Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV31_LEIMU

TriTrypDb:

LmxM.21.0650

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AV31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV31

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.675
CLV_C14_Caspase3-7	343	347	PF00656	0.470
CLV_NRD_NRD_1	230	232	PF00675	0.616
CLV_NRD_NRD_1	237	239	PF00675	0.547
CLV_NRD_NRD_1	310	312	PF00675	0.397
CLV_NRD_NRD_1	589	591	PF00675	0.473
CLV_NRD_NRD_1	604	606	PF00675	0.596
CLV_PCSK_FUR_1	235	239	PF00082	0.528
CLV_PCSK_KEX2_1	230	232	PF00082	0.574
CLV_PCSK_KEX2_1	237	239	PF00082	0.488
CLV_PCSK_KEX2_1	247	249	PF00082	0.424
CLV_PCSK_KEX2_1	310	312	PF00082	0.397
CLV_PCSK_KEX2_1	589	591	PF00082	0.473
CLV_PCSK_KEX2_1	604	606	PF00082	0.426
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.533
CLV_PCSK_PC7_1	585	591	PF00082	0.429
CLV_PCSK_SKI1_1	301	305	PF00082	0.475
CLV_PCSK_SKI1_1	310	314	PF00082	0.402
CLV_PCSK_SKI1_1	351	355	PF00082	0.385
CLV_PCSK_SKI1_1	364	368	PF00082	0.448
CLV_PCSK_SKI1_1	498	502	PF00082	0.446
CLV_PCSK_SKI1_1	536	540	PF00082	0.415
CLV_PCSK_SKI1_1	614	618	PF00082	0.464
DEG_APCC_DBOX_1	236	244	PF00400	0.543
DEG_APCC_DBOX_1	300	308	PF00400	0.288
DEG_APCC_DBOX_1	497	505	PF00400	0.529
DOC_CKS1_1	326	331	PF01111	0.486
DOC_MAPK_gen_1	16	24	PF00069	0.390
DOC_MAPK_gen_1	310	318	PF00069	0.394
DOC_MAPK_gen_1	348	357	PF00069	0.267
DOC_MAPK_MEF2A_6	310	318	PF00069	0.426
DOC_MAPK_MEF2A_6	79	87	PF00069	0.507
DOC_PP1_RVXF_1	236	243	PF00149	0.479
DOC_PP2B_LxvP_1	541	544	PF13499	0.473
DOC_PP2B_PxIxI_1	32	38	PF00149	0.393
DOC_PP4_FxxP_1	481	484	PF00568	0.480
DOC_USP7_MATH_1	110	114	PF00917	0.746
DOC_USP7_MATH_1	129	133	PF00917	0.335
DOC_USP7_MATH_1	195	199	PF00917	0.690
DOC_USP7_MATH_1	3	7	PF00917	0.499
DOC_USP7_MATH_1	382	386	PF00917	0.732
DOC_USP7_MATH_1	398	402	PF00917	0.624
DOC_USP7_MATH_1	420	424	PF00917	0.601
DOC_USP7_MATH_1	490	494	PF00917	0.422
DOC_USP7_MATH_1	503	507	PF00917	0.577
DOC_USP7_MATH_1	78	82	PF00917	0.266
DOC_WW_Pin1_4	158	163	PF00397	0.427
DOC_WW_Pin1_4	29	34	PF00397	0.377
DOC_WW_Pin1_4	310	315	PF00397	0.463
DOC_WW_Pin1_4	325	330	PF00397	0.375
DOC_WW_Pin1_4	522	527	PF00397	0.648
DOC_WW_Pin1_4	551	556	PF00397	0.643
LIG_14-3-3_CanoR_1	351	356	PF00244	0.503
LIG_14-3-3_CanoR_1	433	440	PF00244	0.544
LIG_14-3-3_CanoR_1	492	502	PF00244	0.480
LIG_14-3-3_CanoR_1	79	87	PF00244	0.442
LIG_BIR_II_1	1	5	PF00653	0.382
LIG_BRCT_BRCA1_1	529	533	PF00533	0.502
LIG_deltaCOP1_diTrp_1	464	471	PF00928	0.453
