Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV25_LEIMU

TriTrypDb:

LmxM.21.0580

Length:

461

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AV25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.526
CLV_NRD_NRD_1	125	127	PF00675	0.552
CLV_NRD_NRD_1	379	381	PF00675	0.586
CLV_NRD_NRD_1	453	455	PF00675	0.536
CLV_PCSK_KEX2_1	120	122	PF00082	0.426
CLV_PCSK_KEX2_1	125	127	PF00082	0.452
CLV_PCSK_KEX2_1	379	381	PF00082	0.557
CLV_PCSK_KEX2_1	455	457	PF00082	0.589
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.589
CLV_PCSK_PC7_1	121	127	PF00082	0.466
CLV_PCSK_SKI1_1	242	246	PF00082	0.535
CLV_PCSK_SKI1_1	365	369	PF00082	0.661
CLV_PCSK_SKI1_1	447	451	PF00082	0.610
CLV_Separin_Metazoa	248	252	PF03568	0.568
DEG_APCC_DBOX_1	305	313	PF00400	0.578
DEG_Nend_UBRbox_2	1	3	PF02207	0.371
DEG_SCF_FBW7_1	211	217	PF00400	0.535
DEG_SPOP_SBC_1	166	170	PF00917	0.588
DEG_SPOP_SBC_1	179	183	PF00917	0.571
DEG_SPOP_SBC_1	280	284	PF00917	0.569
DEG_SPOP_SBC_1	75	79	PF00917	0.617
DOC_CKS1_1	211	216	PF01111	0.547
DOC_MAPK_MEF2A_6	242	249	PF00069	0.419
DOC_MAPK_NFAT4_5	242	250	PF00069	0.441
DOC_PP1_RVXF_1	421	427	PF00149	0.683
DOC_PP4_FxxP_1	255	258	PF00568	0.584
DOC_PP4_FxxP_1	409	412	PF00568	0.582
DOC_USP7_MATH_1	166	170	PF00917	0.738
DOC_USP7_MATH_1	180	184	PF00917	0.563
DOC_USP7_MATH_1	186	190	PF00917	0.725
DOC_USP7_MATH_1	203	207	PF00917	0.579
DOC_USP7_MATH_1	223	227	PF00917	0.322
DOC_USP7_MATH_1	234	238	PF00917	0.462
DOC_USP7_MATH_1	280	284	PF00917	0.666
DOC_USP7_MATH_1	297	301	PF00917	0.511
DOC_USP7_MATH_1	343	347	PF00917	0.682
DOC_USP7_MATH_1	73	77	PF00917	0.550
DOC_WW_Pin1_4	184	189	PF00397	0.620
DOC_WW_Pin1_4	201	206	PF00397	0.691
DOC_WW_Pin1_4	210	215	PF00397	0.664
DOC_WW_Pin1_4	353	358	PF00397	0.549
DOC_WW_Pin1_4	71	76	PF00397	0.540
LIG_14-3-3_CanoR_1	222	232	PF00244	0.622
LIG_14-3-3_CanoR_1	260	264	PF00244	0.615
LIG_14-3-3_CanoR_1	47	53	PF00244	0.503
LIG_APCC_ABBAyCdc20_2	242	248	PF00400	0.422
LIG_BRCT_BRCA1_1	168	172	PF00533	0.449
LIG_BRCT_BRCA1_1	251	255	PF00533	0.619
LIG_BRCT_BRCA1_1	261	265	PF00533	0.476
LIG_BRCT_BRCA1_1	355	359	PF00533	0.553
LIG_deltaCOP1_diTrp_1	91	100	PF00928	0.343
LIG_EH1_1	56	64	PF00400	0.330
LIG_FHA_1	132	138	PF00498	0.468
LIG_FHA_1	347	353	PF00498	0.585
LIG_FHA_2	136	142	PF00498	0.438
LIG_FHA_2	75	81	PF00498	0.602
LIG_LIR_Apic_2	252	258	PF02991	0.529
LIG_LIR_Gen_1	356	367	PF02991	0.550
LIG_LIR_Nem_3	356	362	PF02991	0.538
LIG_LIR_Nem_3	373	378	PF02991	0.600
LIG_LIR_Nem_3	391	397	PF02991	0.628
LIG_LIR_Nem_3	54	60	PF02991	0.337
LIG_LIR_Nem_3	91	95	PF02991	0.341
LIG_NRBOX	308	314	PF00104	0.509
LIG_PDZ_Class_3	456	461	PF00595	0.718
LIG_SH2_PTP2	354	357	PF00017	0.619
LIG_SH2_STAP1	363	367	PF00017	0.640
LIG_SH2_STAP1	394	398	PF00017	0.677
LIG_SH2_STAT3	363	366	PF00017	0.640
LIG_SH2_STAT5	246	249	PF00017	0.440
LIG_SH2_STAT5	354	357	PF00017	0.550
LIG_SH2_STAT5	394	397	PF00017	0.674
LIG_SH3_3	125	131	PF00018	0.472
LIG_SH3_3	208	214	PF00018	0.649
MOD_CK1_1	160	166	PF00069	0.652
MOD_CK1_1	170	176	PF00069	0.602
MOD_CK1_1	187	193	PF00069	0.720
MOD_CK1_1	259	265	PF00069	0.587
MOD_CK1_1	281	287	PF00069	0.588
MOD_CK1_1	346	352	PF00069	0.665
MOD_CK1_1	388	394	PF00069	0.701
MOD_CK1_1	74	80	PF00069	0.596
MOD_CK2_1	135	141	PF00069	0.394
MOD_CK2_1	230	236	PF00069	0.488
MOD_CK2_1	74	80	PF00069	0.616
MOD_Cter_Amidation	452	455	PF01082	0.586
MOD_GlcNHglycan	163	166	PF01048	0.524
MOD_GlcNHglycan	173	176	PF01048	0.545
MOD_GlcNHglycan	182	185	PF01048	0.642
MOD_GlcNHglycan	205	208	PF01048	0.651
MOD_GlcNHglycan	232	235	PF01048	0.447
MOD_GlcNHglycan	26	29	PF01048	0.434
MOD_GlcNHglycan	289	292	PF01048	0.689
MOD_GlcNHglycan	327	330	PF01048	0.680
MOD_GlcNHglycan	345	348	PF01048	0.482
MOD_GlcNHglycan	387	390	PF01048	0.656
MOD_GlcNHglycan	433	436	PF01048	0.461
MOD_GlcNHglycan	71	74	PF01048	0.603
MOD_GSK3_1	131	138	PF00069	0.488
MOD_GSK3_1	153	160	PF00069	0.666
MOD_GSK3_1	161	168	PF00069	0.620
MOD_GSK3_1	180	187	PF00069	0.603
MOD_GSK3_1	197	204	PF00069	0.592
MOD_GSK3_1	205	212	PF00069	0.625
MOD_GSK3_1	230	237	PF00069	0.445
MOD_GSK3_1	275	282	PF00069	0.549
MOD_GSK3_1	343	350	PF00069	0.621
MOD_GSK3_1	353	360	PF00069	0.480
MOD_GSK3_1	370	377	PF00069	0.635
MOD_GSK3_1	388	395	PF00069	0.673
MOD_GSK3_1	439	446	PF00069	0.721
MOD_GSK3_1	63	70	PF00069	0.468
MOD_GSK3_1	71	78	PF00069	0.590
MOD_N-GLC_1	160	165	PF02516	0.659
MOD_NEK2_1	224	229	PF00069	0.531
MOD_NEK2_1	249	254	PF00069	0.646
MOD_NEK2_1	279	284	PF00069	0.502
MOD_NEK2_1	393	398	PF00069	0.659
MOD_NEK2_1	63	68	PF00069	0.479
MOD_NEK2_2	374	379	PF00069	0.462
MOD_NEK2_2	99	104	PF00069	0.485
MOD_PIKK_1	249	255	PF00454	0.513
MOD_PIKK_1	439	445	PF00454	0.580
MOD_PKA_1	454	460	PF00069	0.603
MOD_PKA_2	12	18	PF00069	0.507
MOD_PKA_2	224	230	PF00069	0.538
MOD_PKA_2	259	265	PF00069	0.617
MOD_PKA_2	305	311	PF00069	0.687
MOD_PKA_2	370	376	PF00069	0.631
MOD_PKA_2	46	52	PF00069	0.511
MOD_PKB_1	452	460	PF00069	0.598
MOD_Plk_1	275	281	PF00069	0.566
MOD_Plk_1	439	445	PF00069	0.643
MOD_Plk_1	63	69	PF00069	0.457
MOD_Plk_4	347	353	PF00069	0.665
MOD_Plk_4	393	399	PF00069	0.692
MOD_ProDKin_1	184	190	PF00069	0.620
MOD_ProDKin_1	201	207	PF00069	0.687
MOD_ProDKin_1	210	216	PF00069	0.652
MOD_ProDKin_1	353	359	PF00069	0.541
MOD_ProDKin_1	71	77	PF00069	0.543
MOD_SUMO_for_1	145	148	PF00179	0.586
MOD_SUMO_for_1	399	402	PF00179	0.592
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.484
TRG_ENDOCYTIC_2	246	249	PF00928	0.461
TRG_ER_diArg_1	119	121	PF00400	0.528
TRG_ER_diArg_1	125	127	PF00400	0.553
TRG_ER_diArg_1	378	380	PF00400	0.542
TRG_NES_CRM1_1	307	322	PF08389	0.536
TRG_NLS_MonoExtC_3	453	458	PF00514	0.593
TRG_NLS_MonoExtN_4	452	458	PF00514	0.592
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P858	Leptomonas seymouri	52%	100%
A0A1X0NY71	Trypanosomatidae	29%	100%
A0A3Q8IL02	Leishmania donovani	91%	99%
A0A422NH97	Trypanosoma rangeli	31%	100%
A4HBQ5	Leishmania braziliensis	80%	100%
A4HZ57	Leishmania infantum	91%	99%
D0A1I3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4QCF7	Leishmania major	91%	100%
V5DEP6	Trypanosoma cruzi	30%	100%