Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV38_LEIMU

TriTrypDb:

LmxM.21.0720

Length:

310

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AV38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV38

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	184	186	PF00675	0.490
CLV_NRD_NRD_1	191	193	PF00675	0.499
CLV_NRD_NRD_1	227	229	PF00675	0.574
CLV_PCSK_FUR_1	182	186	PF00082	0.506
CLV_PCSK_KEX2_1	184	186	PF00082	0.490
CLV_PCSK_SKI1_1	118	122	PF00082	0.455
CLV_PCSK_SKI1_1	145	149	PF00082	0.420
DEG_Nend_Nbox_1	1	3	PF02207	0.491
DEG_SCF_FBW7_1	262	268	PF00400	0.508
DEG_SCF_FBW7_2	271	278	PF00400	0.614
DEG_SPOP_SBC_1	257	261	PF00917	0.432
DEG_SPOP_SBC_1	300	304	PF00917	0.609
DOC_CKS1_1	262	267	PF01111	0.719
DOC_CKS1_1	272	277	PF01111	0.642
DOC_MAPK_MEF2A_6	126	135	PF00069	0.445
DOC_MAPK_MEF2A_6	169	177	PF00069	0.430
DOC_PP1_RVXF_1	116	122	PF00149	0.494
DOC_PP1_RVXF_1	143	150	PF00149	0.402
DOC_PP1_RVXF_1	98	104	PF00149	0.514
DOC_PP2B_LxvP_1	131	134	PF13499	0.454
DOC_USP7_MATH_1	284	288	PF00917	0.559
DOC_USP7_MATH_1	300	304	PF00917	0.604
DOC_USP7_MATH_1	78	82	PF00917	0.550
DOC_USP7_UBL2_3	44	48	PF12436	0.449
DOC_WW_Pin1_4	261	266	PF00397	0.684
DOC_WW_Pin1_4	271	276	PF00397	0.602
DOC_WW_Pin1_4	277	282	PF00397	0.606
DOC_WW_Pin1_4	301	306	PF00397	0.636
DOC_WW_Pin1_4	7	12	PF00397	0.613
LIG_14-3-3_CanoR_1	18	28	PF00244	0.663
LIG_14-3-3_CanoR_1	208	215	PF00244	0.297
LIG_AP2alpha_1	174	178	PF02296	0.416
LIG_BRCT_BRCA1_1	302	306	PF00533	0.565
LIG_BRCT_BRCA1_1	9	13	PF00533	0.549
LIG_DCNL_PONY_1	1	4	PF03556	0.486
LIG_deltaCOP1_diTrp_1	102	105	PF00928	0.360
LIG_EH_1	171	175	PF12763	0.442
LIG_EH_1	92	96	PF12763	0.405
LIG_EH1_1	197	205	PF00400	0.412
LIG_eIF4E_1	198	204	PF01652	0.465
LIG_FHA_1	123	129	PF00498	0.540
LIG_FHA_1	135	141	PF00498	0.379
LIG_FHA_1	21	27	PF00498	0.653
LIG_FHA_1	65	71	PF00498	0.652
LIG_FHA_2	219	225	PF00498	0.582
LIG_FHA_2	56	62	PF00498	0.538
LIG_GBD_Chelix_1	218	226	PF00786	0.535
LIG_LIR_Gen_1	102	107	PF02991	0.428
LIG_LIR_Gen_1	164	173	PF02991	0.454
LIG_LIR_Gen_1	176	186	PF02991	0.363
LIG_LIR_Nem_3	102	106	PF02991	0.384
LIG_LIR_Nem_3	164	168	PF02991	0.469
LIG_LIR_Nem_3	171	177	PF02991	0.421
LIG_LIR_Nem_3	274	279	PF02991	0.720
LIG_LIR_Nem_3	61	65	PF02991	0.581
LIG_Pex14_2	149	153	PF04695	0.366
LIG_Pex14_2	174	178	PF04695	0.378
LIG_SH2_STAT3	249	252	PF00017	0.692
LIG_SH2_STAT5	114	117	PF00017	0.422
LIG_SH2_STAT5	198	201	PF00017	0.465
LIG_SH2_STAT5	249	252	PF00017	0.633
LIG_SH2_STAT5	263	266	PF00017	0.681
LIG_SH2_STAT5	273	276	PF00017	0.724
LIG_SH3_3	259	265	PF00018	0.603
LIG_TRAF2_1	221	224	PF00917	0.300
LIG_TRAF2_1	31	34	PF00917	0.603
LIG_TRAF2_1	36	39	PF00917	0.580
MOD_CDK_SPxK_1	271	277	PF00069	0.583
MOD_CK1_1	210	216	PF00069	0.452
MOD_CK1_1	261	267	PF00069	0.545
MOD_CK2_1	218	224	PF00069	0.301
MOD_CK2_1	28	34	PF00069	0.613
MOD_CK2_1	55	61	PF00069	0.624
MOD_Cter_Amidation	190	193	PF01082	0.493
MOD_GlcNHglycan	115	118	PF01048	0.416
MOD_GlcNHglycan	245	248	PF01048	0.513
MOD_GlcNHglycan	286	289	PF01048	0.505
MOD_GlcNHglycan	29	33	PF01048	0.606
MOD_GlcNHglycan	296	299	PF01048	0.464
MOD_GlcNHglycan	72	75	PF01048	0.528
MOD_GlcNHglycan	80	83	PF01048	0.488
MOD_GlcNHglycan	87	90	PF01048	0.482
MOD_GSK3_1	202	209	PF00069	0.397
MOD_GSK3_1	210	217	PF00069	0.447
MOD_GSK3_1	218	225	PF00069	0.446
MOD_GSK3_1	257	264	PF00069	0.691
MOD_GSK3_1	300	307	PF00069	0.508
MOD_N-GLC_1	70	75	PF02516	0.561
MOD_NEK2_1	105	110	PF00069	0.369
MOD_NEK2_1	19	24	PF00069	0.697
MOD_NEK2_1	218	223	PF00069	0.480
MOD_NEK2_2	258	263	PF00069	0.439
MOD_PIKK_1	210	216	PF00454	0.523
MOD_PKA_2	168	174	PF00069	0.432
MOD_PKA_2	207	213	PF00069	0.351
MOD_Plk_4	108	114	PF00069	0.505
MOD_Plk_4	199	205	PF00069	0.442
MOD_Plk_4	258	264	PF00069	0.604
MOD_ProDKin_1	261	267	PF00069	0.686
MOD_ProDKin_1	271	277	PF00069	0.606
MOD_ProDKin_1	301	307	PF00069	0.637
MOD_ProDKin_1	7	13	PF00069	0.616
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.580
TRG_ENDOCYTIC_2	273	276	PF00928	0.729
TRG_ENDOCYTIC_2	49	52	PF00928	0.513
TRG_ENDOCYTIC_2	62	65	PF00928	0.579
TRG_ENDOCYTIC_2	87	90	PF00928	0.681
TRG_ER_diArg_1	181	184	PF00400	0.464
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDD8	Leptomonas seymouri	62%	100%
A0A0S4JBH7	Bodo saltans	31%	100%
A0A1X0NXM4	Trypanosomatidae	38%	100%
A0A3Q8IF37	Leishmania donovani	93%	86%
A0A3R7NME4	Trypanosoma rangeli	35%	100%
A4HZ71	Leishmania infantum	92%	86%
D0A1H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	98%
E9AIQ2	Leishmania braziliensis	79%	100%
Q4QCE3	Leishmania major	90%	100%