LeishMANIAdb
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Putative 60S Ribosomal protein L36

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative 60S Ribosomal protein L36
Gene product:
60S ribosomal protein L36, putative
Species:
Leishmania mexicana
UniProt:
E9AV40_LEIMU
TriTrypDb:
LmxM.21.0730
Length:
105

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S Ribosomal L36

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 6
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. yes yes: 30
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 25
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 17
GO:0032991 protein-containing complex 1 19
GO:0043226 organelle 2 18
GO:0043228 non-membrane-bounded organelle 3 18
GO:0043229 intracellular organelle 3 18
GO:0043232 intracellular non-membrane-bounded organelle 4 18
GO:0110165 cellular anatomical entity 1 19
GO:1990904 ribonucleoprotein complex 2 19
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 2
GO:0015934 large ribosomal subunit 4 2
GO:0022625 cytosolic large ribosomal subunit 5 2
GO:0044391 ribosomal subunit 3 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

E9AV40
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV40

PDB structure(s): 6az3_i

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 19
GO:0006518 peptide metabolic process 4 19
GO:0006807 nitrogen compound metabolic process 2 19
GO:0008152 metabolic process 1 19
GO:0009058 biosynthetic process 2 19
GO:0009059 macromolecule biosynthetic process 4 19
GO:0009987 cellular process 1 19
GO:0019538 protein metabolic process 3 19
GO:0034641 cellular nitrogen compound metabolic process 3 19
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 19
GO:0043043 peptide biosynthetic process 5 19
GO:0043170 macromolecule metabolic process 3 19
GO:0043603 amide metabolic process 3 19
GO:0043604 amide biosynthetic process 4 19
GO:0044237 cellular metabolic process 2 19
GO:0044238 primary metabolic process 2 19
GO:0044249 cellular biosynthetic process 3 19
GO:0044260 obsolete cellular macromolecule metabolic process 3 19
GO:0044271 cellular nitrogen compound biosynthetic process 4 19
GO:0071704 organic substance metabolic process 2 19
GO:1901564 organonitrogen compound metabolic process 3 19
GO:1901566 organonitrogen compound biosynthetic process 4 19
GO:1901576 organic substance biosynthetic process 3 19
GO:0002181 cytoplasmic translation 5 2
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 19
GO:0005198 structural molecule activity 1 19

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 22 24 PF00675 0.238
CLV_PCSK_KEX2_1 22 24 PF00082 0.238
CLV_PCSK_KEX2_1 58 60 PF00082 0.230
CLV_PCSK_KEX2_1 70 72 PF00082 0.238
CLV_PCSK_KEX2_1 78 80 PF00082 0.238
CLV_PCSK_KEX2_1 89 91 PF00082 0.254
CLV_PCSK_PC1ET2_1 58 60 PF00082 0.305
CLV_PCSK_PC1ET2_1 70 72 PF00082 0.238
CLV_PCSK_PC1ET2_1 78 80 PF00082 0.238
CLV_PCSK_PC1ET2_1 89 91 PF00082 0.254
CLV_PCSK_SKI1_1 41 45 PF00082 0.263
CLV_PCSK_SKI1_1 70 74 PF00082 0.238
CLV_PCSK_SKI1_1 89 93 PF00082 0.238
CLV_PCSK_SKI1_1 98 102 PF00082 0.254
DOC_MAPK_gen_1 58 66 PF00069 0.438
DOC_PP4_FxxP_1 33 36 PF00568 0.506
DOC_SPAK_OSR1_1 32 36 PF12202 0.487
DOC_USP7_UBL2_3 70 74 PF12436 0.438
DOC_USP7_UBL2_3 88 92 PF12436 0.528
DOC_WW_Pin1_4 2 7 PF00397 0.599
DOC_WW_Pin1_4 25 30 PF00397 0.493
DOC_WW_Pin1_4 51 56 PF00397 0.454
LIG_BIR_II_1 1 5 PF00653 0.589
LIG_FHA_1 6 12 PF00498 0.280
LIG_LIR_Apic_2 31 36 PF02991 0.444
LIG_LIR_Gen_1 62 69 PF02991 0.546
LIG_LIR_Nem_3 62 66 PF02991 0.546
LIG_SH2_STAT5 75 78 PF00017 0.546
LIG_SH3_3 21 27 PF00018 0.514
MOD_CDK_SPK_2 2 7 PF00069 0.599
MOD_CDK_SPxxK_3 25 32 PF00069 0.493
MOD_CDK_SPxxK_3 51 58 PF00069 0.438
MOD_CK1_1 2 8 PF00069 0.618
MOD_CK2_1 51 57 PF00069 0.438
MOD_GlcNHglycan 1 4 PF01048 0.662
MOD_ProDKin_1 2 8 PF00069 0.594
MOD_ProDKin_1 25 31 PF00069 0.493
MOD_ProDKin_1 51 57 PF00069 0.454
MOD_SUMO_for_1 91 94 PF00179 0.428
TRG_ER_diArg_1 22 25 PF00400 0.438
TRG_ER_diLys_1 102 105 PF00400 0.675
TRG_NLS_Bipartite_1 70 92 PF00514 0.438
TRG_NLS_MonoCore_2 86 91 PF00514 0.441
TRG_NLS_MonoExtC_3 76 82 PF00514 0.546
TRG_NLS_MonoExtC_3 87 92 PF00514 0.454
TRG_NLS_MonoExtN_4 74 81 PF00514 0.446
TRG_NLS_MonoExtN_4 87 93 PF00514 0.530

