Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoglucomutase, putative

Species:

Leishmania mexicana

UniProt:

E9AV30_LEIMU

TriTrypDb:

LmxM.21.0640

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AV30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV30

PDB structure(s): 4qg5_A , 4qg5_B , 4qg5_C , 4qg5_D

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	11
GO:0003824	catalytic activity	1	11
GO:0004614	phosphoglucomutase activity	5	11
GO:0005488	binding	1	11
GO:0016853	isomerase activity	2	11
GO:0016866	intramolecular transferase activity	3	11
GO:0016868	intramolecular transferase activity, phosphotransferases	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.401
CLV_NRD_NRD_1	101	103	PF00675	0.312
CLV_NRD_NRD_1	18	20	PF00675	0.312
CLV_NRD_NRD_1	581	583	PF00675	0.557
CLV_NRD_NRD_1	79	81	PF00675	0.401
CLV_PCSK_FUR_1	99	103	PF00082	0.291
CLV_PCSK_KEX2_1	425	427	PF00082	0.359
CLV_PCSK_KEX2_1	79	81	PF00082	0.342
CLV_PCSK_KEX2_1	99	101	PF00082	0.319
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.359
CLV_PCSK_SKI1_1	159	163	PF00082	0.322
CLV_PCSK_SKI1_1	20	24	PF00082	0.333
CLV_PCSK_SKI1_1	511	515	PF00082	0.313
CLV_PCSK_SKI1_1	519	523	PF00082	0.313
DEG_Nend_UBRbox_2	1	3	PF02207	0.515
DEG_SCF_FBW7_1	88	95	PF00400	0.313
DOC_AGCK_PIF_1	177	182	PF00069	0.272
DOC_ANK_TNKS_1	100	107	PF00023	0.359
DOC_CKS1_1	429	434	PF01111	0.359
DOC_CKS1_1	89	94	PF01111	0.294
DOC_MAPK_DCC_7	159	169	PF00069	0.502
DOC_MAPK_MEF2A_6	507	514	PF00069	0.317
DOC_MAPK_RevD_3	569	583	PF00069	0.509
DOC_PP1_RVXF_1	509	515	PF00149	0.313
DOC_PP2B_LxvP_1	238	241	PF13499	0.313
DOC_PP4_FxxP_1	25	28	PF00568	0.373
DOC_PP4_FxxP_1	313	316	PF00568	0.316
DOC_PP4_FxxP_1	366	369	PF00568	0.313
DOC_SPAK_OSR1_1	311	315	PF12202	0.342
DOC_USP7_MATH_1	13	17	PF00917	0.313
DOC_USP7_MATH_1	241	245	PF00917	0.390
DOC_USP7_MATH_1	316	320	PF00917	0.328
DOC_USP7_MATH_1	557	561	PF00917	0.525
DOC_USP7_MATH_1	92	96	PF00917	0.338
DOC_WD40_RPTOR_TOS_1	182	188	PF00400	0.386
DOC_WW_Pin1_4	428	433	PF00397	0.352
DOC_WW_Pin1_4	581	586	PF00397	0.487
DOC_WW_Pin1_4	88	93	PF00397	0.311
LIG_14-3-3_CanoR_1	19	25	PF00244	0.386
LIG_14-3-3_CanoR_1	59	69	PF00244	0.337
LIG_APCC_ABBA_1	215	220	PF00400	0.451
LIG_APCC_ABBA_1	534	539	PF00400	0.313
LIG_BIR_III_4	103	107	PF00653	0.359
LIG_deltaCOP1_diTrp_1	411	419	PF00928	0.294
LIG_FHA_1	13	19	PF00498	0.299
LIG_FHA_1	143	149	PF00498	0.300
LIG_FHA_1	150	156	PF00498	0.286
LIG_FHA_1	246	252	PF00498	0.409
LIG_FHA_1	429	435	PF00498	0.390
LIG_FHA_1	495	501	PF00498	0.453
LIG_FHA_1	531	537	PF00498	0.340
LIG_FHA_1	582	588	PF00498	0.625
LIG_FHA_1	89	95	PF00498	0.308
LIG_FHA_2	161	167	PF00498	0.551
LIG_FHA_2	174	180	PF00498	0.349
LIG_LIR_Apic_2	23	28	PF02991	0.373
LIG_LIR_Apic_2	493	499	PF02991	0.311
LIG_LIR_Gen_1	202	210	PF02991	0.321
LIG_LIR_Gen_1	37	47	PF02991	0.339