LIG_deltaCOP1_diTrp_1	576	584	PF00928	0.400
LIG_eIF4E_1	489	495	PF01652	0.479
LIG_EVH1_1	501	505	PF00568	0.526
LIG_FHA_1	128	134	PF00498	0.414
LIG_FHA_1	30	36	PF00498	0.369
LIG_FHA_1	311	317	PF00498	0.493
LIG_FHA_1	352	358	PF00498	0.506
LIG_FHA_1	387	393	PF00498	0.753
LIG_FHA_1	410	416	PF00498	0.407
LIG_FHA_1	434	440	PF00498	0.592
LIG_FHA_2	253	259	PF00498	0.478
LIG_FHA_2	535	541	PF00498	0.400
LIG_Integrin_RGD_1	394	396	PF01839	0.515
LIG_LIR_Gen_1	401	410	PF02991	0.443
LIG_LIR_Gen_1	537	544	PF02991	0.326
LIG_LIR_Nem_3	401	405	PF02991	0.445
LIG_LIR_Nem_3	423	429	PF02991	0.573
LIG_LIR_Nem_3	485	489	PF02991	0.502
LIG_LIR_Nem_3	537	542	PF02991	0.323
LIG_MYND_1	499	503	PF01753	0.553
LIG_SH2_CRK	427	431	PF00017	0.475
LIG_SH2_CRK	479	483	PF00017	0.500
LIG_SH2_NCK_1	550	554	PF00017	0.588
LIG_SH2_STAP1	534	538	PF00017	0.467
LIG_SH2_STAT5	414	417	PF00017	0.587
LIG_SH3_1	552	558	PF00018	0.471
LIG_SH3_2	523	528	PF14604	0.644
LIG_SH3_3	206	212	PF00018	0.532
LIG_SH3_3	267	273	PF00018	0.337
LIG_SH3_3	290	296	PF00018	0.540
LIG_SH3_3	419	425	PF00018	0.579
LIG_SH3_3	496	502	PF00018	0.543
LIG_SH3_3	504	510	PF00018	0.631
LIG_SH3_3	520	526	PF00018	0.607
LIG_SH3_3	552	558	PF00018	0.638
LIG_SH3_CIN85_PxpxPR_1	160	165	PF14604	0.467
LIG_Sin3_3	567	574	PF02671	0.470
LIG_SUMO_SIM_anti_2	315	320	PF11976	0.468
LIG_SUMO_SIM_par_1	81	91	PF11976	0.485
LIG_TRAF2_1	23	26	PF00917	0.516
LIG_TRAF2_1	609	612	PF00917	0.521
LIG_WRC_WIRS_1	4	9	PF05994	0.356
LIG_WW_3	554	558	PF00397	0.605
MOD_CDC14_SPxK_1	525	528	PF00782	0.645
MOD_CDC14_SPxK_1	554	557	PF00782	0.603
MOD_CDK_SPxK_1	522	528	PF00069	0.649
MOD_CDK_SPxK_1	551	557	PF00069	0.616
MOD_CDK_SPxxK_3	158	165	PF00069	0.360
MOD_CDK_SPxxK_3	29	36	PF00069	0.287
MOD_CK1_1	111	117	PF00069	0.714
MOD_CK1_1	2	8	PF00069	0.408
MOD_CK1_1	289	295	PF00069	0.500
MOD_CK1_1	359	365	PF00069	0.418
MOD_CK1_1	431	437	PF00069	0.594
MOD_CK1_1	493	499	PF00069	0.488
MOD_CK1_1	50	56	PF00069	0.317
MOD_CK1_1	527	533	PF00069	0.536
MOD_CK2_1	213	219	PF00069	0.611
MOD_CK2_1	252	258	PF00069	0.592
MOD_CK2_1	289	295	PF00069	0.499
MOD_CK2_1	534	540	PF00069	0.409
MOD_CK2_1	87	93	PF00069	0.450
MOD_CMANNOS	146	149	PF00535	0.345
MOD_GlcNHglycan	1	4	PF01048	0.503
MOD_GlcNHglycan	110	113	PF01048	0.716
MOD_GlcNHglycan	118	121	PF01048	0.667
MOD_GlcNHglycan	141	144	PF01048	0.396
MOD_GlcNHglycan	227	230	PF01048	0.591
MOD_GlcNHglycan	232	235	PF01048	0.639
MOD_GlcNHglycan	288	291	PF01048	0.612
MOD_GlcNHglycan	384	387	PF01048	0.621
MOD_GlcNHglycan	389	392	PF01048	0.573
MOD_GlcNHglycan	529	532	PF01048	0.607
MOD_GSK3_1	100	107	PF00069	0.508
MOD_GSK3_1	27	34	PF00069	0.452
MOD_GSK3_1	282	289	PF00069	0.497
MOD_GSK3_1	306	313	PF00069	0.564
MOD_GSK3_1	328	335	PF00069	0.602
MOD_GSK3_1	382	389	PF00069	0.705
MOD_GSK3_1	405	412	PF00069	0.370
MOD_GSK3_1	428	435	PF00069	0.607
MOD_N-GLC_1	386	391	PF02516	0.661
MOD_NEK2_1	102	107	PF00069	0.496
MOD_NEK2_1	128	133	PF00069	0.499
MOD_NEK2_1	141	146	PF00069	0.392
MOD_NEK2_1	252	257	PF00069	0.565
MOD_NEK2_1	306	311	PF00069	0.422
MOD_NEK2_1	429	434	PF00069	0.639
MOD_NEK2_1	598	603	PF00069	0.478
MOD_NEK2_1	95	100	PF00069	0.395
MOD_NEK2_2	534	539	PF00069	0.267
MOD_PIKK_1	100	106	PF00454	0.561
MOD_PIKK_1	141	147	PF00454	0.398
MOD_PIKK_1	368	374	PF00454	0.523
MOD_PKA_1	230	236	PF00069	0.597
MOD_PKA_1	589	595	PF00069	0.446
MOD_PKA_2	230	236	PF00069	0.618
MOD_PKA_2	359	365	PF00069	0.453
MOD_PKA_2	368	374	PF00069	0.493
MOD_PKA_2	432	438	PF00069	0.559
MOD_PKA_2	589	595	PF00069	0.472
MOD_PKA_2	78	84	PF00069	0.355
MOD_Plk_1	238	244	PF00069	0.560
MOD_Plk_1	332	338	PF00069	0.530
MOD_Plk_1	387	393	PF00069	0.732
MOD_Plk_1	88	94	PF00069	0.438
MOD_Plk_4	196	202	PF00069	0.623
MOD_Plk_4	238	244	PF00069	0.540
MOD_Plk_4	3	9	PF00069	0.366
MOD_Plk_4	351	357	PF00069	0.559
MOD_Plk_4	410	416	PF00069	0.572
MOD_Plk_4	435	441	PF00069	0.546
MOD_Plk_4	598	604	PF00069	0.551
MOD_ProDKin_1	158	164	PF00069	0.425
MOD_ProDKin_1	29	35	PF00069	0.367
MOD_ProDKin_1	310	316	PF00069	0.461
MOD_ProDKin_1	325	331	PF00069	0.377
MOD_ProDKin_1	522	528	PF00069	0.649
MOD_ProDKin_1	551	557	PF00069	0.641
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.462
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.553
TRG_ENDOCYTIC_2	427	430	PF00928	0.471
TRG_ENDOCYTIC_2	478	481	PF00928	0.483
TRG_ER_diArg_1	230	232	PF00400	0.607
TRG_ER_diArg_1	248	251	PF00400	0.650
TRG_ER_diArg_1	310	312	PF00400	0.397
TRG_ER_diArg_1	588	590	PF00400	0.455
TRG_ER_diArg_1	603	605	PF00400	0.443
TRG_ER_diArg_1	628	631	PF00400	0.443
TRG_NES_CRM1_1	442	455	PF08389	0.540
TRG_NLS_Bipartite_1	230	251	PF00514	0.579
TRG_NLS_MonoExtN_4	244	251	PF00514	0.578
TRG_Pf-PMV_PEXEL_1	310	315	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAU6	Leptomonas seymouri	49%	100%
A0A1X0NYZ1	Trypanosomatidae	24%	100%
A0A3Q8IBW5	Leishmania donovani	90%	100%
A0A422NHB0	Trypanosoma rangeli	25%	100%
A4HBR2	Leishmania braziliensis	77%	100%
A4HZ64	Leishmania infantum	90%	80%
Q4QCF0	Leishmania major	90%	100%
V5BIF6	Trypanosoma cruzi	25%	100%