Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV24_LEIMU

TriTrypDb:

LmxM.21.0570

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AV24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.741
CLV_NRD_NRD_1	162	164	PF00675	0.660
CLV_NRD_NRD_1	213	215	PF00675	0.680
CLV_NRD_NRD_1	267	269	PF00675	0.803
CLV_NRD_NRD_1	338	340	PF00675	0.838
CLV_NRD_NRD_1	428	430	PF00675	0.564
CLV_NRD_NRD_1	432	434	PF00675	0.595
CLV_NRD_NRD_1	52	54	PF00675	0.637
CLV_NRD_NRD_1	66	68	PF00675	0.528
CLV_PCSK_FUR_1	336	340	PF00082	0.543
CLV_PCSK_KEX2_1	213	215	PF00082	0.657
CLV_PCSK_KEX2_1	267	269	PF00082	0.780
CLV_PCSK_KEX2_1	338	340	PF00082	0.743
CLV_PCSK_KEX2_1	402	404	PF00082	0.837
CLV_PCSK_KEX2_1	432	434	PF00082	0.595
CLV_PCSK_KEX2_1	52	54	PF00082	0.637
CLV_PCSK_KEX2_1	66	68	PF00082	0.528
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.837
CLV_PCSK_SKI1_1	236	240	PF00082	0.781
CLV_PCSK_SKI1_1	299	303	PF00082	0.846
CLV_PCSK_SKI1_1	365	369	PF00082	0.577
CLV_PCSK_SKI1_1	403	407	PF00082	0.813
CLV_PCSK_SKI1_1	45	49	PF00082	0.508
CLV_PCSK_SKI1_1	92	96	PF00082	0.698
DEG_APCC_DBOX_1	87	95	PF00400	0.578
DEG_Nend_UBRbox_1	1	4	PF02207	0.705
DEG_SCF_FBW7_1	294	300	PF00400	0.619
DOC_CKS1_1	294	299	PF01111	0.556
DOC_CYCLIN_RxL_1	233	243	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	142	148	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.475
DOC_MAPK_DCC_7	141	150	PF00069	0.646
DOC_MAPK_MEF2A_6	141	150	PF00069	0.533
DOC_MAPK_RevD_3	148	164	PF00069	0.629
DOC_PP2B_LxvP_1	142	145	PF13499	0.554
DOC_PP2B_LxvP_1	358	361	PF13499	0.698
DOC_PP2B_LxvP_1	383	386	PF13499	0.637
DOC_USP7_MATH_1	240	244	PF00917	0.733
DOC_USP7_MATH_1	27	31	PF00917	0.567
DOC_USP7_MATH_1	272	276	PF00917	0.751
DOC_USP7_MATH_1	280	284	PF00917	0.780
DOC_USP7_MATH_1	318	322	PF00917	0.702
DOC_USP7_MATH_1	330	334	PF00917	0.806
DOC_USP7_MATH_1	401	405	PF00917	0.735
DOC_USP7_UBL2_3	402	406	PF12436	0.823
DOC_WW_Pin1_4	104	109	PF00397	0.593
DOC_WW_Pin1_4	247	252	PF00397	0.753
DOC_WW_Pin1_4	276	281	PF00397	0.738
DOC_WW_Pin1_4	283	288	PF00397	0.712
DOC_WW_Pin1_4	293	298	PF00397	0.699
DOC_WW_Pin1_4	331	336	PF00397	0.640
LIG_14-3-3_CanoR_1	2	8	PF00244	0.692
LIG_14-3-3_CanoR_1	224	232	PF00244	0.559
LIG_14-3-3_CanoR_1	254	263	PF00244	0.756
LIG_14-3-3_CanoR_1	267	277	PF00244	0.693
LIG_14-3-3_CanoR_1	306	314	PF00244	0.607
LIG_14-3-3_CanoR_1	317	323	PF00244	0.666
LIG_14-3-3_CanoR_1	403	409	PF00244	0.584
LIG_14-3-3_CanoR_1	45	54	PF00244	0.619
LIG_Actin_WH2_2	196	212	PF00022	0.513
LIG_Clathr_ClatBox_1	68	72	PF01394	0.630
LIG_FHA_1	126	132	PF00498	0.481
LIG_FHA_1	154	160	PF00498	0.624
LIG_FHA_1	195	201	PF00498	0.788
LIG_FHA_1	353	359	PF00498	0.496
LIG_FHA_1	380	386	PF00498	0.426
LIG_FHA_2	93	99	PF00498	0.678
LIG_LIR_Gen_1	154	162	PF02991	0.529
LIG_LIR_Gen_1	166	175	PF02991	0.534
LIG_LIR_Gen_1	366	376	PF02991	0.536
LIG_LIR_Nem_3	112	117	PF02991	0.519
LIG_LIR_Nem_3	125	130	PF02991	0.368
LIG_LIR_Nem_3	154	160	PF02991	0.522
LIG_LIR_Nem_3	166	171	PF02991	0.539
LIG_LIR_Nem_3	326	331	PF02991	0.522
LIG_LIR_Nem_3	366	371	PF02991	0.535
LIG_LIR_Nem_3	418	422	PF02991	0.552
LIG_PCNA_yPIPBox_3	406	420	PF02747	0.718
LIG_SH2_CRK	117	121	PF00017	0.532
LIG_SH2_STAT5	130	133	PF00017	0.583
LIG_SH2_STAT5	43	46	PF00017	0.518
LIG_SH2_STAT5	93	96	PF00017	0.602
LIG_SH3_2	294	299	PF14604	0.556
LIG_SH3_3	103	109	PF00018	0.589
LIG_SH3_3	141	147	PF00018	0.541
LIG_SH3_3	274	280	PF00018	0.742
LIG_SH3_3	291	297	PF00018	0.557
LIG_SUMO_SIM_par_1	146	152	PF11976	0.634
LIG_TRAF2_1	36	39	PF00917	0.541
LIG_TRAF2_1	423	426	PF00917	0.540
LIG_TYR_ITIM	115	120	PF00017	0.651
LIG_WW_3	160	164	PF00397	0.657
LIG_WW_3	179	183	PF00397	0.416
LIG_WW_3	296	300	PF00397	0.558
MOD_CDK_SPK_2	331	336	PF00069	0.640
MOD_CDK_SPxK_1	293	299	PF00069	0.558
MOD_CDK_SPxxK_3	247	254	PF00069	0.633
MOD_CDK_SPxxK_3	331	338	PF00069	0.532
MOD_CK1_1	107	113	PF00069	0.554
MOD_CK1_1	125	131	PF00069	0.480
MOD_CK1_1	215	221	PF00069	0.570
MOD_CK1_1	283	289	PF00069	0.803
MOD_CK1_1	321	327	PF00069	0.734
MOD_CK1_1	392	398	PF00069	0.676
MOD_CK1_1	404	410	PF00069	0.673
MOD_Cter_Amidation	265	268	PF01082	0.551
MOD_GlcNHglycan	124	127	PF01048	0.477
MOD_GlcNHglycan	20	23	PF01048	0.503
MOD_GlcNHglycan	214	217	PF01048	0.826
MOD_GlcNHglycan	242	245	PF01048	0.783
MOD_GlcNHglycan	257	260	PF01048	0.588
MOD_GlcNHglycan	274	277	PF01048	0.602
MOD_GlcNHglycan	29	32	PF01048	0.534
MOD_GlcNHglycan	299	302	PF01048	0.842
MOD_GlcNHglycan	3	6	PF01048	0.764
MOD_GlcNHglycan	395	398	PF01048	0.713
MOD_GlcNHglycan	403	406	PF01048	0.758
MOD_GSK3_1	100	107	PF00069	0.616
MOD_GSK3_1	205	212	PF00069	0.801
MOD_GSK3_1	23	30	PF00069	0.725
MOD_GSK3_1	240	247	PF00069	0.833
MOD_GSK3_1	266	273	PF00069	0.831
MOD_GSK3_1	276	283	PF00069	0.701
MOD_GSK3_1	285	292	PF00069	0.555
MOD_GSK3_1	293	300	PF00069	0.671
MOD_GSK3_1	317	324	PF00069	0.602
MOD_GSK3_1	389	396	PF00069	0.665
MOD_LATS_1	90	96	PF00433	0.692
MOD_NEK2_1	1	6	PF00069	0.774
MOD_NEK2_1	100	105	PF00069	0.595
MOD_NEK2_1	153	158	PF00069	0.612
MOD_NEK2_1	209	214	PF00069	0.812
MOD_NEK2_1	379	384	PF00069	0.491
MOD_PIKK_1	100	106	PF00454	0.589
MOD_PIKK_1	289	295	PF00454	0.849
MOD_PIKK_1	323	329	PF00454	0.803
MOD_PIKK_1	404	410	PF00454	0.576
MOD_PKA_1	267	273	PF00069	0.719
MOD_PKA_2	1	7	PF00069	0.726
MOD_PKA_2	212	218	PF00069	0.738
MOD_PKA_2	266	272	PF00069	0.732
MOD_PKA_2	305	311	PF00069	0.552
MOD_PKA_2	428	434	PF00069	0.577
MOD_Plk_1	379	385	PF00069	0.596
MOD_Plk_4	318	324	PF00069	0.653
MOD_ProDKin_1	104	110	PF00069	0.588
MOD_ProDKin_1	247	253	PF00069	0.748
MOD_ProDKin_1	276	282	PF00069	0.737
MOD_ProDKin_1	283	289	PF00069	0.714
MOD_ProDKin_1	293	299	PF00069	0.704
MOD_ProDKin_1	331	337	PF00069	0.642
MOD_SUMO_rev_2	185	191	PF00179	0.597
TRG_ENDOCYTIC_2	117	120	PF00928	0.641
TRG_ENDOCYTIC_2	168	171	PF00928	0.637
TRG_ER_diArg_1	223	226	PF00400	0.732
TRG_ER_diArg_1	335	338	PF00400	0.796
TRG_ER_diArg_1	52	54	PF00400	0.534
TRG_ER_diArg_1	65	67	PF00400	0.522
TRG_NLS_MonoExtC_3	428	433	PF00514	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U2	Leptomonas seymouri	44%	100%
A0A3S7WWD6	Leishmania donovani	87%	100%
A4HBQ4	Leishmania braziliensis	77%	100%
A4HZ56	Leishmania infantum	87%	100%
Q4QCF8	Leishmania major	86%	100%