Putative DNA polymerase eta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase eta, putative

Species:

Leishmania mexicana

UniProt:

E9AV29_LEIMU

TriTrypDb:

LmxM.21.0620

Length:

772

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005657	replication fork	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0035861	site of double-strand break	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0090734	site of DNA damage	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AV29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV29

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006281	DNA repair	5	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0033554	cellular response to stress	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:0000731	DNA synthesis involved in DNA repair	6	1
GO:0006301	postreplication repair	6	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009314	response to radiation	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019985	translesion synthesis	7	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0042276	error-prone translesion synthesis	8	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0071897	DNA biosynthetic process	5	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003684	damaged DNA binding	5	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003824	catalytic activity	1	1
GO:0003887	DNA-directed DNA polymerase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034061	DNA polymerase activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.749
CLV_C14_Caspase3-7	488	492	PF00656	0.352
CLV_C14_Caspase3-7	539	543	PF00656	0.683
CLV_MEL_PAP_1	439	445	PF00089	0.383
CLV_NRD_NRD_1	150	152	PF00675	0.419
CLV_NRD_NRD_1	182	184	PF00675	0.306
CLV_NRD_NRD_1	364	366	PF00675	0.715
CLV_NRD_NRD_1	471	473	PF00675	0.657
CLV_NRD_NRD_1	507	509	PF00675	0.493
CLV_NRD_NRD_1	519	521	PF00675	0.833
CLV_NRD_NRD_1	635	637	PF00675	0.721
CLV_NRD_NRD_1	755	757	PF00675	0.564
CLV_PCSK_FUR_1	632	636	PF00082	0.541
CLV_PCSK_KEX2_1	150	152	PF00082	0.419
CLV_PCSK_KEX2_1	182	184	PF00082	0.306
CLV_PCSK_KEX2_1	366	368	PF00082	0.653
CLV_PCSK_KEX2_1	471	473	PF00082	0.657
CLV_PCSK_KEX2_1	519	521	PF00082	0.834
CLV_PCSK_KEX2_1	632	634	PF00082	0.720
CLV_PCSK_KEX2_1	635	637	PF00082	0.718
CLV_PCSK_KEX2_1	66	68	PF00082	0.348
CLV_PCSK_KEX2_1	755	757	PF00082	0.564
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.597
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.303
CLV_PCSK_SKI1_1	119	123	PF00082	0.348
CLV_PCSK_SKI1_1	235	239	PF00082	0.338
CLV_PCSK_SKI1_1	490	494	PF00082	0.428
CLV_PCSK_SKI1_1	508	512	PF00082	0.563
CLV_PCSK_SKI1_1	63	67	PF00082	0.296
CLV_PCSK_SKI1_1	736	740	PF00082	0.765
CLV_Separin_Metazoa	203	207	PF03568	0.548
DEG_APCC_DBOX_1	149	157	PF00400	0.621
DEG_SCF_FBW7_1	524	529	PF00400	0.601
DEG_SPOP_SBC_1	384	388	PF00917	0.391
DOC_ANK_TNKS_1	621	628	PF00023	0.611
DOC_CYCLIN_RxL_1	232	243	PF00134	0.548
DOC_MAPK_gen_1	449	459	PF00069	0.572
DOC_MAPK_gen_1	477	485	PF00069	0.532
DOC_MAPK_gen_1	490	500	PF00069	0.354
DOC_MAPK_gen_1	733	743	PF00069	0.663
DOC_MAPK_MEF2A_6	452	461	PF00069	0.551
DOC_MAPK_RevD_3	169	183	PF00069	0.546
DOC_PP2B_LxvP_1	286	289	PF13499	0.485
DOC_PP2B_LxvP_1	555	558	PF13499	0.554
DOC_PP2B_PxIxI_1	128	134	PF00149	0.413
DOC_PP4_FxxP_1	201	204	PF00568	0.548
DOC_PP4_FxxP_1	297	300	PF00568	0.489
DOC_USP7_MATH_1	161	165	PF00917	0.557
DOC_USP7_MATH_1	289	293	PF00917	0.480
DOC_USP7_MATH_1	313	317	PF00917	0.586
DOC_USP7_MATH_1	371	375	PF00917	0.767
DOC_USP7_MATH_1	420	424	PF00917	0.537
DOC_USP7_MATH_1	5	9	PF00917	0.522
DOC_USP7_MATH_1	548	552	PF00917	0.716
DOC_USP7_MATH_1	597	601	PF00917	0.630
DOC_USP7_MATH_1	612	616	PF00917	0.745
DOC_USP7_MATH_1	698	702	PF00917	0.743
DOC_USP7_MATH_1	718	722	PF00917	0.697
DOC_USP7_UBL2_3	505	509	PF12436	0.352
DOC_WW_Pin1_4	125	130	PF00397	0.427
DOC_WW_Pin1_4	369	374	PF00397	0.554
DOC_WW_Pin1_4	40	45	PF00397	0.548
DOC_WW_Pin1_4	463	468	PF00397	0.505
DOC_WW_Pin1_4	522	527	PF00397	0.709
DOC_WW_Pin1_4	699	704	PF00397	0.735
DOC_WW_Pin1_4	761	766	PF00397	0.512
DOC_WW_Pin1_4	83	88	PF00397	0.576
LIG_14-3-3_CanoR_1	193	198	PF00244	0.548
LIG_14-3-3_CanoR_1	291	300	PF00244	0.480
LIG_14-3-3_CanoR_1	442	450	PF00244	0.598
LIG_14-3-3_CanoR_1	519	525	PF00244	0.533
LIG_APCC_ABBAyCdc20_2	250	256	PF00400	0.548
LIG_BIR_II_1	1	5	PF00653	0.546
LIG_BIR_III_2	542	546	PF00653	0.539
LIG_BRCT_BRCA1_1	219	223	PF00533	0.548
LIG_BRCT_BRCA1_1	293	297	PF00533	0.465
LIG_BRCT_BRCA1_1	414	418	PF00533	0.489
LIG_CSL_BTD_1	750	753	PF09270	0.619
LIG_deltaCOP1_diTrp_1	438	443	PF00928	0.390
LIG_eIF4E_1	232	238	PF01652	0.548
LIG_FHA_1	126	132	PF00498	0.448
LIG_FHA_1	174	180	PF00498	0.524
LIG_FHA_1	283	289	PF00498	0.481
LIG_FHA_1	41	47	PF00498	0.430
LIG_FHA_1	725	731	PF00498	0.749
LIG_FHA_1	738	744	PF00498	0.569
LIG_FHA_2	400	406	PF00498	0.632
LIG_FHA_2	706	712	PF00498	0.678
LIG_LIR_Apic_2	294	300	PF02991	0.476
LIG_LIR_Apic_2	327	332	PF02991	0.475
LIG_LIR_Gen_1	139	149	PF02991	0.548
LIG_LIR_Gen_1	25	36	PF02991	0.548
LIG_LIR_Gen_1	438	446	PF02991	0.488
LIG_LIR_Gen_1	603	613	PF02991	0.657
LIG_LIR_LC3C_4	43	47	PF02991	0.413
LIG_LIR_Nem_3	139	145	PF02991	0.506
LIG_LIR_Nem_3	25	31	PF02991	0.548
LIG_LIR_Nem_3	376	382	PF02991	0.756
LIG_LIR_Nem_3	387	393	PF02991	0.453
LIG_LIR_Nem_3	438	443	PF02991	0.477
LIG_LIR_Nem_3	603	608	PF02991	0.654
LIG_PCNA_PIPBox_1	706	715	PF02747	0.676
LIG_SH2_NCK_1	28	32	PF00017	0.548
LIG_SH2_PTP2	142	145	PF00017	0.548
LIG_SH2_SRC	142	145	PF00017	0.518
LIG_SH2_STAP1	259	263	PF00017	0.548
LIG_SH2_STAP1	446	450	PF00017	0.592
LIG_SH2_STAT3	479	482	PF00017	0.605
LIG_SH2_STAT5	142	145	PF00017	0.548
LIG_SH2_STAT5	390	393	PF00017	0.417
LIG_SH3_3	168	174	PF00018	0.548
LIG_SH3_3	400	406	PF00018	0.568
LIG_SH3_3	480	486	PF00018	0.556
LIG_SH3_3	53	59	PF00018	0.548
LIG_SH3_3	538	544	PF00018	0.773
LIG_SH3_3	725	731	PF00018	0.528
LIG_SH3_3	747	753	PF00018	0.705
LIG_SH3_4	280	287	PF00018	0.482
LIG_SUMO_SIM_anti_2	456	461	PF11976	0.542
LIG_SUMO_SIM_anti_2	564	569	PF11976	0.560
LIG_SUMO_SIM_par_1	284	290	PF11976	0.489
LIG_SUMO_SIM_par_1	561	566	PF11976	0.482
LIG_SUMO_SIM_par_1	651	658	PF11976	0.723
LIG_SUMO_SIM_par_1	726	732	PF11976	0.527
LIG_SUMO_SIM_par_1	81	86	PF11976	0.427
LIG_TRAF2_1	764	767	PF00917	0.552
MOD_CDK_SPxxK_3	83	90	PF00069	0.243
MOD_CK1_1	423	429	PF00069	0.552
MOD_CK1_1	606	612	PF00069	0.627
MOD_CK1_1	615	621	PF00069	0.697
MOD_CK1_1	729	735	PF00069	0.696
MOD_CK1_1	8	14	PF00069	0.533
MOD_CK2_1	134	140	PF00069	0.243
