Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AV26_LEIMU

TriTrypDb:

LmxM.21.0590

Length:

384

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AV26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV26

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	346	350	PF00656	0.571
CLV_NRD_NRD_1	258	260	PF00675	0.595
CLV_NRD_NRD_1	299	301	PF00675	0.637
CLV_NRD_NRD_1	364	366	PF00675	0.572
CLV_NRD_NRD_1	381	383	PF00675	0.560
CLV_PCSK_KEX2_1	260	262	PF00082	0.599
CLV_PCSK_KEX2_1	299	301	PF00082	0.637
CLV_PCSK_KEX2_1	343	345	PF00082	0.610
CLV_PCSK_KEX2_1	366	368	PF00082	0.558
CLV_PCSK_KEX2_1	381	383	PF00082	0.570
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.569
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.610
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.550
CLV_PCSK_SKI1_1	276	280	PF00082	0.685
DEG_SPOP_SBC_1	47	51	PF00917	0.643
DOC_CKS1_1	122	127	PF01111	0.483
DOC_CKS1_1	71	76	PF01111	0.585
DOC_MAPK_gen_1	259	268	PF00069	0.648
DOC_MAPK_gen_1	299	308	PF00069	0.607
DOC_PP2B_LxvP_1	236	239	PF13499	0.467
DOC_PP4_FxxP_1	106	109	PF00568	0.485
DOC_USP7_MATH_1	173	177	PF00917	0.706
DOC_USP7_MATH_1	20	24	PF00917	0.548
DOC_USP7_MATH_1	205	209	PF00917	0.655
DOC_USP7_MATH_1	316	320	PF00917	0.668
DOC_USP7_MATH_1	46	50	PF00917	0.639
DOC_WW_Pin1_4	121	126	PF00397	0.485
DOC_WW_Pin1_4	201	206	PF00397	0.522
DOC_WW_Pin1_4	70	75	PF00397	0.585
LIG_14-3-3_CanoR_1	203	211	PF00244	0.662
LIG_14-3-3_CanoR_1	222	227	PF00244	0.426
LIG_14-3-3_CanoR_1	259	268	PF00244	0.651
LIG_14-3-3_CanoR_1	299	309	PF00244	0.722
LIG_14-3-3_CanoR_1	4	14	PF00244	0.598
LIG_APCC_ABBA_1	333	338	PF00400	0.556
LIG_FHA_1	118	124	PF00498	0.642
LIG_FHA_1	178	184	PF00498	0.578
LIG_FHA_1	185	191	PF00498	0.451
LIG_FHA_1	26	32	PF00498	0.664
LIG_FHA_1	301	307	PF00498	0.714
LIG_FHA_1	346	352	PF00498	0.488
LIG_FHA_2	122	128	PF00498	0.513
LIG_FHA_2	229	235	PF00498	0.457
LIG_FHA_2	52	58	PF00498	0.592
LIG_LIR_Apic_2	105	109	PF02991	0.512
LIG_LIR_Gen_1	220	230	PF02991	0.482
LIG_LIR_Nem_3	220	226	PF02991	0.478
LIG_LIR_Nem_3	244	249	PF02991	0.557
LIG_LIR_Nem_3	371	377	PF02991	0.657
LIG_LYPXL_yS_3	246	249	PF13949	0.541
LIG_NRP_CendR_1	381	384	PF00754	0.637
LIG_PCNA_yPIPBox_3	153	164	PF02747	0.620
LIG_SH2_NCK_1	15	19	PF00017	0.599
LIG_SH2_STAP1	223	227	PF00017	0.444
LIG_SH2_STAT5	218	221	PF00017	0.359
LIG_SH2_STAT5	336	339	PF00017	0.712
LIG_SH2_STAT5	376	379	PF00017	0.613
LIG_SH3_1	199	205	PF00018	0.550
LIG_SH3_3	119	125	PF00018	0.681
LIG_SH3_3	199	205	PF00018	0.516
LIG_SH3_3	232	238	PF00018	0.454
LIG_SH3_3	244	250	PF00018	0.538
