Likely part of the mitochondrial MICOS complex, based on homology.. It is possible that this protein only has a single TM segment as the first can also be a transit signal.. Localization: Mitochondrial inner membrane (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 9 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 14 |
| NetGPI | no | yes: 0, no: 14 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0032991 | protein-containing complex | 1 | 15 |
| GO:0061617 | MICOS complex | 4 | 15 |
| GO:0098796 | membrane protein complex | 2 | 15 |
| GO:0098798 | mitochondrial protein-containing complex | 2 | 15 |
| GO:0098800 | inner mitochondrial membrane protein complex | 3 | 15 |
| GO:0005739 | mitochondrion | 5 | 2 |
| GO:0043226 | organelle | 2 | 2 |
| GO:0043227 | membrane-bounded organelle | 3 | 2 |
| GO:0043229 | intracellular organelle | 3 | 2 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 2 |
| GO:0110165 | cellular anatomical entity | 1 | 2 |
Related structures:
AlphaFold database: E9AV41
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_PCSK_SKI1_1 | 70 | 74 | PF00082 | 0.292 |
| CLV_PCSK_SKI1_1 | 9 | 13 | PF00082 | 0.499 |
| DEG_SPOP_SBC_1 | 90 | 94 | PF00917 | 0.497 |
| DOC_USP7_MATH_1 | 90 | 94 | PF00917 | 0.539 |
| LIG_BRCT_BRCA1_1 | 29 | 33 | PF00533 | 0.261 |
| LIG_FHA_1 | 67 | 73 | PF00498 | 0.281 |
| LIG_FHA_2 | 3 | 9 | PF00498 | 0.495 |
| LIG_LIR_Gen_1 | 15 | 26 | PF02991 | 0.261 |
| LIG_LIR_Nem_3 | 15 | 21 | PF02991 | 0.245 |
| LIG_SH2_STAT5 | 20 | 23 | PF00017 | 0.243 |
| LIG_SH2_STAT5 | 66 | 69 | PF00017 | 0.282 |
| LIG_SH2_STAT5 | 71 | 74 | PF00017 | 0.460 |
| LIG_SH3_3 | 84 | 90 | PF00018 | 0.475 |
| MOD_CK1_1 | 19 | 25 | PF00069 | 0.498 |
| MOD_CK1_1 | 46 | 52 | PF00069 | 0.311 |
| MOD_GlcNHglycan | 83 | 86 | PF01048 | 0.637 |
| MOD_GSK3_1 | 12 | 19 | PF00069 | 0.397 |
| MOD_GSK3_1 | 51 | 58 | PF00069 | 0.370 |
| MOD_GSK3_1 | 62 | 69 | PF00069 | 0.328 |
| MOD_NEK2_1 | 1 | 6 | PF00069 | 0.654 |
| MOD_NEK2_1 | 12 | 17 | PF00069 | 0.342 |
| MOD_PIKK_1 | 12 | 18 | PF00454 | 0.432 |
| MOD_Plk_1 | 2 | 8 | PF00069 | 0.476 |
| MOD_Plk_1 | 22 | 28 | PF00069 | 0.250 |
| MOD_Plk_4 | 2 | 8 | PF00069 | 0.614 |
| MOD_Plk_4 | 37 | 43 | PF00069 | 0.292 |
| MOD_Plk_4 | 62 | 68 | PF00069 | 0.243 |
| MOD_Plk_4 | 78 | 84 | PF00069 | 0.452 |
| MOD_SUMO_rev_2 | 65 | 72 | PF00179 | 0.261 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0S4IQE6 | Bodo saltans | 53% | 96% |
| A0A1X0NZ69 | Trypanosomatidae | 65% | 79% |
| A0A3Q8IB36 | Leishmania donovani | 98% | 84% |
| A0A3Q8IHN0 | Leishmania donovani | 28% | 87% |
| A0A422NHB5 | Trypanosoma rangeli | 57% | 82% |
| A4HBS0 | Leishmania braziliensis | 95% | 100% |
| A4HFT1 | Leishmania braziliensis | 28% | 87% |
| A4HZ74 | Leishmania infantum | 98% | 84% |
| A4I2U5 | Leishmania infantum | 28% | 87% |
| D0A1G4 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 66% | 82% |
| E9ADD2 | Leishmania major | 28% | 87% |
| E9AZ57 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 28% | 87% |
| Q4QCE0 | Leishmania major | 98% | 66% |