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IM67 Leptomonas seymouri 96% 100%
A0A0S4JFE8 Bodo saltans 69% 94%
A0A1X0NZ05 Trypanosomatidae 82% 91%
A0A1X0P5V0 Trypanosomatidae 82% 97%
A0A3Q8IDW6 Leishmania donovani 98% 100%
A0A3R7MLS5 Trypanosoma rangeli 82% 92%
A0A3S7X961 Leishmania donovani 100% 100%
A4HBR9 Leishmania braziliensis 96% 100%
A4HML2 Leishmania braziliensis 96% 100%
A4HZ73 Leishmania infantum 98% 100%
A4IB89 Leishmania infantum 100% 100%
C9ZZL6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 77% 96%
D0A1G5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 78% 96%
E9AF13 Leishmania major 99% 100%
E9B669 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
O14455 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 100%
O80929 Arabidopsis thaliana 45% 93%
O94658 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 100%
P05745 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 100%
P39032 Rattus norvegicus 37% 100%
P47964 Mus musculus 37% 100%
P49181 Caenorhabditis elegans 37% 100%
P49630 Drosophila melanogaster 33% 91%
P52866 Daucus carota 38% 99%
P9WEU2 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 41% 100%
Q24F59 Tetrahymena thermophila (strain SB210) 36% 100%
Q3T171 Bos taurus 39% 100%
Q4PM12 Ixodes scapularis 40% 95%
Q4QCE1 Leishmania major 99% 100%
Q55AQ9 Dictyostelium discoideum 43% 100%
Q5RAZ9 Pongo abelii 38% 100%
Q66KU4 Xenopus laevis 40% 100%
Q6DER2 Xenopus tropicalis 40% 100%
Q6Q415 Danio rerio 37% 100%
Q8UW19 Hydrophis hardwickii 40% 100%
Q90YT2 Ictalurus punctatus 37% 100%
Q92365 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 34% 100%
Q98TF6 Gallus gallus 38% 100%
Q9HFR7 Trichoderma hamatum 37% 100%
Q9LRB8 Ulva compressa 43% 100%
Q9LZ57 Arabidopsis thaliana 45% 97%
Q9M352 Arabidopsis thaliana 44% 94%
Q9Y3U8 Homo sapiens 38% 100%
V5BDJ2 Trypanosoma cruzi 80% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS