Putative RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA helicase, putative

Species:

Leishmania mexicana

UniProt:

E9AV28_LEIMU

TriTrypDb:

LmxM.21.0610

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AV28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV28

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.741
CLV_C14_Caspase3-7	331	335	PF00656	0.590
CLV_C14_Caspase3-7	562	566	PF00656	0.370
CLV_C14_Caspase3-7	7	11	PF00656	0.619
CLV_MEL_PAP_1	307	313	PF00089	0.390
CLV_NRD_NRD_1	16	18	PF00675	0.678
CLV_NRD_NRD_1	243	245	PF00675	0.712
CLV_NRD_NRD_1	316	318	PF00675	0.383
CLV_NRD_NRD_1	325	327	PF00675	0.407
CLV_NRD_NRD_1	52	54	PF00675	0.561
CLV_PCSK_FUR_1	14	18	PF00082	0.631
CLV_PCSK_KEX2_1	16	18	PF00082	0.698
CLV_PCSK_KEX2_1	238	240	PF00082	0.622
CLV_PCSK_KEX2_1	316	318	PF00082	0.383
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.622
CLV_PCSK_SKI1_1	101	105	PF00082	0.253
CLV_PCSK_SKI1_1	130	134	PF00082	0.350
CLV_PCSK_SKI1_1	139	143	PF00082	0.350
CLV_PCSK_SKI1_1	165	169	PF00082	0.236
CLV_PCSK_SKI1_1	316	320	PF00082	0.386
CLV_PCSK_SKI1_1	397	401	PF00082	0.471
CLV_PCSK_SKI1_1	420	424	PF00082	0.442
CLV_PCSK_SKI1_1	477	481	PF00082	0.313
CLV_PCSK_SKI1_1	528	532	PF00082	0.355
CLV_PCSK_SKI1_1	551	555	PF00082	0.396
CLV_PCSK_SKI1_1	649	653	PF00082	0.592
CLV_PCSK_SKI1_1	71	75	PF00082	0.558
DEG_SPOP_SBC_1	468	472	PF00917	0.549
DOC_CYCLIN_RxL_1	127	135	PF00134	0.519
DOC_CYCLIN_RxL_1	508	519	PF00134	0.453
DOC_CYCLIN_RxL_1	646	654	PF00134	0.532
DOC_CYCLIN_yClb1_LxF_4	319	325	PF00134	0.388
DOC_CYCLIN_yClb5_NLxxxL_5	639	648	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	644	650	PF00134	0.452
DOC_MAPK_gen_1	16	27	PF00069	0.555
DOC_MAPK_gen_1	174	182	PF00069	0.382
DOC_MAPK_gen_1	316	324	PF00069	0.411
DOC_MAPK_gen_1	545	555	PF00069	0.574
DOC_MAPK_gen_1	625	633	PF00069	0.617
DOC_MAPK_MEF2A_6	174	182	PF00069	0.466
DOC_MAPK_MEF2A_6	625	633	PF00069	0.607
DOC_PP1_RVXF_1	410	417	PF00149	0.351
DOC_PP1_RVXF_1	46	52	PF00149	0.602
DOC_PP1_RVXF_1	509	516	PF00149	0.453
DOC_PP2B_LxvP_1	524	527	PF13499	0.453
DOC_PP4_FxxP_1	668	671	PF00568	0.357
DOC_USP7_MATH_1	265	269	PF00917	0.758
DOC_USP7_MATH_1	328	332	PF00917	0.427
DOC_USP7_MATH_1	467	471	PF00917	0.728
DOC_USP7_MATH_1	530	534	PF00917	0.538
DOC_USP7_MATH_1	586	590	PF00917	0.629
DOC_USP7_MATH_1	606	610	PF00917	0.700
DOC_USP7_MATH_1	612	616	PF00917	0.484
DOC_USP7_MATH_1	66	70	PF00917	0.390
DOC_USP7_UBL2_3	170	174	PF12436	0.406
DOC_USP7_UBL2_3	319	323	PF12436	0.426
DOC_USP7_UBL2_3	451	455	PF12436	0.743
DOC_USP7_UBL2_3	456	460	PF12436	0.654
DOC_USP7_UBL2_3	628	632	PF12436	0.624
DOC_USP7_UBL2_3	81	85	PF12436	0.406
DOC_WW_Pin1_4	288	293	PF00397	0.504
LIG_14-3-3_CanoR_1	239	246	PF00244	0.742
LIG_14-3-3_CanoR_1	310	318	PF00244	0.529
LIG_14-3-3_CanoR_1	395	403	PF00244	0.438
LIG_14-3-3_CanoR_1	477	486	PF00244	0.535
LIG_14-3-3_CanoR_1	539	549	PF00244	0.470
LIG_14-3-3_CanoR_1	669	678	PF00244	0.504
LIG_Actin_WH2_2	164	181	PF00022	0.521
LIG_Actin_WH2_2	307	325	PF00022	0.439
LIG_APCC_ABBA_1	379	384	PF00400	0.461
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_BRCT_BRCA1_1	532	536	PF00533	0.550
LIG_EH_1	621	625	PF12763	0.449
LIG_FHA_1	162	168	PF00498	0.453
LIG_FHA_1	175	181	PF00498	0.453
LIG_FHA_1	20	26	PF00498	0.539
LIG_FHA_1	387	393	PF00498	0.465
LIG_FHA_1	398	404	PF00498	0.413
LIG_FHA_1	541	547	PF00498	0.519
LIG_FHA_1	569	575	PF00498	0.558
LIG_FHA_1	77	83	PF00498	0.474
LIG_FHA_2	219	225	PF00498	0.610
LIG_FHA_2	33	39	PF00498	0.553
LIG_FHA_2	421	427	PF00498	0.515
LIG_FHA_2	514	520	PF00498	0.550
LIG_FHA_2	560	566	PF00498	0.428
LIG_FHA_2	684	690	PF00498	0.534
LIG_GBD_Chelix_1	196	204	PF00786	0.240
LIG_Integrin_isoDGR_2	105	107	PF01839	0.350
LIG_Integrin_isoDGR_2	410	412	PF01839	0.534
LIG_LIR_Apic_2	120	126	PF02991	0.453
LIG_LIR_Gen_1	34	45	PF02991	0.438
LIG_LIR_Gen_1	514	523	PF02991	0.478
LIG_LIR_Gen_1	86	97	PF02991	0.278
LIG_LIR_LC3C_4	615	620	PF02991	0.479
LIG_LIR_Nem_3	34	40	PF02991	0.411
LIG_LIR_Nem_3	514	518	PF02991	0.453
LIG_LIR_Nem_3	86	92	PF02991	0.522
LIG_Pex14_2	150	154	PF04695	0.453
LIG_RPA_C_Fungi	48	60	PF08784	0.547
LIG_SH2_CRK	100	104	PF00017	0.296
LIG_SH2_CRK	123	127	PF00017	0.296
LIG_SH2_CRK	369	373	PF00017	0.403
LIG_SH2_CRK	626	630	PF00017	0.569
LIG_SH2_NCK_1	626	630	PF00017	0.569
LIG_SH2_STAT3	367	370	PF00017	0.384
LIG_SH2_STAT3	685	688	PF00017	0.532
LIG_SH2_STAT5	345	348	PF00017	0.326
LIG_SH2_STAT5	626	629	PF00017	0.574
LIG_SH2_STAT5	685	688	PF00017	0.512
LIG_SH3_3	543	549	PF00018	0.388
LIG_SH3_3	60	66	PF00018	0.452
LIG_SH3_3	617	623	PF00018	0.416
LIG_SH3_3	628	634	PF00018	0.522
LIG_SH3_4	628	635	PF00018	0.580
LIG_SUMO_SIM_par_1	370	376	PF11976	0.479
LIG_SUMO_SIM_par_1	519	525	PF11976	0.182
LIG_TRAF2_1	222	225	PF00917	0.676
LIG_TRAF2_1	253	256	PF00917	0.720
LIG_TRAF2_1	686	689	PF00917	0.482
LIG_UBA3_1	321	327	PF00899	0.392
MOD_CK1_1	117	123	PF00069	0.296
MOD_CK1_1	2	8	PF00069	0.712
MOD_CK1_1	470	476	PF00069	0.470
MOD_CK1_1	559	565	PF00069	0.361
MOD_CK1_1	601	607	PF00069	0.675
MOD_CK1_1	69	75	PF00069	0.550
MOD_CK2_1	163	169	PF00069	0.312
MOD_CK2_1	203	209	PF00069	0.328
MOD_CK2_1	218	224	PF00069	0.605
MOD_CK2_1	420	426	PF00069	0.516
MOD_CK2_1	49	55	PF00069	0.567
MOD_CK2_1	658	664	PF00069	0.510
MOD_CK2_1	683	689	PF00069	0.546
MOD_Cter_Amidation	172	175	PF01082	0.272
MOD_Cter_Amidation	235	238	PF01082	0.714
MOD_Cter_Amidation	314	317	PF01082	0.383
MOD_Cter_Amidation	453	456	PF01082	0.740
