LeishMANIAdb
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Putative ATPase subunit 9

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ATPase subunit 9
Gene product:
ATPase subunit 9, putative
Species:
Leishmania mexicana
UniProt:
E9AV42_LEIMU
TriTrypDb:
LmxM.21.0740
Length:
106

Annotations

LeishMANIAdb annotations

Hyperconserved component of the mitochondrial FoF1 synthase complex. Likely contains a transit signal as well.. Interestingly, this gene duplicated in parazitic kinetoplastids multiple times.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 25
NetGPI no yes: 0, no: 25
Cellular components
Term Name Level Count
GO:0016020 membrane 2 26
GO:0032991 protein-containing complex 1 26
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain 3 26
GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) 4 26
GO:0098796 membrane protein complex 2 26
GO:0110165 cellular anatomical entity 1 26
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) 4 2
GO:0098798 mitochondrial protein-containing complex 2 2
GO:0098800 inner mitochondrial membrane protein complex 3 2
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

E9AV42
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV42

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 26
GO:0006163 purine nucleotide metabolic process 5 26
GO:0006164 purine nucleotide biosynthetic process 6 26
GO:0006725 cellular aromatic compound metabolic process 3 26
GO:0006753 nucleoside phosphate metabolic process 4 26
GO:0006754 ATP biosynthetic process 8 26
GO:0006793 phosphorus metabolic process 3 26
GO:0006796 phosphate-containing compound metabolic process 4 26
GO:0006807 nitrogen compound metabolic process 2 26
GO:0008152 metabolic process 1 26
GO:0009058 biosynthetic process 2 26
GO:0009117 nucleotide metabolic process 5 26
GO:0009141 nucleoside triphosphate metabolic process 5 26
GO:0009142 nucleoside triphosphate biosynthetic process 6 26
GO:0009144 purine nucleoside triphosphate metabolic process 6 26
GO:0009145 purine nucleoside triphosphate biosynthetic process 7 26
GO:0009150 purine ribonucleotide metabolic process 6 26
GO:0009152 purine ribonucleotide biosynthetic process 7 26
GO:0009165 nucleotide biosynthetic process 6 26
GO:0009199 ribonucleoside triphosphate metabolic process 6 26
GO:0009201 ribonucleoside triphosphate biosynthetic process 7 26
GO:0009205 purine ribonucleoside triphosphate metabolic process 7 26
GO:0009206 purine ribonucleoside triphosphate biosynthetic process 8 26
GO:0009259 ribonucleotide metabolic process 5 26
GO:0009260 ribonucleotide biosynthetic process 6 26
GO:0009987 cellular process 1 26
GO:0015986 proton motive force-driven ATP synthesis 9 26
GO:0018130 heterocycle biosynthetic process 4 26
GO:0019438 aromatic compound biosynthetic process 4 26
GO:0019637 organophosphate metabolic process 3 26
GO:0019693 ribose phosphate metabolic process 4 26
GO:0034641 cellular nitrogen compound metabolic process 3 26
GO:0034654 nucleobase-containing compound biosynthetic process 4 26
GO:0044237 cellular metabolic process 2 26
GO:0044238 primary metabolic process 2 26
GO:0044249 cellular biosynthetic process 3 26
GO:0044271 cellular nitrogen compound biosynthetic process 4 26
GO:0044281 small molecule metabolic process 2 26
GO:0046034 ATP metabolic process 7 26
GO:0046390 ribose phosphate biosynthetic process 5 26
GO:0046483 heterocycle metabolic process 3 26
GO:0055086 nucleobase-containing small molecule metabolic process 3 26
GO:0071704 organic substance metabolic process 2 26
GO:0072521 purine-containing compound metabolic process 4 26
GO:0072522 purine-containing compound biosynthetic process 5 26
GO:0090407 organophosphate biosynthetic process 4 26
GO:1901135 carbohydrate derivative metabolic process 3 26
GO:1901137 carbohydrate derivative biosynthetic process 4 26
GO:1901293 nucleoside phosphate biosynthetic process 5 26
GO:1901360 organic cyclic compound metabolic process 3 26
GO:1901362 organic cyclic compound biosynthetic process 4 26
GO:1901564 organonitrogen compound metabolic process 3 26
GO:1901566 organonitrogen compound biosynthetic process 4 26
GO:1901576 organic substance biosynthetic process 3 26
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0005215 transporter activity 1 26
GO:0005488 binding 1 26
GO:0008289 lipid binding 2 26
GO:0008324 monoatomic cation transmembrane transporter activity 4 26
GO:0015075 monoatomic ion transmembrane transporter activity 3 26
GO:0015078 proton transmembrane transporter activity 5 26
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 26
GO:0016787 hydrolase activity 2 12
GO:0022857 transmembrane transporter activity 2 26
GO:0022890 inorganic cation transmembrane transporter activity 4 26

