Putative dual specificity protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dual specificity protein phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AV36_LEIMU

TriTrypDb:

LmxM.21.0700

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AV36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV36

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016311	dephosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004721	phosphoprotein phosphatase activity	3	10
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0016791	phosphatase activity	5	10
GO:0042578	phosphoric ester hydrolase activity	4	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.630
CLV_NRD_NRD_1	272	274	PF00675	0.573
CLV_NRD_NRD_1	287	289	PF00675	0.542
CLV_NRD_NRD_1	518	520	PF00675	0.642
CLV_NRD_NRD_1	533	535	PF00675	0.654
CLV_NRD_NRD_1	608	610	PF00675	0.611
CLV_NRD_NRD_1	618	620	PF00675	0.596
CLV_PCSK_KEX2_1	153	155	PF00082	0.383
CLV_PCSK_KEX2_1	272	274	PF00082	0.574
CLV_PCSK_KEX2_1	287	289	PF00082	0.547
CLV_PCSK_KEX2_1	518	520	PF00082	0.642
CLV_PCSK_KEX2_1	532	534	PF00082	0.554
CLV_PCSK_KEX2_1	544	546	PF00082	0.550
CLV_PCSK_KEX2_1	608	610	PF00082	0.611
CLV_PCSK_KEX2_1	618	620	PF00082	0.596
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.383
CLV_PCSK_PC1ET2_1	544	546	PF00082	0.735
CLV_PCSK_PC7_1	149	155	PF00082	0.276
CLV_PCSK_PC7_1	528	534	PF00082	0.722
CLV_PCSK_SKI1_1	24	28	PF00082	0.398
CLV_PCSK_SKI1_1	347	351	PF00082	0.739
CLV_PCSK_SKI1_1	499	503	PF00082	0.778
DEG_APCC_DBOX_1	299	307	PF00400	0.677
DEG_Nend_UBRbox_2	1	3	PF02207	0.597
DEG_SCF_FBW7_1	458	465	PF00400	0.620
DEG_SPOP_SBC_1	333	337	PF00917	0.778
DEG_SPOP_SBC_1	462	466	PF00917	0.793
DOC_CKS1_1	404	409	PF01111	0.618
DOC_CKS1_1	506	511	PF01111	0.590
DOC_MAPK_gen_1	215	223	PF00069	0.613
DOC_MAPK_gen_1	298	305	PF00069	0.577
DOC_MAPK_gen_1	532	541	PF00069	0.617
DOC_PP1_RVXF_1	218	224	PF00149	0.438
DOC_PP1_RVXF_1	80	87	PF00149	0.276
DOC_PP2B_LxvP_1	379	382	PF13499	0.612
DOC_USP7_MATH_1	333	337	PF00917	0.732
DOC_USP7_MATH_1	414	418	PF00917	0.533
DOC_USP7_MATH_1	444	448	PF00917	0.509
DOC_USP7_MATH_1	462	466	PF00917	0.644
DOC_USP7_MATH_1	467	471	PF00917	0.632
DOC_USP7_MATH_1	491	495	PF00917	0.610
DOC_USP7_MATH_1	509	513	PF00917	0.607
DOC_USP7_MATH_1	514	518	PF00917	0.677
DOC_USP7_MATH_1	63	67	PF00917	0.335
DOC_USP7_UBL2_3	119	123	PF12436	0.276
DOC_USP7_UBL2_3	411	415	PF12436	0.678
DOC_WW_Pin1_4	105	110	PF00397	0.276
DOC_WW_Pin1_4	280	285	PF00397	0.580
DOC_WW_Pin1_4	384	389	PF00397	0.574
DOC_WW_Pin1_4	399	404	PF00397	0.585
DOC_WW_Pin1_4	458	463	PF00397	0.620
DOC_WW_Pin1_4	505	510	PF00397	0.668
DOC_WW_Pin1_4	512	517	PF00397	0.577
DOC_WW_Pin1_4	534	539	PF00397	0.608
DOC_WW_Pin1_4	543	548	PF00397	0.586
DOC_WW_Pin1_4	563	568	PF00397	0.489
LIG_14-3-3_CanoR_1	181	185	PF00244	0.328
LIG_14-3-3_CanoR_1	220	224	PF00244	0.499
LIG_14-3-3_CanoR_1	235	239	PF00244	0.659
LIG_14-3-3_CanoR_1	243	248	PF00244	0.655
LIG_14-3-3_CanoR_1	280	284	PF00244	0.674
LIG_14-3-3_CanoR_1	300	304	PF00244	0.425
LIG_14-3-3_CanoR_1	420	425	PF00244	0.717
LIG_14-3-3_CanoR_1	428	438	PF00244	0.694
LIG_14-3-3_CanoR_1	463	467	PF00244	0.618
LIG_14-3-3_CanoR_1	499	504	PF00244	0.726
LIG_14-3-3_CanoR_1	532	537	PF00244	0.721
LIG_Actin_WH2_2	315	331	PF00022	0.611
LIG_BIR_III_4	62	66	PF00653	0.393
LIG_BRCT_BRCA1_1	446	450	PF00533	0.462
LIG_FHA_1	23	29	PF00498	0.306
LIG_FHA_1	235	241	PF00498	0.664
LIG_FHA_1	31	37	PF00498	0.246
LIG_FHA_1	313	319	PF00498	0.690
LIG_FHA_1	430	436	PF00498	0.673
LIG_FHA_1	472	478	PF00498	0.623
LIG_FHA_1	602	608	PF00498	0.671
LIG_FHA_1	67	73	PF00498	0.316
LIG_FHA_2	220	226	PF00498	0.612
LIG_FHA_2	228	234	PF00498	0.543
LIG_FHA_2	404	410	PF00498	0.649
LIG_FHA_2	411	417	PF00498	0.819
LIG_FHA_2	498	504	PF00498	0.649
LIG_FHA_2	73	79	PF00498	0.177
LIG_LIR_Apic_2	503	509	PF02991	0.617
LIG_LIR_Gen_1	339	349	PF02991	0.638
LIG_LIR_Gen_1	373	382	PF02991	0.673
LIG_LIR_Gen_1	50	59	PF02991	0.393
LIG_LIR_Gen_1	583	588	PF02991	0.498
LIG_LIR_Nem_3	258	262	PF02991	0.606
LIG_LIR_Nem_3	339	344	PF02991	0.680
LIG_LIR_Nem_3	373	379	PF02991	0.662
LIG_LIR_Nem_3	387	392	PF02991	0.457
LIG_LIR_Nem_3	485	489	PF02991	0.582
LIG_LIR_Nem_3	50	56	PF02991	0.393
LIG_LIR_Nem_3	583	587	PF02991	0.539
LIG_NRBOX	184	190	PF00104	0.478
LIG_PCNA_yPIPBox_3	181	189	PF02747	0.467
LIG_PTB_Apo_2	193	200	PF02174	0.481
LIG_PTB_Phospho_1	193	199	PF10480	0.476
LIG_SH2_CRK	376	380	PF00017	0.672
LIG_SH2_CRK	486	490	PF00017	0.576
LIG_SH2_CRK	492	496	PF00017	0.578
LIG_SH2_CRK	506	510	PF00017	0.488
LIG_SH2_STAP1	376	380	PF00017	0.672
LIG_SH2_STAT3	190	193	PF00017	0.496
LIG_SH2_STAT5	130	133	PF00017	0.403
LIG_SH2_STAT5	506	509	PF00017	0.507
LIG_SH2_STAT5	540	543	PF00017	0.624
LIG_SH2_STAT5	55	58	PF00017	0.306
LIG_SH3_3	205	211	PF00018	0.539
LIG_SH3_3	245	251	PF00018	0.689
LIG_SH3_3	355	361	PF00018	0.660
LIG_SH3_3	475	481	PF00018	0.611
LIG_SH3_4	141	148	PF00018	0.393
LIG_SUMO_SIM_anti_2	25	30	PF11976	0.341
LIG_TYR_ITIM	374	379	PF00017	0.671
LIG_UBA3_1	128	132	PF00899	0.341
LIG_UBA3_1	184	191	PF00899	0.388
LIG_UBA3_1	26	31	PF00899	0.341
MOD_CDC14_SPxK_1	515	518	PF00782	0.667
MOD_CDK_SPK_2	403	408	PF00069	0.616
MOD_CDK_SPK_2	458	463	PF00069	0.660