LIG_SH3_3	26	32	PF00018	0.579
LIG_SH3_3	303	309	PF00018	0.674
LIG_SH3_3	68	74	PF00018	0.635
LIG_SH3_3	84	90	PF00018	0.680
LIG_SUMO_SIM_par_1	113	120	PF11976	0.506
LIG_SUMO_SIM_par_1	239	244	PF11976	0.526
LIG_SUMO_SIM_par_1	27	33	PF11976	0.467
LIG_SUMO_SIM_par_1	67	73	PF11976	0.507
LIG_TYR_ITSM	242	249	PF00017	0.541
LIG_WRC_WIRS_1	223	228	PF05994	0.479
MOD_CK1_1	102	108	PF00069	0.675
MOD_CK1_1	204	210	PF00069	0.509
MOD_CK1_1	225	231	PF00069	0.496
MOD_CK1_1	317	323	PF00069	0.667
MOD_CK1_1	345	351	PF00069	0.644
MOD_CK1_1	76	82	PF00069	0.769
MOD_CK2_1	113	119	PF00069	0.766
MOD_CK2_1	121	127	PF00069	0.586
MOD_CK2_1	274	280	PF00069	0.566
MOD_CK2_1	51	57	PF00069	0.512
MOD_CK2_1	69	75	PF00069	0.508
MOD_Cter_Amidation	379	382	PF01082	0.538
MOD_GlcNHglycan	101	104	PF01048	0.572
MOD_GlcNHglycan	110	113	PF01048	0.624
MOD_GlcNHglycan	316	319	PF01048	0.677
MOD_GlcNHglycan	353	356	PF01048	0.710
MOD_GlcNHglycan	7	10	PF01048	0.755
MOD_GlcNHglycan	75	78	PF01048	0.796
MOD_GlcNHglycan	83	86	PF01048	0.790
MOD_GSK3_1	113	120	PF00069	0.752
MOD_GSK3_1	173	180	PF00069	0.574
MOD_GSK3_1	20	27	PF00069	0.650
MOD_GSK3_1	201	208	PF00069	0.522
MOD_GSK3_1	221	228	PF00069	0.365
MOD_GSK3_1	241	248	PF00069	0.628
MOD_GSK3_1	262	269	PF00069	0.593
MOD_GSK3_1	300	307	PF00069	0.600
MOD_GSK3_1	314	321	PF00069	0.678
MOD_GSK3_1	47	54	PF00069	0.667
MOD_GSK3_1	69	76	PF00069	0.687
MOD_GSK3_1	77	84	PF00069	0.742
MOD_NEK2_1	113	118	PF00069	0.507
MOD_NEK2_1	177	182	PF00069	0.571
MOD_NEK2_1	241	246	PF00069	0.559
MOD_NEK2_1	266	271	PF00069	0.683
MOD_NEK2_1	289	294	PF00069	0.708
MOD_NEK2_1	69	74	PF00069	0.787
MOD_PIKK_1	225	231	PF00454	0.486
MOD_PIKK_1	30	36	PF00454	0.463
MOD_PKA_1	259	265	PF00069	0.651
MOD_PKA_2	117	123	PF00069	0.740
MOD_PKA_2	221	227	PF00069	0.475
MOD_PKA_2	351	357	PF00069	0.663
MOD_Plk_1	274	280	PF00069	0.696
MOD_Plk_1	304	310	PF00069	0.579
MOD_Plk_4	21	27	PF00069	0.648
MOD_Plk_4	222	228	PF00069	0.446
MOD_Plk_4	241	247	PF00069	0.545
MOD_Plk_4	274	280	PF00069	0.664
MOD_ProDKin_1	121	127	PF00069	0.483
MOD_ProDKin_1	201	207	PF00069	0.512
MOD_ProDKin_1	70	76	PF00069	0.585
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.606
TRG_ENDOCYTIC_2	223	226	PF00928	0.476
TRG_ENDOCYTIC_2	246	249	PF00928	0.541
TRG_ENDOCYTIC_2	374	377	PF00928	0.543
TRG_ER_diArg_1	298	300	PF00400	0.641
TRG_ER_diArg_1	381	384	PF00400	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I5	Leptomonas seymouri	42%	80%
A0A3S7WWD4	Leishmania donovani	85%	99%
A4HBQ6	Leishmania braziliensis	62%	98%
A4HZ58	Leishmania infantum	85%	99%
Q4QCF6	Leishmania major	80%	100%