Zinc finger (CCCH type) motif-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV45_LEIMU

TriTrypDb:

LmxM.21.0770

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AV45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV45

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	187	189	PF00675	0.442
CLV_NRD_NRD_1	495	497	PF00675	0.741
CLV_NRD_NRD_1	81	83	PF00675	0.309
CLV_PCSK_KEX2_1	187	189	PF00082	0.389
CLV_PCSK_KEX2_1	208	210	PF00082	0.513
CLV_PCSK_KEX2_1	302	304	PF00082	0.609
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.513
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.470
CLV_PCSK_SKI1_1	161	165	PF00082	0.347
CLV_PCSK_SKI1_1	354	358	PF00082	0.554
DEG_APCC_DBOX_1	84	92	PF00400	0.359
DEG_COP1_1	97	106	PF00400	0.376
DEG_SCF_FBW7_1	357	363	PF00400	0.558
DEG_SCF_FBW7_1	409	414	PF00400	0.563
DEG_SPOP_SBC_1	266	270	PF00917	0.575
DOC_CKS1_1	357	362	PF01111	0.668
DOC_CYCLIN_yCln2_LP_2	218	224	PF00134	0.337
DOC_CYCLIN_yCln2_LP_2	84	90	PF00134	0.390
DOC_MAPK_gen_1	82	92	PF00069	0.374
DOC_MAPK_MEF2A_6	82	90	PF00069	0.387
DOC_PP2B_LxvP_1	218	221	PF13499	0.309
DOC_PP2B_LxvP_1	253	256	PF13499	0.410
DOC_PP2B_LxvP_1	84	87	PF13499	0.357
DOC_PP2B_LxvP_1	90	93	PF13499	0.400
DOC_PP4_FxxP_1	13	16	PF00568	0.541
DOC_PP4_FxxP_1	27	30	PF00568	0.530
DOC_USP7_MATH_1	14	18	PF00917	0.575
DOC_USP7_MATH_1	195	199	PF00917	0.544
DOC_USP7_MATH_1	327	331	PF00917	0.671
DOC_USP7_MATH_1	360	364	PF00917	0.607
DOC_USP7_MATH_1	446	450	PF00917	0.586
DOC_USP7_MATH_1	51	55	PF00917	0.746
DOC_USP7_UBL2_3	68	72	PF12436	0.524
DOC_WW_Pin1_4	137	142	PF00397	0.392
DOC_WW_Pin1_4	280	285	PF00397	0.497
DOC_WW_Pin1_4	308	313	PF00397	0.514
DOC_WW_Pin1_4	333	338	PF00397	0.560
DOC_WW_Pin1_4	356	361	PF00397	0.617
DOC_WW_Pin1_4	363	368	PF00397	0.627
DOC_WW_Pin1_4	369	374	PF00397	0.575
DOC_WW_Pin1_4	377	382	PF00397	0.558
DOC_WW_Pin1_4	407	412	PF00397	0.693
DOC_WW_Pin1_4	413	418	PF00397	0.653
DOC_WW_Pin1_4	474	479	PF00397	0.647
DOC_WW_Pin1_4	96	101	PF00397	0.484
LIG_14-3-3_CanoR_1	179	185	PF00244	0.288
LIG_14-3-3_CanoR_1	307	312	PF00244	0.588
LIG_14-3-3_CanoR_1	358	367	PF00244	0.701
LIG_BIR_II_1	1	5	PF00653	0.694
LIG_BRCT_BRCA1_1	313	317	PF00533	0.611
LIG_BRCT_BRCA1_1	371	375	PF00533	0.674
LIG_deltaCOP1_diTrp_1	69	75	PF00928	0.401