MOD_CDK_SPK_2	505	510	PF00069	0.505
MOD_CDK_SPK_2	563	568	PF00069	0.706
MOD_CDK_SPxK_1	512	518	PF00069	0.663
MOD_CDK_SPxxK_3	280	287	PF00069	0.547
MOD_CDK_SPxxK_3	403	410	PF00069	0.620
MOD_CDK_SPxxK_3	512	519	PF00069	0.628
MOD_CK1_1	234	240	PF00069	0.650
MOD_CK1_1	276	282	PF00069	0.641
MOD_CK1_1	283	289	PF00069	0.642
MOD_CK1_1	308	314	PF00069	0.704
MOD_CK1_1	336	342	PF00069	0.589
MOD_CK1_1	367	373	PF00069	0.678
MOD_CK1_1	434	440	PF00069	0.660
MOD_CK1_1	453	459	PF00069	0.599
MOD_CK1_1	482	488	PF00069	0.685
MOD_CK1_1	505	511	PF00069	0.604
MOD_CK1_1	512	518	PF00069	0.646
MOD_CK1_1	54	60	PF00069	0.379
MOD_CK1_1	583	589	PF00069	0.628
MOD_CK1_1	601	607	PF00069	0.564
MOD_CK1_1	613	619	PF00069	0.755
MOD_CK1_1	66	72	PF00069	0.232
MOD_CK2_1	339	345	PF00069	0.674
MOD_CK2_1	363	369	PF00069	0.714
MOD_CK2_1	410	416	PF00069	0.826
MOD_CK2_1	497	503	PF00069	0.646
MOD_CK2_1	551	557	PF00069	0.736
MOD_Cter_Amidation	270	273	PF01082	0.652
MOD_DYRK1A_RPxSP_1	280	284	PF00069	0.567
MOD_DYRK1A_RPxSP_1	563	567	PF00069	0.776
MOD_GlcNHglycan	125	128	PF01048	0.300
MOD_GlcNHglycan	252	255	PF01048	0.741
MOD_GlcNHglycan	307	310	PF01048	0.577
MOD_GlcNHglycan	325	328	PF01048	0.605
MOD_GlcNHglycan	330	333	PF01048	0.749
MOD_GlcNHglycan	366	369	PF01048	0.637
MOD_GlcNHglycan	442	445	PF01048	0.664
MOD_GlcNHglycan	481	484	PF01048	0.694
MOD_GlcNHglycan	528	531	PF01048	0.756
MOD_GlcNHglycan	547	550	PF01048	0.607
MOD_GlcNHglycan	553	556	PF01048	0.622
MOD_GlcNHglycan	576	579	PF01048	0.795
MOD_GlcNHglycan	592	595	PF01048	0.538
MOD_GSK3_1	219	226	PF00069	0.589
MOD_GSK3_1	227	234	PF00069	0.495
MOD_GSK3_1	276	283	PF00069	0.560
MOD_GSK3_1	307	314	PF00069	0.687
MOD_GSK3_1	328	335	PF00069	0.650
MOD_GSK3_1	363	370	PF00069	0.685
MOD_GSK3_1	380	387	PF00069	0.483
MOD_GSK3_1	388	395	PF00069	0.582
MOD_GSK3_1	399	406	PF00069	0.641
MOD_GSK3_1	410	417	PF00069	0.649
MOD_GSK3_1	420	427	PF00069	0.664
MOD_GSK3_1	429	436	PF00069	0.571
MOD_GSK3_1	440	447	PF00069	0.569
MOD_GSK3_1	450	457	PF00069	0.624
MOD_GSK3_1	458	465	PF00069	0.593
MOD_GSK3_1	467	474	PF00069	0.543
MOD_GSK3_1	505	512	PF00069	0.677
MOD_GSK3_1	522	529	PF00069	0.664
MOD_GSK3_1	539	546	PF00069	0.515
MOD_GSK3_1	549	556	PF00069	0.610
MOD_GSK3_1	559	566	PF00069	0.655
MOD_GSK3_1	576	583	PF00069	0.559
MOD_GSK3_1	586	593	PF00069	0.635
MOD_GSK3_1	610	617	PF00069	0.610
MOD_GSK3_1	63	70	PF00069	0.393
MOD_LATS_1	418	424	PF00433	0.776
MOD_N-GLC_1	399	404	PF02516	0.747
MOD_N-GLC_1	430	435	PF02516	0.502
MOD_N-GLC_1	580	585	PF02516	0.703
MOD_N-GLC_1	589	594	PF02516	0.648
MOD_NEK2_1	180	185	PF00069	0.326
MOD_NEK2_1	223	228	PF00069	0.533