MOD_GlcNHglycan	116	119	PF01048	0.314
MOD_GlcNHglycan	241	244	PF01048	0.734
MOD_GlcNHglycan	311	314	PF01048	0.607
MOD_GlcNHglycan	375	378	PF01048	0.640
MOD_GlcNHglycan	448	451	PF01048	0.767
MOD_GlcNHglycan	460	463	PF01048	0.728
MOD_GlcNHglycan	588	591	PF01048	0.702
MOD_GlcNHglycan	600	603	PF01048	0.638
MOD_GlcNHglycan	634	637	PF01048	0.404
MOD_GSK3_1	110	117	PF00069	0.296
MOD_GSK3_1	397	404	PF00069	0.433
MOD_GSK3_1	437	444	PF00069	0.693
MOD_GSK3_1	513	520	PF00069	0.433
MOD_GSK3_1	597	604	PF00069	0.576
MOD_GSK3_1	69	76	PF00069	0.575
MOD_LATS_1	112	118	PF00433	0.296
MOD_LATS_1	137	143	PF00433	0.178
MOD_N-GLC_1	328	333	PF02516	0.463
MOD_NEK2_1	200	205	PF00069	0.332
MOD_NEK2_1	386	391	PF00069	0.557
MOD_NEK2_1	429	434	PF00069	0.567
MOD_NEK2_1	49	54	PF00069	0.636
MOD_NEK2_1	522	527	PF00069	0.181
MOD_NEK2_1	624	629	PF00069	0.565
MOD_NEK2_1	75	80	PF00069	0.529
MOD_NEK2_1	83	88	PF00069	0.403
MOD_NEK2_2	612	617	PF00069	0.502
MOD_NEK2_2	66	71	PF00069	0.392
MOD_OFUCOSY	385	390	PF10250	0.420
MOD_PKA_1	16	22	PF00069	0.593
MOD_PKA_1	174	180	PF00069	0.276
MOD_PKA_2	16	22	PF00069	0.623
MOD_PKA_2	309	315	PF00069	0.396
MOD_PKA_2	442	448	PF00069	0.500
MOD_PKA_2	624	630	PF00069	0.592
MOD_PKB_1	14	22	PF00069	0.475
MOD_PKB_1	395	403	PF00069	0.321
MOD_Plk_1	303	309	PF00069	0.392
MOD_Plk_1	33	39	PF00069	0.400
MOD_Plk_1	404	410	PF00069	0.586
MOD_Plk_1	559	565	PF00069	0.365
MOD_Plk_4	163	169	PF00069	0.312
MOD_Plk_4	21	27	PF00069	0.536
MOD_Plk_4	290	296	PF00069	0.257
MOD_Plk_4	470	476	PF00069	0.563
MOD_Plk_4	517	523	PF00069	0.363
MOD_Plk_4	532	538	PF00069	0.231
MOD_Plk_4	559	565	PF00069	0.429
MOD_ProDKin_1	288	294	PF00069	0.504
TRG_DiLeu_BaEn_1	129	134	PF01217	0.432
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.411
TRG_DiLeu_BaLyEn_6	398	403	PF01217	0.405
TRG_ENDOCYTIC_2	100	103	PF00928	0.296
TRG_ENDOCYTIC_2	368	371	PF00928	0.381
TRG_ER_diArg_1	14	17	PF00400	0.629
TRG_ER_diArg_1	316	318	PF00400	0.363
TRG_NLS_MonoCore_2	237	242	PF00514	0.694
TRG_NLS_MonoExtC_3	16	21	PF00514	0.658
TRG_NLS_MonoExtC_3	236	241	PF00514	0.694
TRG_NLS_MonoExtN_4	14	21	PF00514	0.716
TRG_NLS_MonoExtN_4	237	242	PF00514	0.662
TRG_Pf-PMV_PEXEL_1	130	135	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	401	405	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	477	482	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P856	Leptomonas seymouri	64%	100%
A0A0S4J214	Bodo saltans	46%	100%
A0A1X0NXJ9	Trypanosomatidae	48%	100%
A0A3R7MLR3	Trypanosoma rangeli	50%	100%
A0A3S7WWF8	Leishmania donovani	90%	99%
A4HBQ8	Leishmania braziliensis	80%	100%
A4HZ60	Leishmania infantum	90%	99%
D0A1I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
Q4QCF4	Leishmania major	90%	100%
V5BDT6	Trypanosoma cruzi	48%	100%