LIG_EVH1_2	385	389	PF00568	0.540
LIG_FHA_1	181	187	PF00498	0.357
LIG_FHA_1	2	8	PF00498	0.501
LIG_FHA_1	268	274	PF00498	0.483
LIG_FHA_1	360	366	PF00498	0.594
LIG_FHA_1	48	54	PF00498	0.765
LIG_FHA_1	79	85	PF00498	0.358
LIG_FHA_2	347	353	PF00498	0.520
LIG_FHA_2	38	44	PF00498	0.649
LIG_LIR_Apic_2	25	30	PF02991	0.531
LIG_LIR_Gen_1	198	206	PF02991	0.455
LIG_LIR_Gen_1	292	301	PF02991	0.538
LIG_LIR_Gen_1	481	492	PF02991	0.542
LIG_LIR_Gen_1	70	80	PF02991	0.359
LIG_LIR_Nem_3	157	163	PF02991	0.318
LIG_LIR_Nem_3	198	203	PF02991	0.462
LIG_LIR_Nem_3	292	298	PF02991	0.445
LIG_LIR_Nem_3	349	353	PF02991	0.524
LIG_LIR_Nem_3	481	487	PF02991	0.655
LIG_LIR_Nem_3	70	76	PF02991	0.368
LIG_Pex14_2	27	31	PF04695	0.492
LIG_SH2_CRK	200	204	PF00017	0.470
LIG_SH2_CRK	484	488	PF00017	0.575
LIG_SH2_NCK_1	200	204	PF00017	0.395
LIG_SH2_NCK_1	340	344	PF00017	0.531
LIG_SH2_NCK_1	484	488	PF00017	0.575
LIG_SH2_PTP2	162	165	PF00017	0.354
LIG_SH2_STAP1	3	7	PF00017	0.536
LIG_SH2_STAP1	324	328	PF00017	0.563
LIG_SH2_STAT5	162	165	PF00017	0.354
LIG_SH2_STAT5	189	192	PF00017	0.478
LIG_SH2_STAT5	236	239	PF00017	0.331
LIG_SH2_STAT5	280	283	PF00017	0.497
LIG_SH2_STAT5	3	6	PF00017	0.498
LIG_SH2_STAT5	39	42	PF00017	0.591
LIG_SH2_STAT5	438	441	PF00017	0.580
LIG_SH3_3	345	351	PF00018	0.693
LIG_SH3_3	73	79	PF00018	0.383
LIG_SUMO_SIM_par_1	283	289	PF11976	0.463
LIG_SxIP_EBH_1	123	134	PF03271	0.371
LIG_TRAF2_1	41	44	PF00917	0.572
LIG_TYR_ITIM	133	138	PF00017	0.444
LIG_UBA3_1	217	223	PF00899	0.408
LIG_WW_1	435	438	PF00397	0.624
MOD_CK1_1	139	145	PF00069	0.451
MOD_CK1_1	154	160	PF00069	0.360
MOD_CK1_1	17	23	PF00069	0.612
MOD_CK1_1	2	8	PF00069	0.546
MOD_CK1_1	262	268	PF00069	0.525
MOD_CK1_1	269	275	PF00069	0.451
MOD_CK1_1	363	369	PF00069	0.652
MOD_CK1_1	461	467	PF00069	0.647
MOD_CK1_1	469	475	PF00069	0.654
MOD_CK1_1	485	491	PF00069	0.633
MOD_CK1_1	60	66	PF00069	0.602
MOD_CK2_1	327	333	PF00069	0.457
MOD_CK2_1	37	43	PF00069	0.574
MOD_CK2_1	459	465	PF00069	0.549
MOD_Cter_Amidation	206	209	PF01082	0.399
MOD_GlcNHglycan	127	130	PF01048	0.399
MOD_GlcNHglycan	313	316	PF01048	0.696
MOD_GlcNHglycan	318	321	PF01048	0.670
MOD_GlcNHglycan	340	343	PF01048	0.540
MOD_GlcNHglycan	362	365	PF01048	0.700
MOD_GlcNHglycan	367	370	PF01048	0.652
MOD_GlcNHglycan	405	408	PF01048	0.494
MOD_GlcNHglycan	43	48	PF01048	0.673
MOD_GlcNHglycan	454	457	PF01048	0.548
MOD_GlcNHglycan	487	490	PF01048	0.644
MOD_GlcNHglycan	60	63	PF01048	0.428
MOD_GSK3_1	195	202	PF00069	0.501
MOD_GSK3_1	258	265	PF00069	0.513
MOD_GSK3_1	307	314	PF00069	0.588
MOD_GSK3_1	329	336	PF00069	0.653
MOD_GSK3_1	356	363	PF00069	0.599
MOD_GSK3_1	365	372	PF00069	0.598
MOD_GSK3_1	39	46	PF00069	0.623
MOD_GSK3_1	403	410	PF00069	0.640
MOD_GSK3_1	442	449	PF00069	0.600
MOD_GSK3_1	454	461	PF00069	0.562
MOD_GSK3_1	466	473	PF00069	0.656
MOD_GSK3_1	47	54	PF00069	0.597
MOD_GSK3_1	474	481	PF00069	0.616
MOD_GSK3_1	488	495	PF00069	0.500
MOD_GSK3_1	56	63	PF00069	0.457
MOD_GSK3_1	91	98	PF00069	0.438
MOD_N-GLC_1	307	312	PF02516	0.627
MOD_N-GLC_1	333	338	PF02516	0.534
MOD_N-GLC_1	360	365	PF02516	0.649
MOD_N-GLC_1	403	408	PF02516	0.541
MOD_NEK2_1	1	6	PF00069	0.643
MOD_NEK2_2	313	318	PF00069	0.480
MOD_PIKK_1	379	385	PF00454	0.750
MOD_PKA_1	196	202	PF00069	0.406
MOD_Plk_1	151	157	PF00069	0.349
MOD_Plk_1	360	366	PF00069	0.560
MOD_Plk_4	482	488	PF00069	0.543
MOD_ProDKin_1	137	143	PF00069	0.388
MOD_ProDKin_1	280	286	PF00069	0.505
MOD_ProDKin_1	308	314	PF00069	0.519
MOD_ProDKin_1	333	339	PF00069	0.554
MOD_ProDKin_1	356	362	PF00069	0.619
MOD_ProDKin_1	363	369	PF00069	0.626
MOD_ProDKin_1	377	383	PF00069	0.597
MOD_ProDKin_1	407	413	PF00069	0.697
MOD_ProDKin_1	474	480	PF00069	0.645
MOD_ProDKin_1	96	102	PF00069	0.484
MOD_SUMO_rev_2	294	304	PF00179	0.461
MOD_SUMO_rev_2	52	59	PF00179	0.571
MOD_SUMO_rev_2	64	74	PF00179	0.407
TRG_ENDOCYTIC_2	135	138	PF00928	0.468
TRG_ENDOCYTIC_2	162	165	PF00928	0.375
TRG_ENDOCYTIC_2	200	203	PF00928	0.434
TRG_ENDOCYTIC_2	484	487	PF00928	0.658
TRG_ER_diArg_1	186	188	PF00400	0.436
TRG_ER_diArg_1	233	236	PF00400	0.351
TRG_NLS_Bipartite_1	67	86	PF00514	0.464
TRG_NLS_MonoExtN_4	79	86	PF00514	0.319
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P864	Leptomonas seymouri	66%	100%
A0A3R7KEE9	Trypanosoma rangeli	42%	87%
A0A3S5H796	Leishmania donovani	95%	100%
A4HBS4	Leishmania braziliensis	84%	98%
A4HZ78	Leishmania infantum	95%	100%
D0A1F9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	88%
Q4Q7W7	Leishmania major	28%	100%
Q4QCD6	Leishmania major	94%	100%
V5BMY3	Trypanosoma cruzi	46%	89%