MOD_NEK2_1	278	283	PF00069	0.578
MOD_NEK2_1	328	333	PF00069	0.785
MOD_NEK2_1	363	368	PF00069	0.715
MOD_NEK2_1	392	397	PF00069	0.587
MOD_NEK2_1	450	455	PF00069	0.609
MOD_NEK2_1	580	585	PF00069	0.718
MOD_NEK2_1	98	103	PF00069	0.276
MOD_PIKK_1	166	172	PF00454	0.449
MOD_PIKK_1	380	386	PF00454	0.677
MOD_PIKK_1	549	555	PF00454	0.815
MOD_PK_1	273	279	PF00069	0.609
MOD_PKA_1	227	233	PF00069	0.632
MOD_PKA_1	410	416	PF00069	0.678
MOD_PKA_1	532	538	PF00069	0.783
MOD_PKA_2	180	186	PF00069	0.335
MOD_PKA_2	219	225	PF00069	0.477
MOD_PKA_2	234	240	PF00069	0.606
MOD_PKA_2	279	285	PF00069	0.714
MOD_PKA_2	299	305	PF00069	0.432
MOD_PKA_2	323	329	PF00069	0.611
MOD_PKA_2	364	370	PF00069	0.693
MOD_PKA_2	462	468	PF00069	0.621
MOD_PKA_2	471	477	PF00069	0.641
MOD_PKA_2	479	485	PF00069	0.551
MOD_PKA_2	509	515	PF00069	0.633
MOD_PKA_2	532	538	PF00069	0.635
MOD_Plk_1	166	172	PF00069	0.413
MOD_Plk_1	22	28	PF00069	0.393
MOD_Plk_1	430	436	PF00069	0.539
MOD_Plk_1	580	586	PF00069	0.716
MOD_Plk_4	180	186	PF00069	0.335
MOD_Plk_4	22	28	PF00069	0.393
MOD_Plk_4	255	261	PF00069	0.741
MOD_Plk_4	273	279	PF00069	0.463
MOD_Plk_4	610	616	PF00069	0.588
MOD_Plk_4	67	73	PF00069	0.406
MOD_Plk_4	98	104	PF00069	0.404
MOD_ProDKin_1	105	111	PF00069	0.276
MOD_ProDKin_1	280	286	PF00069	0.580
MOD_ProDKin_1	384	390	PF00069	0.574
MOD_ProDKin_1	399	405	PF00069	0.586
MOD_ProDKin_1	458	464	PF00069	0.621
MOD_ProDKin_1	505	511	PF00069	0.668
MOD_ProDKin_1	512	518	PF00069	0.580
MOD_ProDKin_1	534	540	PF00069	0.611
MOD_ProDKin_1	543	549	PF00069	0.588
MOD_ProDKin_1	563	569	PF00069	0.488
MOD_SUMO_rev_2	137	142	PF00179	0.393
MOD_SUMO_rev_2	339	349	PF00179	0.646
MOD_SUMO_rev_2	554	560	PF00179	0.660
TRG_DiLeu_BaEn_2	254	260	PF01217	0.642
TRG_ENDOCYTIC_2	115	118	PF00928	0.276
TRG_ENDOCYTIC_2	130	133	PF00928	0.276
TRG_ENDOCYTIC_2	376	379	PF00928	0.671
TRG_ENDOCYTIC_2	486	489	PF00928	0.579
TRG_ENDOCYTIC_2	492	495	PF00928	0.580
TRG_ENDOCYTIC_2	55	58	PF00928	0.276
TRG_ER_diArg_1	272	274	PF00400	0.580
TRG_ER_diArg_1	287	289	PF00400	0.556
TRG_ER_diArg_1	532	534	PF00400	0.705
TRG_ER_diArg_1	560	563	PF00400	0.794
TRG_ER_diArg_1	607	609	PF00400	0.613
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	287	292	PF00026	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I8	Leptomonas seymouri	58%	93%
A0A1X0NXL0	Trypanosomatidae	42%	100%
A0A3Q8IAA7	Leishmania donovani	93%	100%
A0A3R7MFE4	Trypanosoma rangeli	41%	100%
A4HBR6	Leishmania braziliensis	79%	100%
A4HZ69	Leishmania infantum	93%	100%
D0A1G8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q4QCE5	Leishmania major	90%	100%