Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV39_LEIMU

TriTrypDb:

LmxM.21.0725

Length:

380

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AV39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV39

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0019538	protein metabolic process	3	12
GO:0030163	protein catabolic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008914	leucyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016755	aminoacyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.355
CLV_C14_Caspase3-7	85	89	PF00656	0.439
CLV_NRD_NRD_1	128	130	PF00675	0.531
CLV_NRD_NRD_1	153	155	PF00675	0.560
CLV_NRD_NRD_1	174	176	PF00675	0.349
CLV_NRD_NRD_1	187	189	PF00675	0.374
CLV_NRD_NRD_1	224	226	PF00675	0.327
CLV_NRD_NRD_1	308	310	PF00675	0.399
CLV_NRD_NRD_1	318	320	PF00675	0.357
CLV_NRD_NRD_1	371	373	PF00675	0.546
CLV_NRD_NRD_1	376	378	PF00675	0.561
CLV_PCSK_KEX2_1	187	189	PF00082	0.456
CLV_PCSK_KEX2_1	308	310	PF00082	0.360
CLV_PCSK_KEX2_1	318	320	PF00082	0.404
CLV_PCSK_KEX2_1	362	364	PF00082	0.594
CLV_PCSK_KEX2_1	376	378	PF00082	0.574
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.594
CLV_PCSK_PC7_1	372	378	PF00082	0.398
CLV_PCSK_SKI1_1	154	158	PF00082	0.435
CLV_PCSK_SKI1_1	212	216	PF00082	0.491
CLV_PCSK_SKI1_1	362	366	PF00082	0.598
CLV_PCSK_SKI1_1	93	97	PF00082	0.281
DEG_APCC_DBOX_1	199	207	PF00400	0.332
DOC_CDC14_PxL_1	107	115	PF14671	0.316
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.375
DOC_MAPK_gen_1	175	182	PF00069	0.409
DOC_MAPK_gen_1	298	306	PF00069	0.380
DOC_MAPK_gen_1	372	380	PF00069	0.414
DOC_MAPK_gen_1	69	78	PF00069	0.421
DOC_MAPK_MEF2A_6	93	102	PF00069	0.353
DOC_PP2B_LxvP_1	108	111	PF13499	0.383
DOC_PP2B_LxvP_1	195	198	PF13499	0.465
DOC_PP4_FxxP_1	53	56	PF00568	0.413
DOC_USP7_MATH_1	160	164	PF00917	0.526
DOC_USP7_UBL2_3	212	216	PF12436	0.454
DOC_USP7_UBL2_3	357	361	PF12436	0.627
DOC_USP7_UBL2_3	362	366	PF12436	0.598
DOC_WW_Pin1_4	233	238	PF00397	0.589
DOC_WW_Pin1_4	76	81	PF00397	0.327
LIG_14-3-3_CanoR_1	28	36	PF00244	0.302
LIG_BRCT_BRCA1_1	78	82	PF00533	0.315
LIG_CaM_IQ_9	3	19	PF13499	0.396
LIG_FHA_1	213	219	PF00498	0.312
LIG_FHA_1	71	77	PF00498	0.321
LIG_LIR_Apic_2	51	56	PF02991	0.421
LIG_LIR_Gen_1	168	173	PF02991	0.360
LIG_LIR_Nem_3	168	172	PF02991	0.357
LIG_LIR_Nem_3	181	186	PF02991	0.326
LIG_LIR_Nem_3	75	81	PF02991	0.397
LIG_PDZ_Class_2	375	380	PF00595	0.423
LIG_Pex14_2	78	82	PF04695	0.328
LIG_PTB_Apo_2	226	233	PF02174	0.327
LIG_SH2_GRB2like	227	230	PF00017	0.433
LIG_SH2_NCK_1	257	261	PF00017	0.319
LIG_SH2_STAP1	213	217	PF00017	0.390
LIG_SH2_STAT5	251	254	PF00017	0.343
LIG_SH2_STAT5	264	267	PF00017	0.332
LIG_SH2_STAT5	329	332	PF00017	0.516
LIG_SH2_STAT5	5	8	PF00017	0.438
LIG_SH3_3	301	307	PF00018	0.351
LIG_SUMO_SIM_par_1	177	184	PF11976	0.364
LIG_WRC_WIRS_1	50	55	PF05994	0.514
MOD_CK1_1	233	239	PF00069	0.545
MOD_CK1_1	31	37	PF00069	0.491
MOD_CK2_1	62	68	PF00069	0.426
MOD_GlcNHglycan	258	261	PF01048	0.312
MOD_GlcNHglycan	266	269	PF01048	0.341
MOD_GlcNHglycan	282	285	PF01048	0.363
MOD_GlcNHglycan	315	318	PF01048	0.481
MOD_GSK3_1	150	157	PF00069	0.442
MOD_GSK3_1	161	168	PF00069	0.355
MOD_GSK3_1	208	215	PF00069	0.379
MOD_GSK3_1	264	271	PF00069	0.372
MOD_GSK3_1	293	300	PF00069	0.555
MOD_N-GLC_1	160	165	PF02516	0.475
MOD_N-GLC_1	208	213	PF02516	0.228
MOD_NEK2_1	1	6	PF00069	0.483
MOD_NEK2_1	150	155	PF00069	0.434
MOD_NEK2_1	207	212	PF00069	0.228
MOD_NEK2_1	272	277	PF00069	0.400
MOD_NEK2_1	293	298	PF00069	0.352
MOD_PIKK_1	28	34	PF00454	0.344
MOD_PIKK_1	355	361	PF00454	0.548
MOD_PKA_1	154	160	PF00069	0.512
MOD_PKA_1	225	231	PF00069	0.349
MOD_PKA_2	128	134	PF00069	0.462
MOD_PKA_2	165	171	PF00069	0.323
MOD_PKA_2	7	13	PF00069	0.458
MOD_PKB_1	223	231	PF00069	0.459
MOD_Plk_2-3	62	68	PF00069	0.435
MOD_Plk_4	1	7	PF00069	0.507
MOD_Plk_4	325	331	PF00069	0.452
MOD_Plk_4	49	55	PF00069	0.477
MOD_Plk_4	82	88	PF00069	0.421
MOD_ProDKin_1	233	239	PF00069	0.575
MOD_ProDKin_1	76	82	PF00069	0.322
MOD_SUMO_for_1	364	367	PF00179	0.581
TRG_DiLeu_BaEn_1	248	253	PF01217	0.365
TRG_ER_diArg_1	186	188	PF00400	0.454
TRG_ER_diArg_1	222	225	PF00400	0.306
TRG_ER_diArg_1	307	309	PF00400	0.330
TRG_ER_diArg_1	376	378	PF00400	0.566
TRG_NLS_MonoExtC_3	360	365	PF00514	0.603
TRG_NLS_MonoExtN_4	361	366	PF00514	0.597
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U9	Leptomonas seymouri	57%	77%
A0A0S4JCB2	Bodo saltans	42%	99%
A0A1X0NY04	Trypanosomatidae	44%	100%
A0A3Q8IAU3	Leishmania donovani	92%	100%
A0A3R7KMU3	Trypanosoma rangeli	47%	100%
A4HBR8	Leishmania braziliensis	84%	100%
A4HZ72	Leishmania infantum	92%	100%
D0A1G6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4QCE2	Leishmania major	94%	100%
V5BIF1	Trypanosoma cruzi	45%	100%