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 12 14 PF00675 0.600
CLV_NRD_NRD_1 3 5 PF00675 0.564
CLV_PCSK_KEX2_1 12 14 PF00082 0.600
CLV_PCSK_KEX2_1 3 5 PF00082 0.564
CLV_PCSK_SKI1_1 76 80 PF00082 0.213
DOC_CYCLIN_yClb5_NLxxxL_5 70 78 PF00134 0.413
DOC_MAPK_MEF2A_6 26 35 PF00069 0.330
DOC_USP7_MATH_1 15 19 PF00917 0.409
LIG_14-3-3_CanoR_1 26 32 PF00244 0.352
LIG_FHA_1 28 34 PF00498 0.341
LIG_FHA_1 73 79 PF00498 0.419
LIG_FHA_1 87 93 PF00498 0.254
LIG_LIR_Nem_3 59 64 PF02991 0.169
LIG_PCNA_yPIPBox_3 70 78 PF02747 0.413
LIG_Pex14_2 101 105 PF04695 0.217
LIG_SH2_CRK 81 85 PF00017 0.413
LIG_SH2_STAT5 40 43 PF00017 0.260
LIG_SUMO_SIM_par_1 29 34 PF11976 0.328
MOD_CK1_1 29 35 PF00069 0.328
MOD_GlcNHglycan 18 21 PF01048 0.567
MOD_GSK3_1 27 34 PF00069 0.338
MOD_N-GLC_1 72 77 PF02516 0.213
MOD_NEK2_2 56 61 PF00069 0.205
MOD_Plk_4 56 62 PF00069 0.191
TRG_ENDOCYTIC_2 81 84 PF00928 0.413
TRG_ER_diArg_1 12 14 PF00400 0.349
TRG_ER_diArg_1 2 4 PF00400 0.359
TRG_Pf-PMV_PEXEL_1 4 8 PF00026 0.651

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC53 Leptomonas seymouri 86% 100%
A0A0N1PD25 Leptomonas seymouri 86% 100%
A0A0S4JH41 Bodo saltans 72% 100%
A0A0S4JIC3 Bodo saltans 77% 100%
A0A1X0NII7 Trypanosomatidae 81% 97%
A0A1X0NQ50 Trypanosomatidae 79% 99%
A0A1X0NXV8 Trypanosomatidae 78% 100%
A0A381MIF8 Leishmania infantum 92% 100%
A0A3R7KS23 Trypanosoma rangeli 79% 99%
A0A3R7NDI3 Trypanosoma rangeli 81% 99%
A0A3S5H621 Leishmania donovani 93% 100%
A0A3S7WZM0 Leishmania donovani 92% 100%
A0A422NA05 Trypanosoma rangeli 78% 100%
A0A422NVI6 Trypanosoma rangeli 80% 97%
A0Q2Z9 Clostridium novyi (strain NT) 35% 100%
A1XQS5 Sus scrofa 47% 78%
A4HBS1 Leishmania braziliensis 86% 100%
A4HEQ2 Leishmania braziliensis 86% 100%
A4HZ75 Leishmania infantum 92% 100%
A8EX89 Rickettsia canadensis (strain McKiel) 39% 100%
A8XDX2 Caenorhabditis briggsae 45% 91%
A9HDM8 Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / CCUG 37298 / CIP 103539 / LMG 7603 / PAl5) 47% 100%
C5CA73 Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) 42% 100%
C9ZS37 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 71% 91%
D0A1G3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 69% 90%
D0A727 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 71% 70%
E9AWQ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
P00842 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 54% 72%
P05496 Homo sapiens 46% 78%
P07926 Bos taurus 41% 74%
P15014 Rhodospirillum rubrum 39% 100%
P17605 Ovis aries 51% 78%
P21537 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 53% 100%
P32876 Bos taurus 51% 78%
P48201 Homo sapiens 42% 75%
P48880 Chondrus crispus 55% 100%
P56383 Mus musculus 51% 73%
P56384 Mus musculus 51% 75%
Q01554 Trichophyton rubrum 56% 100%
Q03672 Podospora anserina 54% 74%
Q06055 Homo sapiens 51% 75%
Q06056 Ovis aries 41% 74%
Q06645 Rattus norvegicus 47% 78%
Q06646 Rattus norvegicus 51% 75%
Q0BQY6 Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1) 51% 100%
Q2GE12 Neorickettsia sennetsu (strain ATCC VR-367 / Miyayama) 38% 100%
Q2LCR3 Dictyostelium citrinum 45% 100%
Q2RPA5 Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1) 39% 100%
Q37315 Dictyostelium discoideum 45% 100%
Q3ZC75 Bos taurus 48% 75%
Q4A8W4 Mesomycoplasma hyopneumoniae (strain 7448) 31% 100%
Q4AAW2 Mesomycoplasma hyopneumoniae (strain J / ATCC 25934 / NCTC 10110) 33% 100%
Q4QAS0 Leishmania major 92% 100%
Q4QCD9 Leishmania major 93% 100%
Q5RAP9 Pongo abelii 51% 75%
Q5RFL2 Pongo abelii 42% 75%
Q602A0 Mesomycoplasma hyopneumoniae (strain 232) 32% 100%
Q68XQ0 Rickettsia typhi (strain ATCC VR-144 / Wilmington) 38% 100%
Q71S46 Rattus norvegicus 42% 75%
Q9BKS0 Caenorhabditis elegans 45% 91%
Q9CR84 Mus musculus 47% 78%
Q9U505 Manduca sexta 52% 81%
Q9ZEC2 Rickettsia prowazekii (strain Madrid E) 36% 100%
V5B9K0 Trypanosoma cruzi 84% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS