220	227	PF00244	0.643
LIG_14-3-3_CanoR_1	310	320	PF00244	0.738
LIG_14-3-3_CanoR_1	361	370	PF00244	0.678
LIG_14-3-3_CanoR_1	446	454	PF00244	0.686
LIG_14-3-3_CanoR_1	551	559	PF00244	0.570
LIG_14-3-3_CanoR_1	568	574	PF00244	0.667
LIG_14-3-3_CanoR_1	603	609	PF00244	0.582
LIG_14-3-3_CanoR_1	626	636	PF00244	0.726
LIG_Actin_WH2_2	209	224	PF00022	0.588
LIG_Actin_WH2_2	552	570	PF00022	0.675
LIG_Actin_WH2_2	751	767	PF00022	0.643
LIG_BIR_III_2	254	258	PF00653	0.580
LIG_BIR_III_4	132	136	PF00653	0.679
LIG_BRCT_BRCA1_1	580	584	PF00533	0.709
LIG_Clathr_ClatBox_1	478	482	PF01394	0.656
LIG_CSL_BTD_1	329	332	PF09270	0.573
LIG_CtBP_PxDLS_1	673	677	PF00389	0.742
LIG_EVH1_2	331	335	PF00568	0.572
LIG_FHA_1	121	127	PF00498	0.746
LIG_FHA_1	192	198	PF00498	0.766
LIG_FHA_1	338	344	PF00498	0.629
LIG_FHA_1	432	438	PF00498	0.696
LIG_FHA_1	662	668	PF00498	0.686
LIG_FHA_1	74	80	PF00498	0.670
LIG_FHA_2	249	255	PF00498	0.600
LIG_FHA_2	313	319	PF00498	0.720
LIG_FHA_2	447	453	PF00498	0.684
LIG_FHA_2	512	518	PF00498	0.581
LIG_FHA_2	556	562	PF00498	0.681
LIG_FHA_2	94	100	PF00498	0.630
LIG_LIR_Gen_1	121	128	PF02991	0.696
LIG_LIR_Gen_1	229	238	PF02991	0.614
LIG_LIR_Gen_1	278	287	PF02991	0.568
LIG_LIR_Gen_1	393	401	PF02991	0.681
LIG_LIR_Gen_1	54	64	PF02991	0.613
LIG_LIR_Nem_3	121	127	PF02991	0.695
LIG_LIR_Nem_3	229	234	PF02991	0.584
LIG_LIR_Nem_3	268	274	PF02991	0.584
LIG_LIR_Nem_3	278	282	PF02991	0.388
LIG_LIR_Nem_3	283	289	PF02991	0.546
LIG_LIR_Nem_3	328	333	PF02991	0.675
LIG_LIR_Nem_3	393	397	PF02991	0.679
LIG_LIR_Nem_3	54	59	PF02991	0.543
LIG_LIR_Nem_3	560	566	PF02991	0.618
LIG_LIR_Nem_3	691	697	PF02991	0.655
LIG_NRBOX	581	587	PF00104	0.688
LIG_OCRL_FandH_1	393	405	PF00620	0.601
LIG_PCNA_yPIPBox_3	765	779	PF02747	0.451
LIG_Pex14_1	84	88	PF04695	0.533
LIG_Pex14_2	14	18	PF04695	0.579
LIG_Pex14_2	88	92	PF04695	0.532
LIG_PTB_Apo_2	86	93	PF02174	0.533
LIG_REV1ctd_RIR_1	11	21	PF16727	0.669
LIG_RPA_C_Fungi	279	291	PF08784	0.594
LIG_RPA_C_Fungi	377	389	PF08784	0.670
LIG_SH2_CRK	271	275	PF00017	0.566
LIG_SH2_CRK	286	290	PF00017	0.559
LIG_SH2_CRK	694	698	PF00017	0.688
LIG_SH2_NCK_1	124	128	PF00017	0.699
LIG_SH2_NCK_1	430	434	PF00017	0.703
LIG_SH2_PTP2	279	282	PF00017	0.560
LIG_SH2_SRC	430	433	PF00017	0.668
LIG_SH2_SRC	467	470	PF00017	0.634
LIG_SH2_STAP1	124	128	PF00017	0.699
LIG_SH2_STAP1	286	290	PF00017	0.634
LIG_SH2_STAP1	606	610	PF00017	0.540
LIG_SH2_STAT3	606	609	PF00017	0.650
LIG_SH2_STAT3	621	624	PF00017	0.676
LIG_SH2_STAT5	231	234	PF00017	0.530
LIG_SH2_STAT5	248	251	PF00017	0.554
LIG_SH2_STAT5	279	282	PF00017	0.560
LIG_SH2_STAT5	56	59	PF00017	0.625
LIG_SH2_STAT5	750	753	PF00017	0.668
LIG_SH2_STAT5	93	96	PF00017	0.566
LIG_SH3_3	165	171	PF00018	0.736
LIG_SH3_3	367	373	PF00018	0.693
LIG_SH3_3	37	43	PF00018	0.712
LIG_SH3_3	666	672	PF00018	0.707
LIG_SH3_3	706	712	PF00018	0.633
LIG_SUMO_SIM_anti_2	406	412	PF11976	0.726
LIG_SUMO_SIM_anti_2	615	620	PF11976	0.656
LIG_SUMO_SIM_par_1	272	278	PF11976	0.566
LIG_SUMO_SIM_par_1	672	678	PF11976	0.741
LIG_SUMO_SIM_par_1	71	76	PF11976	0.658
LIG_TRAF2_1	159	162	PF00917	0.650
LIG_TRAF2_1	442	445	PF00917	0.410
LIG_TRAF2_1	473	476	PF00917	0.652
LIG_UBA3_1	264	272	PF00899	0.597
LIG_WRC_WIRS_1	547	552	PF05994	0.538
LIG_WRC_WIRS_1	56	61	PF05994	0.553
MOD_CDC14_SPxK_1	634	637	PF00782	0.757
MOD_CDK_SPK_2	305	310	PF00069	0.647
MOD_CDK_SPxK_1	631	637	PF00069	0.749
MOD_CK1_1	325	331	PF00069	0.724
MOD_CK1_1	368	374	PF00069	0.659
MOD_CK1_1	470	476	PF00069	0.680
MOD_CK1_1	539	545	PF00069	0.643
MOD_CK1_1	661	667	PF00069	0.557
MOD_CK1_1	713	719	PF00069	0.603
MOD_CK2_1	106	112	PF00069	0.672
MOD_CK2_1	156	162	PF00069	0.616
MOD_CK2_1	253	259	PF00069	0.534
MOD_CK2_1	312	318	PF00069	0.754
MOD_CK2_1	331	337	PF00069	0.396
MOD_CK2_1	38	44	PF00069	0.693
MOD_CK2_1	470	476	PF00069	0.694
MOD_CK2_1	497	503	PF00069	0.799
MOD_CK2_1	528	534	PF00069	0.757
MOD_Cter_Amidation	508	511	PF01082	0.781
MOD_GlcNHglycan	179	182	PF01048	0.765
MOD_GlcNHglycan	327	330	PF01048	0.730
MOD_GlcNHglycan	357	360	PF01048	0.727
MOD_GlcNHglycan	363	366	PF01048	0.752
MOD_GlcNHglycan	373	376	PF01048	0.707
MOD_GlcNHglycan	472	475	PF01048	0.649
MOD_GlcNHglycan	538	541	PF01048	0.685
MOD_GlcNHglycan	637	640	PF01048	0.602
MOD_GlcNHglycan	67	70	PF01048	0.641
MOD_GlcNHglycan	700	703	PF01048	0.685
MOD_GlcNHglycan	711	715	PF01048	0.565
MOD_GlcNHglycan	718	721	PF01048	0.426
MOD_GSK3_1	106	113	PF00069	0.540
MOD_GSK3_1	173	180	PF00069	0.654
MOD_GSK3_1	192	199	PF00069	0.442
MOD_GSK3_1	31	38	PF00069	0.793
MOD_GSK3_1	361	368	PF00069	0.710
MOD_GSK3_1	528	535	PF00069	0.656
MOD_GSK3_1	546	553	PF00069	0.527
MOD_GSK3_1	555	562	PF00069	0.569
MOD_GSK3_1	627	634	PF00069	0.667
MOD_GSK3_1	710	717	PF00069	0.527
MOD_N-GLC_1	337	342	PF02516	0.677
MOD_NEK2_1	265	270	PF00069	0.581
MOD_NEK2_1	390	395	PF00069	0.642
MOD_NEK2_1	550	555	PF00069	0.484
MOD_NEK2_1	559	564	PF00069	0.591
MOD_NEK2_1	567	572	PF00069	0.643
MOD_NEK2_2	546	551	PF00069	0.599
MOD_NEK2_2	578	583	PF00069	0.588
MOD_PIKK_1	265	271	PF00454	0.619
MOD_PIKK_1	528	534	PF00454	0.762
MOD_PIKK_1	620	626	PF00454	0.681
MOD_PIKK_1	773	779	PF00454	0.741
MOD_PKA_1	511	517	PF00069	0.544
MOD_PKA_2	110	116	PF00069	0.618
MOD_PKA_2	205	211	PF00069	0.701
MOD_PKA_2	511	517	PF00069	0.633
MOD_PKA_2	550	556	PF00069	0.535
MOD_PKA_2	567	573	PF00069	0.626
MOD_PKA_2	604	610	PF00069	0.602
MOD_PKB_1	627	635	PF00069	0.632
MOD_Plk_1	120	126	PF00069	0.773
MOD_Plk_1	139	145	PF00069	0.734
MOD_Plk_1	191	197	PF00069	0.483
MOD_Plk_1	337	343	PF00069	0.619
MOD_Plk_1	467	473	PF00069	0.617
MOD_Plk_1	484	490	PF00069	0.611
MOD_Plk_1	502	508	PF00069	0.708
MOD_Plk_1	73	79	PF00069	0.615
MOD_Plk_4	192	198	PF00069	0.698
MOD_Plk_4	406	412	PF00069	0.704
MOD_Plk_4	45	51	PF00069	0.598
MOD_Plk_4	456	462	PF00069	0.517
MOD_Plk_4	484	490	PF00069	0.607
MOD_Plk_4	55	61	PF00069	0.564
MOD_Plk_4	93	99	PF00069	0.644
MOD_ProDKin_1	173	179	PF00069	0.651
MOD_ProDKin_1	248	254	PF00069	0.560
MOD_ProDKin_1	305	311	PF00069	0.711
MOD_ProDKin_1	31	37	PF00069	0.595
MOD_ProDKin_1	39	45	PF00069	0.645
MOD_ProDKin_1	412	418	PF00069	0.653
MOD_ProDKin_1	631	637	PF00069	0.728
MOD_ProDKin_1	765	771	PF00069	0.682
MOD_SUMO_rev_2	131	141	PF00179	0.788
TRG_DiLeu_BaEn_1	406	411	PF01217	0.728
TRG_DiLeu_BaEn_1	74	79	PF01217	0.610
TRG_DiLeu_BaEn_2	579	585	PF01217	0.656
TRG_DiLeu_BaLyEn_6	316	321	PF01217	0.702
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.541
TRG_DiLeu_BaLyEn_6	562	567	PF01217	0.634
TRG_ENDOCYTIC_2	124	127	PF00928	0.698
TRG_ENDOCYTIC_2	231	234	PF00928	0.530
TRG_ENDOCYTIC_2	271	274	PF00928	0.570
TRG_ENDOCYTIC_2	279	282	PF00928	0.461
TRG_ENDOCYTIC_2	286	289	PF00928	0.540
TRG_ENDOCYTIC_2	430	433	PF00928	0.575
TRG_ENDOCYTIC_2	56	59	PF00928	0.625
TRG_ENDOCYTIC_2	694	697	PF00928	0.685
TRG_ER_diArg_1	102	105	PF00400	0.701
TRG_ER_diArg_1	242	244	PF00400	0.542
TRG_ER_diArg_1	284	286	PF00400	0.658
TRG_ER_diArg_1	380	382	PF00400	0.544
TRG_ER_diArg_1	386	388	PF00400	0.522
TRG_ER_diArg_1	519	521	PF00400	0.685
TRG_ER_diArg_1	563	565	PF00400	0.546
TRG_ER_diArg_1	567	569	PF00400	0.544
TRG_ER_diArg_1	626	629	PF00400	0.621
TRG_NES_CRM1_1	651	663	PF08389	0.494
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.693

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ90	Leptomonas seymouri	57%	72%
A0A3R7K7W4	Trypanosoma rangeli	31%	83%
A0A3S7WWF2	Leishmania donovani	89%	100%
A4HBS5	Leishmania braziliensis	81%	100%
A4HZ79	Leishmania infantum	89%	100%
D0A1F7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	96%
Q4QCD5	Leishmania major	89%	99%
V5DEN0	Trypanosoma cruzi	31%	83%