LIG_LIR_Gen_1	411	422	PF02991	0.294
LIG_LIR_Gen_1	456	465	PF02991	0.389
LIG_LIR_LC3C_4	50	54	PF02991	0.373
LIG_LIR_Nem_3	174	180	PF02991	0.439
LIG_LIR_Nem_3	192	196	PF02991	0.213
LIG_LIR_Nem_3	202	206	PF02991	0.318
LIG_LIR_Nem_3	37	42	PF02991	0.295
LIG_LIR_Nem_3	370	375	PF02991	0.285
LIG_LIR_Nem_3	389	393	PF02991	0.294
LIG_LIR_Nem_3	411	417	PF02991	0.294
LIG_LIR_Nem_3	441	447	PF02991	0.331
LIG_LIR_Nem_3	456	460	PF02991	0.357
LIG_PCNA_PIPBox_1	437	446	PF02747	0.373
LIG_Pex14_1	414	418	PF04695	0.313
LIG_Pex14_2	294	298	PF04695	0.313
LIG_Rb_LxCxE_1	389	409	PF01857	0.296
LIG_SH2_NCK_1	457	461	PF00017	0.413
LIG_SH2_SRC	457	460	PF00017	0.382
LIG_SH2_STAP1	149	153	PF00017	0.313
LIG_SH2_STAP1	180	184	PF00017	0.437
LIG_SH2_STAP1	193	197	PF00017	0.334
LIG_SH2_STAP1	265	269	PF00017	0.294
LIG_SH2_STAP1	30	34	PF00017	0.359
LIG_SH2_STAP1	61	65	PF00017	0.359
LIG_SH2_STAT3	180	183	PF00017	0.414
LIG_SH2_STAT3	537	540	PF00017	0.337
LIG_SH2_STAT3	8	11	PF00017	0.464
LIG_SH2_STAT5	175	178	PF00017	0.536
LIG_SH2_STAT5	229	232	PF00017	0.373
LIG_SH2_STAT5	30	33	PF00017	0.294
LIG_SH2_STAT5	496	499	PF00017	0.427
LIG_SH2_STAT5	537	540	PF00017	0.337
LIG_SH2_STAT5	61	64	PF00017	0.316
LIG_SH3_1	426	432	PF00018	0.359
LIG_SH3_3	118	124	PF00018	0.339
LIG_SH3_3	222	228	PF00018	0.362
LIG_SH3_3	426	432	PF00018	0.377
LIG_SUMO_SIM_anti_2	317	324	PF11976	0.313
LIG_SUMO_SIM_anti_2	50	55	PF11976	0.405
LIG_UBA3_1	417	425	PF00899	0.359
LIG_WRC_WIRS_1	291	296	PF05994	0.359
MOD_CK1_1	336	342	PF00069	0.315
MOD_CK1_1	347	353	PF00069	0.299
MOD_CK1_1	399	405	PF00069	0.313
MOD_CK1_1	503	509	PF00069	0.366
MOD_CK1_1	530	536	PF00069	0.353
MOD_CK2_1	160	166	PF00069	0.554
MOD_CK2_1	546	552	PF00069	0.271
MOD_CK2_1	571	577	PF00069	0.471
MOD_Cter_Amidation	580	583	PF01082	0.544
MOD_GlcNHglycan	133	136	PF01048	0.283
MOD_GlcNHglycan	15	18	PF01048	0.314
MOD_GlcNHglycan	225	228	PF01048	0.342
MOD_GlcNHglycan	335	338	PF01048	0.438
MOD_GlcNHglycan	350	353	PF01048	0.258
MOD_GlcNHglycan	458	463	PF01048	0.492
MOD_GlcNHglycan	524	527	PF01048	0.337
MOD_GlcNHglycan	529	532	PF01048	0.313
MOD_GlcNHglycan	563	566	PF01048	0.325
MOD_GlcNHglycan	72	75	PF01048	0.359
MOD_GSK3_1	149	156	PF00069	0.360
MOD_GSK3_1	241	248	PF00069	0.454
MOD_GSK3_1	331	338	PF00069	0.360
MOD_GSK3_1	344	351	PF00069	0.307
MOD_GSK3_1	468	475	PF00069	0.587
MOD_GSK3_1	522	529	PF00069	0.313
MOD_GSK3_1	551	558	PF00069	0.371
MOD_GSK3_1	571	578	PF00069	0.439
MOD_GSK3_1	88	95	PF00069	0.326
MOD_LATS_1	157	163	PF00433	0.273
MOD_N-GLC_1	261	266	PF02516	0.294
MOD_N-GLC_1	28	33	PF02516	0.445
MOD_NEK2_1	113	118	PF00069	0.294
MOD_NEK2_1	160	165	PF00069	0.462
MOD_NEK2_1	245	250	PF00069	0.490
MOD_NEK2_1	333	338	PF00069	0.358
MOD_NEK2_1	34	39	PF00069	0.313
MOD_NEK2_1	418	423	PF00069	0.313
MOD_NEK2_1	522	527	PF00069	0.364
MOD_NEK2_1	551	556	PF00069	0.316
MOD_NEK2_1	571	576	PF00069	0.390
MOD_NEK2_1	70	75	PF00069	0.359
MOD_NEK2_2	149	154	PF00069	0.337
MOD_NEK2_2	241	246	PF00069	0.427
MOD_PIKK_1	143	149	PF00454	0.484
MOD_PIKK_1	331	337	PF00454	0.408
MOD_PKA_1	20	26	PF00069	0.385
MOD_PKA_2	522	528	PF00069	0.326
MOD_Plk_1	149	155	PF00069	0.313
MOD_Plk_1	178	184	PF00069	0.276
MOD_Plk_1	261	267	PF00069	0.294
MOD_Plk_1	396	402	PF00069	0.294
MOD_Plk_1	472	478	PF00069	0.416
MOD_Plk_1	492	498	PF00069	0.307
MOD_Plk_1	551	557	PF00069	0.467
MOD_Plk_2-3	492	498	PF00069	0.427
MOD_Plk_4	20	26	PF00069	0.373
MOD_Plk_4	241	247	PF00069	0.384
MOD_Plk_4	413	419	PF00069	0.313
MOD_Plk_4	583	589	PF00069	0.446
MOD_Plk_4	93	99	PF00069	0.359
MOD_ProDKin_1	428	434	PF00069	0.352
MOD_ProDKin_1	581	587	PF00069	0.485
MOD_ProDKin_1	88	94	PF00069	0.311
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.322
TRG_ENDOCYTIC_2	457	460	PF00928	0.363
TRG_ER_diArg_1	78	80	PF00400	0.401
TRG_ER_diArg_1	98	101	PF00400	0.315
TRG_Pf-PMV_PEXEL_1	511	515	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD7	Leptomonas seymouri	78%	99%
A0A0S4IYR2	Bodo saltans	60%	100%
A0A1X0NXZ7	Trypanosomatidae	64%	100%
A0A3Q8IBZ3	Leishmania donovani	95%	100%
A0A3S5IR70	Trypanosoma rangeli	61%	100%
A4HBR1	Leishmania braziliensis	90%	100%
A4HZ63	Leishmania infantum	95%	100%
D3ZVR9	Rattus norvegicus	44%	100%
O02606	Paramecium tetraurelia	49%	100%
O15820	Entamoeba histolytica	45%	100%
O18719	Entamoeba dispar	45%	100%
O49299	Arabidopsis thaliana	55%	100%
O74374	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
P00949	Oryctolagus cuniculus	49%	100%
P33401	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	100%
P36871	Homo sapiens	50%	100%
P36938	Escherichia coli (strain K12)	28%	100%
P37012	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	100%
P38569	Komagataeibacter xylinus	26%	100%
P38652	Rattus norvegicus	49%	100%
P39671	Rhizobium radiobacter	50%	100%
P47244	Paramecium tetraurelia	49%	100%
P57749	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	48%	100%
P93262	Mesembryanthemum crystallinum	54%	100%
P93804	Zea mays	56%	100%
P93805	Zea mays	55%	100%
Q08DP0	Bos taurus	49%	100%
Q15124	Homo sapiens	43%	100%
Q23919	Dictyostelium discoideum	48%	100%
Q4QCF1	Leishmania major	95%	100%
Q4R5E4	Macaca fascicularis	49%	100%
Q4WY53	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	48%	100%
Q8BZF8	Mus musculus	44%	100%
Q9D0F9	Mus musculus	49%	100%
Q9M4G4	Solanum tuberosum	55%	100%
Q9M4G5	Solanum tuberosum	50%	93%
Q9P931	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	49%	100%
Q9SCY0	Arabidopsis thaliana	50%	95%
Q9SGC1	Arabidopsis thaliana	56%	100%
Q9SM59	Pisum sativum	51%	94%
Q9SM60	Pisum sativum	54%	100%
Q9SMM0	Brassica napus	50%	94%
Q9SNX2	Bromus inermis	56%	100%
Q9VUY9	Drosophila melanogaster	49%	100%
Q9ZSQ4	Populus tremula	55%	100%
V5BMZ6	Trypanosoma cruzi	63%	98%