Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV27_LEIMU

TriTrypDb:

LmxM.21.0600

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AV27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	153	159	PF00089	0.325
CLV_NRD_NRD_1	155	157	PF00675	0.314
CLV_NRD_NRD_1	7	9	PF00675	0.458
CLV_PCSK_KEX2_1	155	157	PF00082	0.314
CLV_PCSK_SKI1_1	298	302	PF00082	0.508
CLV_PCSK_SKI1_1	314	318	PF00082	0.434
CLV_PCSK_SKI1_1	378	382	PF00082	0.499
CLV_PCSK_SKI1_1	420	424	PF00082	0.425
CLV_Separin_Metazoa	11	15	PF03568	0.465
DEG_Nend_Nbox_1	1	3	PF02207	0.450
DOC_CKS1_1	405	410	PF01111	0.560
DOC_CKS1_1	439	444	PF01111	0.437
DOC_MAPK_gen_1	155	163	PF00069	0.325
DOC_MAPK_gen_1	8	15	PF00069	0.430
DOC_MAPK_gen_1	89	98	PF00069	0.439
DOC_MAPK_MEF2A_6	307	315	PF00069	0.523
DOC_USP7_MATH_1	190	194	PF00917	0.664
DOC_USP7_MATH_1	239	243	PF00917	0.470
DOC_WW_Pin1_4	401	406	PF00397	0.647
DOC_WW_Pin1_4	438	443	PF00397	0.423
LIG_14-3-3_CanoR_1	155	163	PF00244	0.536
LIG_14-3-3_CanoR_1	248	253	PF00244	0.602
LIG_14-3-3_CanoR_1	273	283	PF00244	0.421
LIG_14-3-3_CanoR_1	91	96	PF00244	0.421
LIG_FHA_1	167	173	PF00498	0.566
LIG_FHA_1	263	269	PF00498	0.501
LIG_FHA_1	55	61	PF00498	0.423
LIG_FHA_1	99	105	PF00498	0.299
LIG_FHA_2	115	121	PF00498	0.484
LIG_FHA_2	227	233	PF00498	0.567
LIG_FHA_2	249	255	PF00498	0.557
LIG_FHA_2	330	336	PF00498	0.487
LIG_FHA_2	339	345	PF00498	0.411
LIG_FHA_2	76	82	PF00498	0.469
LIG_Integrin_isoDGR_2	82	84	PF01839	0.561
LIG_LIR_Gen_1	177	184	PF02991	0.438
LIG_LIR_Gen_1	269	276	PF02991	0.554
LIG_LIR_Gen_1	421	431	PF02991	0.460
LIG_LIR_Nem_3	127	132	PF02991	0.475
LIG_LIR_Nem_3	133	138	PF02991	0.424
LIG_LIR_Nem_3	140	146	PF02991	0.399
LIG_LIR_Nem_3	177	182	PF02991	0.491
LIG_LIR_Nem_3	269	274	PF02991	0.588
LIG_LIR_Nem_3	421	426	PF02991	0.499
LIG_NRBOX	296	302	PF00104	0.451
LIG_NRBOX	357	363	PF00104	0.401
LIG_PAM2_1	52	64	PF00658	0.485
LIG_Pex14_1	139	143	PF04695	0.422
LIG_Pex14_1	252	256	PF04695	0.548
LIG_SH2_CRK	143	147	PF00017	0.493
LIG_SH2_CRK	179	183	PF00017	0.442
LIG_SH2_NCK_1	179	183	PF00017	0.442
LIG_SH2_PTP2	271	274	PF00017	0.559
LIG_SH2_SRC	135	138	PF00017	0.297
LIG_SH2_STAT5	271	274	PF00017	0.588
LIG_SH2_STAT5	329	332	PF00017	0.432
LIG_SH2_STAT5	74	77	PF00017	0.360
LIG_SH3_3	233	239	PF00018	0.360
LIG_SH3_3	333	339	PF00018	0.338
LIG_SH3_3	399	405	PF00018	0.674
LIG_SH3_3	436	442	PF00018	0.442
LIG_SUMO_SIM_par_1	158	164	PF11976	0.438
LIG_TRAF2_1	117	120	PF00917	0.450
LIG_TRAF2_1	251	254	PF00917	0.552
LIG_TYR_ITSM	139	146	PF00017	0.493
LIG_TYR_ITSM	175	182	PF00017	0.470
MOD_CK1_1	159	165	PF00069	0.529
MOD_CK1_1	166	172	PF00069	0.490
MOD_CK1_1	193	199	PF00069	0.588
MOD_CK1_1	291	297	PF00069	0.435
MOD_CK1_1	337	343	PF00069	0.508
MOD_CK1_1	391	397	PF00069	0.648
MOD_CK1_1	404	410	PF00069	0.479
MOD_CK2_1	114	120	PF00069	0.502
MOD_CK2_1	248	254	PF00069	0.564
MOD_CK2_1	29	35	PF00069	0.355
MOD_CK2_1	290	296	PF00069	0.487
MOD_CK2_1	329	335	PF00069	0.474
MOD_CK2_1	338	344	PF00069	0.416
MOD_CK2_1	75	81	PF00069	0.446
MOD_Cter_Amidation	6	9	PF01082	0.462
MOD_GlcNHglycan	143	146	PF01048	0.432
MOD_GlcNHglycan	165	168	PF01048	0.511
MOD_GlcNHglycan	188	191	PF01048	0.643
MOD_GlcNHglycan	192	195	PF01048	0.633
MOD_GlcNHglycan	199	202	PF01048	0.572
MOD_GlcNHglycan	207	211	PF01048	0.388
MOD_GlcNHglycan	241	244	PF01048	0.493
MOD_GlcNHglycan	293	296	PF01048	0.451
MOD_GlcNHglycan	335	339	PF01048	0.404
MOD_GlcNHglycan	374	377	PF01048	0.559
MOD_GlcNHglycan	46	49	PF01048	0.458
MOD_GSK3_1	137	144	PF00069	0.455
MOD_GSK3_1	155	162	PF00069	0.516
MOD_GSK3_1	174	181	PF00069	0.351
MOD_GSK3_1	182	189	PF00069	0.616
MOD_GSK3_1	193	200	PF00069	0.628
MOD_GSK3_1	202	209	PF00069	0.419
MOD_GSK3_1	287	294	PF00069	0.445
MOD_GSK3_1	334	341	PF00069	0.463
MOD_GSK3_1	40	47	PF00069	0.595
MOD_GSK3_1	400	407	PF00069	0.622
MOD_LATS_1	154	160	PF00433	0.332
MOD_N-GLC_1	98	103	PF02516	0.277
MOD_NEK2_1	161	166	PF00069	0.434
MOD_NEK2_1	262	267	PF00069	0.467
MOD_NEK2_1	40	45	PF00069	0.518
MOD_NEK2_1	75	80	PF00069	0.476
MOD_NEK2_1	98	103	PF00069	0.316
MOD_NEK2_2	309	314	PF00069	0.435
MOD_NEK2_2	329	334	PF00069	0.299
MOD_PIKK_1	106	112	PF00454	0.446
MOD_PIKK_1	193	199	PF00454	0.635
MOD_PIKK_1	274	280	PF00454	0.439
MOD_PK_1	156	162	PF00069	0.323
MOD_PK_1	29	35	PF00069	0.300
MOD_PK_1	91	97	PF00069	0.418
MOD_PKA_1	155	161	PF00069	0.323
MOD_PKA_2	141	147	PF00069	0.425
MOD_PKA_2	155	161	PF00069	0.514
MOD_PKA_2	186	192	PF00069	0.492
MOD_PKA_2	247	253	PF00069	0.606
MOD_PKA_2	262	268	PF00069	0.376
MOD_PKA_2	274	280	PF00069	0.473
MOD_Plk_1	287	293	PF00069	0.380
MOD_Plk_2-3	114	120	PF00069	0.502
MOD_Plk_4	156	162	PF00069	0.625
MOD_Plk_4	29	35	PF00069	0.300
MOD_Plk_4	338	344	PF00069	0.597
MOD_Plk_4	91	97	PF00069	0.467
MOD_ProDKin_1	401	407	PF00069	0.638
MOD_ProDKin_1	438	444	PF00069	0.438
TRG_DiLeu_BaEn_1	11	16	PF01217	0.462
TRG_DiLeu_BaEn_1	296	301	PF01217	0.490
TRG_DiLeu_BaEn_1	353	358	PF01217	0.425
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.538
TRG_DiLeu_LyEn_5	11	16	PF01217	0.462
TRG_ENDOCYTIC_2	135	138	PF00928	0.485
TRG_ENDOCYTIC_2	143	146	PF00928	0.486
TRG_ENDOCYTIC_2	179	182	PF00928	0.505
TRG_ENDOCYTIC_2	271	274	PF00928	0.591
TRG_ENDOCYTIC_2	74	77	PF00928	0.387
TRG_ER_diArg_1	155	157	PF00400	0.314
TRG_ER_diArg_1	272	275	PF00400	0.580
TRG_Pf-PMV_PEXEL_1	298	303	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM65	Leptomonas seymouri	37%	74%
A0A3S7WWF0	Leishmania donovani	90%	84%
A4HBQ7	Leishmania braziliensis	73%	100%
A4HZ59	Leishmania infantum	89%	84%
Q4QCF5	Leishmania major	90%	100%