MOD_CK2_1	441	447	PF00069	0.601
MOD_CK2_1	720	726	PF00069	0.784
MOD_CK2_1	756	762	PF00069	0.665
MOD_Cter_Amidation	363	366	PF01082	0.568
MOD_DYRK1A_RPxSP_1	369	373	PF00069	0.554
MOD_GlcNHglycan	10	13	PF01048	0.597
MOD_GlcNHglycan	260	264	PF01048	0.414
MOD_GlcNHglycan	275	278	PF01048	0.489
MOD_GlcNHglycan	290	294	PF01048	0.500
MOD_GlcNHglycan	301	304	PF01048	0.499
MOD_GlcNHglycan	315	318	PF01048	0.370
MOD_GlcNHglycan	425	428	PF01048	0.454
MOD_GlcNHglycan	551	554	PF01048	0.774
MOD_GlcNHglycan	592	596	PF01048	0.730
MOD_GlcNHglycan	605	608	PF01048	0.635
MOD_GlcNHglycan	610	613	PF01048	0.607
MOD_GlcNHglycan	614	617	PF01048	0.693
MOD_GlcNHglycan	636	639	PF01048	0.626
MOD_GlcNHglycan	692	696	PF01048	0.630
MOD_GlcNHglycan	720	723	PF01048	0.705
MOD_GSK3_1	103	110	PF00069	0.414
MOD_GSK3_1	4	11	PF00069	0.608
MOD_GSK3_1	441	448	PF00069	0.600
MOD_GSK3_1	522	529	PF00069	0.685
MOD_GSK3_1	531	538	PF00069	0.624
MOD_GSK3_1	544	551	PF00069	0.689
MOD_GSK3_1	608	615	PF00069	0.568
MOD_GSK3_1	714	721	PF00069	0.758
MOD_N-GLC_1	663	668	PF02516	0.692
MOD_NEK2_1	217	222	PF00069	0.516
MOD_NEK2_1	412	417	PF00069	0.431
MOD_NEK2_1	460	465	PF00069	0.349
MOD_NEK2_1	608	613	PF00069	0.536
MOD_NEK2_1	91	96	PF00069	0.243
MOD_PIKK_1	385	391	PF00454	0.355
MOD_PIKK_1	93	99	PF00454	0.243
MOD_PK_1	756	762	PF00069	0.485
MOD_PKA_1	508	514	PF00069	0.409
MOD_PKA_1	634	640	PF00069	0.536
MOD_PKA_2	192	198	PF00069	0.414
MOD_PKA_2	412	418	PF00069	0.439
MOD_PKA_2	441	447	PF00069	0.568
MOD_PKA_2	634	640	PF00069	0.536
MOD_PKA_2	714	720	PF00069	0.681
MOD_PKB_1	632	640	PF00069	0.714
MOD_Plk_1	563	569	PF00069	0.444
MOD_Plk_1	736	742	PF00069	0.520
MOD_Plk_2-3	134	140	PF00069	0.243
MOD_Plk_2-3	663	669	PF00069	0.749
MOD_Plk_4	282	288	PF00069	0.479
MOD_Plk_4	49	55	PF00069	0.392
MOD_Plk_4	563	569	PF00069	0.483
MOD_ProDKin_1	125	131	PF00069	0.243
MOD_ProDKin_1	369	375	PF00069	0.557
MOD_ProDKin_1	40	46	PF00069	0.414
MOD_ProDKin_1	463	469	PF00069	0.507
MOD_ProDKin_1	522	528	PF00069	0.710
MOD_ProDKin_1	699	705	PF00069	0.734
MOD_ProDKin_1	761	767	PF00069	0.515
MOD_ProDKin_1	83	89	PF00069	0.452
MOD_SUMO_rev_2	488	495	PF00179	0.343
MOD_SUMO_rev_2	678	685	PF00179	0.693
TRG_DiLeu_BaEn_1	234	239	PF01217	0.516
TRG_DiLeu_BaEn_1	453	458	PF01217	0.551
TRG_DiLeu_BaEn_1	502	507	PF01217	0.492
TRG_DiLeu_BaEn_3	744	750	PF01217	0.544
TRG_DiLeu_BaEn_3	766	772	PF01217	0.501
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.414
TRG_ENDOCYTIC_2	142	145	PF00928	0.414
TRG_ENDOCYTIC_2	254	257	PF00928	0.414
TRG_ENDOCYTIC_2	28	31	PF00928	0.414
TRG_ER_diArg_1	249	252	PF00400	0.422
TRG_ER_diArg_1	393	396	PF00400	0.487
TRG_ER_diArg_1	570	573	PF00400	0.563
TRG_ER_diArg_1	631	634	PF00400	0.720
TRG_NLS_MonoExtC_3	364	369	PF00514	0.799
TRG_NLS_MonoExtN_4	365	370	PF00514	0.607
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	396	401	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	646	651	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	707	711	PF00026	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEU7	Leptomonas seymouri	50%	97%
A0A3S5H795	Leishmania donovani	85%	100%
A4HBQ9	Leishmania braziliensis	72%	100%
A4HZ61	Leishmania infantum	80%	98%
E8NHQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QCF3	Leishmania major	78%	100%